NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|194239697|ref|NP_006662|]
View 

excitatory amino acid transporter 5 isoform 4 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
15-475 4.24e-113

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 342.09  E-value: 4.24e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  15 RRNGLLILSVLSVIVGCLLGFFLRtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTV 93
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLP-----ELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  94 AYYLWTTFMAVIVGIFMVSIIHPGSAAQkETTEQSGKPIMSSADALLDLIRNMFPANLVEAtfkqyrtkttpvvkspkva 173
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLN-LDLADAAAAEAAEAPSLLDFLLNIIPSNIFEA------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 174 peeapprriliygvqeengshvqnFAldltpppevvyksepgtsDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCL 253
Cdd:COG1301  136 ------------------------FA------------------EG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESL 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 254 NESVMKIVAVAVWYFPFGIVFLIAGKILEMDDprAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQ 333
Cdd:COG1301  173 SEVMFKIVGWVMKLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRP 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 334 ALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITAT 413
Cdd:COG1301  251 ALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAV 330

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194239697 414 AASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAH 475
Cdd:COG1301  331 LASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
15-475 4.24e-113

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 342.09  E-value: 4.24e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  15 RRNGLLILSVLSVIVGCLLGFFLRtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTV 93
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLP-----ELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  94 AYYLWTTFMAVIVGIFMVSIIHPGSAAQkETTEQSGKPIMSSADALLDLIRNMFPANLVEAtfkqyrtkttpvvkspkva 173
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLN-LDLADAAAAEAAEAPSLLDFLLNIIPSNIFEA------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 174 peeapprriliygvqeengshvqnFAldltpppevvyksepgtsDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCL 253
Cdd:COG1301  136 ------------------------FA------------------EG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESL 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 254 NESVMKIVAVAVWYFPFGIVFLIAGKILEMDDprAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQ 333
Cdd:COG1301  173 SEVMFKIVGWVMKLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRP 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 334 ALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITAT 413
Cdd:COG1301  251 ALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAV 330

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194239697 414 AASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAH 475
Cdd:COG1301  331 LASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
19-476 7.09e-113

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 341.04  E-value: 7.09e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697   19 LLILSVLSVIVGCLLGFFLrtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYL 97
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697   98 WTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPImSSADALLDLIRNMFPANLVEATFKQyrtkttpvvkspkvapeea 177
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLALIAASLKEAKA-AEAPSLLDFILNIIPSNIFEALAEG------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  178 pprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESV 257
Cdd:pfam00375 135 -------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVM 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  258 MKIVAVAVWYFPFGIVFLIAGKILEMDdpRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLI 337
Cdd:pfam00375 172 MKVIGWVMKLAPIGVFALIANTVGTYG--LGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLT 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  338 ALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASI 417
Cdd:pfam00375 250 AFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASI 329

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 194239697  418 GAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHI 476
Cdd:pfam00375 330 GAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 19-474 1.07e-39

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 149.91  E-value: 1.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  19 LLILSVLSVIVGCLLGFFLRTRR------LSPQeisyfqfpGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVL 91
Cdd:PRK11283  12 ILIALVLGILLGAYLHYHSDSRDwlvsnlLSPA--------GDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  92 TVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETT--------EQSGKPIMSSADALLDLIRNMFPANLVEATFKQyrtkt 163
Cdd:PRK11283  84 TIIYFEVITTVAIILGITLANVFQPGAGIDMSQLatvdiskyQSTTEEVQSHSHGLMGTILSLIPTNIFASMAKG----- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 164 tpvvkspkvapeeapprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRM-GDS 242
Cdd:PRK11283 159 ---------------------------------------------------------EMLPIIFFSVLFGLGLSSLpATH 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 243 GAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKIlemddpravgKKLGFYSVTVVCGLVLhgLFILPLLYFF---- 318
Cdd:PRK11283 182 REPLVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTV----------ANFGFASLWPLAKLVL--LVYFAILFFAlvvl 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 319 -----ITKKNPIVFIRGILQALLIALATSSSSATLPITFKcLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIA 393
Cdd:PRK11283 250 givarLCGLSIWILIRILKDELILAYSTASSETVLPRIIE-KMEAYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIA 328

