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Conserved domains on  [gi|20070166|ref|NP_002227|]
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potassium voltage-gated channel subfamily F member 1 [Homo sapiens]

Protein Classification

potassium voltage-gated channel subfamily F member 1( domain architecture ID 13034954)

potassium voltage-gated channel subfamily F member 1 (KCNF1) functions as a regulatory alpha-subunit of the voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_Kv5_KCNF1 cd18381
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-138 1.38e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


:

Pssm-ID: 349690  Cd Length: 116  Bit Score: 253.53  E-value: 1.38e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  23 IEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKK 102
Cdd:cd18381   1 TEIVVNVGGVRQVLYGDVLNRYPETRLAELLNCLSGGYDAIFSLCDDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKK 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20070166 103 GICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREEL 138
Cdd:cd18381  81 GICPICFKNEMDFWRVDLDFLDECCKCHLSEKREEL 116
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 181-417 1.02e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 175.53  E-value: 1.02e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   181 ARVVAVLSFLLILVSSVVMCMGTIPELQvldaegnRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDV 260
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE-------EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   261 LAILPFYVSLtlthlgarMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSA 340
Cdd:pfam00520  74 VVVLPSLISL--------VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   341 LGYTM---------EQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLN-------AAISFLCGVIAIALPIHP 404
Cdd:pfam00520 146 IGYQLfggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfwayiyfVSFIILGGFLLLNLFIAV 225

                         250
                  ....*....|...
gi 20070166   405 IINNFVRYYNKQR 417
Cdd:pfam00520 226 IIDNFQELTERTE 238
 
Name Accession Description Interval E-value
BTB_POZ_Kv5_KCNF1 cd18381
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-138 1.38e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349690  Cd Length: 116  Bit Score: 253.53  E-value: 1.38e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  23 IEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKK 102
Cdd:cd18381   1 TEIVVNVGGVRQVLYGDVLNRYPETRLAELLNCLSGGYDAIFSLCDDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKK 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20070166 103 GICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREEL 138
Cdd:cd18381  81 GICPICFKNEMDFWRVDLDFLDECCKCHLSEKREEL 116
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 181-417 1.02e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 175.53  E-value: 1.02e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   181 ARVVAVLSFLLILVSSVVMCMGTIPELQvldaegnRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDV 260
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE-------EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   261 LAILPFYVSLtlthlgarMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSA 340
Cdd:pfam00520  74 VVVLPSLISL--------VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   341 LGYTM---------EQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLN-------AAISFLCGVIAIALPIHP 404
Cdd:pfam00520 146 IGYQLfggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfwayiyfVSFIILGGFLLLNLFIAV 225

                         250
                  ....*....|...
gi 20070166   405 IINNFVRYYNKQR 417
Cdd:pfam00520 226 IIDNFQELTERTE 238
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 25-126 9.11e-18

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 78.40  E-value: 9.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166    25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLaggydtifslCDDYDPGKREFYFDRDPDAFKCVIEVYY-FGEVHMKKG 103
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE----------CDDYDDDTNEYFFDRSPKHFETILNFYRtGGKLHRPEE 70

                          90       100
                  ....*....|....*....|...
gi 20070166   104 ICPICFKNEMDFWKVDLKFLDDC 126
Cdd:pfam02214  71 VCLDEFLEEAEFYGLDELALELC 93
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 25-135 2.44e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 48.84  E-value: 2.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166     25 IVVNVGGVRQVLYGDLLSQYPETRLAelinclaggydtIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGi 104
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKA------------LFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE- 68

                           90       100       110
                   ....*....|....*....|....*....|.
gi 20070166    105 CPICFKNEMDFWKVDlkFLDDCCKSHLSEKR 135
Cdd:smart00225  69 NVEELLELADYLQIP--GLVELCEEFLLKLL 97
PRK10537 PRK10537
voltage-gated potassium channel protein;
356-408 1.13e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 47.71  E-value: 1.13e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20070166  356 SIPQSFWWAIITMTTVGYGDIYPKTTLGKLnaaisFLCGVI---------AIALPIHPIINN 408
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARL-----FTISVIilgitvfatSISAIFGPVIRG 224
 
Name Accession Description Interval E-value
BTB_POZ_Kv5_KCNF1 cd18381
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-138 1.38e-83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349690  Cd Length: 116  Bit Score: 253.53  E-value: 1.38e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  23 IEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKK 102
Cdd:cd18381   1 TEIVVNVGGVRQVLYGDVLNRYPETRLAELLNCLSGGYDAIFSLCDDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKK 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 20070166 103 GICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREEL 138
Cdd:cd18381  81 GICPICFKNEMDFWRVDLDFLDECCKCHLSEKREEL 116
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 181-417 1.02e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 175.53  E-value: 1.02e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   181 ARVVAVLSFLLILVSSVVMCMGTIPELQvldaegnRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDV 260
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE-------EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   261 LAILPFYVSLtlthlgarMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSA 340
Cdd:pfam00520  74 VVVLPSLISL--------VLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAI 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   341 LGYTM---------EQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLN-------AAISFLCGVIAIALPIHP 404
Cdd:pfam00520 146 IGYQLfggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfwayiyfVSFIILGGFLLLNLFIAV 225

                         250
                  ....*....|...
gi 20070166   405 IINNFVRYYNKQR 417
Cdd:pfam00520 226 IIDNFQELTERTE 238
BTB_POZ_Kv2_KCNB cd18378
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-130 1.41e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349687 [Multi-domain]  Cd Length: 109  Bit Score: 111.72  E-value: 1.41e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  27 VNVGGVRQVLYGDLLSQYPETRLAELINCLAggYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICP 106
Cdd:cd18378   6 LNVGGVRHEVLWRTLDRLPRTRLGRLRECNT--HESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMCV 83

                        90       100
                ....*....|....*....|....
gi 20070166 107 ICFKNEMDFWKVDLKFLDDCCKSH 130
Cdd:cd18378  84 LSFSQELEYWGIDEIYLESCCQHR 107
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-117 9.53e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 108.46  E-value: 9.53e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAggydtifslcdDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESH-----------AYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNV 69

                        90
                ....*....|...
gi 20070166 105 CPICFKNEMDFWK 117
Cdd:cd18317  70 CPASFKEELEFWG 82
BTB_POZ_KCNS2 cd18427
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-129 9.37e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349734  Cd Length: 107  Bit Score: 106.86  E-value: 9.37e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  24 EIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGgyDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKG 103
Cdd:cd18427   1 EISINVGGFKKRLRSHTLLRFPETRLGRLLSCRSK--ESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGE 78

                        90       100
                ....*....|....*....|....*.
gi 20070166 104 ICPICFKNEMDFWKVDLKFLDDCCKS 129
Cdd:cd18427  79 LCVFSFSQEIEYWGINEFFIDSCCSY 104
BTB_POZ_KCNS1 cd18426
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-127 1.68e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349733 [Multi-domain]  Cd Length: 106  Bit Score: 100.35  E-value: 1.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINClaGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18426   1 ININVGGLKRRLSSSTLSKFPDTRLGRLLSC--DSEESILQICDDYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEEL 78

                        90       100
                ....*....|....*....|...
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCC 127
Cdd:cd18426  79 CVFSFSQEIEYWGINEFFLDSCC 101
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-136 1.43e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 95.27  E-value: 1.43e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAggyDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18424   1 FTINVGGSRFVLSQQVLSSHPETRLGKLAVSVR---DSVLELCDDANFVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEEL 77

                        90       100       110
                ....*....|....*....|....*....|..
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEKRE 136
Cdd:cd18424  78 CAISFLQEIEYWGIDELSIDSCCRERYYRRKE 109
BTB_POZ_Kv9_KCNS cd18384
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-128 2.05e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349692  Cd Length: 106  Bit Score: 94.51  E-value: 2.05e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAggYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18384   1 IRINVGGFRRRLSASALLRFPGTRLGRLLACHS--EEAILELCDDYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDEL 78

                        90       100
                ....*....|....*....|....
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCK 128
Cdd:cd18384  79 CVFSFSQEIEYWGINEFFLDSCCS 102
BTB_POZ_KCNS3 cd18428
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-127 1.61e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349735  Cd Length: 108  Bit Score: 92.21  E-value: 1.61e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAggYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18428   3 INLNVGGFKQSVDQSTLLRFPHTRLGKLLNCHS--EEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEEL 80

