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Conserved domains on  [gi|118918397|ref|NP_055738|]
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fibronectin type-III domain-containing protein 3A isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
410-799 5.22e-20

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 5.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 484
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 564
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  565 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 642
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  643 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 720
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  721 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 799
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
755-1014 3.44e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 831
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  832 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 904
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  905 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 981
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 118918397  982 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 315-406 2.25e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  315 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 118918397  394 GTSGFSEEVLYYT 406
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 211-310 2.27e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  211 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 289
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 118918397  290 KVQAEYNSIKGTPSEAEIFTT 310
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
410-799 5.22e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 5.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 484
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 564
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  565 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 642
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  643 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 720
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  721 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 799
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
755-1014 3.44e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 831
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  832 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 904
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  905 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 981
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 118918397  982 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 315-406 2.25e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  315 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 118918397  394 GTSGFSEEVLYYT 406
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 411-503 2.45e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  411 PSMPASPVLTKAGITWLSLQWSKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 118918397  490 EGKSNPSEVVEFTT 503
Cdd:cd00063    80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
809-884 2.13e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   809 DEIENPHYSP--STCLAISWEKPCDHGSEILAYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 879
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 118918397   880 AGPFS 884
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 819-891 8.82e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  819 STCLAISWEKPCDHGSEILAYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 700-782 1.04e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.04e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    700 PGPPdqcKPPQVTCRSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQAL 776
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 118918397    777 SVVGAG 782
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 211-310 2.27e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  211 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 289
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 118918397  290 KVQAEYNSIKGTPSEAEIFTT 310
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
709-785 2.62e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   709 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 315-396 8.25e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 8.25e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    315 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 392
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 118918397    393 YGTS 396
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
318-399 1.26e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   318 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 395
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 118918397   396 SGFS 399
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 819-881 3.30e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.30e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    819 STCLAISWEKPCDHG--SEILAYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
216-303 4.30e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   216 PVASDIQARTVVLTWSPPSSLiNGEtdessvpeLYGYEVLISSTGKDGKYKSVYV-GEETNITLNDLKPAMDYHAKVQAE 294
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG-NGP--------ITGYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 118918397   295 YNSIKGTPS 303
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 211-296 1.09e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 1.09e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    211 SNIVKPVASDIQARTVVLTWSPPSslingetDESSVPELYGYEVLISSTGKDGKYKSVyVGEETNITLNDLKPAMDYHAK 290
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-------DDGITGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 118918397    291 VQAEYN 296
Cdd:smart00060   74 VRAVNG 79
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
410-799 5.22e-20

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 95.84  E-value: 5.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  410 APSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDG-----EDLAYTVKNLRRSTKYKFKV 484
Cdd:COG3401   130 AVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSltvtsTTLVDGGGDIEPGTTYYYRV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  485 IAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGkIHSHSFKITWDPPKDNGgatINKYVVEMAEGSNGnKWEMIYSGAT 564
Cdd:COG3401   210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA-DTPGSVTLSWDPVTESD---ATGYRVYRSNSGDG-PFTKVATVTT 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  565 REHLCDRLNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPKA-KEIQLRWGPPLvdgGSPISCYS 642
Cdd:COG3401   285 TSYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAA--PSGLTATAVGsSSITLSWTASS---DADVTGYN 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  643 VEMSPIEKDEPREVYQG-SEVECTVSSLLPGKTYSFRLRAANKMG-FGPFSEKCDITTAPGPPDQcKPPQVTCRSATCAQ 720
Cdd:COG3401   360 VYRSTSGGGTYTKIAETvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE-SLTASVDAVPLTDV 438

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  721 VNWEVPLSNGTDvTEYRLEWGGVEGSMQICYCGPGLSYE-IKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGI 799
Cdd:COG3401   439 AGATAAASAASN-PGVSAAVLADGGDTGNAVPFTTTSSTvTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
385-611 1.71e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  385 FRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDegiSYILEMEEETSGyGFKPKYDG 464
Cdd:COG3401   207 YRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDAT---GYRVYRSNSGDG-PFTKVATV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  465 EDLAYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEFTTCPDKPGIPVkpSVKGKIHSHSF-KITWDPPKDNGgatINK 542
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSiTLSWTASSDAD---VTG 357

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 118918397  543 YVVEMAEGSNGNkWEMIYSGATREHLCDR-LNPGCFYRLRVYCI-SDGGQSAVSESLLVQTPAVPPGPCLP 611
Cdd:COG3401   358 YNVYRSTSGGGT-YTKIAETVTTTSYTDTgLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAASGESLT 427
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
755-1014 3.44e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  755 GLSYEIKGLSPATTYYCRVQALSVVGAGPFS---EVVACVTPPSVPGIVTcLQEISDDEIEnphyspstclaISWEKPCD 831
Cdd:COG3401   191 TLVDGGGDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTE 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  832 HGseILAYSI-----DFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLG-AGPFSHMIKLKTKPLPPDPPR-LECV 904
Cdd:COG3401   259 SD--ATGYRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTAT 336

