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Conserved domains on  [gi|166362728|ref|NP_001954|]
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pro-epidermal growth factor isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 635-676 2.40e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.40e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 166362728    635 VIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKR 676
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 547-587 7.52e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 7.52e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 166362728    547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK 587
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-633 1.70e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 1.70e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 166362728    590 KIITKENISQPRGIAVHPMAKRLFWTDTGiNPRIESSSLQGLGR 633
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 745-780 5.82e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 5.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 166362728   745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-546 6.50e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 6.50e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 166362728    505 TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
870-910 1.92e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 1.92e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 166362728    870 DIDECEMGVPvCPPASsKCINTEGGYVCRCSEGYQgDGIHC 910
Cdd:smart00179    1 DIDECASGNP-CQNGG-TCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
912-940 2.09e-07

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.00  E-value: 2.09e-07
                           10        20
                   ....*....|....*....|....*....
gi 166362728   912 DIDECQLGEHSCGENASCTNTEGGYTCMC 940
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
356-395 2.49e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 166362728    356 DVNECAFWN---HGCTlgCKNTPGSYYCTCPVGFVllpDGKRC 395
Cdd:smart00179    1 DIDECASGNpcqNGGT--CVNTVGSYRCECPPGYT---DGRNC 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 439-476 6.89e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 6.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 166362728   439 CSSpDNGGCSQLCVPlSPVSWECDCFPGYDLQLDEKSC 476
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 152-189 5.08e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 5.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 166362728    152 ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDG 189
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 408-436 1.55e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.55e-04
                           10        20
                   ....*....|....*....|....*....
gi 166362728   408 CSHDCVLTSEGPLCFCPEGSVLERDGKTC 436
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03099 super family cl31525
epidermal growth factor-like protein (EGF-like protein); Provisional
 976-1014 4.22e-04

epidermal growth factor-like protein (EGF-like protein); Provisional


The actual alignment was detected with superfamily member PHA03099:

Pssm-ID: 165381  Cd Length: 139  Bit Score: 41.93  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 166362728  976 CPLSHDGYCLHdGVCMYIEALDKYACNCVVGYIGERCQY 1014
Cdd:PHA03099   45 CGPEGDGYCLH-GDCIHARDIDGMYCRCSHGYTGIRCQH 82
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 677-718 1.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 166362728    677 RRLTQNDVGHP--FAVAVFEDYVWFSDWAMPsVMRVNKRTGKDR 718
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 835-864 3.86e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.86e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 166362728   835 CAPVGCSMYARCISEGEDATCQCLKGFAGD 864
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
TolB super family cl43285
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 47-190 5.77e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG0823:

Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728   47 FLIFSHGNS-IFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWV--DLERQLLQRVFLNGSRQERVCNIEKNVSGMAI 123
Cdd:COG0823     3 FTLSRDGNSdIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166362728  124 NWINEEVIWSNQQEGI--ITVTDMKGNNSHILLSALKYPanvAVDPVERFIFWSSEVAGS--LYRADLDGV 190
Cdd:COG0823    83 SPDGKRLAFVSRSDGRfdIYVLDLDGGAPRRLTDGPGSP---SWSPDGRRIVFSSDRGGRpdLYVVDLDGR 150
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 635-676 2.40e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.40e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 166362728    635 VIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKR 676
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 547-587 7.52e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 7.52e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 166362728    547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK 587
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-633 1.70e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 1.70e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 166362728    590 KIITKENISQPRGIAVHPMAKRLFWTDTGiNPRIESSSLQGLGR 633
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 745-780 5.82e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 5.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 166362728   745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-546 6.50e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 6.50e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 166362728    505 TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 654-694 1.73e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 166362728   654 DKLYWCDAKQS-VIEMANLDGSKRRRLTQNDVGHPFAVAVFE 694
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
870-910 1.92e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 1.92e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 166362728    870 DIDECEMGVPvCPPASsKCINTEGGYVCRCSEGYQgDGIHC 910
Cdd:smart00179    1 DIDECASGNP-CQNGG-TCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
912-940 2.09e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.00  E-value: 2.09e-07
                           10        20
                   ....*....|....*....|....*....
gi 166362728   912 DIDECQLGEHSCGENASCTNTEGGYTCMC 940
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
EGF_CA pfam07645
Calcium-binding EGF domain;
870-902 4.54e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 4.54e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 166362728   870 DIDECEMGVPVCPpASSKCINTEGGYVCRCSEG 902
Cdd:pfam07645    1 DVDECATGTHNCP-ANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 870-910 1.75e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 166362728  870 DIDECEMGVPvCPPaSSKCINTEGGYVCRCSEGYQGDgiHC 910
Cdd:cd00054     1 DIDECASGNP-CQN-GGTCVNTVGSYRCSCPPGYTGR--NC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
356-395 2.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 166362728    356 DVNECAFWN---HGCTlgCKNTPGSYYCTCPVGFVllpDGKRC 395
Cdd:smart00179    1 DIDECASGNpcqNGGT--CVNTVGSYRCECPPGYT---DGRNC 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 352-393 2.59e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 49.69  E-value: 2.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 166362728  352 KYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGK 393
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 611-650 6.31e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 6.31e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 166362728   611 RLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITID 650
Cdd:pfam00058    2 RLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 364-395 6.69e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 6.69e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 166362728   364 NHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Cdd:pfam14670    5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 439-476 6.89e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 6.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 166362728   439 CSSpDNGGCSQLCVPlSPVSWECDCFPGYDLQLDEKSC 476
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-607 6.97e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 6.97e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 166362728   567 RRFYWTDRG-KSLIGRSDLNGKRSKIITKENISQPRGIAVHP 607
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-940 8.43e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.43e-06
                          10        20
                  ....*....|....*....|....*....
gi 166362728  912 DIDECQLGeHSCGENASCTNTEGGYTCMC 940
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
512-661 1.03e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  512 GMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDvPEGLAVDWIGRRFYWTDRGKSLIGRSDL-NGKRSK 590
Cdd:COG3391    68 ADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLYVADSGNGRVSVIDTaTGKVVA 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 166362728  591 IITKENisQPRGIAVHPMAKRLFWTDTGiNPR-------IESSSLQGLGRLVIASSdliwPSGITIDFLTDKLYWCDA 661
Cdd:COG3391   147 TIPVGA--GPHGIAVDPDGKRLYVANSG-SNTvsvivsvIDTATGKVVATIPVGGG----PVGVAVSPDGRRLYVANR 217
EGF_CA smart00179
Calcium-binding EGF-like domain;
912-940 1.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.93e-05
                            10        20
                    ....*....|....*....|....*....
gi 166362728    912 DIDECQLGeHSCGENASCTNTEGGYTCMC 940
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCEC 28
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 152-189 5.08e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 5.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 166362728    152 ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDG 189
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 408-436 1.55e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.55e-04
                           10        20
                   ....*....|....*....|....*....
gi 166362728   408 CSHDCVLTSEGPLCFCPEGSVLERDGKTC 436
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 976-1014 4.22e-04