                        90       100
                ....*....|....*....|...
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCC 127
Cdd:cd18428  81 CVFSFCQEIEYWGINELFIDSCC 103
BTB_POZ_Kv6_KCNG cd18382
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-134 5.03e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349691 [Multi-domain]  Cd Length: 109  Bit Score: 90.96  E-value: 5.03e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINClaGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSRLKAC--RSEDDILRVCDDYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREM 78

                        90       100       110
                ....*....|....*....|....*....|
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEK 134
Cdd:cd18382  79 CALSFQEELAYWGIEEAHLERCCKRRLLRR 108
BTB_POZ_Shab-like cd18413
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-128 1.63e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349720 [Multi-domain]  Cd Length: 109  Bit Score: 89.55  E-value: 1.63e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINClaGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18413   4 VVINVGGVKHEVLWRTLDRMPHTRLGKLRDS--NTHEAIVELCDDYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEEM 81

                        90       100
                ....*....|....*....|....
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCK 128
Cdd:cd18413  82 CVLAFSDDLEYWGVDELYLESCCQ 105
BTB_POZ_KCNB2 cd18412
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-135 1.69e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349719 [Multi-domain]  Cd Length: 127  Bit Score: 90.07  E-value: 1.69e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  10 PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINClaGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCV 89
Cdd:cd18412   4 PEPVEIIRSKACSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDC--NTHESLLEVCDDYNLNENEYFFDRHPGAFTSI 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 20070166  90 IEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKR 135
Cdd:cd18412  82 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127
BTB_POZ_KCNG4 cd18423
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-134 2.22e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349730 [Multi-domain]  Cd Length: 112  Bit Score: 89.11  E-value: 2.22e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  24 EIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAggYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKG 103
Cdd:cd18423   3 EIIINVGGIKYLMPWSTLDEFPLTRLGKLKFCSS--YEEIVQICDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLRE 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 20070166 104 ICPICFKNEMDFWKVDLKFLDDCCKSHLSEK 134
Cdd:cd18423  81 MCALSFQEELTYWGIEEANLERCCLRKLFQK 111
BTB_POZ_KCNB1 cd18411
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-129 2.95e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349718 [Multi-domain]  Cd Length: 117  Bit Score: 86.21  E-value: 2.95e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINClaGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18411  12 VKLNVGGLAHEVLWRTLDRLPRTRLGKLRDC--NTHESLMEICDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEM 89

                        90       100
                ....*....|....*....|....*
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKS 129
Cdd:cd18411  90 CALSFSQELDYWGIDEIYLESCCQA 114
BTB_POZ_KCNG1_2 cd18421
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-134 5.34e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349728 [Multi-domain]  Cd Length: 114  Bit Score: 85.19  E-value: 5.34e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINClaGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18421   6 VIINVGGIKYRIPWTTLEEFPLTRLGQLKSC--NNFDEIMDICDDYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREM 83

                        90       100       110
                ....*....|....*....|....*....|
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEK 134
Cdd:cd18421  84 CALSFQEELLYWGIEEENLEWCCRRRLLQK 113
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-139 1.59e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 83.60  E-value: 1.59e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDtifslcddYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAFD--------YDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPADV 72

                        90       100       110
                ....*....|....*....|....*....|....*
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELE 139
Cdd:cd18379  73 CGPLFEEELAFWGIDETQIEPCCWMTYRQHRDAQE 107
BTB_Shaw-like cd18416
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-142 4.65e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349723 [Multi-domain]  Cd Length: 112  Bit Score: 79.62  E-value: 4.65e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  22 DIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAggydtifslcdDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMK 101
Cdd:cd18416   1 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALA-----------NYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYP 69

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20070166 102 KGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIA 142
Cdd:cd18416  70 TDVCGPLFEEELEFWGLDANQVEPCCWMTYTAHRDTQETLA 110
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 25-126 9.11e-18

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 78.40  E-value: 9.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166    25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLaggydtifslCDDYDPGKREFYFDRDPDAFKCVIEVYY-FGEVHMKKG 103
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE----------CDDYDDDTNEYFFDRSPKHFETILNFYRtGGKLHRPEE 70

