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prolyl endopeptidase-like isoform 1 [Homo sapiens]
Protein Classification
S9 family peptidase ( domain architecture ID 1001746 )
peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues
List of domain hits
Name
Accession
Description
Interval
E-value
PtrB super family
cl34357 Protease II [Amino acid transport and metabolism];
113-649
9.95e-104
Protease II [Amino acid transport and metabolism];
COG1770 :Pssm-ID: 441376 [Multi-domain]
Cd Length: 686
Bit Score: 332.43
E-value: 9.95e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 113 V EVKH GG FV YY Q --- EG C --- CLV R SKDEE A DN dny EVL FNLEE L KLDQP F IDC -- IR V A PD EKYV A AKIR T ED SE AS T C 184
Cdd:COG1770 83 V PYRD GG YW YY S rte EG K qyp IYC R KPASG A GE --- EVL LDGNA L AEGHD F FSL gg LS V S PD GRLL A YSVD T VG SE RY T L 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 185 V I IK L SDQPVMEASFP N V S - SFE W V kde E D EDV LFYT FQR - N LR CHD V Y R ATF G - D NKRNERF Y T EKD PSY FV FLYL T KD 261
Cdd:COG1770 160 R I KD L ETGEDLPDVIE N T S g GLV W A --- A D NRT LFYT RVD e T LR PYQ V W R HRL G t D PAEDVLV Y E EKD ERF FV GVGK T RS 236
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 262 S R FLT I NIMNK TTSEV W L I D GLS P WDP P V L IQK R IH GV L Y Y VEH RD D EL YILTN VGE P t E FKL M R TAA D T P AIM NW DLFF 341
Cdd:COG1770 237 G R YIV I GSGST TTSEV R L L D ADD P TAE P R L VAP R EE GV E Y S VEH AG D RF YILTN DDA P - N FKL V R APV D A P SRE NW QELI 315
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 342 TMKRNTKVIDL D M FKDH C V LFLKHSN L LYVN V IG L A D DSVRSLKLPPW A CGFIMDT N SDP k NCP --- FQLC S PIR P PKY Y 418
Cdd:COG1770 316 PHRPGVLLEGV D A FKDH L V VSERENG L PRIR V RD L D D GEEHEIAFDEE A YTAGLGG N PEF - DTD tlr YSYS S LTT P SSV Y 394
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 419 T Y KF A E G KL fe ETGHEDPITK ------- T S R vl RL E A KSK DG KL VP MTVFHKT D SEDLQKK PLL VHV YG A YG MDLKMN F R 491
Cdd:COG1770 395 D Y DL A T G ER -- TLLKQQEVPG gfdpady V S E -- RL W A TAR DG TK VP VSLVYRK D TKLDGSA PLL LYG YG S YG ISIDPS F S 470
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 492 PE R RV L V D D G WIL A YC H V RGGGELG LQ W HA DG R L T KK L N GLA D LE AC IKT L HG QG FSQ P SLTTLTAF SAGG V L A GA LC N S 571
Cdd:COG1770 471 TS R LS L L D R G FVY A IA H I RGGGELG RR W YE DG K L L KK K N TFT D FI AC AEH L IA QG YTS P GRIVAMGG SAGG L L M GA VA N M 550
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 70778815 572 N PEL VRA V TLEA PF L DVL N TM M D ttlpltleelee WGNP SS D EKHKN Y I K R Y C PY Q N I K P Q H YP S I HI T AYE ND E RV P 649
Cdd:COG1770 551 A PEL FAG V IAQV PF V DVL T TM L D pslplttgewde WGNP LN D KEAYD Y M K S Y S PY D N V K A Q A YP A I LV T TGL ND S RV Q 628
Name
Accession
Description
Interval
E-value
PtrB
COG1770 Protease II [Amino acid transport and metabolism];
113-649
9.95e-104
Protease II [Amino acid transport and metabolism];
