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Conserved domains on  [gi|56243590|ref|NP_060853|]
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pre-mRNA 3' end processing protein WDR33 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-402 1.51e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.51e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNN-VKMFQ 199
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQ 279
Cdd:cd00200   91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT--IKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  280 SLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLLFW 359
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVW 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 56243590  360 HVGVEKEVGGMEmAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:cd00200  247 DLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 618-864 3.92e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 3.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   618 GPPGPQGQFRPPGPQGQMGPQGPPlhqggggPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQrhpgphgplgpqgppgpqg 697
Cdd:NF038329  123 GPAGPAGPAGEQGPRGDRGETGPA-------GPAGPPGPQGERGEKGPAGPQGEAGPQGPA------------------- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   698 ssgpqghmgpqgppgpqghigpqgppGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLM 777
Cdd:NF038329  177 --------------------------GKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPA 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   778 GLNPRGMQGPPGPRENQGPApqgmimghppqemrGPHPPGgllghGPQEMRGPQEIRGMQGPPPQGSMLGPPqelrGPPG 857
Cdd:NF038329  231 GDGQQGPDGDPGPTGEDGPQ--------------GPDGPA-----GKDGPRGDRGEAGPDGPDGKDGERGPV----GPAG 287


                  ....*..
gi 56243590   858 SQSQQGP 864
Cdd:NF038329  288 KDGQNGK 294
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 556-676 2.16e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 48.65  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    556 LEQLKIERLAQKQVE--QIQPP---PSSGTPLLG---PQPFPGQGPMSQIPQ-----GFQQPHPSQQMPMnmaqmGPPGP 622
Cdd:TIGR01628  360 LAQRKEQRRAHLQDQfmQLQPRmrqLPMGSPMGGamgQPPYYGQGPQQQFNGqplgwPRMSMMPTPMGPG-----GPLRP 434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56243590    623 QGqFRPPGPQGQMGPQGPPL-HQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQG 676
Cdd:TIGR01628  435 NG-LAPMNAVRAPSRNAQNAaQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGG 488
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 796-946 5.52e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 5.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    796 PAPQGMIMGHPPQEmrGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLG-PPQELRGPPGSQSQQGPPQGSlgpppq 874
Cdd:pfam09770  211 AQQPAPAPAQPPAA--PPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGhPVTILQRPQSPQPDPAQPSIQ------ 282

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56243590    875 ggmqgppgpqGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQ-STGPPPLIPGLGQQGAQGRIPPL 946
Cdd:pfam09770  283 ----------PQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQpGVQPAPAHQAHRQQGSFGRQAPI 345
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-402 1.51e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.51e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNN-VKMFQ 199
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQ 279
Cdd:cd00200   91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT--IKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  280 SLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLLFW 359
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVW 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 56243590  360 HVGVEKEVGGMEmAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:cd00200  247 DLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
121-402 1.50e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.76  E-value: 1.50e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNN-VKMFQ 199
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKlLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQ 279
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT--VRLWDLATGE 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  280 SLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLLFW 359
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 56243590  360 HVGVEKEVGGMEmAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:COG2319  358 DLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-230 7.16e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 7.16e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 56243590     191 NMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWD 230
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 205-319 2.82e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.98  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   205 IREASFSPTDN-KFATCSDDGTVRIWDFlrcHEERI----------LRGHGADVKCVDWHPT-KGLVVSGSKDSQqpIKF 272
Cdd:PTZ00421   78 IIDVAFNPFDPqKLFTASEDGTIMGWGI---PEEGLtqnisdpivhLQGHTKKVGIVSFHPSaMNVLASAGADMV--VNV 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 56243590   273 WDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRN 319
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 618-864 3.92e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 3.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   618 GPPGPQGQFRPPGPQGQMGPQGPPlhqggggPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQrhpgphgplgpqgppgpqg 697
Cdd:NF038329  123 GPAGPAGPAGEQGPRGDRGETGPA-------GPAGPPGPQGERGEKGPAGPQGEAGPQGPA------------------- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   698 ssgpqghmgpqgppgpqghigpqgppGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLM 777
Cdd:NF038329  177 --------------------------GKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPA 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   778 GLNPRGMQGPPGPRENQGPApqgmimghppqemrGPHPPGgllghGPQEMRGPQEIRGMQGPPPQGSMLGPPqelrGPPG 857
Cdd:NF038329  231 GDGQQGPDGDPGPTGEDGPQ--------------GPDGPA-----GKDGPRGDRGEAGPDGPDGKDGERGPV----GPAG 287