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 394 QVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIM 473
Cdd:PRK11283 329 QLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVI 408


                 .
gi 194239697 474 A 474
Cdd:PRK11283 409 A 409
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
15-475 4.24e-113

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 342.09  E-value: 4.24e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  15 RRNGLLILSVLSVIVGCLLGFFLRtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTV 93
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLP-----ELVAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  94 AYYLWTTFMAVIVGIFMVSIIHPGSAAQkETTEQSGKPIMSSADALLDLIRNMFPANLVEAtfkqyrtkttpvvkspkva 173
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLN-LDLADAAAAEAAEAPSLLDFLLNIIPSNIFEA------------------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 174 peeapprriliygvqeengshvqnFAldltpppevvyksepgtsDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCL 253
Cdd:COG1301  136 ------------------------FA------------------EG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESL 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 254 NESVMKIVAVAVWYFPFGIVFLIAGKILEMDDprAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQ 333
Cdd:COG1301  173 SEVMFKIVGWVMKLAPIGVFALIAATVAKYGL--DALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRP 250

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 334 ALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITAT 413
Cdd:COG1301  251 ALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAV 330

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194239697 414 AASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAH 475
Cdd:COG1301  331 LASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
19-476 7.09e-113

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 341.04  E-value: 7.09e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697   19 LLILSVLSVIVGCLLGFFLrtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYL 97
Cdd:pfam00375   1 LLLQILIALVLGILIGLFF------PELAAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697   98 WTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPImSSADALLDLIRNMFPANLVEATFKQyrtkttpvvkspkvapeea 177
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLALIAASLKEAKA-AEAPSLLDFILNIIPSNIFEALAEG------------------- 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  178 pprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESV 257
Cdd:pfam00375 135 -------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVM 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  258 MKIVAVAVWYFPFGIVFLIAGKILEMDdpRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLI 337
Cdd:pfam00375 172 MKVIGWVMKLAPIGVFALIANTVGTYG--LGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLT 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  338 ALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASI 417
Cdd:pfam00375 250 AFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASI 329

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 194239697  418 GAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHI 476
Cdd:pfam00375 330 GAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 19-474 1.07e-39

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 149.91  E-value: 1.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  19 LLILSVLSVIVGCLLGFFLRTRR------LSPQeisyfqfpGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVL 91
Cdd:PRK11283  12 ILIALVLGILLGAYLHYHSDSRDwlvsnlLSPA--------GDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  92 TVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETT--------EQSGKPIMSSADALLDLIRNMFPANLVEATFKQyrtkt 163
Cdd:PRK11283  84 TIIYFEVITTVAIILGITLANVFQPGAGIDMSQLatvdiskyQSTTEEVQSHSHGLMGTILSLIPTNIFASMAKG----- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 164 tpvvkspkvapeeapprriliygvqeengshvqnfaldltpppevvyksepgtsdgmNVLGIVFFSATMGIMLGRM-GDS 242
Cdd:PRK11283 159 ---------------------------------------------------------EMLPIIFFSVLFGLGLSSLpATH 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 243 GAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKIlemddpravgKKLGFYSVTVVCGLVLhgLFILPLLYFF---- 318
Cdd:PRK11283 182 REPLVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTV----------ANFGFASLWPLAKLVL--LVYFAILFFAlvvl 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 319 -----ITKKNPIVFIRGILQALLIALATSSSSATLPITFKcLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIA 393
Cdd:PRK11283 250 givarLCGLSIWILIRILKDELILAYSTASSETVLPRIIE-KMEAYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIA 328

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 394 QVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIM 473
Cdd:PRK11283 329 QLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVI 408


                 .
gi 194239697 474 A 474
Cdd:PRK11283 409 A 409
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 24-474 5.69e-33