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  905 AFSHQNLKLKWGegtpKTLSTDSIQYHL-QMEDKNGRFVSLYRGPC-HTYKVQRLNESTSYKFCIQACNEAG-EGPLSQE 981
Cdd:COG3401   337 AVGSSSITLSWT----ASSDADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEE 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 118918397  982 -YIFTTPKSVPAALKAPKIEKVNDHICEITWECL 1014
Cdd:COG3401   413 vSATTASAASGESLTASVDAVPLTDVAGATAAAS 446
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 315-406 2.25e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  315 PDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDY 393
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 118918397  394 GTSGFSEEVLYYT 406
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 411-503 2.45e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 66.75  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  411 PSMPASPVLTKAGITWLSLQWSKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 489
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 118918397  490 EGKSNPSEVVEFTT 503
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 622-698 4.94e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.98  E-value: 4.94e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 118918397  622 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREV--YQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDITT 698
Cdd:cd00063    16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
217-556 9.15e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.34  E-value: 9.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  217 VASDIQARTVVLTWSPpssliNGETDESsvpelyGYEVLISSTGkDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAE-Y 295
Cdd:COG3401   240 TATADTPGSVTLSWDP-----VTESDAT------GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdA 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  296 NSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGskIQNFVLEWDEGKGnGEFCQ-CYMGSQKQFKI 374
Cdd:COG3401   308 AGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSGG-GTYTKiAETVTTTSYTD 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  375 TKLSPAMGCKFRLSARNDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETS 454
Cdd:COG3401   385 TGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDT 464

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  455 GYGFKPKYDGEDLAYTVKNLRRSTKYkfKVIAYNSEGKSNPSEVVEFTTcPDKPGIPVKPSVKGKIHShsfKITWDPPKD 534
Cdd:COG3401   465 GNAVPFTTTSSTVTATTTDTTTANLS--VTTGSLVGGSGASSVTNSVSV-IGASAAAAVGGAPDGTPN---VTGASPVTV 538

                         330       340
                  ....*....|....*....|..
gi 118918397  535 NGGATINKYVVEMAEGSNGNKW 556
Cdd:COG3401   539 GASTGDVLITDLVSLTTSASSS 560
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 700-792 1.53e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  700 PGPPDQckpPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGGV-EGSMQIC--YCGPGLSYEIKGLSPATTYYCRVQAL 776
Cdd:cd00063     1 PSPPTN---LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 118918397  777 SVVGAGPFSEVVACVT 792
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
809-884 2.13e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   809 DEIENPHYSP--STCLAISWEKPCDHGSEILAYSIDF------GDKQSLTVGKVT-SYIINNLQPDTTYRIRIQALNSLG 879
Cdd:pfam00041    1 SAPSNLTVTDvtSTSLTVSWTPPPDGNGPITGYEVEYrpknsgEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 118918397   880 AGPFS 884
Cdd:pfam00041   81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 508-601 4.87e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 4.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  508 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGAtINKYVVEMAEgSNGNKWEMI--YSGATREHLCDRLNPGCFYRLRVYCI 585
Cdd:cd00063     1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGGP-ITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 118918397  586 SDGGQSAVSESLLVQT 601
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 819-891 8.82e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  819 STCLAISWEKPCDHGSEILAYSIDFGDKQS-------LTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKT 891
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKGSgdwkeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
816-1109 4.36e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.87  E-value: 4.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  816 YSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLP 895
Cdd:COG3401   153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  896 PDPP-RLECVAFSHQNLKLKWGEGTpktlSTDSIQYHL-QMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEA 973
Cdd:COG3401   233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  974 G-EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWeclQPMKGDPVI-YSLQVMLGKDSEFKQIYKGPDS-SFRYS 1050
Cdd:COG3401   309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTTtSYTDT 385

