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Conserved domains on  [gi|227908867|ref|NP_060607|]
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protein arginine N-methyltransferase 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
51-223 1.33e-46

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.33e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  51 YSDVSVHEEMIADRVRTDAYRLGILRnwAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA-IWQQAREVVRFNGL 129
Cdd:COG4076    6 FFVPRWHHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867 130 EDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWS 209
Cdd:COG4076   84 SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDWQ 163

                        170
                 ....*....|....
gi 227908867 210 QvkqhYGVDMSCLE 223
Cdd:COG4076  164 F----DGFDFRLFG 173
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
51-223 1.33e-46

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.33e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  51 YSDVSVHEEMIADRVRTDAYRLGILRnwAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA-IWQQAREVVRFNGL 129
Cdd:COG4076    6 FFVPRWHHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867 130 EDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWS 209
Cdd:COG4076   84 SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDWQ 163

                        170
                 ....*....|....
gi 227908867 210 QvkqhYGVDMSCLE 223
Cdd:COG4076  164 F----DGFDFRLFG 173
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 86-182 8.94e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.04  E-value: 8.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   86 VLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREVVRFNGLedRVHVLPGPVETVELP-EQVDAIVSeWMGYGLLH 163
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAEDLPFPdGSFDLVVS-SGVLHHLP 77

                          90
                  ....*....|....*....
gi 227908867  164 ESMLSSVLHARTKWLKEGG 182
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 85-185 3.33e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  85 TVLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREVVRfNGLEDRVHVLPGPVETVEL--PEQVDAIVSEWMGYGL 161
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVaLELARKAAA-ALLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....
gi 227908867 162 LHEsmLSSVLHARTKWLKEGGLLL 185
Cdd:cd02440   80 VED--LARFLEEARRLLKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
81-138 3.51e-09

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 56.70  E-value: 3.51e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227908867  81 LRGKTVLDVGAGTGILSIFCAQAGARRVYAV---EAsAIwQQAREVVRFNGLEDRVHVLPG 138
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKLGAKKVLAVdidPQ-AV-EAARENAELNGVELNVYLPQG 176
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 85-137 4.53e-06

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 45.76  E-value: 4.53e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 227908867   85 TVLDVGAGTGILSIFCAQAGAR-RVYAVEASA-IWQQAREVVRFNGLEDrVHVLP 137
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLPdAYEILEENVKLNNLPN-VVLLN 54
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
51-223 1.33e-46

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 158.66  E-value: 1.33e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  51 YSDVSVHEEMIADRVRTDAYRLGILRnwAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA-IWQQAREVVRFNGL 129
Cdd:COG4076    6 FFVPRWHHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867 130 EDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWS 209
Cdd:COG4076   84 SDRITVINADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAEGFEDWQ 163

                        170
                 ....*....|....
gi 227908867 210 QvkqhYGVDMSCLE 223
Cdd:COG4076  164 F----DGFDFRLFG 173
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 79-185 4.98e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 68.12  E-value: 4.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  79 AALRGKTVLDVGAGTGILSIFCAQAGArRVYAVEASAiwqQAREVVRFNGLEDRVHVLPGPVETVELP-EQVDAIVSewm 157
Cdd:COG2227   21 LLPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISP---EALEIARERAAELNVDFVQGDLEDLPLEdGSFDLVIC--- 93

                         90       100
                 ....*....|....*....|....*...
gi 227908867 158 GYGLLHESMLSSVLHARTKWLKEGGLLL 185
Cdd:COG2227   94 SEVLEHLPDPAALLRELARLLKPGGLLL 121
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
80-153 5.66e-13

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 68.66  E-value: 5.66e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227908867  80 ALRGKTVLDVGAGTGILSIFCAQAGARRVYAV--EASAIwQQAREVVRFNGLEDRVHVLPGPVETvelPEQVDAIV 153
Cdd:COG2264  146 LKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVdiDPVAV-EAARENAELNGVEDRIEVVLGDLLE---DGPYDLVV 217
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 83-185 1.39e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 64.95  E-value: 1.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  83 GKTVLDVGAGTGILSIFCAQAGARRVYAVEASAiwQQ---AREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVS----E 155
Cdd:COG2230   52 GMRVLDIGCGWGGLALYLARRYGVRVTGVTLSP--EQleyARERAAEAGLADRVEVRLADYRDLPADGQFDAIVSigmfE 129