                  ....*..
gi 56243590   858 SQSQQGP 864
Cdd:NF038329  288 KDGQNGK 294
WD40 pfam00400
WD domain, G-beta repeat;
195-230 7.54e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 7.54e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 56243590    195 VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWD 230
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 585-863 3.11e-07

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 54.53  E-value: 3.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   585 PQPFPGQGPmsQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPplhqggggpqgfmgpqgpqgppqg 664
Cdd:NF038329  122 PGPAGPAGP--AGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGP------------------------ 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   665 lPRPQDMHGPQGMQrhpgphgplgpqgppgpqgssgpqghmgpqgppgpqghigpqgppgpqghlGPQGPPGTQGMQGPP 744
Cdd:NF038329  176 -AGKDGEAGAKGPA---------------------------------------------------GEKGPQGPRGETGPA 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   745 GPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPlmgLNPRGMQGPPGPRENQGPAPQGmimghppqemrGPHPPGGLLGH-G 823
Cdd:NF038329  204 GEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQ---QGPDGDPGPTGEDGPQGPDGPA-----------GKDGPRGDRGEaG 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 56243590   824 PQEMRGPQEIRGMQGPPPQGSMLGPpqelRGPPGSQSQQG 863
Cdd:NF038329  270 PDGPDGKDGERGPVGPAGKDGQNGK----DGLPGKDGKDG 305
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 564-932 3.92e-07

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 54.63  E-value: 3.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    564 LAQKQVEQIQPPPSSGT--PLLGPQPFPGQGPMsqiPQGFQQPHPSQQMPMNmAQMGPPGPQG--QFRPPGPQGQMGPQG 639
Cdd:pfam09606   63 PQGGQGNGGMGGGQQGMpdPINALQNLAGQGTR---PQMMGPMGPGPGGPMG-QQMGGPGTASnlLASLGRPQMPMGGAG 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    640 PPlhqggGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGP 719
Cdd:pfam09606  139 FP-----SQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPA 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    720 QGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGI----------------QGGPGSQGIQGPVSQGPLMGLNPRG 783
Cdd:pfam09606  214 DAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGqqsqlgmginqmqqmpQGVGGGAGQGGPGQPMGPPGQQPGA 293

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    784 M------QGPPGPRENQGPAPQ----GMIMGHPPQEMRGPHPPGGLLGHGPQEM---------RGPQEIRGMQGPPPQgs 844
Cdd:pfam09606  294 MpnvmsiGDQNNYQQQQTRQQQqqqgGNHPAAHQQQMNQSVGQGGQVVALGGLNhletwnpgnFGGLGANPMQRGQPG-- 371

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    845 MLGPPQELRG-------PPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAP 917
Cdd:pfam09606  372 MMSSPSPVPGqqvrqvtPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGGS 451

                          410
                   ....*....|....*
gi 56243590    918 FNQEGQSTGPPPLIP 932
Cdd:pfam09606  452 LNTPGQSAVNSPLNP 466
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 556-676 2.16e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 48.65  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    556 LEQLKIERLAQKQVE--QIQPP---PSSGTPLLG---PQPFPGQGPMSQIPQ-----GFQQPHPSQQMPMnmaqmGPPGP 622
Cdd:TIGR01628  360 LAQRKEQRRAHLQDQfmQLQPRmrqLPMGSPMGGamgQPPYYGQGPQQQFNGqplgwPRMSMMPTPMGPG-----GPLRP 434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56243590    623 QGqFRPPGPQGQMGPQGPPL-HQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQG 676
Cdd:TIGR01628  435 NG-LAPMNAVRAPSRNAQNAaQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGG 488
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 796-946 5.52e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 5.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    796 PAPQGMIMGHPPQEmrGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLG-PPQELRGPPGSQSQQGPPQGSlgpppq 874
Cdd:pfam09770  211 AQQPAPAPAQPPAA--PPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGhPVTILQRPQSPQPDPAQPSIQ------ 282

