BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGK 114
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCSQVGGSDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 24497462 115 LHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 158
Cdd:cd18415  81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 124

Potassium voltage-gated channel; Fast inactivation of voltage-dependant potassium channels occurs by a 'ball-and-chain'-type mechanism. It controls membrane excitability and signal propagation in central neurons. Inactivation is regulated by protein phosphorylation where phosphorylation of serine residues leads to a reduction of the fast inactivation.

                          10        20
                  ....*....|....*....|....*....
gi 24497462     1 MISSVCVSSYRGRKSGNKPPSKTCLKEEM 29
Cdd:pfam11404   1 MISSVCVSSFRGRKSGNKSPSKSCLDEDM 29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGK 114
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCSQVGGSDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 24497462 115 LHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 158
Cdd:cd18415  81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 124

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462    38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGG-RPETDgggvgssgssggggcEFFFDRHPGVFAYVLNYYRT-GKL 115
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELECDDyDDDTN---------------EYFFDRSPKHFETILNFYRTgGKL 65

                          90       100
                  ....*....|....*....|....*...
gi 24497462   116 HCPADVCGPLFEEELTFWGIDETDVEPC 143
Cdd:pfam02214  66 HRPEEVCLDEFLEEAEFYGLDELALELC 93

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462     38 IIINVGGTRHETYRSTLRTLPGTRLAWLAdpdgGGRPETDGGgvgssgssggggCEFFFDRHPGVFAYVLNYYRTGKLHC 117
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFS----SDFKESDKS------------EIYLDDVSPEDFRALLNFLYTGKLDL 65

                           90       100       110
                   ....*....|....*....|....*....|....
gi 24497462    118 PADvCGPLFEEELTFWGIDEtDVEPCCWMTYRQH 151
Cdd:smart00225  66 PEE-NVEELLELADYLQIPG-LVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGK 114
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCSQVGGSDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 24497462 115 LHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 158
Cdd:cd18415  81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGrPETDGGGvgssgssggggCEFFFDRHPGVFAYVLNYYRTGKLHC 117
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASA-FDYDPVT-----------GEFFFDRHPGVFAQILNYYRTGKLHC 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 24497462 118 PADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 158
Cdd:cd18379  69 PADVCGPLFEEELAFWGIDETQIEPCCWMTYRQHRDAQETL 109

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462   225 ARVVAFASLFFILVSITTFCLETHeafnidrnvteilrvgnitsvhFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCP 304
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETY----------------------FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAG 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462   305 DTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSkaardvLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLL 384
Cdd:pfam00520  59 FKKRYFRSPWNILDFVVVLPSLISLVLSSVGS------LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNL 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462   385 IIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM-------LVGALCA 457
Cdd:pfam00520 133 LLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFII 212

                         250       260
                  ....*....|....*....|....*.
gi 24497462   458 LAGVLTIAMPVPVIVNNFGMYYSLAM 483
Cdd:pfam00520 213 LGGFLLLNLFIAVIIDNFQELTERTE 238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDgggvgssgssggggcEFFFDRHPGVFAYVLNYYRTGKLHC 117
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHAYDESTN---------------EYFFDRNPEVFEAILDYYRTGELHL 65

                        90
                ....*....|....*..
gi 24497462 118 PADVCGPLFEEELTFWG 134
Cdd:cd18317  66 PSNVCPASFKEELEFWG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  37 KIIINVGGTRHETYRSTLRTLPGTRLA-----WLADPDGGgrpetdgggvgssgssggggcEFFFDRHPGVFAYVLNYYR 111
Cdd:cd18380   1 RIVINVSGRRFETWKNTLEKYPDTLLGstekeFFYDDDTK---------------------EYFFDRDPEIFRHILNFYR 59

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 24497462 112 TGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152
Cdd:cd18380  60 TGKLHYPRHECISAYDDELAFFGILPEIIGDCCYEDYRDRK 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDgggrpeTDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGK 114
Cdd:cd18412  16 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCN------THESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGK 89

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 24497462 115 LHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152
Cdd:cd18412  90 LHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTRLawladpdggGRPETDGGGVGSSGssggggcEFFFDRHPGVFAYVLNYYRTGKL 115
Cdd:cd18420  36 EKLIINVSGRRFETWRNTLEKYPDTLL---------GSNEREFFYDEETK-------EYFFDRDPDIFRHILNYYRTGKL 99

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24497462 116 HCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152
Cdd:cd18420 100 HYPKHECLTAYDEELAFFGIMPDIIGDCCYEDYRDRK 136

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTRLawladpdggGRPETDGGGVGSSGssggggcEFFFDRHPGVFAYVLNYYRTGKL 115
Cdd:cd18419  35 ELIVLNVSGRRFQTWRTTLERYPDTLL---------GSTEKEFFFNEDTK-------EYFFDRDPEVFRCVLNFYRTGKL 98

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24497462 116 HCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152
Cdd:cd18419  99 HYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRK 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  13 RKSGNKPPSKTclkeemaKGEASEKIIINVGGTRHETYRSTLRTLPGTRLawladpdggGRPETDGGGVGSSGssggggc 92
Cdd:cd18417  19 KKPMPKPPSDK-------KRRNDEILVVNVSGRRFQTWKNTLDRYPDTLL---------GSSEKEFFYNEDTQ------- 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  93 EFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 152
Cdd:cd18417  76 EYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRK 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  38 IIINVGGTRHETYRSTLRTLPGTRLAWL--ADPDGGGRPETDGGGVGSSgssggggcEFFFDRHPGVFAYVLNYYRTGKL 115
Cdd:cd18384   1 IRINVGGFRRRLSASALLRFPGTRLGRLlaCHSEEAILELCDDYDVAAR--------EFYFDRNPGFFLYVLHFYRTGKL 72

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24497462 116 HCPADVCGPLFEEELTFWGIDETDVEPCCwmTYRQH 151
Cdd:cd18384  73 HVMDELCVFSFSQEIEYWGINEFFLDSCC--SYRYH 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  38 IIINVGGTRHETYRSTLRTLPGTRLAWLAdpdgGGRPETDGGGVGSSGSSGGGgcEFFFDRHPGVFAYVLNYYRTGKLHC 117
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSRLK----ACRSEDDILRVCDDYDVERN--EFFFDRSPEAFGVILLFLRAGKLRL 74

                        90       100       110
                ....*....|....*....|....*....|...
gi 24497462 118 PADVCGPLFEEELTFWGIDETDVEPCCWMTYRQ 150
Cdd:cd18382  75 LREMCALSFQEELAYWGIEEAHLERCCKRRLLR 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDgggrpeTDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKL 115
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRFPHTRLGKLLNCH------SEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKL 74

                        90       100
                ....*....|....*....|....*....
gi 24497462 116 HCPADVCGPLFEEELTFWGIDETDVEPCC 144
Cdd:cd18428  75 HVMEELCVFSFCQEIEYWGINELFIDSCC 103

Potassium voltage-gated channel; Fast inactivation of voltage-dependant potassium channels occurs by a 'ball-and-chain'-type mechanism. It controls membrane excitability and signal propagation in central neurons. Inactivation is regulated by protein phosphorylation where phosphorylation of serine residues leads to a reduction of the fast inactivation.

                          10        20
                  ....*....|....*....|....*....
gi 24497462     1 MISSVCVSSYRGRKSGNKPPSKTCLKEEM 29
Cdd:pfam11404   1 MISSVCVSSFRGRKSGNKSPSKSCLDEDM 29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGggvgssgssggggcEFFFDRHPGVFAYVLNYYRTGKLHC 117
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDEDG--------------SIFIDRDPELFRHILNFLRTGKLPL 66

                ...
gi 24497462 118 PAD 120
Cdd:cd18316  67 PSD 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLA---------------DPDGGgrpetdgggvgssgssggggcEFFFDRHP 100
Cdd:cd18423   2 REIIINVGGIKYLMPWSTLDEFPLTRLGKLKfcssyeeivqicddyDEDTN---------------------EFFFDRNP 60

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 24497462 101 GVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCC 144
Cdd:cd18423  61 CAFRMIVSFLAAGKLRLLREMCALSFQEELTYWGIEEANLERCC 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTrlaWLADPDGGGRPETDGGGvgssgssggggcEFFFDRHPGVFAYVLNYYRT-GK 114
Cdd:cd18408   6 ERVVLNVAGLRFETRARTLGRFPDT---LLGDPARRGRFYDDRRR------------EYFFDRHRPSFDAVLYYYQSgGR 70

                        90       100
                ....*....|....*....|...
gi 24497462 115 LHCPADVCGPLFEEELTFWGIDE 137
Cdd:cd18408  71 LRRPAHVPLDVFLEEVAFYGLGA 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTrlaWLADPDGGGR---PETDgggvgssgssggggcEFFFDRHPGVFAYVLNYYRT 112
Cdd:cd18377   1 ERVVINVSGLRFETQLKTLAQFPNT---LLGDPNKRMRffdPLRN---------------EYFFDRNRPSFDAILYYYQS 62