                         90       100       110
                 ....*....|....*....|....*....|
gi 227908867 156 WMGYGLLHESMlsSVLHArtkWLKEGGLLL 185
Cdd:COG2230  130 HVGPENYPAYF--AKVAR---LLKPGGRLL 154
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 64-154 1.91e-12

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 66.32  E-value: 1.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  64 RVRTDAYRLGilrNWAALR-GKTVLDVGAGTGILSIFCAQ-AGARRVYAVEA-SAIWQQAREVVRFNGLEDRVHVLPGPV 140
Cdd:COG4123   21 RFGTDAVLLA---AFAPVKkGGRVLDLGTGTGVIALMLAQrSPGARITGVEIqPEAAELARRNVALNGLEDRITVIHGDL 97

                         90
                 ....*....|....*..
gi 227908867 141 ETVE---LPEQVDAIVS 154
Cdd:COG4123   98 KEFAaelPPGSFDLVVS 114
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
61-154 2.94e-12

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 64.93  E-value: 2.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  61 IADRVRTDAYRLGILRnwaalrGKTVLDVGAGTGILSIFCAQAGARRVYAVEA--SAIwQQAREVVRfnGLEDRVHVLPG 138
Cdd:COG2263   30 LAAELLHLAYLRGDIE------GKTVLDLGCGTGMLAIGAALLGAKKVVGVDIdpEAL-EIARENAE--RLGVRVDFIRA 100

                         90
                 ....*....|....*.
gi 227908867 139 PVETVELPEQVDAIVS 154
Cdd:COG2263  101 DVTRIPLGGSVDTVVM 116
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 86-182 8.94e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 61.04  E-value: 8.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   86 VLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREVVRFNGLedRVHVLPGPVETVELP-EQVDAIVSeWMGYGLLH 163
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAEDLPFPdGSFDLVVS-SGVLHHLP 77

                          90
                  ....*....|....*....
gi 227908867  164 ESMLSSVLHARTKWLKEGG 182
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 85-185 3.33e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  85 TVLDVGAGTGILSIFCAQAGARRVYAVEASAI-WQQAREVVRfNGLEDRVHVLPGPVETVEL--PEQVDAIVSEWMGYGL 161
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVaLELARKAAA-ALLADNVEVLKGDAEELPPeaDESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....
gi 227908867 162 LHEsmLSSVLHARTKWLKEGGLLL 185
Cdd:cd02440   80 VED--LARFLEEARRLLKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
81-138 3.51e-09

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 56.70  E-value: 3.51e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227908867  81 LRGKTVLDVGAGTGILSIFCAQAGARRVYAV---EAsAIwQQAREVVRFNGLEDRVHVLPG 138
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKLGAKKVLAVdidPQ-AV-EAARENAELNGVELNVYLPQG 176
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 74-185 2.33e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 52.30  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  74 ILRNWAALRGKTVLDVGAGTGILSIFCAQAGArRVYAVEAS-AIWQQAREvvRFNGLEDRVHVLPGPVETVELP-EQVDA 151
Cdd:COG2226   14 LLAALGLRPGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARE--RAAEAGLNVEFVVGDAEDLPFPdGSFDL 90

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 227908867 152 IVSewmGYGLLHESMLSSVLH--ARTkwLKEGGLLL 185
Cdd:COG2226   91 VIS---SFVLHHLPDPERALAeiARV--LKPGGRLV 121
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-185 3.17e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.74  E-value: 3.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   87 LDVGAGTGILSIFCAQAGArRVYAVEasaIWQQAREVVRFNGLEDRVHVLPGPVETVELP-EQVDAIVSEWMgygLLHES 165
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVD---ISPEMLELAREKAPREGLTFVVGDAEDLPFPdNSFDLVLSSEV---LHHVE 73

                          90       100
                  ....*....|....*....|
gi 227908867  166 MLSSVLHARTKWLKEGGLLL 185
Cdd:pfam08241  74 DPERALREIARVLKPGGILI 93
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 83-153 5.79e-08

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 53.42  E-value: 5.79e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227908867   83 GKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRFNGLEDRVHV-LPGpvetvELP-EQVDAIV 153
Cdd:pfam06325 162 GESVLDVGCGSGILAIAALKLGAKKVVGVDIDpvAV-RAAKENAELNGVEARLEVyLPG-----DLPkEKADVVV 230
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
82-185 6.86e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 49.82  E-value: 6.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  82 RGKTVLDVGAGTGILS-IFCAQAGARRVYAVEASA--IwQQAREVVrfngleDRVHVLPGPVETVELPEQVDAIVS---- 154
Cdd:COG4106    1 PPRRVLDLGCGTGRLTaLLAERFPGARVTGVDLSPemL-ARARARL------PNVRFVVADLRDLDPPEPFDLVVSnaal 73