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 130.56  E-value: 5.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  24 VLSVIVGCLLGFFLrtrrlsPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYLWTTFM 102
Cdd:PRK13027  13 VIALVLGVALGAFF------PHFAESLKPLGDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 103 AVIVGIFMVSIIHPGSAAqketteqsgkpimssadalldlirNMFPANLVEATFKQYRTKTTPVvkspkvapeeapprri 182
Cdd:PRK13027  87 ALVIGLVLAYLTGPGVGM------------------------NIDLRSLDAASLAGYAKNAQSL---------------- 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 183 liygvqeengSHVQNFALDLTPPPEVvyksePGTSDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVA 262
Cdd:PRK13027 127 ----------KGTAGFLLKLIPTTAV-----DAFAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSHVLFRIMG 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 263 VAVWYFPFGIVFLIA---GKiLEMDDPRAVGKKLG-FYS-----VTVVCGLV--LHGLFILPLlyffitkknpivfIRGI 331
Cdd:PRK13027 191 FIIKLAPLGVLGAIAfttGK-YGVGSLKQLGMLVAvFYLtcfvfVVVVLGAVmrLAGFSVFKL-------------IRYL 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 332 LQALLIALATSSSSATLPITFKcLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISIT 411
Cdd:PRK13027 257 REELLIVLGTASSDAVLPQVMR-KLEHMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLV 335

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194239697 412 ATAASIGAAGIPQAGLVTMVIVLTSVG-LPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMA 474
Cdd:PRK13027 336 SLVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGNCVATVVVA 399
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 24-484 1.86e-31

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 126.56  E-value: 1.86e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  24 VLSVIVGCLLGFFlrtrrlSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYLWTTFM 102
Cdd:PRK01663  14 LVAIIIGILLGHF------YPELGAQMKPLGDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 103 AVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADA-----LLDLIRNMFPANLVEAtfkqyrtkttpvvkspkvapeea 177
Cdd:PRK01663  88 ALIIGLIVVNVVQPGAGMNIDPATLDAKAVAQYAAQaheqgTVDFLMDIIPTTVVGA----------------------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 178 pprriliygvqeengshvqnFAldltpppevvyksepgtsDGmNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESV 257
Cdd:PRK01663 145 --------------------FA------------------SG-DILQVLLFAVLFGFALARLGEKGKPVFDFIESLSHVL 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 258 MKIVAVAVWYFPFG----IVFLIA----GKILEMddpravGKKLG-FYS-----VTVVCGLV--LHGLFILPllyffitk 321
Cdd:PRK01663 186 FGIVNMIMKLAPIGafgaMAFTIGkygvGSLVQL------GQLIGcFYItcilfVFVVLGAIarLTGFSIFK-------- 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 322 knpivFIRGILQALLIALATSSSSATLP-ITFKclLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYEL 400
Cdd:PRK01663 252 -----FIRYIKEELLIVLGTSSSESALPrMMEK--MEKLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPL 324

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 401 DFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVG-LPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICrK 479
Cdd:PRK01663 325 SIGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNGVATVVVAKWE-K 403


                 ....*
gi 194239697 480 DFARD 484
Cdd:PRK01663 404 ELDRE 408
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 45-479 1.23e-20

