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Conserved domains on  [gi|15487670|ref|NP_006353|]
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nuclear RNA export factor 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tap-RNA_bind pfam09162
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ...
 119-198 4.08e-50

Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.


:

Pssm-ID: 462696  Cd Length: 80  Bit Score: 168.12  E-value: 4.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670   119 WFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKILDRENRRISIIINSSAPPH 198
Cdd:pfam09162   1 WFKVTIPYGKKYDKKWLLNSIQSLCSVPFTPVDFHYEKNRAVFFVEDASTASALKKVSRKITDEDGRKISIFVNPSAPPY 80
TAP_C smart00804
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ...
 556-618 2.00e-31

C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.


:

Pssm-ID: 197882  Cd Length: 63  Bit Score: 116.25  E-value: 2.00e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15487670    556 SSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFM 618
Cdd:smart00804   1 PASPKPTLSPEQQEMVQAFSAQTGMNAEYSQMCLEDNNWDYERALKNFTELKSEGSIPPEAFA 63
NTF2 cd00780
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ...
 382-538 1.46e-22

Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins.


:

Pssm-ID: 238403  Cd Length: 119  Bit Score: 93.12  E-value: 1.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 382 NLKSLVLHFLQQYYAIYDsGDRQGLLDAYHDGACCSLSIpfipqnparsslaeyfkdsrnvkklkdptlrfRLLKHTRLN 461
Cdd:cd00780   1 SAEDVAKAFVQQYYSIFD-NNREGLHRLYGDTSMLSREG--------------------------------MKQVTGRDA 47

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15487670 462 VVAFLNELP--KTQHDVNSfvVDISAQTSTLLCFSVNGVFKEVDgksrDSLRAFTRTFIAVPaSNSGLCIVNDELFVRN 538
Cdd:cd00780  48 IVEKLSSLPfqKTKHKITT--VDSQPTPSGGVIVMVTGSLKLDE----QPPRKFSQTFVLAP-QNGGYFVLNDIFRFVD 119
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
263-389 2.74e-07

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 2.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 263 NIPELLSLNLSNNRLyrlDDMSSIVQKAPNLKILNLSGNELKS-ERELDKIKglKLEELWLDGNSLcdtfrdqsTYISAI 341
Cdd:COG4886 180 NLTNLKELDLSNNQI---TDLPEPLGNLTNLEELDLSGNQLTDlPEPLANLT--NLETLDLSNNQL--------TDLPEL 246

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15487670 342 rERFPKL--LRLDGHELpppiafdveapTTLPPCKgsyfGTENLKSLVLH 389
Cdd:COG4886 247 -GNLTNLeeLDLSNNQL-----------TDLPPLA----NLTNLKTLDLS 280
 
Name Accession Description Interval E-value
Tap-RNA_bind pfam09162
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ...
 119-198 4.08e-50

Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.


Pssm-ID: 462696  Cd Length: 80  Bit Score: 168.12  E-value: 4.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670   119 WFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKILDRENRRISIIINSSAPPH 198
Cdd:pfam09162   1 WFKVTIPYGKKYDKKWLLNSIQSLCSVPFTPVDFHYEKNRAVFFVEDASTASALKKVSRKITDEDGRKISIFVNPSAPPY 80
TAP_C smart00804
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ...
 556-618 2.00e-31

C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.


Pssm-ID: 197882  Cd Length: 63  Bit Score: 116.25  E-value: 2.00e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15487670    556 SSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFM 618
Cdd:smart00804   1 PASPKPTLSPEQQEMVQAFSAQTGMNAEYSQMCLEDNNWDYERALKNFTELKSEGSIPPEAFA 63
UBA_TAP-C cd14342
UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF ...
 567-617 7.89e-26

UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF family of mRNA nuclear export factors including vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. It is a multi-domain protein with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export.