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227908867 155 EWMGyglLHESMLSSVLHArtkwLKEGGLLL 185
Cdd:COG4106   74 HWLP---DHAALLARLAAA----LAPGGVLA 97
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 82-185 6.90e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 52.23  E-value: 6.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  82 RGKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRFNGLeDRVHVLPGPV-ETVELP-EQVDAIVSewm 157
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSpeAI-ALARARAAKAGL-GNVEFLVADLaELDPLPaESFDLVVA--- 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 227908867 158 gYGLLH---ESMLSSVLHARTKWLKEGGLLL 185
Cdd:COG0500  101 -FGVLHhlpPEEREALLRELARALKPGGVLL 130
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 75-154 1.09e-06

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 48.36  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   75 LRNWAALRGKTVLDVGAGTGILSIFCAQAGAR-RVYAVEAS--AIWqQAREVVRFNGLEDrVHVLPGPV-ETVElPEQVD 150
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKESPDaELTMVDINarALE-SARENLAANGLEN-GEVVASDVySGVE-DGKFD 100


                  ....
gi 227908867  151 AIVS 154
Cdd:pfam05175 101 LIIS 104
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 76-153 1.40e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 49.79  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  76 RNWAALRG-KTVLDVGAGTGILSIFCAQAgARRVYAVE--ASAIwQQAREVVRFNGLeDRVHVLPGPVETV----ELPEQ 148
Cdd:COG2265  226 LEWLDLTGgERVLDLYCGVGTFALPLARR-AKKVIGVEivPEAV-EDARENARLNGL-KNVEFVAGDLEEVlpelLWGGR 302


                 ....*
gi 227908867 149 VDAIV 153
Cdd:COG2265  303 PDVVV 307
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 81-135 1.69e-06

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 48.34  E-value: 1.69e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 227908867  81 LRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAiwqQAREVVRFNGLEDRVHV 135
Cdd:COG3897   69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDP---EALAALRLNAALNGVAI 120
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
74-185 2.00e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 47.69  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  74 ILRNWAALRGKTVLDVGAGTGILSIFCAQAGaRRVYAVEASA--IwQQAREvvrfNGLEDRVHVLpGPVETVELPEQVDA 151
Cdd:COG4976   38 LLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGVDLSEemL-AKARE----KGVYDRLLVA-DLADLAEPDGRFDL 110

                         90       100       110
                 ....*....|....*....|....*....|....
gi 227908867 152 IVSeWMGYGLLHEsmLSSVLHARTKWLKEGGLLL 185
Cdd:COG4976  111 IVA-ADVLTYLGD--LAAVFAGVARALKPGGLFI 141
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 62-184 2.86e-06

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 47.38  E-value: 2.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  62 ADRVRtdayrlGILRNW--AALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAiwqQAREVVRFN----GLEDRVHV 135
Cdd:COG0742   25 TDRVR------EALFNIlgPDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDR---KAAAVIRKNleklGLEDRARV 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 227908867 136 LPGPVETV---ELPEQVDAIvsewmgygLL----HESMLSSVLHA--RTKWLKEGGLL 184
Cdd:COG0742   96 IRGDALRFlkrLAGEPFDLV--------FLdppyAKGLLEKALELlaENGLLAPGGLI 145
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 85-137 4.53e-06

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 45.76  E-value: 4.53e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 227908867   85 TVLDVGAGTGILSIFCAQAGAR-RVYAVEASA-IWQQAREVVRFNGLEDrVHVLP 137
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEgRVIAFEPLPdAYEILEENVKLNNLPN-VVLLN 54
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 74-154 4.79e-06

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 47.45  E-value: 4.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  74 ILRNWAALRGKTVLDVGAGTGILSIFCAQAGAR-RVYAVEAS--AIwQQAREVVRFNGLEDRVHVLPGPV-ETVELPEQV 149
Cdd:COG2890  104 ALALLPAGAPPRVLDLGTGSGAIALALAKERPDaRVTAVDISpdAL-AVARRNAERLGLEDRVRFLQGDLfEPLPGDGRF 182