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 41.93  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 166362728  976 CPLSHDGYCLHdGVCMYIEALDKYACNCVVGYIGERCQY 1014
Cdd:PHA03099   45 CGPEGDGYCLH-GDCIHARDIDGMYCRCSHGYTGIRCQH 82
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 523-650 6.91e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.05  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  523 ENKIYFAHTALKWIERANMDGSQRERLIEEGVDV----PEGLAVDwiGRRFYWTDRGKSLIGRSDLNGKRSKIITKE--- 595
Cdd:cd14963    66 DGNIYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgse 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166362728  596 --NISQPRGIAVHPmAKRLFWTDTGiNPRIESSSLQGLGRLVIASSD-----LIWPSGITID 650
Cdd:cd14963   144 pgELSYPNGIAVDE-DGNIYVADSG-NGRIQVFDKNGKFIKELNGSPdgksgFVNPRGIAVD 203
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 677-718 1.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 166362728    677 RRLTQNDVGHP--FAVAVFEDYVWFSDWAMPsVMRVNKRTGKDR 718
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 524-564 1.87e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 1.87e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 166362728   524 NKIYFAHTALKW-IERANMDGSQRERLIEEGVDVPEGLAVDW 564
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 835-864 3.86e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.86e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 166362728   835 CAPVGCSMYARCISEGEDATCQCLKGFAGD 864
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 47-190 5.77e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728   47 FLIFSHGNS-IFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWV--DLERQLLQRVFLNGSRQERVCNIEKNVSGMAI 123
Cdd:COG0823     3 FTLSRDGNSdIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166362728  124 NWINEEVIWSNQQEGI--ITVTDMKGNNSHILLSALKYPanvAVDPVERFIFWSSEVAGS--LYRADLDGV 190
Cdd:COG0823    83 SPDGKRLAFVSRSDGRfdIYVLDLDGGAPRRLTDGPGSP---SWSPDGRRIVFSSDRGGRpdLYVVDLDGR 150
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 70-106 9.85e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 9.85e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 166362728     70 VVDAGVSVI--MDFHYNEKRIYWVDLERQLLQRVFLNGS 106
Cdd:smart00135    3 LLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 635-676 2.40e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.54  E-value: 2.40e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 166362728    635 VIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKR 676
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 547-587 7.52e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.00  E-value: 7.52e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 166362728    547 ERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK 587
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-633 1.70e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.45  E-value: 1.70e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 166362728    590 KIITKENISQPRGIAVHPMAKRLFWTDTGiNPRIESSSLQGLGR 633
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 745-780 5.82e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.55  E-value: 5.82e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 166362728   745 CLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-546 6.50e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 6.50e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 166362728    505 TLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQR 546
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 654-694 1.73e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 1.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 166362728   654 DKLYWCDAKQS-VIEMANLDGSKRRRLTQNDVGHPFAVAVFE 694
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
870-910 1.92e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.40  E-value: 1.92e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 166362728    870 DIDECEMGVPvCPPASsKCINTEGGYVCRCSEGYQgDGIHC 910
Cdd:smart00179    1 DIDECASGNP-CQNGG-TCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
912-940 2.09e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.00  E-value: 2.09e-07
                           10        20
                   ....*....|....*....|....*....
gi 166362728   912 DIDECQLGEHSCGENASCTNTEGGYTCMC 940
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRC 29
EGF_CA pfam07645
Calcium-binding EGF domain;
870-902 4.54e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 4.54e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 166362728   870 DIDECEMGVPVCPpASSKCINTEGGYVCRCSEG 902
Cdd:pfam07645    1 DVDECATGTHNCP-ANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 870-910 1.75e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.75e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 166362728  870 DIDECEMGVPvCPPaSSKCINTEGGYVCRCSEGYQGDgiHC 910
Cdd:cd00054     1 DIDECASGNP-CQN-GGTCVNTVGSYRCSCPPGYTGR--NC 37
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 888-910 1.92e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 1.92e-06
                           10        20
                   ....*....|....*....|...
gi 166362728   888 CINTEGGYVCRCSEGYQGDGIHC 910
Cdd:pfam12947   14 CTNTGGSFTCTCNDGYTGDGVTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
356-395 2.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.49e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 166362728    356 DVNECAFWN---HGCTlgCKNTPGSYYCTCPVGFVllpDGKRC 395
Cdd:smart00179    1 DIDECASGNpcqNGGT--CVNTVGSYRCECPPGYT---DGRNC 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 352-393 2.59e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 49.69  E-value: 2.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 166362728  352 KYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGK 393
Cdd:cd01475   182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 611-650 6.31e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 6.31e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 166362728   611 RLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITID 650
Cdd:pfam00058    2 RLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 364-395 6.69e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 6.69e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 166362728   364 NHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRC 395
Cdd:pfam14670    5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 439-476 6.89e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.77  E-value: 6.89e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 166362728   439 CSSpDNGGCSQLCVPlSPVSWECDCFPGYDLQLDEKSC 476
Cdd:pfam14670    1 CSV-NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 567-607 6.97e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 44.07  E-value: 6.97e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 166362728   567 RRFYWTDRG-KSLIGRSDLNGKRSKIITKENISQPRGIAVHP 607
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 912-940 8.43e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.43e-06
                          10        20
                  ....*....|....*....|....*....
gi 166362728  912 DIDECQLGeHSCGENASCTNTEGGYTCMC 940
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSC 28
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
512-661 1.03e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  512 GMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDvPEGLAVDWIGRRFYWTDRGKSLIGRSDL-NGKRSK 590
Cdd:COG3391    68 ADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGGRLYVADSGNGRVSVIDTaTGKVVA 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 166362728  591 IITKENisQPRGIAVHPMAKRLFWTDTGiNPR-------IESSSLQGLGRLVIASSdliwPSGITIDFLTDKLYWCDA 661
Cdd:COG3391   147 TIPVGA--GPHGIAVDPDGKRLYVANSG-SNTvsvivsvIDTATGKVVATIPVGGG----PVGVAVSPDGRRLYVANR 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 356-395 1.39e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 166362728  356 DVNECAFwNHGCTLG--CKNTPGSYYCTCPVGFVllpdGKRC 395
Cdd:cd00054     1 DIDECAS-GNPCQNGgtCVNTVGSYRCSCPPGYT----GRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
912-940 1.93e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 1.93e-05
                            10        20
                    ....*....|....*....|....*....
gi 166362728    912 DIDECQLGeHSCGENASCTNTEGGYTCMC 940
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCEC 28
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 916-940 2.01e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.59  E-value: 2.01e-05
                           10        20
                   ....*....|....*....|....*
gi 166362728   916 CQLGEHSCGENASCTNTEGGYTCMC 940
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTC 25
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
510-715 3.40e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.94  E-value: 3.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  510 QMGMVYALDHDPvENKIYFAHTALKWIERANMDGSQRERL-IEEGVDVPEGLAVDwiGRRFYW-TDRGKSLIGRSDL-NG 586
Cdd:COG4257    57 GGSGPHGIAVDP-DGNLWFTDNGNNRIGRIDPKTGEITTFaLPGGGSNPHGIAFD--PDGNLWfTDQGGNRIGRLDPaTG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  587 KRSKIITKENISQPRGIAVHPmAKRLFWTDTGINP--RIESSSlqGLGRLVIASSDLIWPSGITIDFlTDKLYWCDAKQS 664
Cdd:COG4257   134 EVTEFPLPTGGAGPYGIAVDP-DGNLWVTDFGANAigRIDPDT--GTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGSG 209