Pssm-ID: 270527  Cd Length: 51  Bit Score: 99.96  E-value: 7.89e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15487670 567 QQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAF 617
Cdd:cd14342   1 QQQMVQQLSAQTGMNLEWSQKCLEDNGWDYEKALANFEELKAQGKIPPEAF 51
TAP_C pfam03943
TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling ...
 569-617 6.84e-25

TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. The structure of the C-terminal domain is composed of four helices. The structure is related to the UBA domain.


Pssm-ID: 461102  Cd Length: 49  Bit Score: 97.22  E-value: 6.84e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15487670   569 EMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAF 617
Cdd:pfam03943   1 EMVQQFSQQTGMNLEWSEKCLEQNNWDYERALQNFTELKAQGKIPPEAF 49
NTF2 cd00780
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ...
 382-538 1.46e-22

Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins.


Pssm-ID: 238403  Cd Length: 119  Bit Score: 93.12  E-value: 1.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 382 NLKSLVLHFLQQYYAIYDsGDRQGLLDAYHDGACCSLSIpfipqnparsslaeyfkdsrnvkklkdptlrfRLLKHTRLN 461
Cdd:cd00780   1 SAEDVAKAFVQQYYSIFD-NNREGLHRLYGDTSMLSREG--------------------------------MKQVTGRDA 47

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15487670 462 VVAFLNELP--KTQHDVNSfvVDISAQTSTLLCFSVNGVFKEVDgksrDSLRAFTRTFIAVPaSNSGLCIVNDELFVRN 538
Cdd:cd00780  48 IVEKLSSLPfqKTKHKITT--VDSQPTPSGGVIVMVTGSLKLDE----QPPRKFSQTFVLAP-QNGGYFVLNDIFRFVD 119
NTF2 pfam02136
Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like ...
 386-535 5.87e-14

Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.


Pssm-ID: 396625  Cd Length: 116  Bit Score: 68.53  E-value: 5.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670   386 LVLHFLQQYYAIYDSGDRQGLLDAYHDGACCslsipfipqnparsslaEYFKDSRNVKKLKDptlrfrllkhtrlnVVAF 465
Cdd:pfam02136   1 VGNAFVQQYYAALDAHDPEGLHALYADDASM-----------------LTPPGSDPVVGLEA--------------INEF 49

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15487670   466 LNELPKT--QHDVNSFVVDiSAQTSTLLCFSVNGVFKeVDGKSRdslRAFTRTFIAVPAsNSGLCIVNDELF 535
Cdd:pfam02136  50 FDSLPFTriQHKITSVDSQ-PASLKDGVLVMVTGELT-VDDFPR---RRFSQTFLLAPQ-RGGYFVLNDIFR 115
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-389 2.74e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 2.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 263 NIPELLSLNLSNNRLyrlDDMSSIVQKAPNLKILNLSGNELKS-ERELDKIKglKLEELWLDGNSLcdtfrdqsTYISAI 341
Cdd:COG4886 180 NLTNLKELDLSNNQI---TDLPEPLGNLTNLEELDLSGNQLTDlPEPLANLT--NLETLDLSNNQL--------TDLPEL 246

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15487670 342 rERFPKL--LRLDGHELpppiafdveapTTLPPCKgsyfGTENLKSLVLH 389
Cdd:COG4886 247 -GNLTNLeeLDLSNNQL-----------TDLPPLA----NLTNLKTLDLS 280
LRR_8 pfam13855
Leucine rich repeat;
265-327 8.51e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.51e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15487670   265 PELLSLNLSNNRLYRLDDmsSIVQKAPNLKILNLSGNELK--SERELDKIKglKLEELWLDGNSL 327
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD--GAFKGLSNLKVLDLSNNLLTtlSPGAFSGLP--SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 257-352 4.10e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 4.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 257 LRIIE--ENIPELLSLNLSNNRL-----YRLDDMS--SIvqkAPNLKILNLSGNELkseRELDKIKGLK-LEELWLDGNS 326
Cdd:cd21340  80 ISVVEglENLTNLEELHIENQRLppgekLTFDPRSlaAL---SNSLRVLNISGNNI---DSLEPLAPLRnLEQLDASNNQ 153

                        90       100
                ....*....|....*....|....*.
gi 15487670 327 LCDtFRDQSTYISaireRFPKLLRLD 352
Cdd:cd21340 154 ISD-LEELLDLLS----SWPSLRELD 174
 
Name Accession Description Interval E-value
Tap-RNA_bind pfam09162
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ...
 119-198 4.08e-50

Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element.


