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Conserved domains on  [gi|68163411|ref|NP_001618|]
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CD166 antigen isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 137-231 1.69e-22

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


:

Pssm-ID: 400489  Cd Length: 89  Bit Score: 91.71  E-value: 1.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411   137 PEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLhplegaVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQM 216
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPL------EAAETSSEQDPESGLVTVTSELKLVPSRSDHGQ 74

                          90
                  ....*....|....*
gi 68163411   217 PFTCSVTYYGPSGQK 231
Cdd:pfam08205  75 SLTCQVSYGALRGSI 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 255-329 8.37e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.42  E-value: 8.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411    255 PPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQP-------EGIRSSNTYTLT--DVRRNATGDYKCSLIDKKSMIAST 325
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLlaesgrfSVSRSGSTSTLTisNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 68163411    326 A-ITV 329
Cdd:smart00410  81 TtLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 415-489 1.35e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.32  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411   415 KPQIKMTKK--TDPSGLSKTIICHVEGFPKPAIQWTItgSGSVINQTEESPYINGRYYSKIIIS---PEENVTLTCTAEN 489
Cdd:pfam13927   1 KPVITVSPSsvTVREGETVTLTCEATGSPPPTITWYK--NGEPISSGSTRSRSLSGSNSTLTISnvtRSDAGTYTCVASN 78
IGv smart00406
Immunoglobulin V-Type;
38-113 1.96e-05

Immunoglobulin V-Type;


:

Pssm-ID: 214650  Cd Length: 81  Bit Score: 43.14  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411     38 TIIIPCRLDVPQN-LMFGKWKYEKPDGSPVFIAFRSStkKSVQYDDvPEYKDRLNLSEN-----YTLSISNARISDEKRF 111
Cdd:smart00406   1 SVTLSCKFSGSTFsSYYVSWVRQPPGKGLEWLGYIGS--NGSSYYQ-ESYKGRFTISKDtskndVSLTISNLRVEDTGTY 77


                   ..
gi 68163411    112 VC 113
Cdd:smart00406  78 YC 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 339-393 2.62e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.18  E-value: 2.62e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411    339 SGEVTRQIGDALPVSCTISASRNATVVWMK---------DNIRLRSSPSFSSLH-----YQDAGNYVCE 393
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKqggkllaesGRFSVSRSGSTSTLTisnvtPEDSGTYTCA 69
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 137-231 1.69e-22

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 91.71  E-value: 1.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411   137 PEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLhplegaVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQM 216
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPL------EAAETSSEQDPESGLVTVTSELKLVPSRSDHGQ 74

                          90
                  ....*....|....*
gi 68163411   217 PFTCSVTYYGPSGQK 231
Cdd:pfam08205  75 SLTCQVSYGALRGSI 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 255-329 8.37e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.42  E-value: 8.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411    255 PPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQP-------EGIRSSNTYTLT--DVRRNATGDYKCSLIDKKSMIAST 325
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLlaesgrfSVSRSGSTSTLTisNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 68163411    326 A-ITV 329
Cdd:smart00410  81 TtLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 415-489 1.35e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.32  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411   415 KPQIKMTKK--TDPSGLSKTIICHVEGFPKPAIQWTItgSGSVINQTEESPYINGRYYSKIIIS---PEENVTLTCTAEN 489
Cdd:pfam13927   1 KPVITVSPSsvTVREGETVTLTCEATGSPPPTITWYK--NGEPISSGSTRSRSLSGSNSTLTISnvtRSDAGTYTCVASN 78
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 128-226 1.47e-05

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 43.99  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411 128 VKVFKQPSKPEIVSKALFLeteqlkklgdCISEDSYPDG-NITWYRNGKvlhPLEGAVVIIFKKEmdPVTQLYTMTSTLE 206
Cdd:cd00098   2 VTLLPPSPEEKGGGKVTLV----------CLVSGFYPKDiTVTWLKNGV---PLTSGVSTSSPVE--PNDGTYSVTSSLT 66

                        90       100
                ....*....|....*....|
gi 68163411 207 YKTTKADIQMPFTCSVTYYG 226
Cdd:cd00098  67 VPPSDWDEGATYTCVVTHES 86
IGv smart00406
Immunoglobulin V-Type;
38-113 1.96e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 43.14  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411     38 TIIIPCRLDVPQN-LMFGKWKYEKPDGSPVFIAFRSStkKSVQYDDvPEYKDRLNLSEN-----YTLSISNARISDEKRF 111
Cdd:smart00406   1 SVTLSCKFSGSTFsSYYVSWVRQPPGKGLEWLGYIGS--NGSSYYQ-ESYKGRFTISKDtskndVSLTISNLRVEDTGTY 77


                   ..
gi 68163411    112 VC 113
Cdd:smart00406  78 YC 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 250-313 2.12e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.94  E-value: 2.12e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68163411   250 TIQVLPPKNAIKEGDNITLKCLGNGNPPPeEFLFYLPGQPEG---------IRSSNTYTLTDVRRNATGDYKC 313
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKNGEPISsgstrsrslSGSNSTLTISNVTRSDAGTYTC 74
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 432-497 1.00e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.78  E-value: 1.00e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411 432 TIICHVEGFPKPAIQWTItgSGSVINQTEESPYINGRYYSKIIIS---PEENVTLTCTAENQLERTVNS 497
Cdd:cd00096   2 TLTCSASGNPPPTITWYK--NGKPLPPSSRDSRRSELGNGTLTISnvtLEDSGTYTCVASNSAGGSASA 68
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 339-393 2.62e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.18  E-value: 2.62e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411    339 SGEVTRQIGDALPVSCTISASRNATVVWMK---------DNIRLRSSPSFSSLH-----YQDAGNYVCE 393
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKqggkllaesGRFSVSRSGSTSTLTisnvtPEDSGTYTCA 69
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 255-313 2.82e-04

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 39.65  E-value: 2.82e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68163411 255 PPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQ--PEgirSSNTYTLTDVRRNATGDYKC 313
Cdd:cd05752   7 PPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHNGTliSS---TSSSYRIVAATVNDSGEYRC 64
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 336-412 5.59e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.92  E-value: 5.59e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411   336 LNPSGEVTRQiGDALPVSCTISASRNATVVWMKDNIRLRSSPSF--SSLHYQDAGNYVCETALQevEGLKKRESLTLIV 412
Cdd:pfam13895   4 LTPSPTVVTE-GEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFftLSVSAEDSGTYTCVARNG--RGGKVSNPVELTV 79
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 29-117 6.08e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 39.74  E-value: 6.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411  29 YTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDG--SPVFIAFRSSTKKSVQyddvPEYKDRLNL------SENYTLSI 100
Cdd:cd05718   7 TEVTGFLGGSVTLPCSLTSPGTTKITQVTWMKIGAgsSQNVAVFHPQYGPSVP----NPYAERVEFlaarlgLRNATLRI 82

                        90
                ....*....|....*..
gi 68163411 101 SNARISDEKRFVCMLVT 117
Cdd:cd05718  83 RNLRVEDEGNYICEFAT 99
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 352-393 9.88e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.00  E-value: 9.88e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68163411 352 VSCTISASRNATVVWMKDNIRLRSSP-------------SFSSLHYQDAGNYVCE 393
Cdd:cd00096   3 LTCSASGNPPPTITWYKNGKPLPPSSrdsrrselgngtlTISNVTLEDSGTYTCV 57
 
Name Accession Description Interval E-value
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 137-231 1.69e-22

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 91.71  E-value: 1.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411   137 PEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLhplegaVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQM 216
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWYLDGKPL------EAAETSSEQDPESGLVTVTSELKLVPSRSDHGQ 74

                          90
                  ....*....|....*
gi 68163411   217 PFTCSVTYYGPSGQK 231
Cdd:pfam08205  75 SLTCQVSYGALRGSI 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 255-329 8.37e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 44.42  E-value: 8.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411    255 PPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQP-------EGIRSSNTYTLT--DVRRNATGDYKCSLIDKKSMIAST 325
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGGKLlaesgrfSVSRSGSTSTLTisNVTPEDSGTYTCAATNSSGSASSG 80


                   ....*
gi 68163411    326 A-ITV 329
Cdd:smart00410  81 TtLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 415-489 1.35e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.32  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411   415 KPQIKMTKK--TDPSGLSKTIICHVEGFPKPAIQWTItgSGSVINQTEESPYINGRYYSKIIIS---PEENVTLTCTAEN 489
Cdd:pfam13927   1 KPVITVSPSsvTVREGETVTLTCEATGSPPPTITWYK--NGEPISSGSTRSRSLSGSNSTLTISnvtRSDAGTYTCVASN 78
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 128-226 1.47e-05