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56243590    875 ggmqgppgpqGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQ-STGPPPLIPGLGQQGAQGRIPPL 946
Cdd:pfam09770  283 ----------PQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQpGVQPAPAHQAHRQQGSFGRQAPI 345
PHA03378 PHA03378
EBNA-3B; Provisional
 735-984 6.57e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   735 PGTQGMQGPPGPRGMQGPPHPHGIQGGPGsqgiqgPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPH 814
Cdd:PHA03378  598 PVPHPSQTPEPPTTQSHIPETSAPRQWPM------PLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGH 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   815 PPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQElrGPPGSQSqqgPPQGSLGPPPQGGMQGPPGPQGQQNPARGPH 894
Cdd:PHA03378  672 IPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPA--APPGRAQ---RPAAATGRARPPAAAPGRARPPAAAPGRARP 746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   895 PSQGPIPFQQqktPLLGDGP-RAPFNQEGQST-GPPPLIPGLGQQGAQGRIPPLNPGQ-GPGPNKGDSRGPPNHHMGPMS 971
Cdd:PHA03378  747 PAAAPGRARP---PAAAPGRaRPPAAAPGAPTpQPPPQAPPAPQQRPRGAPTPQPPPQaGPTSMQLMPRAAPGQQGPTKQ 823

                         250
                  ....*....|...
gi 56243590   972 ERRHEQSGGPEHG 984
Cdd:PHA03378  824 ILRQLLTGGVKRG 836
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
666-949 8.07e-05

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 46.95  E-value: 8.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  666 PRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMgpqgppgpqghigpqgppgpqghlGPQGPPGTQGMQGPPG 745
Cdd:COG5164   12 SDPGGVTTPAGSQGSTKPAQNQGSTRPAGNTGGTRPAQNQ------------------------GSTTPAGNTGGTRPAG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  746 PRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMG-LNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGP 824
Cdd:COG5164   68 NQGATGPAQNQGGTTPAQNQGGTRPAGNTGGTTpAGDGGATGPPDDGGATGPPDDGGSTTPPSGGSTTPPGDGGSTPPGP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  825 qemrGPQEIRGMQGPPPQGSMLGPPQE--LRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPF 902
Cdd:COG5164  148 ----GSTGPGGSTTPPGDGGSTTPPGPggSTTPPDDGGSTTPPNKGETGTDIPTGGTPRQGPDGPVKKDDKNGKGNPPDD 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 56243590  903 QQQKTPllGDGPRAPFNQEGQS--TGPPPLIPGLGQQGAQGRIPPLNPG 949
Cdd:COG5164  224 RGGKTG--PKDQRPKTNPIERRgpERPEAAALPAELTALEAENRAANPE 270
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 509-629 3.08e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 44.81  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   509 MQNKVPIPAPNEV-----------LNDRKEDIKLEEKKKTQAEIEQEMATLQ-----YTNPQLLEQLKIERLAQ------ 566
Cdd:PRK13729   38 MSGNGEAVAEQEPvpdmtgvvdttFDDKVRQHATTEMQVTAAQMQKQYEEIRreldvLNKQRGDDQRRIEKLGQdnaala 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56243590   567 KQVEQI---------QPPPSSGTPLLGPQ--PFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPP 629
Cdd:PRK13729  118 EQVKALganpvtatgEPVPQMPASPPGPEgePQPGNTPVSFPPQGSVAVPPPTAFYPGNGVTPPPQVTYQSVPV 191
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 533-643 2.90e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    533 EKKKTQAEIEQEMATLQYTNPQL------LEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHP 606
Cdd:pfam09770  167 PKKAAAPAPAPQPAAQPASLPAPsrkmmsLEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 56243590    607 sQQMPMNMAQMGPPGP-------QGQFRPPGPQGQMGPQGPPLH 643
Cdd:pfam09770  247 -QQQPQQPQQHPGQGHpvtilqrPQSPQPDPAQPSIQPQAQQFH 289
PHA03247 PHA03247
large tegument protein UL36; Provisional
 733-1027 5.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   733 GPPGTQGMQGPPGPRGMQGPPH--PHGIQGGPGsqgiQGPVSQGPLMGLNPRGMQG----------PPGPRENQGPAPQG 800
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRvsRPRRARRLG----RAAQASSPPQRPRRRAARPtvgsltsladPPPPPPTPEPAPHA 2714

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   801 MIMGHP----PQEMRGPHPP------------GGLLGHGPQEMRGPQEIRGMQGP-PPQGSMLGPPQELRGPPGSQSQQG 863
Cdd:PHA03247 2715 LVSATPlppgPAAARQASPAlpaapappavpaGPATPGGPARPARPPTTAGPPAPaPPAAPAAGPPRRLTRPAVASLSES 2794

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   864 PPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGP-------PPLIPGLGQ 936
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrPPSRSPAAK 2874

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   937 QGAQGRI-------PPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHgPERGPFRGGQdcrgPPDRRGPHPDf 1009
Cdd:PHA03247 2875 PAAPARPpvrrlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-PQPPPPPPPR----PQPPLAPTTD- 2948