Pssm-ID: 462696  Cd Length: 80  Bit Score: 168.12  E-value: 4.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670   119 WFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKILDRENRRISIIINSSAPPH 198
Cdd:pfam09162   1 WFKVTIPYGKKYDKKWLLNSIQSLCSVPFTPVDFHYEKNRAVFFVEDASTASALKKVSRKITDEDGRKISIFVNPSAPPY 80
TAP_C smart00804
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ...
 556-618 2.00e-31

C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain.


Pssm-ID: 197882  Cd Length: 63  Bit Score: 116.25  E-value: 2.00e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15487670    556 SSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAFM 618
Cdd:smart00804   1 PASPKPTLSPEQQEMVQAFSAQTGMNAEYSQMCLEDNNWDYERALKNFTELKSEGSIPPEAFA 63
UBA_TAP-C cd14342
UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF ...
 567-617 7.89e-26

UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF family of mRNA nuclear export factors including vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. It is a multi-domain protein with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export.


Pssm-ID: 270527  Cd Length: 51  Bit Score: 99.96  E-value: 7.89e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 15487670 567 QQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAF 617
Cdd:cd14342   1 QQQMVQQLSAQTGMNLEWSQKCLEDNGWDYEKALANFEELKAQGKIPPEAF 51
TAP_C pfam03943
TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling ...
 569-617 6.84e-25

TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. The structure of the C-terminal domain is composed of four helices. The structure is related to the UBA domain.


Pssm-ID: 461102  Cd Length: 49  Bit Score: 97.22  E-value: 6.84e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15487670   569 EMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSAQAFTHLKAKGEIPEVAF 617
Cdd:pfam03943   1 EMVQQFSQQTGMNLEWSEKCLEQNNWDYERALQNFTELKAQGKIPPEAF 49
NTF2 cd00780
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ...
 382-538 1.46e-22

Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins.


Pssm-ID: 238403  Cd Length: 119  Bit Score: 93.12  E-value: 1.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 382 NLKSLVLHFLQQYYAIYDsGDRQGLLDAYHDGACCSLSIpfipqnparsslaeyfkdsrnvkklkdptlrfRLLKHTRLN 461
Cdd:cd00780   1 SAEDVAKAFVQQYYSIFD-NNREGLHRLYGDTSMLSREG--------------------------------MKQVTGRDA 47

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15487670 462 VVAFLNELP--KTQHDVNSfvVDISAQTSTLLCFSVNGVFKEVDgksrDSLRAFTRTFIAVPaSNSGLCIVNDELFVRN 538
Cdd:cd00780  48 IVEKLSSLPfqKTKHKITT--VDSQPTPSGGVIVMVTGSLKLDE----QPPRKFSQTFVLAP-QNGGYFVLNDIFRFVD 119
NTF2 pfam02136
Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like ...
 386-535 5.87e-14

Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.


Pssm-ID: 396625  Cd Length: 116  Bit Score: 68.53  E-value: 5.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670   386 LVLHFLQQYYAIYDSGDRQGLLDAYHDGACCslsipfipqnparsslaEYFKDSRNVKKLKDptlrfrllkhtrlnVVAF 465
Cdd:pfam02136   1 VGNAFVQQYYAALDAHDPEGLHALYADDASM-----------------LTPPGSDPVVGLEA--------------INEF 49

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15487670   466 LNELPKT--QHDVNSFVVDiSAQTSTLLCFSVNGVFKeVDGKSRdslRAFTRTFIAVPAsNSGLCIVNDELF 535
Cdd:pfam02136  50 FDSLPFTriQHKITSVDSQ-PASLKDGVLVMVTGELT-VDDFPR---RRFSQTFLLAPQ-RGGYFVLNDIFR 115
NTF2_like cd00531
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ...
 390-535 1.87e-09

Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes.