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 166362728  665 VIEMANL-DGSKRRRLTQNDVGHPFAVAV-FEDYVWFSDWAMPSVMRVNKRTG 715
Cdd:COG4257   210 RIGRFDPkTGTVTEYPLPGGGARPYGVAVdGDGRVWFAESGANRIVRFDPDTE 262
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 152-189 5.08e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 5.08e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 166362728    152 ILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDG 189
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDG 40
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
512-733 7.77e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 45.78  E-value: 7.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  512 GMVYALDHDPVENkIYFAHTALKWIERANM-DGSQRERLIEEGvDVPEGLAVD-----WIgrrfywTDRGKSLIGRSDL- 584
Cdd:COG4257    17 SGPRDVAVDPDGA-VWFTDQGGGRIGRLDPaTGEFTEYPLGGG-SGPHGIAVDpdgnlWF------TDNGNNRIGRIDPk 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  585 NGKRSKIITKENISQPRGIAVHPmAKRLFWTDTGINpriessslqGLGRLVIASSDLIW---------PSGITID----- 650
Cdd:COG4257    89 TGEITTFALPGGGSNPHGIAFDP-DGNLWFTDQGGN---------RIGRLDPATGEVTEfplptggagPYGIAVDpdgnl 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  651 ----FLTDKLYWCDAKQSVIEMANLdgskrrrltQNDVGHPFAVAV-FEDYVWFSDWAMPSVMRVNKRTGK-DRVRLQGS 724
Cdd:COG4257   159 wvtdFGANAIGRIDPDTGTLTEYAL---------PTPGAGPRGLAVdPDGNLWVADTGSGRIGRFDPKTGTvTEYPLPGG 229


                  ....*....
gi 166362728  725 MLKPSSLVV 733
Cdd:COG4257   230 GARPYGVAV 238
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 408-436 1.55e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.92  E-value: 1.55e-04
                           10        20
                   ....*....|....*....|....*....
gi 166362728   408 CSHDCVLTSEGPLCFCPEGSVLERDGKTC 436
Cdd:pfam14670    8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
356-385 1.87e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.91  E-value: 1.87e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 166362728   356 DVNECAFWNHGCTLG--CKNTPGSYYCTCPVG 385
Cdd:pfam07645    1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 360-395 4.18e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 4.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 166362728   360 CAFWNHGCTLG--CKNTPGSYYCTCPVGFVLlpDGKRC 395
Cdd:pfam12947    1 CSDNNGGCHPNatCTNTGGSFTCTCNDGYTG--DGVTC 36
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 976-1014 4.22e-04