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 94.89  E-value: 1.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697  45 QEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASL-DAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSI-------IHP 116
Cdd:COG1823   61 QSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLkNASSLGKISGLIIGILLGTTAIAALVGILVALLfgltaegLTQ 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 117 GSAaqkETTEqsGKPIMSSADALLDL-----IRNMFPANLveatfkqyrtkttpvvkspkvapeeapprriliygvqeen 191
Cdd:COG1823  141 GAA---ETAR--GEALEERLGEVEDLslpqqILSFIPTNP---------------------------------------- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 192 gshvqnFAlDLTpppevvyKSEPgTSdgmnVLGIVFFSATMGI----MLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWY 267
Cdd:COG1823  176 ------FA-DLT-------GARP-TS----TIAVVIFAAFLGIaalgLRRKKPEQAETFLKGIDALQAIVMRLVRLVLRL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 268 FPFGIVFLIAgKILEMDDPRAVGKKLGFysvTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSAT 347
Cdd:COG1823  237 TPYGVLALMT-KVVATSDFADILNLGKF---VVASYVALIIMFIVHLLLLALAGLNPLTYFKKVWPVLTFAFTSRSSAGT 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 348 LPITFKCLLENNHIDRRIARFVLPVGATINMDGTA-LYEAVAAIFIA-QVNNYELDFGQIITISITATAASIGAAGIPQA 425
Cdd:COG1823  313 IPLNIETQTKRLGVPEGIANFAASFGATIGQNGCAgIYPAMLAVMIApTVGINPLDPSFILTLIAVVTISSFGVAGVGGG 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194239697 426 GLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRK 479
Cdd:COG1823  393 ATFAALIVLSAMGLPVALAGLLISIEPLIDMGRTALNVSGSMTAGTVTSRLLGQ 446
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 221-472 2.16e-09

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 58.91  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 221 NVLGIVFFSATMGIMLGRMGDSGAPLVsfcQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEmddpRAVGK--KLGFYSV 298
Cdd:PRK14695  60 NYIGILSWAVIFGIAMREASKNSKELL---KTIADVTSKIVEWIINLAPFGILGLVFKTISD----KGVGSlaNYGILLV 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 299 TVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQ-ALLIALATSSSSATLPITFKcLLENNHIDRRIARFVLPVGATIN 377
Cdd:PRK14695 133 LLVTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRvSGVTAFFTRSSATNIPVNMK-LCHDLGLNPDTYSVSIPLGSTIN 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 378 MDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWAL--- 454
Cdd:PRK14695 212 MAGVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgvi 291

                        250
                 ....*....|....*....
gi 194239697 455 -DRFRTMINVLGDALAAGI 472
Cdd:PRK14695 292 qDSCETALNSSTDVLFTAV 310
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 221-422 4.98e-08

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 55.25  E-value: 4.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 221 NVLGIVFFSATMGIMLGRMGDSGAPLVsfcQCLNESVMKIVAVAVWYFPFGIVFLIAGKILE--MDDPRAVGKKLGfysV 298
Cdd:PRK13628 146 NYIGILAWAIGLGLALRHASDTTKNVV---NDLSEAVSQIVKWVIRFAPIGIFGLVASTLAEtgFSALAGYAQLLA---V 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 299 TVVCGLVLhGLFILPLLYFFITKKNP--IVFiRGILQALLIALATSSSSATLPITFKcLLENNHIDRRIARFVLPVGATI 376
Cdd:PRK13628 220 LVGCMLFV-ALVVNPLIVFWKIRRNPypLVF-TCLRESGVTAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATI 296

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194239697 377 NMDGtalyeavAAIFI-----AQVN--NYELDFGQIITISITATAASIGAAGI 422
Cdd:PRK13628 297 NMAG-------AAITItvltlAAVHtlGIPVDLPTALLLSVVAAISACGASGV 342
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
221-423 1.95e-07

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 53.25  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 221 NVLGIVFFSATMGIMLGRMGDSGAPLVSfcqCLNESVMKIVAVAVWYFPFGIVFLIAGKILEmddpraVG-KKLGFYS-- 297
Cdd:COG3633  145 NYIGILAWAIGLGLALRHASDTTKTVLS---DLSDAVSKIVRWVIRFAPLGIFGLVASTVAT------TGfSALLGYAhl 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239697 298 --VTVVCGLVLhGLFILPLLYFFITKKNP--IVFiRGILQALLIALATSSSSATLPITFKcLLENNHIDRRIARFVLPVG 373
Cdd:COG3633  216 laVLVGCMLFV-ALVVNPLIVFLKIRRNPypLVF-TCLRESGITAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLG 292

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194239697 374 ATINMDGtalyeavAAIFI-----AQVN--NYELDFGQIITISITATAASIGAAGIP 423
Cdd:COG3633  293 ATINMAG-------AAITItvltlAAVHtlGIEVDLPTALLLSVVAAVSACGASGVA 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH