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Conserved domains on  [gi|2154713088|ref|NP_001384558|]
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transient receptor potential cation channel subfamily M member 8 isoform 17 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LSDAT_euk super family cl39032
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
39-150 2.80e-44

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


The actual alignment was detected with superfamily member pfam18139:

Pssm-ID: 476852  Cd Length: 266  Bit Score: 146.57  E-value: 2.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154713088  39 KYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGE 117
Cdd:pfam18139   2 KYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKgLLKAAKTTGAWIITGGTNTGVMRHVGD 81
                          90       100       110
                  ....*....|....*....|....*....|...
gi 2154713088 118 VVRDNTISRSSeeNIVAIGIAAWGMVSNRDTLI 150
Cdd:pfam18139  82 ALKDLGSQSRR--KIVTIGIAPWGIIKNREDLI 112
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
39-150 2.80e-44

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 146.57  E-value: 2.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154713088  39 KYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGE 117
Cdd:pfam18139   2 KYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKgLLKAAKTTGAWIITGGTNTGVMRHVGD 81
                          90       100       110
                  ....*....|....*....|....*....|...
gi 2154713088 118 VVRDNTISRSSeeNIVAIGIAAWGMVSNRDTLI 150
Cdd:pfam18139  82 ALKDLGSQSRR--KIVTIGIAPWGIIKNREDLI 112
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
39-150 2.80e-44

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 146.57  E-value: 2.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2154713088  39 KYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGE 117
Cdd:pfam18139   2 KYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKgLLKAAKTTGAWIITGGTNTGVMRHVGD 81
                          90       100       110
                  ....*....|....*....|....*....|...
gi 2154713088 118 VVRDNTISRSSeeNIVAIGIAAWGMVSNRDTLI 150
Cdd:pfam18139  82 ALKDLGSQSRR--KIVTIGIAPWGIIKNREDLI 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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