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 43.99  E-value: 1.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411 128 VKVFKQPSKPEIVSKALFLeteqlkklgdCISEDSYPDG-NITWYRNGKvlhPLEGAVVIIFKKEmdPVTQLYTMTSTLE 206
Cdd:cd00098   2 VTLLPPSPEEKGGGKVTLV----------CLVSGFYPKDiTVTWLKNGV---PLTSGVSTSSPVE--PNDGTYSVTSSLT 66

                        90       100
                ....*....|....*....|
gi 68163411 207 YKTTKADIQMPFTCSVTYYG 226
Cdd:cd00098  67 VPPSDWDEGATYTCVVTHES 86
IGv smart00406
Immunoglobulin V-Type;
38-113 1.96e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 43.14  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411     38 TIIIPCRLDVPQN-LMFGKWKYEKPDGSPVFIAFRSStkKSVQYDDvPEYKDRLNLSEN-----YTLSISNARISDEKRF 111
Cdd:smart00406   1 SVTLSCKFSGSTFsSYYVSWVRQPPGKGLEWLGYIGS--NGSSYYQ-ESYKGRFTISKDtskndVSLTISNLRVEDTGTY 77


                   ..
gi 68163411    112 VC 113
Cdd:smart00406  78 YC 79
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 250-313 2.12e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.94  E-value: 2.12e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68163411   250 TIQVLPPKNAIKEGDNITLKCLGNGNPPPeEFLFYLPGQPEG---------IRSSNTYTLTDVRRNATGDYKC 313
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKNGEPISsgstrsrslSGSNSTLTISNVTRSDAGTYTC 74
IgI_2_Necl-1 cd07705
Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set ...
 134-224 4.54e-05

Second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1); member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1; also known as cell adhesion molecule3 (CADM3)). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains is essential to cell-cell adhesion and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Ig domains are likely to participate in ligand binding and recognition.


Pssm-ID: 409502  Cd Length: 103  Bit Score: 42.65  E-value: 4.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411 134 PSKPEIVSKALFLETEQLKKLgDCISEDSYPDGNITWYRNGKVLHpleGAVVIIFKkemDPVTQLYTMTSTLEYKTTKAD 213
Cdd:cd07705   4 PQKPQITGYESAFKEKDKAKL-RCTSSGSKPAANIKWRKGDQELE---GAPTSVQE---DGNGKTFTVSSSVEFQVTRED 76

                        90
                ....*....|.
gi 68163411 214 IQMPFTCSVTY 224
Cdd:cd07705  77 DGAEITCSVGH 87
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 432-497 1.00e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.78  E-value: 1.00e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411 432 TIICHVEGFPKPAIQWTItgSGSVINQTEESPYINGRYYSKIIIS---PEENVTLTCTAENQLERTVNS 497
Cdd:cd00096   2 TLTCSASGNPPPTITWYK--NGKPLPPSSRDSRRSELGNGTLTISnvtLEDSGTYTCVASNSAGGSASA 68
IgC1_TCR_beta cd05769
T cell receptor (TCR) beta chain constant immunoglobulin domain; member of the C1-set of Ig ...
 124-233 1.37e-04

T cell receptor (TCR) beta chain constant immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the T cell receptor (TCR) beta chain constant immunoglobulin domain. TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the beta chain. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The antigen binding site is formed by the variable domains of the alpha and beta chains, located at the N-terminus of each chain. Alpha/beta TCRs recognize antigens differently from gamma/delta TCRs.


Pssm-ID: 409426 [Multi-domain]  Cd Length: 116  Bit Score: 41.59  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411 124 APTiVKVFKqPSKPEIvskalfleTEQLKKLGDCISEDSYPDG-NITWYRNGKVLHplEGAvviifkkEMDPVTQ----- 197
Cdd:cd05769   2 PPT-VALFP-PSEAEI--------RNKRKATLVCLATGFYPDHvSLSWKVNGKEVK--DGV-------ATDPQALrents 62

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 68163411 198 LYTMTSTLEYKTTK-ADIQMPFTCSVTYYGPSGQKTI 233
Cdd:cd05769  63 TYSLSSRLRVSATEwFNPRNTFTCIVKFYGGTDTDTW 99
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 339-393 2.62e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.18  E-value: 2.62e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411    339 SGEVTRQIGDALPVSCTISASRNATVVWMK---------DNIRLRSSPSFSSLH-----YQDAGNYVCE 393
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKqggkllaesGRFSVSRSGSTSTLTisnvtPEDSGTYTCA 69
Ig1_FcgammaR_like cd05752
First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 255-313 2.82e-04

First immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409410 [Multi-domain]  Cd Length: 79  Bit Score: 39.65  E-value: 2.82e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68163411 255 PPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQ--PEgirSSNTYTLTDVRRNATGDYKC 313
Cdd:cd05752   7 PPWTTVFQGEKVTLTCQGFYSPEQNSTQWYHNGTliSS---TSSSYRIVAATVNDSGEYRC 64
IgI_2_Follistatin_like cd05736
Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; ...
 416-500 2.95e-04

Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain found in human Follistatin-related protein 5 (FSTL5) and a follistatin-like molecule encoded by the CNS-related Mahya gene. Mahya genes have been retained in certain Bilaterian branches during evolution. They are conserved in Hymenoptera and Deuterostomes, but are absent from other metazoan species such as fruit fly and nematode. Mahya proteins are secretory, with a follistatin-like domain (Kazal-type serine/threonine protease inhibitor domain and EF-hand calcium-binding domain), two Ig-like domains, and a novel C-terminal domain. Mahya may be involved in learning and memory and in processing of sensory information in Hymenoptera and vertebrates. Follistatin is a secreted, multidomain protein that binds activins with high affinity and antagonizes their signaling.


Pssm-ID: 409399 [Multi-domain]  Cd Length: 93  Bit Score: 39.94  E-value: 2.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411 416 PQIKMTKKTDPS--GLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYI-NGryySKIIISP---EENVTLTCTAEN 489
Cdd:cd05736   1 PVIRVYPEFQAKepGVEASLRCHAEGIPLPRVQWLKNGMDINPKLSKQLTLIaNG---SELHISNvryEDTGAYTCIAKN 77

                        90
                ....*....|...
gi 68163411 490 Q--LERTVNSLNV 500
Cdd:cd05736  78 EggVDEDISSLFV 90
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 336-412 5.59e-04

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 38.92  E-value: 5.59e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411   336 LNPSGEVTRQiGDALPVSCTISASRNATVVWMKDNIRLRSSPSF--SSLHYQDAGNYVCETALQevEGLKKRESLTLIV 412
Cdd:pfam13895   4 LTPSPTVVTE-GEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNFftLSVSAEDSGTYTCVARNG--RGGKVSNPVELTV 79
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 29-117 6.08e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 39.74  E-value: 6.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411  29 YTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDG--SPVFIAFRSSTKKSVQyddvPEYKDRLNL------SENYTLSI 100
Cdd:cd05718   7 TEVTGFLGGSVTLPCSLTSPGTTKITQVTWMKIGAgsSQNVAVFHPQYGPSVP----NPYAERVEFlaarlgLRNATLRI 82

                        90
                ....*....|....*..
gi 68163411 101 SNARISDEKRFVCMLVT 117
Cdd:cd05718  83 RNLRVEDEGNYICEFAT 99
IgI_2_KIRREL3-like cd05759
Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar ...
 157-232 6.40e-04

Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2). This protein has five Ig-like domains, one transmembrane domain, and a cytoplasmic tail. Included in this group is mammalian Kirrel (Neph1), Kirrel2 (Neph3), and Drosophila RST (irregular chiasm C-roughest) protein. These proteins contain multiple Ig domains, have properties of cell adhesion molecules, and are important in organ development.


Pssm-ID: 409416  Cd Length: 98  Bit Score: 39.36  E-value: 6.40e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68163411 157 CISEDSYPDGNITWYRNGKvlhPLEGAVviiFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYG-PSGQKT 232
Cdd:cd05759  22 CRARGAKPAAEIIWFRDGE---QLEGAV---YSKELLKDGKRETTVSTLLITPSDLDTGRTFTCRARNEAiPNGKET 92
IgC1_CD80 cd16083
Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) ...
 157-224 1.06e-03

Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin constant (IgC)-like domain of the antigen receptor Cluster of Differentiation (CD) 80. CD80 (also known as glycoprotein B7-1) and CD86 (also known as glycoprotein B7-2) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. CD80 contains two Ig-like domains, an amino-terminal immunoglobulin variable (IgV)-like domain characteristic of adhesion molecules, and a membrane proximal immunoglobulin constant (IgC)-like domain similar to the constant domains of antigen receptors. Members of the Ig family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, and the IgC domain is involved in oligomerization and molecular interactions.