                         330
                  ....*....|....*...
gi 56243590  1010 PDDFSRPDDFHPDKRFGH 1027
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGA 2966
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-402 1.51e-66

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 1.51e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNN-VKMFQ 199
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQ 279
Cdd:cd00200   91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT--IKLWDLRTGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  280 SLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLLFW 359
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVW 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 56243590  360 HVGVEKEVGGMEmAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:cd00200  247 DLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
121-402 1.50e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.76  E-value: 1.50e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNN-VKMFQ 199
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKlLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQ 279
Cdd:COG2319  202 GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT--VRLWDLATGE 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  280 SLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLLFW 359
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 56243590  360 HVGVEKEVGGMEmAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:COG2319  358 DLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
121-402 2.38e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.74  E-value: 2.38e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQ-SNMNNVKMFQ 199
Cdd:COG2319   38 AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlATGLLLRTLT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQ 279
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT--VRLWDLATGK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  280 SLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvhEG-LFASGGSDGSLLF 358
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRSVAFSP--DGrLLASGSADGTVRL 272

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 56243590  359 WHVGvEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:COG2319  273 WDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
121-361 1.94e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 1.94e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWqsNMNN---VKM 197
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATgklLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  198 FQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKT 277
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT--VRLWDLAT 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  278 GQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLL 357
Cdd:COG2319  320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVR 397


                 ....
gi 56243590  358 FWHV 361
Cdd:COG2319  398 LWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-402 4.11e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.42  E-value: 4.11e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  194 NVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFW 273
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT--IRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  274 DPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvhEGLFASGGS- 352
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSP--DGTFVASSSq 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 56243590  353 DGSLLFWHVGVEKEVGGMEmAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:cd00200  156 DGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
126-402 3.17e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 3.17e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  126 RWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHND-MWMLTADHGGYVKYWQSNMNNVKMFQAHKEA 204
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGaRLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  205 IREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQSLATL 284
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  285 HAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKeELQVFRGHKKEATAVAWHPvhEG-LFASGGSDGSLLFWHVGV 363
Cdd:COG2319  159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSP--DGkLLASGSADGTVRLWDLAT 235

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 56243590  364 EKEVGGMEmAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:COG2319  236 GKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 119-359 4.22e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 4.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  119 KCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAmtwshndmwmltadhggyvkywqsnmnnvkmf 198
Cdd:cd00200   93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS-------------------------------- 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  199 qahkeaireASFSPtDNKF-ATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKT 277
Cdd:cd00200  141 ---------VAFSP-DGTFvASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT--IKLWDLST 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  278 GQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNlKEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLL 357
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIR 286


                 ..
gi 56243590  358 FW 359
Cdd:cd00200  287 IW 288
WD40 COG2319
WD40 repeat [General function prediction only];
121-319 7.38e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.45  E-value: 7.38e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  121 PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQ-SNMNNVKMFQ 199
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELLRTLT 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  200 AHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWDPKTGQ 279
Cdd:COG2319  286 GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT--VRLWDLATGE 363

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 56243590  280 SLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRN 319
Cdd:COG2319  364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 119-274 1.52e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  119 KCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNM-NNVKM 197
Cdd:cd00200  135 TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTgKCLGT 214

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56243590  198 FQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWD 274
Cdd:cd00200  215 LRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-230 7.16e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.70  E-value: 7.16e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 56243590     191 NMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWD 230
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 205-319 2.82e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.98  E-value: 2.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   205 IREASFSPTDN-KFATCSDDGTVRIWDFlrcHEERI----------LRGHGADVKCVDWHPT-KGLVVSGSKDSQqpIKF 272
Cdd:PTZ00421   78 IIDVAFNPFDPqKLFTASEDGTIMGWGI---PEEGLtqnisdpivhLQGHTKKVGIVSFHPSaMNVLASAGADMV--VNV 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 56243590   273 WDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRN 319
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 618-864 3.92e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 3.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   618 GPPGPQGQFRPPGPQGQMGPQGPPlhqggggPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQrhpgphgplgpqgppgpqg 697
Cdd:NF038329  123 GPAGPAGPAGEQGPRGDRGETGPA-------GPAGPPGPQGERGEKGPAGPQGEAGPQGPA------------------- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   698 ssgpqghmgpqgppgpqghigpqgppGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLM 777
Cdd:NF038329  177 --------------------------GKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDGPAGPA 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   778 GLNPRGMQGPPGPRENQGPApqgmimghppqemrGPHPPGgllghGPQEMRGPQEIRGMQGPPPQGSMLGPPqelrGPPG 857
Cdd:NF038329  231 GDGQQGPDGDPGPTGEDGPQ--------------GPDGPA-----GKDGPRGDRGEAGPDGPDGKDGERGPV----GPAG 287