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 41.93  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 166362728  976 CPLSHDGYCLHdGVCMYIEALDKYACNCVVGYIGERCQY 1014
Cdd:PHA03099   45 CGPEGDGYCLH-GDCIHARDIDGMYCRCSHGYTGIRCQH 82
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 523-650 6.91e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 43.05  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  523 ENKIYFAHTALKWIERANMDGSQRERLIEEGVDV----PEGLAVDwiGRRFYWTDRGKSLIGRSDLNGKRSKIITKE--- 595
Cdd:cd14963    66 DGNIYVADLYNGRIQVFDPDGKFLKYFPEKKDRVklisPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgse 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 166362728  596 --NISQPRGIAVHPmAKRLFWTDTGiNPRIESSSLQGLGRLVIASSD-----LIWPSGITID 650
Cdd:cd14963   144 pgELSYPNGIAVDE-DGNIYVADSG-NGRIQVFDKNGKFIKELNGSPdgksgFVNPRGIAVD 203
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 677-718 1.27e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.58  E-value: 1.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 166362728    677 RRLTQNDVGHP--FAVAVFEDYVWFSDWAMPsVMRVNKRTGKDR 718
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 524-564 1.87e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.14  E-value: 1.87e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 166362728   524 NKIYFAHTALKW-IERANMDGSQRERLIEEGVDVPEGLAVDW 564
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
PHA02887 PHA02887
EGF-like protein; Provisional
 975-1013 2.37e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 39.53  E-value: 2.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 166362728  975 ECPLSHDGYCLHdGVCMYIEALDKYACNCVVGYIGERCQ 1013
Cdd:PHA02887   85 KCKNDFNDFCIN-GECMNIIDLDEKFCICNKGYTGIRCD 122
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 557-692 2.91e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.03  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  557 PEGLAVDWIGRrFYWTDRGKSLIGRSDLNGKRSKIITKE---NISQPRGIAVHPmAKRLFWTDTGiNPRIESSSLQGLGR 633
Cdd:cd14962    14 PYGVAADGRGR-IYVADTGRGAVFVFDLPNGKVFVIGNAgpnRFVSPIGVAIDA-NGNLYVSDAE-LGKVFVFDRDGKFL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 166362728  634 LVIASSDLIW-PSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVG-----HPFAVAV 692
Cdd:cd14962    91 RAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSGpgefnLPTDLAV 155
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 835-864 3.86e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.86e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 166362728   835 CAPVGCSMYARCISEGEDATCQCLKGFAGD 864
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 557-666 5.36e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 39.99  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728  557 PEGLAVDWIGRrFYWTDRGKSLIGRSDLNGKR-----SKIITKENISQPRGIAVHPMAkRLFWTDTGiNPRI-----ESS 626
Cdd:cd05819   151 PTGVAVDSDGN-IYVADTGNHRIQVFDPDGNFlttfgSTGTGPGQFNYPTGIAVDSDG-NIYVADSG-NNRVqvfdpDGA 227

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 166362728  627 SLQGLGRLVIASSDLIWPSGITIDfLTDKLYWCDAKQSVI 666
Cdd:cd05819   228 GFGGNGNFLGSDGQFNRPSGLAVD-SDGNLYVADTGNNRI 266
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 47-190 5.77e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 5.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166362728   47 FLIFSHGNS-IFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWV--DLERQLLQRVFLNGSRQERVCNIEKNVSGMAI 123
Cdd:COG0823     3 FTLSRDGNSdIYVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdRGGGPQIYVVDADGGEPRRLTFGGGYNASPSW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 166362728  124 NWINEEVIWSNQQEGI--ITVTDMKGNNSHILLSALKYPanvAVDPVERFIFWSSEVAGS--LYRADLDGV 190
Cdd:COG0823    83 SPDGKRLAFVSRSDGRfdIYVLDLDGGAPRRLTDGPGSP---SWSPDGRRIVFSSDRGGRpdLYVVDLDGR 150
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 873-910 9.61e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 9.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 166362728  873 ECEMGVPvCPPaSSKCINTEGGYVCRCSEGYQGDGiHC 910
Cdd:cd00053     1 ECAASNP-CSN-GGTCVNTPGSYRCVCPPGYTGDR-SC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 70-106 9.85e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.27  E-value: 9.85e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 166362728     70 VVDAGVSVI--MDFHYNEKRIYWVDLERQLLQRVFLNGS 106
Cdd:smart00135    3 LLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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