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Conserved domains on  [gi|1859877220|ref|NP_001371430|]
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interferon alpha/beta receptor 1 isoform 5 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 126-224 1.82e-28

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 108.97  E-value: 1.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 126 AQIGPPEVHLEAEDKAIVIHISP----GTKDSVMWALDGlSFTYSLVIWKNSSGVEE-RIENIYSRHKIYKLSPETTYCL 200
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDpetrEGKNLSLRDLYG-SLQYRVSYWKNSSNGEKkNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 1859877220 201 KVKAALLTSWKIGVYSPVHCIKTT 224
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 329-425 1.97e-16

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


:

Pssm-ID: 462746  Cd Length: 103  Bit Score: 75.07  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 329 PPVFNIRSLSDSFHIYIGAPKQSGNTPVI--QDYP-LIYEIIFWENTSNAERKIIEKKTD-VTVPNLKPLTVYCVKARAH 404
Cdd:pfam09294   5 PPEVELEVEGGSLNVTVKDPETREGKNLSlrDLYGsLQYRVSYWKNSSNGEKKNTTSTNSfVVLSDLEPGTTYCVSVQAF 84

                          90       100
                  ....*....|....*....|.
gi 1859877220 405 TMdeKLNKSSVFSDAVCEKTK 425
Cdd:pfam09294  85 SP--LDNKSSQRSPPQCIRTT 103
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 20-114 1.21e-14

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 70.11  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220  20 VLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEE 99
Cdd:pfam01108  12 ALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTET 91

                          90
                  ....*....|....*.
gi 1859877220 100 IKLRIRAEKEN-TSSW 114
Cdd:pfam01108  92 YYARVRAVSGGgTSSW 107
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 228-313 1.36e-09

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 55.47  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 228 ELPPPENIEVSVQNQNYVLKWDYTYA---NMTFQVQwLQNPGNHlyKWKQIPDCENVKTTQC---VFPQNVFQKgiYLLR 301
Cdd:pfam01108  21 SLPAPQNVTFQSTNFKNILTWEPGPNsppDVVYTVQ-YKIYGSG--DWKNVPNCTNITRTECdltDETSDLTET--YYAR 95

                          90
                  ....*....|..
gi 1859877220 302 VQASDGNNTSFW 313
Cdd:pfam01108  96 VRAVSGGGTSSW 107
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 126-224 1.82e-28

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 108.97  E-value: 1.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 126 AQIGPPEVHLEAEDKAIVIHISP----GTKDSVMWALDGlSFTYSLVIWKNSSGVEE-RIENIYSRHKIYKLSPETTYCL 200
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDpetrEGKNLSLRDLYG-SLQYRVSYWKNSSNGEKkNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 1859877220 201 KVKAALLTSWKIGVYSPVHCIKTT 224
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 329-425 1.97e-16

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 75.07  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 329 PPVFNIRSLSDSFHIYIGAPKQSGNTPVI--QDYP-LIYEIIFWENTSNAERKIIEKKTD-VTVPNLKPLTVYCVKARAH 404
Cdd:pfam09294   5 PPEVELEVEGGSLNVTVKDPETREGKNLSlrDLYGsLQYRVSYWKNSSNGEKKNTTSTNSfVVLSDLEPGTTYCVSVQAF 84

                          90       100
                  ....*....|....*....|.
gi 1859877220 405 TMdeKLNKSSVFSDAVCEKTK 425
Cdd:pfam09294  85 SP--LDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 20-114 1.21e-14

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 70.11  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220  20 VLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEE 99
Cdd:pfam01108  12 ALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTET 91

                          90
                  ....*....|....*.
gi 1859877220 100 IKLRIRAEKEN-TSSW 114
Cdd:pfam01108  92 YYARVRAVSGGgTSSW 107
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 228-313 1.36e-09

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 55.47  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 228 ELPPPENIEVSVQNQNYVLKWDYTYA---NMTFQVQwLQNPGNHlyKWKQIPDCENVKTTQC---VFPQNVFQKgiYLLR 301
Cdd:pfam01108  21 SLPAPQNVTFQSTNFKNILTWEPGPNsppDVVYTVQ-YKIYGSG--DWKNVPNCTNITRTECdltDETSDLTET--YYAR 95

                          90
                  ....*....|..
gi 1859877220 302 VQASDGNNTSFW 313
Cdd:pfam01108  96 VRAVSGGGTSSW 107
 
Name Accession Description Interval E-value
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 126-224 1.82e-28

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 108.97  E-value: 1.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 126 AQIGPPEVHLEAEDKAIVIHISP----GTKDSVMWALDGlSFTYSLVIWKNSSGVEE-RIENIYSRHKIYKLSPETTYCL 200
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVTVKDpetrEGKNLSLRDLYG-SLQYRVSYWKNSSNGEKkNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|....
gi 1859877220 201 KVKAALLTSWKIGVYSPVHCIKTT 224
Cdd:pfam09294  80 SVQAFSPLDNKSSQRSPPQCIRTT 103
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 329-425 1.97e-16

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 75.07  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 329 PPVFNIRSLSDSFHIYIGAPKQSGNTPVI--QDYP-LIYEIIFWENTSNAERKIIEKKTD-VTVPNLKPLTVYCVKARAH 404
Cdd:pfam09294   5 PPEVELEVEGGSLNVTVKDPETREGKNLSlrDLYGsLQYRVSYWKNSSNGEKKNTTSTNSfVVLSDLEPGTTYCVSVQAF 84

                          90       100
                  ....*....|....*....|.
gi 1859877220 405 TMdeKLNKSSVFSDAVCEKTK 425
Cdd:pfam09294  85 SP--LDNKSSQRSPPQCIRTT 103
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 20-114 1.21e-14

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 70.11  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220  20 VLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLSGCQNITSTKCNFSSLKLNVYEE 99
Cdd:pfam01108  12 ALASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTET 91

                          90
                  ....*....|....*.
gi 1859877220 100 IKLRIRAEKEN-TSSW 114
Cdd:pfam01108  92 YYARVRAVSGGgTSSW 107
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 228-313 1.36e-09

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 55.47  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859877220 228 ELPPPENIEVSVQNQNYVLKWDYTYA---NMTFQVQwLQNPGNHlyKWKQIPDCENVKTTQC---VFPQNVFQKgiYLLR 301
Cdd:pfam01108  21 SLPAPQNVTFQSTNFKNILTWEPGPNsppDVVYTVQ-YKIYGSG--DWKNVPNCTNITRTECdltDETSDLTET--YYAR 95

                          90
                  ....*....|..
gi 1859877220 302 VQASDGNNTSFW 313
Cdd:pfam01108  96 VRAVSGGGTSSW 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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