                  ....*..
gi 56243590   858 SQSQQGP 864
Cdd:NF038329  288 KDGQNGK 294
WD40 pfam00400
WD domain, G-beta repeat;
195-230 7.54e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 7.54e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 56243590    195 VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWD 230
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 215-359 1.86e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.86  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   215 NKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWH---PTkgLVVSGSKDSQqpIKFWDPKTGQSLATLHAHKNTV 291
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSsadPT--LLASGSDDGS--VKLWSINQGVSIGTIKTKANIC 621

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56243590   292 MEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWhpVHEGLFASGGSDGSLLFW 359
Cdd:PLN00181  622 CVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLW 687
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 585-863 3.11e-07

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 54.53  E-value: 3.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   585 PQPFPGQGPmsQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPplhqggggpqgfmgpqgpqgppqg 664
Cdd:NF038329  122 PGPAGPAGP--AGEQGPRGDRGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGP------------------------ 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   665 lPRPQDMHGPQGMQrhpgphgplgpqgppgpqgssgpqghmgpqgppgpqghigpqgppgpqghlGPQGPPGTQGMQGPP 744
Cdd:NF038329  176 -AGKDGEAGAKGPA---------------------------------------------------GEKGPQGPRGETGPA 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   745 GPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPlmgLNPRGMQGPPGPRENQGPAPQGmimghppqemrGPHPPGGLLGH-G 823
Cdd:NF038329  204 GEQGPAGPAGPDGEAGPAGEDGPAGPAGDGQ---QGPDGDPGPTGEDGPQGPDGPA-----------GKDGPRGDRGEaG 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 56243590   824 PQEMRGPQEIRGMQGPPPQGSMLGPpqelRGPPGSQSQQG 863
Cdd:NF038329  270 PDGPDGKDGERGPVGPAGKDGQNGK----DGLPGKDGKDG 305
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 564-932 3.92e-07

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 54.63  E-value: 3.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    564 LAQKQVEQIQPPPSSGT--PLLGPQPFPGQGPMsqiPQGFQQPHPSQQMPMNmAQMGPPGPQG--QFRPPGPQGQMGPQG 639
Cdd:pfam09606   63 PQGGQGNGGMGGGQQGMpdPINALQNLAGQGTR---PQMMGPMGPGPGGPMG-QQMGGPGTASnlLASLGRPQMPMGGAG 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    640 PPlhqggGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGP 719
Cdd:pfam09606  139 FP-----SQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPA 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    720 QGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGI----------------QGGPGSQGIQGPVSQGPLMGLNPRG 783
Cdd:pfam09606  214 DAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGqqsqlgmginqmqqmpQGVGGGAGQGGPGQPMGPPGQQPGA 293

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    784 M------QGPPGPRENQGPAPQ----GMIMGHPPQEMRGPHPPGGLLGHGPQEM---------RGPQEIRGMQGPPPQgs 844
Cdd:pfam09606  294 MpnvmsiGDQNNYQQQQTRQQQqqqgGNHPAAHQQQMNQSVGQGGQVVALGGLNhletwnpgnFGGLGANPMQRGQPG-- 371

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    845 MLGPPQELRG-------PPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAP 917
Cdd:pfam09606  372 MMSSPSPVPGqqvrqvtPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGGS 451

                          410
                   ....*....|....*
gi 56243590    918 FNQEGQSTGPPPLIP 932
Cdd:pfam09606  452 LNTPGQSAVNSPLNP 466
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-274 5.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 5.82e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 56243590     238 RILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWD 274
Cdd:smart00320    6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGT--IKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
238-274 3.35e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 3.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 56243590    238 RILRGHGADVKCVDWHPTKGLVVSGSKDSQqpIKFWD 274
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGT--VKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 321-360 4.26e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 4.26e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 56243590     321 KEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLLFWH 360
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 730-950 5.87e-06