Pssm-ID: 441376 [Multi-domain]
Cd Length: 686
Bit Score: 332.43
E-value: 9.95e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 113 V EVKH GG FV YY Q --- EG C --- CLV R SKDEE A DN dny EVL FNLEE L KLDQP F IDC -- IR V A PD EKYV A AKIR T ED SE AS T C 184
Cdd:COG1770 83 V PYRD GG YW YY S rte EG K qyp IYC R KPASG A GE --- EVL LDGNA L AEGHD F FSL gg LS V S PD GRLL A YSVD T VG SE RY T L 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 185 V I IK L SDQPVMEASFP N V S - SFE W V kde E D EDV LFYT FQR - N LR CHD V Y R ATF G - D NKRNERF Y T EKD PSY FV FLYL T KD 261
Cdd:COG1770 160 R I KD L ETGEDLPDVIE N T S g GLV W A --- A D NRT LFYT RVD e T LR PYQ V W R HRL G t D PAEDVLV Y E EKD ERF FV GVGK T RS 236
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 262 S R FLT I NIMNK TTSEV W L I D GLS P WDP P V L IQK R IH GV L Y Y VEH RD D EL YILTN VGE P t E FKL M R TAA D T P AIM NW DLFF 341
Cdd:COG1770 237 G R YIV I GSGST TTSEV R L L D ADD P TAE P R L VAP R EE GV E Y S VEH AG D RF YILTN DDA P - N FKL V R APV D A P SRE NW QELI 315
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 342 TMKRNTKVIDL D M FKDH C V LFLKHSN L LYVN V IG L A D DSVRSLKLPPW A CGFIMDT N SDP k NCP --- FQLC S PIR P PKY Y 418
Cdd:COG1770 316 PHRPGVLLEGV D A FKDH L V VSERENG L PRIR V RD L D D GEEHEIAFDEE A YTAGLGG N PEF - DTD tlr YSYS S LTT P SSV Y 394
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 419 T Y KF A E G KL fe ETGHEDPITK ------- T S R vl RL E A KSK DG KL VP MTVFHKT D SEDLQKK PLL VHV YG A YG MDLKMN F R 491
Cdd:COG1770 395 D Y DL A T G ER -- TLLKQQEVPG gfdpady V S E -- RL W A TAR DG TK VP VSLVYRK D TKLDGSA PLL LYG YG S YG ISIDPS F S 470
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 492 PE R RV L V D D G WIL A YC H V RGGGELG LQ W HA DG R L T KK L N GLA D LE AC IKT L HG QG FSQ P SLTTLTAF SAGG V L A GA LC N S 571
Cdd:COG1770 471 TS R LS L L D R G FVY A IA H I RGGGELG RR W YE DG K L L KK K N TFT D FI AC AEH L IA QG YTS P GRIVAMGG SAGG L L M GA VA N M 550
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 70778815 572 N PEL VRA V TLEA PF L DVL N TM M D ttlpltleelee WGNP SS D EKHKN Y I K R Y C PY Q N I K P Q H YP S I HI T AYE ND E RV P 649
Cdd:COG1770 551 A PEL FAG V IAQV PF V DVL T TM L D pslplttgewde WGNP LN D KEAYD Y M K S Y S PY D N V K A Q A YP A I LV T TGL ND S RV Q 628
PRK10115
PRK10115 protease 2; Provisional
201-662
9.53e-53
protease 2; Provisional
Pssm-ID: 182247 [Multi-domain]
Cd Length: 686
Bit Score: 194.34
E-value: 9.53e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 201 NV S - SF E W VK D EE ded VLF Y TFQR -- N L RCHD V Y R A T F G D - NKRN E RF Y T EKD PSYF V F L YL T KDSRFLT I NIMNK TTSE 276
Cdd:PRK10115 172 NV E p SF V W AN D SW --- TFY Y VRKH pv T L LPYQ V W R H T I G T p ASQD E LV Y E EKD DTFY V S L HK T TSKHYVV I HLASA TTSE 248
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 277 V W L I D GLSPWDP P VLIQK R IHGVL Y YVE H RDDEL Y ILT N v GEPTE F K L M RT AADTPA im N W DLFFTMKR N TKVIDLDM F K 356