Pssm-ID: 238296 [Multi-domain]  Cd Length: 124  Bit Score: 55.98  E-value: 1.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 390 FLQQYYAIYDSGDRQGLLDAYHDGAccslsipfipqnparsslaeYFKDSRNVKKLKDPTLRFRLLKHtrlnvVAFLNEL 469
Cdd:cd00531   4 FLYRYARLLDAGDREWLALLYADDA--------------------YFEPPGGDGLIYPDDGREAIEDR-----VRRLPFG 58

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15487670 470 PKTQHDVNSFVVDISAQTSTLLCFSVNGVFkEVDGKSRDSLRAFTRTFIAVPaSNSGLCIVNDELF 535
Cdd:cd00531  59 PSRTRHLVSNVDVQPGDDGEGVVVSVFGVL-RTRGDGEQDVFAGGQTFVLRP-QGGGGKIANRRFR 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-389 2.74e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 2.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 263 NIPELLSLNLSNNRLyrlDDMSSIVQKAPNLKILNLSGNELKS-ERELDKIKglKLEELWLDGNSLcdtfrdqsTYISAI 341
Cdd:COG4886 180 NLTNLKELDLSNNQI---TDLPEPLGNLTNLEELDLSGNQLTDlPEPLANLT--NLETLDLSNNQL--------TDLPEL 246

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15487670 342 rERFPKL--LRLDGHELpppiafdveapTTLPPCKgsyfGTENLKSLVLH 389
Cdd:COG4886 247 -GNLTNLeeLDLSNNQL-----------TDLPPLA----NLTNLKTLDLS 280
LRR_8 pfam13855
Leucine rich repeat;
265-327 8.51e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 8.51e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15487670   265 PELLSLNLSNNRLYRLDDmsSIVQKAPNLKILNLSGNELK--SERELDKIKglKLEELWLDGNSL 327
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD--GAFKGLSNLKVLDLSNNLLTtlSPGAFSGLP--SLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
262-361 2.35e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 2.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 262 ENIPELLSLNLSNNRLyrlDDMSSIVQKAPNLKILNLSGNELKSEREldKIKGLK-LEELWLDGNSLcdtfrdqsTYISA 340
Cdd:COG4886 110 SNLTNLESLDLSGNQL---TDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTnLKSLDLSNNQL--------TDLPE 176

                        90       100
                ....*....|....*....|....*.
gi 15487670 341 IRERFPKL--LRLDG---HELPPPIA 361
Cdd:COG4886 177 ELGNLTNLkeLDLSNnqiTDLPEPLG 202
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 291-333 1.22e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 1.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15487670   291 PNLKILNLSGNELKSERELDKIKglKLEELWLDGNSLCDTFRD 333
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLP--NLETLDLSGNNKITDLSD 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 265-316 1.68e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15487670   265 PELLSLNLSNNRLYRLDDMSSIvqkaPNLKILNLSGNELksereLDKIKGLK 316
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKL----PNLETLDLSGNNK-----ITDLSDLA 43
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 257-352 4.10e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 4.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15487670 257 LRIIE--ENIPELLSLNLSNNRL-----YRLDDMS--SIvqkAPNLKILNLSGNELkseRELDKIKGLK-LEELWLDGNS 326
Cdd:cd21340  80 ISVVEglENLTNLEELHIENQRLppgekLTFDPRSlaAL---SNSLRVLNISGNNI---DSLEPLAPLRnLEQLDASNNQ 153

                        90       100
                ....*....|....*....|....*.
gi 15487670 327 LCDtFRDQSTYISaireRFPKLLRLD 352
Cdd:cd21340 154 ISD-LEELLDLLS----SWPSLRELD 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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