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 50.78  E-value: 5.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    730 GPQGPPGTQgmQGPPG--------------PRGMQGPPHPHGIQGGPGSQGIQGPVSQgPLMGLNPRGMQGPPGPRENQG 795
Cdd:pfam09606  105 GPGGPMGQQ--MGGPGtasnllaslgrpqmPMGGAGFPSQMSRVGRMQPGGQAGGMMQ-PSSGQPGSGTPNQMGPNGGPG 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    796 --------PAPQGMIMGHPPQEMRGPHPPGGLLGHGpqemRGPQEIRGMQGPPPQGSMLGPPQELRGppGSQSQQGPPQG 867
Cdd:pfam09606  182 qgqaggmnGGQQGPMGGQMPPQMGVPGMPGPADAGA----QMGQQAQANGGMNPQQMGGAPNQVAMQ--QQQPQQQGQQS 255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    868 SLGPPPQGGMQGPPGPQGQQnPARGPHPSQGPIPFQQQKTPLLGdGPRAPFNQEGQSTGPPplipglgQQGAQGRIPPLN 947
Cdd:pfam09606  256 QLGMGINQMQQMPQGVGGGA-GQGGPGQPMGPPGQQPGAMPNVM-SIGDQNNYQQQQTRQQ-------QQQQGGNHPAAH 326


                   ...
gi 56243590    948 PGQ 950
Cdd:pfam09606  327 QQQ 329
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 373-402 7.17e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 7.17e-06
                            10        20        30
                    ....*....|....*....|....*....|
gi 56243590     373 AHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:smart00320   10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 277-316 1.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 1.15e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 56243590     277 TGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFD 316
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
278-316 1.40e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 1.40e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 56243590    278 GQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFD 316
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 612-989 1.50e-05

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 49.62  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    612 MNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQgppqglPRPQDMHGPQGMQRHPGPHGPLGPQG 691
Cdd:pfam09606   53 MSKKAAQQQQPQGGQGNGGMGGGQQGMPDPINALQNLAGQGTRPQMMG------PMGPGPGGPMGQQMGGPGTASNLLAS 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    692 PPGPQGSSGpqghmgpqgppgpqghiGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPV 771
Cdd:pfam09606  127 LGRPQMPMG-----------------GAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMN 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    772 --SQGPLMGLNPRGM--QGPPGPRE--NQGPAPQGMIMGHPPQEMRGPHP-------PGGLLGHGPQEMRGPQEIRGMQG 838
Cdd:pfam09606  190 ggQQGPMGGQMPPQMgvPGMPGPADagAQMGQQAQANGGMNPQQMGGAPNqvamqqqQPQQQGQQSQLGMGINQMQQMPQ 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    839 PPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQqnpARGPHPSQGPipfQQQKTPLLGDGPRAPF 918
Cdd:pfam09606  270 GVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQ---QGGNHPAAHQ---QQMNQSVGQGGQVVAL 343

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56243590    919 NQEGQS-TGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGP-EHGPERGP 989
Cdd:pfam09606  344 GGLNHLeTWNPGNFGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPgSQPPQSHP 416
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 556-676 2.16e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 48.65  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    556 LEQLKIERLAQKQVE--QIQPP---PSSGTPLLG---PQPFPGQGPMSQIPQ-----GFQQPHPSQQMPMnmaqmGPPGP 622
Cdd:TIGR01628  360 LAQRKEQRRAHLQDQfmQLQPRmrqLPMGSPMGGamgQPPYYGQGPQQQFNGqplgwPRMSMMPTPMGPG-----GPLRP 434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 56243590    623 QGqFRPPGPQGQMGPQGPPL-HQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQG 676
Cdd:TIGR01628  435 NG-LAPMNAVRAPSRNAQNAaQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGG 488
WD40 pfam00400
WD domain, G-beta repeat;
373-402 5.50e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 5.50e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 56243590    373 AHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Cdd:pfam00400    9 GHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 796-946 5.52e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.72  E-value: 5.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    796 PAPQGMIMGHPPQEmrGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLG-PPQELRGPPGSQSQQGPPQGSlgpppq 874
Cdd:pfam09770  211 AQQPAPAPAQPPAA--PPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGhPVTILQRPQSPQPDPAQPSIQ------ 282

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 56243590    875 ggmqgppgpqGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQ-STGPPPLIPGLGQQGAQGRIPPL 946
Cdd:pfam09770  283 ----------PQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQpGVQPAPAHQAHRQQGSFGRQAPI 345
PTZ00421 PTZ00421
coronin; Provisional
 288-398 6.50e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   288 KNTVMEVKLN-LNGNWLLTASRDHLCKLFDI------RNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360
Cdd:PTZ00421   75 EGPIIDVAFNpFDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWD 154

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 56243590   361 V--GVEKEVggmEMAHEGMIWSLAWHPLGHILCSGSNDHT 398
Cdd:PTZ00421  155 VerGKAVEV---IKCHSDQITSLEWNLDGSLLCTTSKDKK 191
PHA03378 PHA03378
EBNA-3B; Provisional
 735-984 6.57e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 6.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   735 PGTQGMQGPPGPRGMQGPPHPHGIQGGPGsqgiqgPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPH 814
Cdd:PHA03378  598 PVPHPSQTPEPPTTQSHIPETSAPRQWPM------PLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGH 671

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   815 PPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQElrGPPGSQSqqgPPQGSLGPPPQGGMQGPPGPQGQQNPARGPH 894
Cdd:PHA03378  672 IPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPA--APPGRAQ---RPAAATGRARPPAAAPGRARPPAAAPGRARP 746

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   895 PSQGPIPFQQqktPLLGDGP-RAPFNQEGQST-GPPPLIPGLGQQGAQGRIPPLNPGQ-GPGPNKGDSRGPPNHHMGPMS 971
Cdd:PHA03378  747 PAAAPGRARP---PAAAPGRaRPPAAAPGAPTpQPPPQAPPAPQQRPRGAPTPQPPPQaGPTSMQLMPRAAPGQQGPTKQ 823

                         250
                  ....*....|...
gi 56243590   972 ERRHEQSGGPEHG 984
Cdd:PHA03378  824 ILRQLLTGGVKRG 836
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
666-949 8.07e-05

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 46.95  E-value: 8.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  666 PRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMgpqgppgpqghigpqgppgpqghlGPQGPPGTQGMQGPPG 745
Cdd:COG5164   12 SDPGGVTTPAGSQGSTKPAQNQGSTRPAGNTGGTRPAQNQ------------------------GSTTPAGNTGGTRPAG 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  746 PRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMG-LNPRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGP 824
Cdd:COG5164   68 NQGATGPAQNQGGTTPAQNQGGTRPAGNTGGTTpAGDGGATGPPDDGGATGPPDDGGSTTPPSGGSTTPPGDGGSTPPGP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590  825 qemrGPQEIRGMQGPPPQGSMLGPPQE--LRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPF 902
Cdd:COG5164  148 ----GSTGPGGSTTPPGDGGSTTPPGPggSTTPPDDGGSTTPPNKGETGTDIPTGGTPRQGPDGPVKKDDKNGKGNPPDD 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 56243590  903 QQQKTPllGDGPRAPFNQEGQS--TGPPPLIPGLGQQGAQGRIPPLNPG 949
Cdd:COG5164  224 RGGKTG--PKDQRPKTNPIERRgpERPEAAALPAELTALEAENRAANPE 270
WD40 pfam00400
WD domain, G-beta repeat;
321-359 1.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.60e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 56243590    321 KEELQVFRGHKKEATAVAWHPvHEGLFASGGSDGSLLFW 359
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-188 2.25e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.25e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 56243590     150 TFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYW 188
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 731-969 2.38e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   731 PQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGMQGPPGPRENQGPAPQGMI------MG 804
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLppptsaQP 2836

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   805 HPPQEMRGPHPP-----GGLLGHGPQEMRGPQeirGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQgslgppPQGGMQG 879
Cdd:PHA03247 2837 TAPPPPPGPPPPslplgGSVAPGGDVRRRPPS---RSPAAKPAAPARPPVRRLARPAVSRSTESFAL------PPDQPER 2907

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   880 PPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGlGQQGA---------QGRIPPLNPgq 950
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ-PWLGAlvpgrvavpRFRVPQPAP-- 2984

                         250
                  ....*....|....*....
gi 56243590   951 gPGPNKGDSRGPPNHHMGP 969
Cdd:PHA03247 2985 -SREAPASSTPPLTGHSLS 3002
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 509-629 3.08e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 44.81  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   509 MQNKVPIPAPNEV-----------LNDRKEDIKLEEKKKTQAEIEQEMATLQ-----YTNPQLLEQLKIERLAQ------ 566
Cdd:PRK13729   38 MSGNGEAVAEQEPvpdmtgvvdttFDDKVRQHATTEMQVTAAQMQKQYEEIRreldvLNKQRGDDQRRIEKLGQdnaala 117

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56243590   567 KQVEQI---------QPPPSSGTPLLGPQ--PFPGQGPMSQIPQGFQQPHPSQQMPMNMAQMGPPGPQGQFRPP 629
Cdd:PRK13729  118 EQVKALganpvtatgEPVPQMPASPPGPEgePQPGNTPVSFPPQGSVAVPPPTAFYPGNGVTPPPQVTYQSVPV 191
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 730-791 9.01e-04

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 38.63  E-value: 9.01e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56243590    730 GPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGpvsqgplmglnPRGMQGPPGPR 791
Cdd:pfam01391    7 GPPGPPGPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPG-----------PPGAPGAPGPP 57
PTZ00420 PTZ00420
coronin; Provisional
 284-397 1.42e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   284 LHAHKNTVMEVKLN-LNGNWLLTASRDHLCKLFDIRN-------LKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGS 355
Cdd:PTZ00420   70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHndesvkeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSF 149

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 56243590   356 LLFWHVGVEKEVGGMEMAHEgmIWSLAWHPLGHIL---CSGSNDH 397
Cdd:PTZ00420  150 VNIWDIENEKRAFQINMPKK--LSSLKWNIKGNLLsgtCVGKHMH 192
PTZ00420 PTZ00420
coronin; Provisional
 198-274 1.76e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   198 FQAHKEAIREASFSPTDNK-FATCSDDGTVRIWDfLRCHEER---------ILRGHGADVKCVDWHPTKGLVVSGSK-DS 266
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCFSEiLASGSEDLTIRVWE-IPHNDESvkeikdpqcILKGHKKKISIIDWNPMNYYIMCSSGfDS 148


                  ....*...
gi 56243590   267 QqpIKFWD 274
Cdd:PTZ00420  149 F--VNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
151-188 2.52e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 56243590    151 FNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYW 188
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 533-643 2.90e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590    533 EKKKTQAEIEQEMATLQYTNPQL------LEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHP 606
Cdd:pfam09770  167 PKKAAAPAPAPQPAAQPASLPAPsrkmmsLEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 56243590    607 sQQMPMNMAQMGPPGP-------QGQFRPPGPQGQMGPQGPPLH 643
Cdd:pfam09770  247 -QQQPQQPQQHPGQGHpvtilqrPQSPQPDPAQPSIQPQAQQFH 289
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 541-643 5.56e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   541 IEQEMATLQYTNPQLLEQLKIERLA-QKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQGFQQPHPSQQMPMNmaqmgP 619
Cdd:PRK10263  749 VEPVQQPQQPVAPQQQYQQPQQPVApQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ-----P 823

                          90       100
                  ....*....|....*....|....
gi 56243590   620 PGPQGQFRPPGPQGQMGPQGPPLH 643
Cdd:PRK10263  824 VAPQPQYQQPQQPVAPQPQDTLLH 847
PHA03247 PHA03247
large tegument protein UL36; Provisional
 733-1027 5.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   733 GPPGTQGMQGPPGPRGMQGPPH--PHGIQGGPGsqgiQGPVSQGPLMGLNPRGMQG----------PPGPRENQGPAPQG 800
Cdd:PHA03247 2639 DPHPPPTVPPPERPRDDPAPGRvsRPRRARRLG----RAAQASSPPQRPRRRAARPtvgsltsladPPPPPPTPEPAPHA 2714

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   801 MIMGHP----PQEMRGPHPP------------GGLLGHGPQEMRGPQEIRGMQGP-PPQGSMLGPPQELRGPPGSQSQQG 863
Cdd:PHA03247 2715 LVSATPlppgPAAARQASPAlpaapappavpaGPATPGGPARPARPPTTAGPPAPaPPAAPAAGPPRRLTRPAVASLSES 2794

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   864 PPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKTPLLGDGPRAPFNQEGQSTGP-------PPLIPGLGQ 936
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvrrrPPSRSPAAK 2874

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   937 QGAQGRI-------PPLNPGQGPGPNKGDSRGPPNHHMGPMSERRHEQSGGPEHgPERGPFRGGQdcrgPPDRRGPHPDf 1009
Cdd:PHA03247 2875 PAAPARPpvrrlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-PQPPPPPPPR----PQPPLAPTTD- 2948

                         330
                  ....*....|....*...
gi 56243590  1010 PDDFSRPDDFHPDKRFGH 1027
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGA 2966
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 734-917 8.97e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 8.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   734 PPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLNPRGmQGPPGPRENQGPAPQGMIMGHPPQEMRGP 813
Cdd:PRK07764  615 PAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD-GGDGWPAKAGGAAPAAPPPAPAPAAPAAP 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56243590   814 HPPGGllghGPQEMRGPQEIRGMQGPPPQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGP 893
Cdd:PRK07764  694 AGAAP----AQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAA 769

                         170       180
                  ....*....|....*....|....
gi 56243590   894 HPSQGPIPFQQQKTPLLGDGPRAP 917
Cdd:PRK07764  770 PAAAPPPSPPSEEEEMAEDDAPSM 793
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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