                          90       100
                  ....*....|....*....|...
gi 20070166   104 ICPICFKNEMDFWKVDLKFLDDC 126
Cdd:pfam02214  71 VCLDEFLEEAEFYGLDELALELC 93
BTB_POZ_KCNV2 cd18425
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-134 1.82e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349732  Cd Length: 108  Bit Score: 77.88  E-value: 1.82e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  27 VNVGG-VRQVLYGdLLSQYPETRLAELINclAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGIC 105
Cdd:cd18425   3 INVGGtSYQISYR-VAASYPKTRIGRLAT--YTDRSRKLDLCDDYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELC 79

                        90       100
                ....*....|....*....|....*....
gi 20070166 106 PICFKNEMDFWKVDLKFLDDCCKSHLSEK 134
Cdd:cd18425  80 PRNFLEEINYWGVRIKNTPRCCRISFEER 108
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-141 2.10e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 78.07  E-value: 2.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  24 EIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYdtiFslcdDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKG 103
Cdd:cd18414   4 RIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSN---F----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPAD 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 20070166 104 ICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEI 141
Cdd:cd18414  77 VCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 114
BTB_POZ_KCNG3 cd18422
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-137 3.93e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349729  Cd Length: 111  Bit Score: 77.21  E-value: 3.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAggYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18422   1 VTLNVGGTRYSFSREVIKDFPLRRVSRLHGCLS--EQDVLEVCDDYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQM 78

                        90       100       110
                ....*....|....*....|....*....|...
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEKREE 137
Cdd:cd18422  79 CELSFYNEMIYWGLERSHLEYCCQRRLDDRMSD 111
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-137 2.72e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 74.33  E-value: 2.72e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETrlaelincLAGGYDTIFSlcddYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18380   2 IVINVSGRRFETWKNTLEKYPDT--------LLGSTEKEFF----YDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHE 69

                        90       100       110
                ....*....|....*....|....*....|...
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEKREE 137
Cdd:cd18380  70 CISAYDDELAFFGILPEIIGDCCYEDYRDRKRE 102
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-137 5.60e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 71.91  E-value: 5.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   6 ERSLPEPGSQSSAASDDIeIVVNVGGVRQVLYGDLLSQYPETrlaelincLAGGYDTIFSlcddYDPGKREFYFDRDPDA 85
Cdd:cd18417  19 KKPMPKPPSDKKRRNDEI-LVVNVSGRRFQTWKNTLDRYPDT--------LLGSSEKEFF----YNEDTQEYFFDRDPEM 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 20070166  86 FKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREE 137
Cdd:cd18417  86 FRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRKKE 137
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-137 7.92e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 67.29  E-value: 7.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETrlaelincLAGGYDTIFSlcddYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18418   2 IVLNVSGTRFQTWRNTLERYPDT--------LLGSSERDFF----YHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHE 69

                        90       100       110
                ....*....|....*....|....*....|...
gi 20070166 105 CPICFKNEMDFWKVDLKFLDDCCKSHLSEKREE 137
Cdd:cd18418  70 CISAYDEELAFFGIIPEIIGDCCYEEYKDRRRE 102
BTB_KCNC2_4 cd18415
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-127 1.54e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349722 [Multi-domain]  Cd Length: 124  Bit Score: 67.11  E-value: 1.54e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELI------NCLAGGYDTIFSlcDDYDPGKREFYFDRDPDAFKCVIEVYYFGEV 98
Cdd:cd18415   4 IILNVGGTRHETYRSTLKTLPGTRLALLAssdpqgDCLTQCSQVGGS--DGSPGGGNEFFFDRHPGVFAYVLNYYRTGKL 81