Cdd:PRK10115 249 V L L L D AELADAE P FVFLP R RKDHE Y SLD H YQHRF Y LRS N - RHGKN F G L Y RT RVRDEQ -- Q W EELIPPRE N IMLEGFTL F T 325
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 357 D HC V L -------- F L KHS N LLYVN VIG L A D D SVRSLK lpp W acgfi MDT N SD P KNCPF qlcspirpp K Y - Y TYKFAEGK L 427
Cdd:PRK10115 326 D WL V V eerqrglt S L RQI N RKTRE VIG I A F D DPAYVT --- W ----- IAY N PE P ETSRL --------- R Y g Y SSMTTPDT L 388
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 428 FE --- E TG HEDPITK T S --------- R VLR L EAKSK DG KL VP MTVFHKTDSEDLQKK PLLV HV YG A YG MDLKMN F RPE R R 495
Cdd:PRK10115 389 FE ldm D TG ERRVLKQ T E vpgfdaany R SEH L WITAR DG VE VP VSLVYHRKHFRKGHN PLLV YG YG S YG ASIDAD F SFS R L 468
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 496 V L V D D G WIL A YC HVRGGGELG L QW HA DG RLT KK L N GLA D - L E AC i KT L HGQ G FSQ PSL TTLTAF SAGG V L A G ALC N SN PE 574
Cdd:PRK10115 469 S L L D R G FVY A IV HVRGGGELG Q QW YE DG KFL KK K N TFN D y L D AC - DA L LKL G YGS PSL CYGMGG SAGG M L M G VAI N QR PE 547
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 575 L VRA V TLEA PF L DV LN TM M D TTL PLT LE E L EEWGNP s S D EKHKN Y I K R Y C PY Q N IKP Q H YP SIHI T AYEN D ER V PLKGIV 654
Cdd:PRK10115 548 L FHG V IAQV PF V DV VT TM L D ESI PLT TG E F EEWGNP - Q D PQYYE Y M K S Y S PY D N VTA Q A YP HLLV T TGLH D SQ V QYWEPA 626
....*...
gi 70778815 655 SYTE KL K E 662
Cdd:PRK10115 627 KWVA KL R E 634
Peptidase_S9_N
pfam02897 Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
108-427
6.63e-23
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.
Pssm-ID: 397164 [Multi-domain]
Cd Length: 414
Bit Score: 102.00
E-value: 6.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 108 Y EI I NVEVKH GG FV YY Q -- E G CC ---- L V R SKDEEADNDNY EV LFNLEE L KL D QP F -- IDCIRVA PD EKYV A AKIRTED S 179
Cdd:pfam02897 68 Y DD I SAPFRK GG YY YY F rn D G GK nqsv L Y R QDALPGEGKPE EV FLDPNT L SE D GT F ta LGGFAFS PD GRLL A YSLSLSG S 147
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 180 EAS T CVIIKLSDQPVMEASFPN V -- S SFE W VK D E ede DVL FYT ---------- FQR NL R c HD V Y R ATF G DNKRNER -- F Y 245
Cdd:pfam02897 148 DWY T IRFRDVETGEDLPDVLEG V kf S GIV W AP D G --- KGF FYT rydkpdersd TGT NL N - QK V W R HRL G TPQSQDV lv F E 223
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 246 TE KDP SYFVFLYLTK D SRF L T I NIMNK T - T S E VWLI D GLSPWDPPVLIQKRIHGVL Y Y VEH RD - D EL Y I LTN V G E P T e F K 323
Cdd:pfam02897 224 FP KDP LWSLGAERSE D GKY L F I SSASG T d T N E LYYL D LTKETGDTLKLVDGRFDGE Y D VEH NE g D RF Y F LTN D G A P N - F R 302
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 324 L M R TAADT P AIMN W DLFFTMKRNTKVIDLDM F KDHC VL FLKHSN L LYVN V IG L ADDS V R S LKL P PWAC G FIMDTNSDPKN 403
Cdd:pfam02897 303 L V R VDLND P SPSE W KDLVPEREDVVLEEITV F GNYL VL SYRRDA L SRLQ V FD L KTGK V L S REF P LPGV G SVSGFSGEYDD 382
330 340
....*....|....*....|....*.
gi 70778815 404 CP -- FQLC S PIR P PKY Y TYKF A E G K L 427
Cdd:pfam02897 383 SE lr YSFS S FLT P GTI Y DLDL A T G E L 408
Name
Accession
Description
Interval
E-value
PtrB
COG1770 Protease II [Amino acid transport and metabolism];
113-649
9.95e-104
Protease II [Amino acid transport and metabolism];
Pssm-ID: 441376 [Multi-domain]
Cd Length: 686
Bit Score: 332.43
E-value: 9.95e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 113 V EVKH GG FV YY Q --- EG C --- CLV R SKDEE A DN dny EVL FNLEE L KLDQP F IDC -- IR V A PD EKYV A AKIR T ED SE AS T C 184
Cdd:COG1770 83 V PYRD GG YW YY S rte EG K qyp IYC R KPASG A GE --- EVL LDGNA L AEGHD F FSL gg LS V S PD GRLL A YSVD T VG SE RY T L 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 185 V I IK L SDQPVMEASFP N V S - SFE W V kde E D EDV LFYT FQR - N LR CHD V Y R ATF G - D NKRNERF Y T EKD PSY FV FLYL T KD 261
Cdd:COG1770 160 R I KD L ETGEDLPDVIE N T S g GLV W A --- A D NRT LFYT RVD e T LR PYQ V W R HRL G t D PAEDVLV Y E EKD ERF FV GVGK T RS 236
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 262 S R FLT I NIMNK TTSEV W L I D GLS P WDP P V L IQK R IH GV L Y Y VEH RD D EL YILTN VGE P t E FKL M R TAA D T P AIM NW DLFF 341
Cdd:COG1770 237 G R YIV I GSGST TTSEV R L L D ADD P TAE P R L VAP R EE GV E Y S VEH AG D RF YILTN DDA P - N FKL V R APV D A P SRE NW QELI 315
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 342 TMKRNTKVIDL D M FKDH C V LFLKHSN L LYVN V IG L A D DSVRSLKLPPW A CGFIMDT N SDP k NCP --- FQLC S PIR P PKY Y 418
Cdd:COG1770 316 PHRPGVLLEGV D A FKDH L V VSERENG L PRIR V RD L D D GEEHEIAFDEE A YTAGLGG N PEF - DTD tlr YSYS S LTT P SSV Y 394
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 419 T Y KF A E G KL fe ETGHEDPITK ------- T S R vl RL E A KSK DG KL VP MTVFHKT D SEDLQKK PLL VHV YG A YG MDLKMN F R 491
Cdd:COG1770 395 D Y DL A T G ER -- TLLKQQEVPG gfdpady V S E -- RL W A TAR DG TK VP VSLVYRK D TKLDGSA PLL LYG YG S YG ISIDPS F S 470
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 492 PE R RV L V D D G WIL A YC H V RGGGELG LQ W HA DG R L T KK L N GLA D LE AC IKT L HG QG FSQ P SLTTLTAF SAGG V L A GA LC N S 571
Cdd:COG1770 471 TS R LS L L D R G FVY A IA H I RGGGELG RR W YE DG K L L KK K N TFT D FI AC AEH L IA QG YTS P GRIVAMGG SAGG L L M GA VA N M 550
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 70778815 572 N PEL VRA V TLEA PF L DVL N TM M D ttlpltleelee WGNP SS D EKHKN Y I K R Y C PY Q N I K P Q H YP S I HI T AYE ND E RV P 649
Cdd:COG1770 551 A PEL FAG V IAQV PF V DVL T TM L D pslplttgewde WGNP LN D KEAYD Y M K S Y S PY D N V K A Q A YP A I LV T TGL ND S RV Q 628
PRK10115
PRK10115 protease 2; Provisional
201-662
9.53e-53
protease 2; Provisional
Pssm-ID: 182247 [Multi-domain]
Cd Length: 686
Bit Score: 194.34
E-value: 9.53e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 201 NV S - SF E W VK D EE ded VLF Y TFQR -- N L RCHD V Y R A T F G D - NKRN E RF Y T EKD PSYF V F L YL T KDSRFLT I NIMNK TTSE 276
Cdd:PRK10115 172 NV E p SF V W AN D SW --- TFY Y VRKH pv T L LPYQ V W R H T I G T p ASQD E LV Y E EKD DTFY V S L HK T TSKHYVV I HLASA TTSE 248
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 277 V W L I D GLSPWDP P VLIQK R IHGVL Y YVE H RDDEL Y ILT N v GEPTE F K L M RT AADTPA im N W DLFFTMKR N TKVIDLDM F K 356
Cdd:PRK10115 249 V L L L D AELADAE P FVFLP R RKDHE Y SLD H YQHRF Y LRS N - RHGKN F G L Y RT RVRDEQ -- Q W EELIPPRE N IMLEGFTL F T 325
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 357 D HC V L -------- F L KHS N LLYVN VIG L A D D SVRSLK lpp W acgfi MDT N SD P KNCPF qlcspirpp K Y - Y TYKFAEGK L 427
Cdd:PRK10115 326 D WL V V eerqrglt S L RQI N RKTRE VIG I A F D DPAYVT --- W ----- IAY N PE P ETSRL --------- R Y g Y SSMTTPDT L 388
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 428 FE --- E TG HEDPITK T S --------- R VLR L EAKSK DG KL VP MTVFHKTDSEDLQKK PLLV HV YG A YG MDLKMN F RPE R R 495
Cdd:PRK10115 389 FE ldm D TG ERRVLKQ T E vpgfdaany R SEH L WITAR DG VE VP VSLVYHRKHFRKGHN PLLV YG YG S YG ASIDAD F SFS R L 468
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 496 V L V D D G WIL A YC HVRGGGELG L QW HA DG RLT KK L N GLA D - L E AC i KT L HGQ G FSQ PSL TTLTAF SAGG V L A G ALC N SN PE 574
Cdd:PRK10115 469 S L L D R G FVY A IV HVRGGGELG Q QW YE DG KFL KK K N TFN D y L D AC - DA L LKL G YGS PSL CYGMGG SAGG M L M G VAI N QR PE 547
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 575 L VRA V TLEA PF L DV LN TM M D TTL PLT LE E L EEWGNP s S D EKHKN Y I K R Y C PY Q N IKP Q H YP SIHI T AYEN D ER V PLKGIV 654
Cdd:PRK10115 548 L FHG V IAQV PF V DV VT TM L D ESI PLT TG E F EEWGNP - Q D PQYYE Y M K S Y S PY D N VTA Q A YP HLLV T TGLH D SQ V QYWEPA 626
....*...
gi 70778815 655 SYTE KL K E 662
Cdd:PRK10115 627 KWVA KL R E 634
PreP
COG1505 Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
78-648
2.06e-32
Prolyl endopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism];
Pssm-ID: 441114 [Multi-domain]
Cd Length: 673
Bit Score: 133.71
E-value: 2.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 78 VK QE N EKPLP -- ENMDAF E KV R TK L E tqpqeey E II N VE ----- V K H GG FV Y Y ------ Q E - G cc LV R SK D ee ADNDNY E 143
Cdd:COG1505 39 VK AQ N AVTRA yl AAIPRR E AL R AR L L ------- E LL N YD ripap F K R GG RY Y N fwndgl Q N q G -- VL R VR D -- GLDPEW E 107
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 144 VL FNLEE L KL D QP - FIDCIRVA PD EKYV A AKIRTED S E A STCVIIKLSDQPVM E AS F PNV -- S SFE W V kdee D EDVLF Y T 220
Cdd:COG1505 108 VL LDPNA L SE D GT w VLGAWSLS PD GRRL A YSLSEGG S D A RVVRVFDVATGEFV E DG F EWE kk S GVA W L ---- D GTGFV Y S 183
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 221 ------------- FQ R NLRC H -------- D VY ra T F GD nkrnerfy TEK DP SYF V FLYLTK D S R F L T I NIMNKT - TS E VW 278
Cdd:COG1505 184 rygepegsltdsg YP R KVYY H rrgtpqse D EL -- V F EG -------- PPD DP ERY V GVSVSE D G R Y L L I SRALGF y RN E LY 253
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 279 L I D ---- G L S P W D P P V liqkrih GVL Y YVEHRDDE LY I LT NVGE P T e FK L MRTAADT P AIM NW DL F FTMKRNT k VIDLDM 354
Cdd:COG1505 254 L L D lpdg E L V P L D L P F ------- DAD Y SGVVNGGW LY L LT RLDA P R - GR L VAIDLAA P GPR NW TE F IPEAEAV - LEGVSW 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 355 FKDH cv L F L khsn LLYVN V IG ------ L ADDS VR SLK LP PWACGFIMDTNS D PKNCPFQLC S PIR PP KY Y T Y KFAE G KL - 427
Cdd:COG1505 325 TGGR -- L V L ---- SYLDD V VS rvrvyd L DGKL VR EVP LP GLGSVSGFSGDD D GDELFYSFT S FLT PP TL Y R Y DLGT G ES e 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 428 -------- F EETGH E dpitktsr V LRLE A K SKDG KL VP MTVF HK TDSEDLQKK P L L VHV YG AYGMD L KMNFRPERRVLVD 499
Cdd:COG1505 399 llkkppap F DASDY E -------- V EQVF A T SKDG TR VP YFIV HK KGLKLDGPN P T L LYG YG GFNIS L TPSYSASGLAWLE 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 500 D G WIL A YCHV RGGGE L G LQ WH AD G RLTK K L N GLA D LE A CIKT L HGQ G FSQ P SLTTLTAF S A GG V L A GA LCNSN PEL VR AV 579
Cdd:COG1505 471 R G GVY A VANL RGGGE Y G PA WH QA G LKEN K Q N VFD D FI A AAED L IAR G YTS P ERLAIQGG S N GG L L V GA ALTQR PEL FG AV 550
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 70778815 580 TLEA P F LD V L NT --------- MMD ttlpltleelee W G N P s S D EKHKN Y IKR Y C PY Q N I K P - QH YP SIHI T AYEN D E RV 648
Cdd:COG1505 551 VCAV P L LD M L RY hkftagasw IAE ------------ Y G D P - D D PEEFA Y LYA Y S PY H N V K A g VA YP ATLF T TADH D D RV 616
Peptidase_S9_N
pfam02897 Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded ...
108-427
6.63e-23
Prolyl oligopeptidase, N-terminal beta-propeller domain; This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see pfam00326), excluding larger peptides and proteins from proteolysis in the cytosol.
Pssm-ID: 397164 [Multi-domain]
Cd Length: 414
Bit Score: 102.00
E-value: 6.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 108 Y EI I NVEVKH GG FV YY Q -- E G CC ---- L V R SKDEEADNDNY EV LFNLEE L KL D QP F -- IDCIRVA PD EKYV A AKIRTED S 179
Cdd:pfam02897 68 Y DD I SAPFRK GG YY YY F rn D G GK nqsv L Y R QDALPGEGKPE EV FLDPNT L SE D GT F ta LGGFAFS PD GRLL A YSLSLSG S 147
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 180 EAS T CVIIKLSDQPVMEASFPN V -- S SFE W VK D E ede DVL FYT ---------- FQR NL R c HD V Y R ATF G DNKRNER -- F Y 245
Cdd:pfam02897 148 DWY T IRFRDVETGEDLPDVLEG V kf S GIV W AP D G --- KGF FYT rydkpdersd TGT NL N - QK V W R HRL G TPQSQDV lv F E 223
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 246 TE KDP SYFVFLYLTK D SRF L T I NIMNK T - T S E VWLI D GLSPWDPPVLIQKRIHGVL Y Y VEH RD - D EL Y I LTN V G E P T e F K 323
Cdd:pfam02897 224 FP KDP LWSLGAERSE D GKY L F I SSASG T d T N E LYYL D LTKETGDTLKLVDGRFDGE Y D VEH NE g D RF Y F LTN D G A P N - F R 302
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 324 L M R TAADT P AIMN W DLFFTMKRNTKVIDLDM F KDHC VL FLKHSN L LYVN V IG L ADDS V R S LKL P PWAC G FIMDTNSDPKN 403
Cdd:pfam02897 303 L V R VDLND P SPSE W KDLVPEREDVVLEEITV F GNYL VL SYRRDA L SRLQ V FD L KTGK V L S REF P LPGV G SVSGFSGEYDD 382
330 340
....*....|....*....|....*.