                 ....*
gi 227908867 150 DAIVS 154
Cdd:COG2890  183 DLIVS 187
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 75-154 6.17e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 46.34  E-value: 6.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  75 LRNWAALRGKTVLDVGAGTGILSIFCAQAGA-RRVYAVEAS--AIwQQAREVVRFNGLEDrVHVLPGPV-ETVElPEQVD 150
Cdd:COG2813   42 LEHLPEPLGGRVLDLGCGYGVIGLALAKRNPeARVTLVDVNarAV-ELARANAAANGLEN-VEVLWSDGlSGVP-DGSFD 118


                 ....
gi 227908867 151 AIVS 154
Cdd:COG2813  119 LILS 122
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 57-143 8.42e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 46.37  E-value: 8.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  57 HEEMIaDRVrtdayrLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGArRVYAVE-ASAIWQQAREVVRFNGLEDRVHV 135
Cdd:PRK07580  45 HQRMR-DTV------LSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDiSPQMVEEARERAPEAGLAGNITF 116


                 ....*...
gi 227908867 136 LPGPVETV 143
Cdd:PRK07580 117 EVGDLESL 124
PRK14968 PRK14968
putative methyltransferase; Provisional
 83-161 1.07e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 45.66  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  83 GKTVLDVGAGTGILSIFCAQAGARRV------YAVEasaiwqQAREVVRFNGLEDR-VHVL---------PGPVETV--- 143
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKKVVgvdinpYAVE------CAKCNAKLNNIRNNgVEVIrsdlfepfrGDKFDVIlfn 97

                         90       100
                 ....*....|....*....|
gi 227908867 144 --ELPEQVDAIVSEWMGYGL 161
Cdd:PRK14968  98 ppYLPTEEEEEWDDWLNYAL 117
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 75-153 1.71e-05

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 46.33  E-value: 1.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  75 LRNWAalRGKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRFNGLEDRVHVLPGPV-----ETVELPE 147
Cdd:COG1092  211 VAELA--KGKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSatAL-EWAKENAALNGLDDRHEFVQADAfdwlrELAREGE 287


                 ....*.
gi 227908867 148 QVDAIV 153
Cdd:COG1092  288 RFDLII 293
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
79-153 2.14e-05

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 45.67  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  79 AALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVvrfN----GLED-RVHVLPGPVETV--ELP-EQVD 150
Cdd:COG2521  129 GVRRGDRVLDTCTGLGYTAIEALKRGAREVITVEKDPNVLELAEL---NpwsrELANeRIKIILGDASEVikTFPdESFD 205


                 ...
gi 227908867 151 AIV 153
Cdd:COG2521  206 AII 208
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 42-158 2.38e-05

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 44.50  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   42 ERDQLYYECYsdvsvhEEMIADrvrtdayrlgILRNWAALRGKT-----VLDVGAGTGIL---SIFCAQAGAR--RVYAV 111
Cdd:pfam05185  34 EKDPVKYDLY------ERAIEK----------ALSDRVPEKKKTskllvILVVGAGRGPLvdrALRAAEETGTkvKIYAV 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 227908867  112 EA--SAIWQ-QARevVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMG 158
Cdd:pfam05185  98 EKnpNAYVTlQKR--INFEKWGDKVTIISSDMREWQGPEKADILVSELLG 145
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
63-135 3.14e-05

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 44.15  E-value: 3.14e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227908867   63 DRVRtdayrlGILRNW--AALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQA-REVVRFNGLEDRVHV 135
Cdd:pfam03602  26 DRVR------EALFNWlaPYIEGARVLDLFAGSGALGLEALSRGAKRVTLVEKDKRAVQIlKENLQLLGLPGAVLV 95
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 87-184 1.33e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.43  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   87 LDVGAGTGILSIFCAQAGAR-RVYAVEAS--AIwQQAREVVRFNGLEDRVHV-LPGPVETVELPEQVDAIVSewmgYGLL 162
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGlEYTGLDISpaAL-EAARERLAALGLLNAVRVeLFQLDLGELDPGSFDVVVA----SNVL 75

                          90       100
                  ....*....|....*....|...
gi 227908867  163 HE-SMLSSVLHARTKWLKEGGLL 184
Cdd:pfam08242  76 HHlADPRAVLRNIRRLLKPGGVL 98
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 82-184 1.45e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 41.86  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  82 RGKTVLDVGAGTGILSIFCAQAGaRRVYAVEASAIW-QQAREVVRFNGLEDrVHVLPGPVETVELP-EQVDAIVSEwMGY 159
Cdd:COG1041   26 EGDTVLDPFCGTGTILIEAGLLG-RRVIGSDIDPKMvEGARENLEHYGYED-ADVIRGDARDLPLAdESVDAIVTD-PPY 102

