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Conserved domains on  [gi|1862351654|ref|NP_001371700|]
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putative solute carrier family 22 member 31 isoform g [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-237 1.73e-62

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17443:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 343  Bit Score: 201.16  E-value: 1.73e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1862351654 161 AAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 237
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIR 292
 
Name Accession Description Interval E-value
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 1-237 1.73e-62

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 201.16  E-value: 1.73e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1862351654 161 AAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 237
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIR 292
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 4-248 2.67e-13

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 70.04  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654   4 GLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPGDSS 83
Cdd:TIGR00898 222 QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF---VPESPRWLISQGRIEEALKILQRIAKINGKKLPAEV 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  84 LeenslatELTMLSARSPQPRYHSPLGLLRTRVTWRNGLIL---GFSSLVGggirasfRRSLAPQVPTF----YLPYFLE 156
Cdd:TIGR00898 299 L-------SLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLmmlWFTTAFS-------YYGLVLDLGNLggniYLDLFIS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 157 AGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPgWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVI 236
Cdd:TIGR00898 365 GLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLY-FLRTALAVLGKFGITSAFQMVYLYTAELYPTVV 443

                         250
                  ....*....|...
gi 1862351654 237 RAEA-GGCPSHCR 248
Cdd:TIGR00898 444 RNLGvGVCSTMAR 456
Sugar_tr pfam00083
Sugar (and other) transporter;
24-183 7.28e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 44.19  E-value: 7.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  24 WRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPgdssleenSLATELTMLsARSPQP 103
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLF---LPESPRWLVEKGRLEEAREVLAKLRGVPDVDR--------ELDEIKDSL-EAGQEA 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 104 RYHSPLGLLRTRvTWRNGLILGFSSLVGG---GIRASFrrslapqvptFYLPYFLE-AGLE-------------AAALVF 166
Cdd:pfam00083 238 EKASWKELFSTK-TRRQRLLIGVMLQIFQqltGINAIF----------YYSTTIFEnLGLSdsflvtiivgvvnFVFTFI 306

                         170
                  ....*....|....*..
gi 1862351654 167 LLLTADCCGRRPVLLLG 183
Cdd:pfam00083 307 AIFLVDRFGRRPLLLLG 323
 
Name Accession Description Interval E-value
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 1-237 1.73e-62

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 201.16  E-value: 1.73e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLLLYWCFPS---------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLE 160
Cdd:cd17443   174 --------------------------------------RNGLILGFTAFIGGGIRYCFARNLAPFVPTFYLPYFLQAGLE 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1862351654 161 AAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 237
Cdd:cd17443   216 ALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIR 292
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 1-237 7.20e-51

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 171.16  E-value: 7.20e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPAlfpespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17373   117 MVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSIFP---------------------------------- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSLAPQVP-TFYLPYFLEAGL 159
Cdd:cd17373   163 --------------------------------------KNILILGFNSLTGYGIRHCFARSMMGHEPeNFYLDYYLTAGI 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 160 EAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPG---------------WTVLFLSVLGLLASRAVSALS 224
Cdd:cd17373   205 AAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGLLNLIGKysqhpdsgmsdsvkdKFSIAFSVLGLFASHAVGSLS 284

                         250
                  ....*....|...
gi 1862351654 225 SLFAAEVFPTVIR 237
Cdd:cd17373   285 VLFAAEVTPTVIR 297
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 119-242 8.32e-19

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 85.21  E-value: 8.32e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 119 RNGLILGFSSLVGGGIR---ASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLL 195
Cdd:cd17445   174 KNLLILGFTTFIAHAIShcyQSFSDDVRGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASLILL 253

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1862351654 196 AGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRAEAGG 242
Cdd:cd17445   254 GLMDYLNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLG 300
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 4-248 2.67e-13

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 70.04  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654   4 GLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPGDSS 83
Cdd:TIGR00898 222 QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF---VPESPRWLISQGRIEEALKILQRIAKINGKKLPAEV 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  84 LeenslatELTMLSARSPQPRYHSPLGLLRTRVTWRNGLIL---GFSSLVGggirasfRRSLAPQVPTF----YLPYFLE 156
Cdd:TIGR00898 299 L-------SLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLmmlWFTTAFS-------YYGLVLDLGNLggniYLDLFIS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 157 AGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPgWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVI 236
Cdd:TIGR00898 365 GLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLY-FLRTALAVLGKFGITSAFQMVYLYTAELYPTVV 443

                         250
                  ....*....|...
gi 1862351654 237 RAEA-GGCPSHCR 248
Cdd:TIGR00898 444 RNLGvGVCSTMAR 456
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 1-237 2.72e-07

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 51.39  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654   1 MGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFpalFPespcwllatgqvararkilwrfaeasgvgpg 80
Cdd:cd17444   128 MVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCI---FP------------------------------- 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  81 dssleenslateltmlsarspqpryhsplgllrtrvtwRNGLILGFSSLVGGGIRASFRRSL------APQVPTFYLPYF 154
Cdd:cd17444   174 --------------------------------------KNIVVLCVNSLTGYGIHHCFAKSMmdhemkGSFLHNFYAEYY 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 155 LEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLF---------------LSVLGLLASRA 219
Cdd:cd17444   216 TMAVIALASCLAMCPVVGFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPdsgmsdevkdkfsvtFSIVGMFSSHA 295

                         250
                  ....*....|....*...
gi 1862351654 220 VSALSSLFAAEVFPTVIR 237
Cdd:cd17444   296 VGSLSVFFCAEITPTVIR 313
Sugar_tr pfam00083
Sugar (and other) transporter;
24-183 7.28e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 44.19  E-value: 7.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654  24 WRLLQGLGALMSGLLLLFWGFpalFPESPCWLLATGQVARARKILWRFAEASGVGPgdssleenSLATELTMLsARSPQP 103
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLF---LPESPRWLVEKGRLEEAREVLAKLRGVPDVDR--------ELDEIKDSL-EAGQEA 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 104 RYHSPLGLLRTRvTWRNGLILGFSSLVGG---GIRASFrrslapqvptFYLPYFLE-AGLE-------------AAALVF 166
Cdd:pfam00083 238 EKASWKELFSTK-TRRQRLLIGVMLQIFQqltGINAIF----------YYSTTIFEnLGLSdsflvtiivgvvnFVFTFI 306

                         170
                  ....*....|....*..
gi 1862351654 167 LLLTADCCGRRPVLLLG 183
Cdd:pfam00083 307 AIFLVDRFGRRPLLLLG 323
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 149-237 2.27e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 42.18  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 149 FYLPYFLEAGLEAAALVFLLLTADCCGRRPvLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFA 228
Cdd:cd17317   193 LYLNFFLSGLVEIPAYFLALLLLDRLGRRW-TLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYT 271


                  ....*....
gi 1862351654 229 AEVFPTVIR 237
Cdd:cd17317   272 AELYPTVVR 280
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 150-243 3.62e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 38.49  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1862351654 150 YLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAA 229
Cdd:cd17378   204 YLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTV 283

                          90
                  ....*....|....
gi 1862351654 230 EVFPTVIRAEAGGC 243
Cdd:cd17378   284 ELFPTCVRNAALGM 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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