gi 70778815 404 CP -- FQLC S PIR P PKY Y TYKF A E G K L 427
Cdd:pfam02897 383 SE lr YSFS S FLT P GTI Y DLDL A T G E L 408
Peptidase_S9
pfam00326 Prolyl oligopeptidase family;
490-713
1.82e-21
Prolyl oligopeptidase family;
Pssm-ID: 459761 [Multi-domain]
Cd Length: 213
Bit Score: 93.45
E-value: 1.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 490 F RPERRV L V D D G WIL A YCHV RG G G EL G LQW H AD G RLTKKL N GLA D LE A CIKT L HG QG FSQ P SLTTLTAF S A GG V L A GA LC 569
Cdd:pfam00326 3 F SWNAQL L A D R G YVV A IANG RG S G GY G EAF H DA G KGDLGQ N EFD D FI A AAEY L IE QG YTD P DRLAIWGG S Y GG Y L T GA AL 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 570 N SN P E L VR A VTLEA P FL D V L n TM M DT T LPLTL E ELE EWGNP SSD E KHKN Y IKR Y C P YQ N I K P qh YP SIHITAYEN D E RVP 649
Cdd:pfam00326 83 N QR P D L FK A AVAHV P VV D W L - AY M SD T SLPFT E RYM EWGNP WDN E EGYD Y LSP Y S P AD N V K V -- YP PLLLIHGLL D D RVP 159
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 70778815 650 LKGIVSYTEK L KEA iaehakdt G EGYQ tpnii L D I Q P GGN H V I -- EDSHKKIT A QI - K FL Y E E LG LD 713
Cdd:pfam00326 160 PWQSLKLVAA L QRK -------- G VPFL ----- L L I F P DEG H G I gk PRNKVEEY A RE l A FL L E Y LG GT 213
DAP2
COG1506 Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
449-711
2.22e-11
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
Pssm-ID: 441115 [Multi-domain]
Cd Length: 234
Bit Score: 64.27
E-value: 2.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 449 KS K DG KLV P MTVFHKT D SE dlq K K P LL V H V Y G a YGMDLKMN F R P ERRV L VDD G WILAYCHV RG G GE LGLQ W HA D grltkk 528
Cdd:COG1506 3 KS A DG TTL P GWLYLPA D GK --- K Y P VV V Y V H G - GPGSRDDS F L P LAQA L ASR G YAVLAPDY RG Y GE SAGD W GG D ------ 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 529 ln GLA D LE A C I KT L HGQGFSQ P SLTTLTAF S A GG VL A GALCNSN P ELVR A VTLE A PFL D vlnt MMDTTLPLTLEELEEW G 608
Cdd:COG1506 73 -- EVD D VL A A I DY L AARPYVD P DRIGIYGH S Y GG YM A LLAAARH P DRFK A AVAL A GVS D ---- LRSYYGTTREYTERLM G 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70778815 609 N P SS D EKH knyikrycp Y QNIK P QH Y - PSIH ---- ITAY E N D E RVP lkgi VSYT E K L K EA IAEHA K DTG egyqtpnii L D 683
Cdd:COG1506 147 G P WE D PEA --------- Y AARS P LA Y a DKLK tpll LIHG E A D D RVP ---- PEQA E R L Y EA LKKAG K PVE --------- L L 204
250 260 270
....*....|....*....|....*....|
gi 70778815 684 IQ PG GN H VIEDSHKK -- ITAQIK FL YEE L G 711
Cdd:COG1506 205 VY PG EG H GFSGAGAP dy LERILD FL DRH L K 234
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
