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Conserved domains on  [gi|62243290|ref|NP_001543|]
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insulin-like growth factor-binding protein 4 precursor [Homo sapiens]

Protein Classification

insulin-like growth factor-binding protein( domain architecture ID 11254546)

insulin-like growth factor-binding protein (IGFBP) controls the bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-101 3.44e-27

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 99.85  E-value: 3.44e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62243290     25 IHCPPCSEEKLARCrpPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCM 101
Cdd:smart00121   1 ARCPPCDPARCPPC--PPGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 174-249 1.95e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 74.26  E-value: 1.95e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62243290   174 CQSELHRALERLAASQSrtHEDLYIipiPNCDRNGNFHPKQCHpaldGQRGKCWCVDRKtGVKLPGGLEPKGELDC 249
Cdd:pfam00086   1 CERERARALEQAASGRP--ASGLYI---PNCDEDGFYKPVQCH----GSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-101 3.44e-27

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 99.85  E-value: 3.44e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62243290     25 IHCPPCSEEKLARCrpPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCM 101
Cdd:smart00121   1 ARCPPCDPARCPPC--PPGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 174-249 1.95e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 74.26  E-value: 1.95e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62243290   174 CQSELHRALERLAASQSrtHEDLYIipiPNCDRNGNFHPKQCHpaldGQRGKCWCVDRKtGVKLPGGLEPKGELDC 249
Cdd:pfam00086   1 CERERARALEQAASGRP--ASGLYI---PNCDEDGFYKPVQCH----GSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 173-249 7.59e-15

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 67.49  E-value: 7.59e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62243290 173 SCQSELHRALERLAasqsrtHEDLYIIPIPNCDRNGNFHPKQCHPALdgqrGKCWCVDRKtGVKLPGGLEPKGELDC 249
Cdd:cd00191   1 PCERERASALESLA------GPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPNC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
28-80 2.77e-13

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 62.73  E-value: 2.77e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 62243290    28 PPCSEEKLARcrPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRC 80
Cdd:pfam00219   3 PPCDPERCPP--PPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 201-251 3.29e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 59.70  E-value: 3.29e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 62243290    201 IPNCDRNGNFHPKQCHPAldgqRGKCWCVDRkTGVKLPGGLEPKGELDCHQ 251
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDA-TGREIPGTRTEGGDPDCPS 46
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-101 3.44e-27

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 99.85  E-value: 3.44e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62243290     25 IHCPPCSEEKLARCrpPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCM 101
Cdd:smart00121   1 ARCPPCDPARCPPC--PPGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 174-249 1.95e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 74.26  E-value: 1.95e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62243290   174 CQSELHRALERLAASQSrtHEDLYIipiPNCDRNGNFHPKQCHpaldGQRGKCWCVDRKtGVKLPGGLEPKGELDC 249
Cdd:pfam00086   1 CERERARALEQAASGRP--ASGLYI---PNCDEDGFYKPVQCH----GSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 173-249 7.59e-15

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 67.49  E-value: 7.59e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62243290 173 SCQSELHRALERLAasqsrtHEDLYIIPIPNCDRNGNFHPKQCHPALdgqrGKCWCVDRKtGVKLPGGLEPKGELDC 249
Cdd:cd00191   1 PCERERASALESLA------GPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPNC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
28-80 2.77e-13

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 62.73  E-value: 2.77e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 62243290    28 PPCSEEKLARcrPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRC 80
Cdd:pfam00219   3 PPCDPERCPP--PPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 201-251 3.29e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 59.70  E-value: 3.29e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 62243290    201 IPNCDRNGNFHPKQCHPAldgqRGKCWCVDRkTGVKLPGGLEPKGELDCHQ 251
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDA-TGREIPGTRTEGGDPDCPS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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