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Conserved domains on  [gi|33188461|ref|NP_002043|]
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transcription factor GATA-4 isoform 2 [Homo sapiens]

Protein Classification

GATA-type transcription factor( domain architecture ID 11786012)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GATA-N super family cl25837
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
1-205 1.80e-30

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


The actual alignment was detected with superfamily member pfam05349:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 115.61  E-value: 1.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461     1 MYQSLAMAANHGPPPgayEAGGPGAFMHGAgaASSPVYVPTPRVPSSVLGLSYLQGGGAGSASGGASggssggaasgagp 80
Cdd:pfam05349   1 MYQSLALAANHGQAA---YDHDSGGFLHSA--ASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVS------------- 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461    81 gtqqGSPGWSQAGADGAAYTP--PPVSPRFSFPGTTgslaaaaaaAAAREAAAYSSGGGAAGAGLAGREQYG--RAGFAG 156
Cdd:pfam05349  63 ----SHSGWAQAGAESSSYNPgsPHPSPRFSYSHSP---------PGSNGTSRDAAYQSPLLISAGGREQYGalGRPLGG 129
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 33188461   157 SYSSPYPAYMAdvgasWAAAAAASAGPFDSPVLHSLPGRANP-AARHPNL 205
Cdd:pfam05349 130 SYPSPYPAYVS-----PEMAPSWTAGPFDSSVLHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
270-321 3.39e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 86.27  E-value: 3.39e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 33188461 270 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 321
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
216-266 1.25e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.25e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 33188461 216 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
1-205 1.80e-30

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 115.61  E-value: 1.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461     1 MYQSLAMAANHGPPPgayEAGGPGAFMHGAgaASSPVYVPTPRVPSSVLGLSYLQGGGAGSASGGASggssggaasgagp 80
Cdd:pfam05349   1 MYQSLALAANHGQAA---YDHDSGGFLHSA--ASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVS------------- 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461    81 gtqqGSPGWSQAGADGAAYTP--PPVSPRFSFPGTTgslaaaaaaAAAREAAAYSSGGGAAGAGLAGREQYG--RAGFAG 156
Cdd:pfam05349  63 ----SHSGWAQAGAESSSYNPgsPHPSPRFSYSHSP---------PGSNGTSRDAAYQSPLLISAGGREQYGalGRPLGG 129
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 33188461   157 SYSSPYPAYMAdvgasWAAAAAASAGPFDSPVLHSLPGRANP-AARHPNL 205
Cdd:pfam05349 130 SYPSPYPAYVS-----PEMAPSWTAGPFDSSVLHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
270-321 3.39e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 86.27  E-value: 3.39e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 33188461 270 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 321
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
216-266 1.25e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.25e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 33188461 216 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
268-315 1.89e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.92  E-value: 1.89e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 33188461    268 GLSCANCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMRKEGI 315
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
271-305 3.05e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 66.19  E-value: 3.05e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 33188461   271 CANCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 305
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
212-257 5.53e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.90  E-value: 5.53e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 33188461    212 SEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGI-NRPLIKP 257
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
217-249 2.48e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.79  E-value: 2.48e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 33188461   217 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 249
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
192-324 2.34e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.95  E-value: 2.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461 192 LPGRANPAARHPNLDMFDDFSegRECVNCGAMSTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:COG5641 138 NPGGTSSLNPNNNQSDNSNQP--HVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRS 215
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 33188461 267 VGLSCANCQTTT-TTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMRKEGIQTRKRKPKN 324
Cdd:COG5641 216 SRSSHNNNDSNGeNANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKS 272
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
267-341 1.07e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.64  E-value: 1.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461 267 VGLSCANCQTTTTTLWRR-----NAEGEPVCNACGLYMKLHGVPR-PLAMRKEGIQTR-KRKPKNLNKSKtpAAPSGSES 339
Cdd:COG5641 157 QPHVCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRsSRSSHNNNDSN--GENANTES 234

                ..
gi 33188461 340 LP 341
Cdd:COG5641 235 IG 236
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
1-205 1.80e-30

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 115.61  E-value: 1.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461     1 MYQSLAMAANHGPPPgayEAGGPGAFMHGAgaASSPVYVPTPRVPSSVLGLSYLQGGGAGSASGGASggssggaasgagp 80
Cdd:pfam05349   1 MYQSLALAANHGQAA---YDHDSGGFLHSA--ASSPVYVPTTRVPSMLPTLPYLQGCGSSQQSHPVS------------- 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461    81 gtqqGSPGWSQAGADGAAYTP--PPVSPRFSFPGTTgslaaaaaaAAAREAAAYSSGGGAAGAGLAGREQYG--RAGFAG 156
Cdd:pfam05349  63 ----SHSGWAQAGAESSSYNPgsPHPSPRFSYSHSP---------PGSNGTSRDAAYQSPLLISAGGREQYGalGRPLGG 129
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 33188461   157 SYSSPYPAYMAdvgasWAAAAAASAGPFDSPVLHSLPGRANP-AARHPNL 205
Cdd:pfam05349 130 SYPSPYPAYVS-----PEMAPSWTAGPFDSSVLHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
270-321 3.39e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 86.27  E-value: 3.39e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 33188461 270 SCANCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMRKEG-IQTRKRK 321
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
216-266 1.25e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 76.26  E-value: 1.25e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 33188461 216 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
268-315 1.89e-17

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 75.92  E-value: 1.89e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 33188461    268 GLSCANCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMRKEGI 315
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
271-305 3.05e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 66.19  E-value: 3.05e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 33188461   271 CANCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 305
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
212-257 5.53e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.90  E-value: 5.53e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 33188461    212 SEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGI-NRPLIKP 257
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
217-249 2.48e-12

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 60.79  E-value: 2.48e-12
                          10        20        30
                  ....*....|....*....|....*....|....
gi 33188461   217 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 249
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
192-324 2.34e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.95  E-value: 2.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461 192 LPGRANPAARHPNLDMFDDFSegRECVNCGAMSTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRR 266
Cdd:COG5641 138 NPGGTSSLNPNNNQSDNSNQP--HVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRS 215
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 33188461 267 VGLSCANCQTTT-TTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMRKEGIQTRKRKPKN 324
Cdd:COG5641 216 SRSSHNNNDSNGeNANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKS 272
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
219-335 4.48e-07

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 52.18  E-value: 4.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461 219 NCGAMSTPLWRR-DGTGHYLCNACGLYHKMNGINRPLikPQRRLSASRRVGLSCANCQTTTTTLWRrnaEGEPVCNACGL 297
Cdd:COG5641 303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGA 377
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 33188461 298 YMKLHGVPRPLAMRKEGIQTRKRKPKN---LNKSKTPAAPS 335
Cdd:COG5641 378 QVKLPNQTRSTGATKKKITRRRMNSGKipaLSSSMKNPVPK 418
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
267-341 1.07e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 50.64  E-value: 1.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33188461 267 VGLSCANCQTTTTTLWRR-----NAEGEPVCNACGLYMKLHGVPR-PLAMRKEGIQTR-KRKPKNLNKSKtpAAPSGSES 339
Cdd:COG5641 157 QPHVCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRsSRSSHNNNDSN--GENANTES 234

                ..
gi 33188461 340 LP 341
Cdd:COG5641 235 IG 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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