                         90       100       110
                 ....*....|....*....|....*....|..
gi 227908867 160 GLLH-------ESMLSSVLHARTKWLKEGGLL 184
Cdd:COG1041  103 GRSSkisgeelLELYEKALEEAARVLKPGGRV 134
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 79-185 1.53e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 42.09  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  79 AALRGKTVLDVGAGTGILSIFCAQAGAR--RVYAVEASAIWQQ-AREVVRFNGLEDRVHVLPGPVETV--ELPEQ----- 148
Cdd:COG4122   13 RLLGAKRILEIGTGTGYSTLWLARALPDdgRLTTIEIDPERAAiARENFARAGLADRIRLILGDALEVlpRLADGpfdlv 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 227908867 149 -VDAIVSEWMGYglLHESMlssvlhartKWLKEGGLLL 185
Cdd:COG4122   93 fIDADKSNYPDY--LELAL---------PLLRPGGLIV 119
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 74-154 4.80e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 41.30  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  74 ILRNWAALRGKTVLDVGAGTGILSI----FCAQAgarRVYAVEASAiwqQAREVVRFN---GLEDRVHVLPGPVETVELP 146
Cdd:PRK09328 100 ALEALLLKEPLRVLDLGTGSGAIALalakERPDA---EVTAVDISP---EALAVARRNakhGLGARVEFLQGDWFEPLPG 173


                 ....*...
gi 227908867 147 EQVDAIVS 154
Cdd:PRK09328 174 GRFDLIVS 181
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 83-153 7.42e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 40.53  E-value: 7.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227908867  83 GKTVLDVGAGTGILSIFCAQA----GarRVYAVEASAIWQ-QAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIV 153
Cdd:COG2519   92 GARVLEAGTGSGALTLALARAvgpeG--KVYSYERREDFAeIARKNLERFGLPDNVELKLGDIREGIDEGDVDAVF 165
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 66-185 7.57e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 39.72  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   66 RTDAYRLGILRNWAALR-GKTVLDVGAGTGILSIFCAQAGArRVYAVEASAIWQQAREVVRFNGLEDRVHVLPgpvetve 144
Cdd:pfam13489   5 RERLLADLLLRLLPKLPsPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIAIERALLNVRFDQFDEQEAAV------- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 227908867  145 LPEQVDAIVSeWMGYGLLHEsmLSSVLHARTKWLKEGGLLL 185
Cdd:pfam13489  77 PAGKFDVIVA-REVLEHVPD--PPALLRQIAALLKPGGLLL 114
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
82-152 7.59e-04

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 39.98  E-value: 7.59e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 227908867  82 RGKTVLDVGAGTGILSIfcaQAGAR----RVYAVE--ASAIWQQAREVVRFnGLEDrVHVLPGpVETVELPEQVDAI 152
Cdd:PRK08287  31 RAKHLIDVGAGTGSVSI---EAALQfpslQVTAIErnPDALRLIKENRQRF-GCGN-IDIIPG-EAPIELPGKADAI 101
PRK14967 PRK14967
putative methyltransferase; Provisional
 83-134 8.61e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 40.42  E-value: 8.61e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 227908867  83 GKTVLDVGAGTGILSIFCAQAGARRVYAVEAS--AIwQQAREVVRFNGLEDRVH 134
Cdd:PRK14967  37 GRRVLDLCTGSGALAVAAAAAGAGSVTAVDISrrAV-RSARLNALLAGVDVDVR 89
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 82-111 1.05e-03

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 39.49  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 227908867   82 RGKTVLDVGAGTGILSIFCAQAGARRVYAV 111
Cdd:pfam01728  21 PGKTVLDLGAAPGGWSQVALQRGAGKVVGV 50
YqxC COG1189
Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure ...
 81-111 1.16e-03

Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440802 [Multi-domain]  Cd Length: 248  Bit Score: 40.04  E-value: 1.16e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 227908867  81 LRGKTVLDVGAGTGIlsiF--CA-QAGARRVYAV 111
Cdd:COG1189   76 VAGKVCLDIGASTGG---FtdCLlQRGAAKVYAV 106
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 83-154 1.29e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 40.00  E-value: 1.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227908867   83 GKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQ-QAREVVRFNGLEDRVHVLPGPVEtvELPEQVDAIVS 154
Cdd:pfam02353  62 GMTLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYkLARKRVAAEGLARKVEVLLQDYR--DFDEPFDRIVS 132
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-185 1.35e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 38.06  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   87 LDVGAGTGILSIFCAQA----GARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVeLPEQVDAivsewmGYGLL 162
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAAlrdnGLGRLTAVDPDPGAEEAGALLRKAGLDDRVRLIVGDSREA-LPSLADG------PIDLL 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 227908867  163 H-------ESMLSSVLHARtKWLKEGGLLL 185
Cdd:pfam13578  74 FidgdhtyEAVLNDLELWL-PRLAPGGVIL 102
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
83-154 2.19e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 39.50  E-value: 2.19e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 227908867  83 GKTVLDVGAGTGILSIFCAQAgARRVYAVEA-SAIWQQAREvvRFNgLEDRVHVLPGPVETVELPEqVDAIVS 154
Cdd:PRK14896  30 GDPVLEIGPGKGALTDELAKR-AKKVYAIELdPRLAEFLRD--DEI-AAGNVEIIEGDALKVDLPE-FNKVVS 97
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 79-138 3.65e-03

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 38.99  E-value: 3.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 227908867  79 AALR---GKTVLDVGAGTGILSIFCAQAGAR-RVYAVEASAiwqQAREVVRFN----GLeDRVHVLPG 138
Cdd:COG2242  241 AKLAlrpGDVLWDIGAGSGSVSIEAARLAPGgRVYAIERDP---ERAALIRANarrfGV-PNVEVVEG 304
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 82-188 3.95e-03

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 36.92  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867   82 RGKTVLDVGAGTGILSIFCA-QAGARRVYAVEAS--AIWQQAREVVRFngLEDRVHVLPG--PVETVELPEQVDAIVSEW 156
Cdd:TIGR02469  19 PGDVLWDIGAGTGSVTIEAArLVPNGRVYAIERNpeALDLIERNLRRF--GVSNIVIVEGdaPEAPEALLPDPDAVFVGG 96

                          90       100       110
                  ....*....|....*....|....*....|...
gi 227908867  157 MGyGLLHEsmlssVLHARTKWLKEGG-LLLPAS 188
Cdd:TIGR02469  97 SG-GLLQE-----ILEAVERRLRPGGrIVLNAI 123
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 72-116 4.14e-03

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 38.68  E-value: 4.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 227908867  72 LGILRNWAALRGKTVLDVGAGTGILSIFCAQAGArrvyAVEASAI 116
Cdd:PLN02585 134 LLWLAEDGSLAGVTVCDAGCGTGSLAIPLALEGA----IVSASDI 174
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 82-154 4.94e-03

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 37.82  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  82 RGKTVLDVGAGTG----ILSIFCAQagaRRVYAVEAS---AIWQqaREVVRFNGLEDrVHVLPGPVETVELPEQVDAIVS 154
Cdd:COG0357   67 EGARVLDVGSGAGfpgiPLAIARPD---LQVTLVDSLgkkIAFL--REVVRELGLKN-VTVVHGRAEELAPREKFDVVTA 140
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
81-158 5.79e-03

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 38.30  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  81 LRGKTVLDVGAGTG-----ILSifcaqAGARRVYAVEASAI--WQ-QAreVVRFNGLEDRVHVLPGPVETVELPEQVDAI 152
Cdd:PRK15068 121 LKGRTVLDVGCGNGyhmwrMLG-----AGAKLVVGIDPSQLflCQfEA--VRKLLGNDQRAHLLPLGIEQLPALKAFDTV 193


                 ....*.
gi 227908867 153 VSewMG 158
Cdd:PRK15068 194 FS--MG 197
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 83-184 9.43e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 37.53  E-value: 9.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227908867  83 GKTVLDVGAGTGILSIFCAQAGARRVYAVEA--SAIwQQAREVVRFNGLEDRVHVLPGPVETV--ELPEQVDAIVsewMG 158
Cdd:COG2520  181 GERVLDMFAGVGPFSIPIAKRSGAKVVAIDInpDAV-EYLKENIRLNKVEDRVTPILGDAREVapELEGKADRII---MN 256

                         90       100
                 ....*....|....*....|....*..
gi 227908867 159 Y-GLLHESMLSSVLHartkwLKEGGLL 184
Cdd:COG2520  257 LpHSADEFLDAALRA-----LKPGGVI 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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