Pssm-ID: 409505  Cd Length: 91  Bit Score: 38.59  E-value: 1.06e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68163411 157 CISEDSYPDGNITWYRNGKVLHPLEGAVViifkkeMDPVTQLYTMTSTLEYKTTKadiQMPFTCSVTY 224
Cdd:cd16083  21 CSTSGGFPEPRLSWLENGEELNAINTTVS------QDPETELYTVSSELDFNVTY---NHSIVCLIKY 79
IgI_4_Robo cd05726
Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 253-335 1.60e-03

Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; Members here are composed the fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, Robo3), and three mammalian Slit homologs (Slit-1, Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, and Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409391 [Multi-domain]  Cd Length: 98  Bit Score: 38.01  E-value: 1.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411 253 VLPPKNAI-KEGDNITLKCLGNGNPPPEEF---------LF-YLPGQPEG---IRSSNTYTLTDVRRNATGDYKCSLIDk 318
Cdd:cd05726   3 VVKPRDQVvALGRTVTFQCETKGNPQPAIFwqkegsqnlLFpYQPPQPSSrfsVSPTGDLTITNVQRSDVGYYICQALN- 81

                        90
                ....*....|....*..
gi 68163411 319 ksmIASTAITVHYLDLS 335
Cdd:cd05726  82 ---VAGSILAKAQLEVT 95
IgI_2_Necl-1-4 cd05761
Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of ...
 134-222 4.81e-03

Second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 - Necl-4; member of the I-set of Ig superfamily domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 or CADM3), Necl-2 (also known as CADM1), Necl-3 (also known as CADM2) and Necl-4 (also known as CADM4). These nectin-like molecules have similar domain structures to those of nectins. At least five nectin-like molecules have been identified (Necl-1 through Necl-5). These have an extracellular region containing three Ig-like domains, one transmembrane region, and one cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1 and Necl-2 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues, and is a putative tumour suppressor gene, which is downregulated in aggressive neuroblastoma. Necl-3 has been shown to accumulate in tissues of the central and peripheral nervous system, where it is expressed in ependymal cells and myelinated axons. It is observed at the interface between the axon shaft and the myelin sheath. Necl-4 is expressed on Schwann cells, and plays a key part in initiating peripheral nervous system (PNS) myelination. Necl-4 participates in cell-cell adhesion and is proposed to play a role in tumor suppression.


Pssm-ID: 409418  Cd Length: 102  Bit Score: 37.02  E-value: 4.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68163411 134 PSKPEI-VSKALFLETEQLKKlgDCISEDSYPDGNITWYRNGKVLHpleGAVVIifkkEMDPVTQLYTMTSTLEYKTTKA 212
Cdd:cd05761   4 PEKPVItGFTSPVVEGDEITL--TCTTSGSKPAADIRWFKNDKELK---GVKEV----QESGAGKTFTVTSTLRFRVDRD 74

                        90
                ....*....|
gi 68163411 213 DIQMPFTCSV 222
Cdd:cd05761  75 DDGVAVICRV 84
IgC1_SIRP_domain_2 cd05772
Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig ...
 157-222 7.14e-03

Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in Signal-Regulatory Protein (SIRP), domain 2 (C1 repeat 1). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three Immunoglobulin superfamily domains, a single V-set and two C1-set IgSF domains. Their cytoplasmic tails contain either ITIMs or transmembrane regions that have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47, but with much less affinity.


Pssm-ID: 409429  Cd Length: 102  Bit Score: 36.53  E-value: 7.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68163411 157 CISEDSYP-DGNITWYRNGKVLHPLEGAVviifKKEMDPVTqlYTMTSTLEYKTTKADIQMPFTCSV 222
Cdd:cd05772  24 CKSHGFSPrDITLKWFKNGNELSALQTTV----FPEGDSVS--YSVSSTVQVVLTKDDVHSQLTCEV 84
I-set pfam07679
Immunoglobulin I-set domain;
342-392 7.61e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 36.08  E-value: 7.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68163411   342 VTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPSF--------SSLHYQ-----DAGNYVC 392
Cdd:pfam07679  10 VEVQEGESARFTCTVTGTPDPEVSWFKDGQPLRSSDRFkvtyeggtYTLTISnvqpdDSGKYTC 73
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 338-393 8.85e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 35.62  E-value: 8.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68163411   338 PSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPS-------------FSSLHYQDAGNYVCE 393
Cdd:pfam13927   7 SPSSVTVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTrsrslsgsnstltISNVTRSDAGTYTCV 75
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 352-393 9.88e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.00  E-value: 9.88e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 68163411 352 VSCTISASRNATVVWMKDNIRLRSSP-------------SFSSLHYQDAGNYVCE 393
Cdd:cd00096   3 LTCSASGNPPPTITWYKNGKPLPPSSrdsrrselgngtlTISNVTLEDSGTYTCV 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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