epoxide hydrolase 1 isoform d [Homo sapiens]
Protein Classification
epoxide hydrolase( domain architecture ID 10534184)
epoxide hydrolase catalyzes the conversion of epoxides to trans-dihydrodiols, thus preventing or reducing their reaction with cellular macromolecules such as protein or DNA; epoxide hydrolase such as juvenile hormone epoxide hydrolase, which catalyzes juvenile hormone hydrolysis
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| EHN | pfam06441 | Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ... |
48-124 | 2.66e-32 | ||||
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561. : Pssm-ID: 461913 Cd Length: 106 Bit Score: 117.18 E-value: 2.66e-32
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| Abhydrolase super family | cl21494 | alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ... |
121-328 | 9.47e-18 | ||||
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom. The actual alignment was detected with superfamily member pfam00561: Pssm-ID: 473884 [Multi-domain] