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Conserved domains on  [gi|118582284|ref|NP_002439|]
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homeobox protein MSX-1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677
PubMed:  26464018

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
173-229 1.44e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 101.42  E-value: 1.44e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 118582284  173 RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKR 229
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 105-248 3.94e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118582284 105 APDAPSSPRPLGHFSVGGLLKLPEdalvKAESPEKPERTPWMQSPRFSPPPARRLSP--PACT--LRKHKTNRKPRTPFt 180
Cdd:PTZ00449 593 EPKKPKRPRSAQRPTRPKSPKLPE----LLDIPKSPKRPESPKSPKRPPPPQRPSSPerPEGPkiIKSPKPPKSPKPPF- 667

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118582284 181 taqllalERKFRQKQYLSIAERAEFSSslsltETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPP 248
Cdd:PTZ00449 668 -------DPKFKEKFYDDYLDAAAKSK-----ETKTTVVLDESFESILKETLPETPGTPFTTPRPLPP 723
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
173-229 1.44e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 101.42  E-value: 1.44e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 118582284  173 RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKR 229
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 172-228 1.49e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.16  E-value: 1.49e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 118582284   172 NRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAK 228
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 173-231 5.44e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.61  E-value: 5.44e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 118582284 173 RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQ 231
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
173-238 1.93e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.30  E-value: 1.93e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 118582284 173 RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKL 238
Cdd:COG5576   52 KSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQR 117
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 105-248 3.94e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118582284 105 APDAPSSPRPLGHFSVGGLLKLPEdalvKAESPEKPERTPWMQSPRFSPPPARRLSP--PACT--LRKHKTNRKPRTPFt 180
Cdd:PTZ00449 593 EPKKPKRPRSAQRPTRPKSPKLPE----LLDIPKSPKRPESPKSPKRPPPPQRPSSPerPEGPkiIKSPKPPKSPKPPF- 667

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118582284 181 taqllalERKFRQKQYLSIAERAEFSSslsltETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPP 248
Cdd:PTZ00449 668 -------DPKFKEKFYDDYLDAAAKSK-----ETKTTVVLDESFESILKETLPETPGTPFTTPRPLPP 723
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
173-229 1.44e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 101.42  E-value: 1.44e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 118582284  173 RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKR 229
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 172-228 1.49e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.16  E-value: 1.49e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 118582284   172 NRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAK 228
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 173-231 5.44e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 89.61  E-value: 5.44e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 118582284 173 RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQ 231
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
173-238 1.93e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 61.30  E-value: 1.93e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 118582284 173 RKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKL 238
Cdd:COG5576   52 KSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQR 117
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 105-248 3.94e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.90  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118582284 105 APDAPSSPRPLGHFSVGGLLKLPEdalvKAESPEKPERTPWMQSPRFSPPPARRLSP--PACT--LRKHKTNRKPRTPFt 180
Cdd:PTZ00449 593 EPKKPKRPRSAQRPTRPKSPKLPE----LLDIPKSPKRPESPKSPKRPPPPQRPSSPerPEGPkiIKSPKPPKSPKPPF- 667

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 118582284 181 taqllalERKFRQKQYLSIAERAEFSSslsltETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPP 248
Cdd:PTZ00449 668 -------DPKFKEKFYDDYLDAAAKSK-----ETKTTVVLDESFESILKETLPETPGTPFTTPRPLPP 723
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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