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 118918397 1051 SLQLNCEYRFRVCAIrqcqDSLGhqdLVGPYSTTVLFISQRTEPPASTNRDTVESTRTR 1109
Cdd:COG3401   386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESLTASVDAVPLTD 437
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 700-782 1.04e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.08  E-value: 1.04e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    700 PGPPdqcKPPQVTCRSATCAQVNWEVPLSNGTD--VTEYRLEWGGVEGSMQICYCGPG-LSYEIKGLSPATTYYCRVQAL 776
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 118918397    777 SVVGAG 782
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 211-310 2.27e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  211 SNIVKPVASDIQARTVVLTWSPPsslingetdESSVPELYGYEVLISSTGKDGKYK-SVYVGEETNITLNDLKPAMDYHA 289
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPP---------EDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 118918397  290 KVQAEYNSIKGTPSEAEIFTT 310
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
709-785 2.62e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   709 PQVTCRSATCAQVNWEVPLSNGTDVTEYRLEW---GGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFS 785
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 606-688 3.89e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.89e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    606 PGPclPPRLQGRPKAKE-IQLRWGPPLVDGG-SPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAAN 683
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 118918397    684 KMGFG 688
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 315-396 8.25e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 8.25e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    315 PDIPNPPRIANRTKNSLTLQWKAPSDNG--SKIQNFVLEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSARND 392
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 118918397    393 YGTS 396
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
318-399 1.26e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   318 PNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSARNDYGT 395
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 118918397   396 SGFS 399
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 411-493 1.97e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.97e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    411 PSMPASPVLTKAGITWLSLQWSKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 487
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 118918397    488 NSEGKS 493
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
622-691 2.27e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 2.27e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 118918397   622 EIQLRWGPPLvDGGSPISCYSVEMSPIEKDEPREVYQ--GSEVECTVSSLLPGKTYSFRLRAANKMGFGPFS 691
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 819-881 3.30e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.30e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    819 STCLAISWEKPCDHG--SEILAYSIDFGDKQSL-----TVGKVTSYIINNLQPDTTYRIRIQALNSLGAG 881
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 896-986 9.41e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 9.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  896 PDPPR-LECVAFSHQNLKLKWGEgtPKTLSTDSIQYHLQMEDKNGRFVSLYRGPC---HTYKVQRLNESTSYKFCIQACN 971
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 118918397  972 EAGEGPLSQEYIFTT 986
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 508-591 3.42e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.42e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    508 PGIPVKPSVKGkIHSHSFKITWDPPKDNGGatiNKYVVE--MAEGSNGNKWEMIY-SGATREHLCDRLNPGCFYRLRVYC 584
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPDDGI---TGYIVGyrVEYREEGSEWKEVNvTPSSTSYTLTGLKPGTEYEFRVRA 76


                    ....*..
gi 118918397    585 ISDGGQS 591
Cdd:smart00060   77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
216-303 4.30e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   216 PVASDIQARTVVLTWSPPSSLiNGEtdessvpeLYGYEVLISSTGKDGKYKSVYV-GEETNITLNDLKPAMDYHAKVQAE 294
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPDG-NGP--------ITGYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 118918397   295 YNSIKGTPS 303
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 895-976 6.58e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 6.58e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    895 PPDPPRLECVAFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHT-YKVQRLNESTSYKFCIQACNEA 973
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 118918397    974 GEG 976
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
522-594 1.41e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.41e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118918397   522 SHSFKITWDPPKDNGGaTINKYVVEMAEGSNGNKW-EMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS 594
Cdd:pfam00041   13 STSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
414-496 1.60e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   414 PASPVLTKAGITWLSLQWSKPSgTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSEGK 492
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 118918397   493 SNPS 496
Cdd:pfam00041   82 GPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 211-296 1.09e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 1.09e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397    211 SNIVKPVASDIQARTVVLTWSPPSslingetDESSVPELYGYEVLISSTGKDGKYKSVyVGEETNITLNDLKPAMDYHAK 290
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPP-------DDGITGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 118918397    291 VQAEYN 296
Cdd:smart00060   74 VRAVNG 79
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
654-780 6.81e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.78  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  654 REVYQGSEVECTVSSLLPGkTYSFRLRAANKMG---FGPFSEKCDITTAPGPPdqckpPQVTCRSATC----AQVNWEVP 726
Cdd:COG4733   579 VSVPRTSGTSFEVPGIYAG-DYEVRVRAINALGvssAWAASSETTVTGKTAPP-----PAPTGLTATGglggITLSWSFP 652

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 118918397  727 lsNGTDVTEYRLEWGGV---EGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVG 780
Cdd:COG4733   653 --VDADTLRTEIRYSTTgdwASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
719-879 1.29e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  719 AQVNWEVPlsngTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLsPATTYYCRVQALSVVG------AGPFSEVVACVT 792
Cdd:COG4733   554 LTVSWDAP----AGAVAYEVEWRRDDGNWVSVPRTSGTSFEVPGI-YAGDYEVRVRAINALGvssawaASSETTVTGKTA 628

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397  793 PPSVP-GIVTclqEISDDEIEnphyspstclaISWEKPCDhgSEILAYSI---DFGDKQSLTV----GKVTSYIINNLQP 864
Cdd:COG4733   629 PPPAPtGLTA---TGGLGGIT-----------LSWSFPVD--ADTLRTEIrysTTGDWASATVaqalYPGNTYTLAGLKA 692

                         170
                  ....*....|....*
gi 118918397  865 DTTYRIRIQALNSLG 879
Cdd:COG4733   693 GQTYYYRARAVDRSG 707
fn3 pfam00041
Fibronectin type III domain;
896-979 6.33e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 6.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118918397   896 PDPPRLECVAFSHQNLKLKWGEgtPKTLSTDSIQYHLQMEDKNGRFVSLYR---GPCHTYKVQRLNESTSYKFCIQACNE 972
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTP--PPDGNGPITGYEVEYRPKNSGEPWNEItvpGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 118918397   973 AGEGPLS 979
Cdd:pfam00041   79 GGEGPPS 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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