                        90       100
                ....*....|....*....|....*....
gi 20070166  99 HMKKGICPICFKNEMDFWKVDLKFLDDCC 127
Cdd:cd18415  82 HCPADVCGPLFEEELAFWGIDETDVEPCC 110
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-137 3.76e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 66.53  E-value: 3.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   9 LPEPGSQSSAASDDIeIVVNVGGVRQVLYGDLLSQYPETrlaelincLAGGYDTIFSLCDDydpgKREFYFDRDPDAFKC 88
Cdd:cd18419  22 MPLAPADKNKRQDEL-IVLNVSGRRFQTWRTTLERYPDT--------LLGSTEKEFFFNED----TKEYFFDRDPEVFRC 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 20070166  89 VIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREE 137
Cdd:cd18419  89 VLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRKRE 137
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-136 4.37e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 66.41  E-value: 4.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  10 PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETrlaelincLAGGYDTIFSlcddYDPGKREFYFDRDPDAFKCV 89
Cdd:cd18420  23 PPPVDQERRRTDDEKLIINVSGRRFETWRNTLEKYPDT--------LLGSNEREFF----YDEETKEYFFDRDPDIFRHI 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 20070166  90 IEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCC-KSHLSEKRE 136
Cdd:cd18420  91 LNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCCyEDYRDRKRE 138
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 331-412 2.06e-11

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 59.59  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166   331 LAVGIFVFSALGYTMEqshpETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLnaaISFLCGVIAIALPIhPIINNFV 410
Cdd:pfam07885   2 VLLLVLIFGTVYYLLE----EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRL---FTIFYILIGIPLFA-IFLAVLG 73


                  ..
gi 20070166   411 RY 412
Cdd:pfam07885  74 RF 75
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-116 8.34e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 52.48  E-value: 8.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDtifslcddyDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFTF---------PNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGI 71

                        90
                ....*....|..
gi 20070166 105 CPICFKNEMDFW 116
Cdd:cd18187  72 SIPDLREECDFY 83
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 25-135 2.44e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 48.84  E-value: 2.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166     25 IVVNVGGVRQVLYGDLLSQYPETRLAelinclaggydtIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGi 104
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKA------------LFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE- 68

                           90       100       110
                   ....*....|....*....|....*....|.
gi 20070166    105 CPICFKNEMDFWKVDlkFLDDCCKSHLSEKR 135
Cdd:smart00225  69 NVEELLELADYLQIP--GLVELCEEFLLKLL 97
PRK10537 PRK10537
voltage-gated potassium channel protein;
356-408 1.13e-05

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 47.71  E-value: 1.13e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20070166  356 SIPQSFWWAIITMTTVGYGDIYPKTTLGKLnaaisFLCGVI---------AIALPIHPIINN 408
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARL-----FTISVIilgitvfatSISAIFGPVIRG 224
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-87 3.58e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 39.46  E-value: 3.58e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINClaggydtIFSLCDDYDPgkrEFYFDRDPDAFK 87
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSG-------RWPLPRDEDG---SIFIDRDPELFR 53
BTB_POZ_KCNA4 cd18405
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-125 3.37e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349712  Cd Length: 97  Bit Score: 36.90  E-value: 3.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINclAGGYdtifslcddYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGI 104
Cdd:cd18405   3 VVINVSGLRFETQLKTLAQFPETLLGDPEK--RMRY---------FDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVN 71

                        90       100
                ....*....|....*....|....*.
gi 20070166 105 CPI-CFKNEMDFWKVD----LKFLDD 125
Cdd:cd18405  72 VPFdIFSEEVKFYELGeealLKFRED 97
BTB_POZ_KCNRG cd18375
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-91 5.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349684  Cd Length: 97  Bit Score: 36.25  E-value: 5.70e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETRLAELINclagGYDTifslcdDYDPGKREFYFDRDPDAFKCVIE 91
Cdd:cd18375   3 VTLNVGGKKFTTRPSTLRRFPDSRLARMLD----GKDQ------DFKVVNGQFFVDRDGSLFSYILD 59
BTB_POZ_Kv1_KCNA cd18377
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-95 7.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349686  Cd Length: 85  Bit Score: 35.73  E-value: 7.34e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20070166  25 IVVNVGGVRQVLYGDLLSQYPETrlaelincLAGGYDTIFSLcddYDPGKREFYFDRDPDAFKCVIevYYF 95
Cdd:cd18377   3 VVINVSGLRFETQLKTLAQFPNT--------LLGDPNKRMRF---FDPLRNEYFFDRNRPSFDAIL--YYY 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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