                        90       100
                ....*....|....*....|..
gi 24497462 113 -GKLHCPADVCGPLFEEELTFW 133
Cdd:cd18377  63 gGRLRRPVNVPLDIFLEEIRFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLADpdgGGRPETDGGGVgssgssggggcEFFFDRHPGVFAYVLNYYRTGKL 115
Cdd:cd18375   1 ELVTLNVGGKKFTTRPSTLRRFPDSRLARMLD---GKDQDFKVVNG-----------QFFVDRDGSLFSYILDYLRTGQL 66

                ....*
gi 24497462 116 HCPAD 120
Cdd:cd18375  67 TLPTE 71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTrlaWLADPDGGGR---PETDgggvgssgssggggcEFFFDRHPGVFAYVLNYYRT 112
Cdd:cd18403   1 ERVVINISGLRFETQLKTLAQFPET---LLGDPKKRMRyfdPLRN---------------EYFFDRNRPSFDAILYYYQS 62

                        90       100       110
                ....*....|....*....|....*....|
gi 24497462 113 -GKLHCPADVCGPLFEEELTFWGIDETDVE 141
Cdd:cd18403  63 gGRLRRPVNVPLDIFSEEIRFYELGEEAME 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGTRLawladpdggGRPETDGGGVGSSGSsggggcEFFFDRHPGVFAYVLNYYRT-GK 114
Cdd:cd18409   1 QKVIINIAGLRFETQLKTLDQFPDTLL---------GDPEKRMKYFDSMRN------EYFFDRNRPSFDGILYYYQSgGK 65

                        90
                ....*....|....*....
gi 24497462 115 LHCPADVCGPLFEEELTFW 133
Cdd:cd18409  66 IRRPANVPLDVFADEIIFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 1 (KCNA1); KCNA1 is also called voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, or voltage-gated potassium channel subunit Kv1.1. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. It is involved in the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  33 EASEKIIINVGGTRHETYRSTLRTLPGTRLawladpdggGRPETDGGGVGSSGSsggggcEFFFDRHPGVFAYVLNYYRT 112
Cdd:cd18402   6 ECCERVVINIAGLRFETQLKTLAQFPNTLL---------GNPKKRMRYFDPLRN------EYFFDRNRPSFDAILYYYQS 70

                        90       100
                ....*....|....*....|....*.
gi 24497462 113 -GKLHCPADVCGPLFEEELTFWGIDE 137
Cdd:cd18402  71 gGRLRRPVNVPLDMFSEEIKFYELGE 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  36 EKIIINVGGTRHETYRSTLRTLPGT--------RLAWLADPDGGgrpetdgggvgssgssggggceFFFDRHPGVFAYVL 107
Cdd:cd18393   2 EVIHLNVGGKRFSTSRQTLTWIPDSffssllsgRISTLKDETGA----------------------IFIDRDPTVFAPIL 59

                        90       100
                ....*....|....*....|....*...
gi 24497462 108 NYYRTGKLHcPADVCGPLFEEELTFWGI 135
Cdd:cd18393  60 NFLRTKELD-PRGIHVSLLLHEAQFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLAdpDGGGRPETDGGGvgssgssggggcEFFFDRHPGVFAYVLNYYRTGK 114
Cdd:cd18371   1 SQVVSLNVGGHIYTTTLSTLRKFPGSKLAELF--NGQPKLRTDSEG------------RYFIDRDGTYFRYILEYLRTNQ 66

                        90       100
                ....*....|....*....|....*...
gi 24497462 115 LhcPADVCGPLFEEELTFwgidetDVEP 142
Cdd:cd18371  67 V--PTQHIQEVYKEALFY------DIEP 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24497462  40 INVGGTRHETYRSTLRTLPGTRLAWLA--DPD-GGGRPETDGggvgssgssggggceFFFDRHPGVFAYVLNYYRTGKL 115
Cdd:cd18362   4 LNVGGTYFLTTRTTLCRDPKSFLCRLCqeDPDlPSDKDETGA---------------YLIDRDPTYFGPILNYLRHGKL 67

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24497462  40 INVGGTrheTYRSTLRTL---PGTRLAWLADpdgGGRPetdgggvgssGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLH 116
Cdd:cd18361   3 IDVGGH---IYTSSLETLtkyPESRLGKLFN---GSIP----------IVLDSLKQHYFIDRDGKMFRHILNFLRTSKLL 66

                        90       100
                ....*....|....*....|..
gi 24497462 117 CPADVCG-PLFEEELTFWGIDE 137
Cdd:cd18361  67 LPDDFTEfDLLYEEARYYELQP 88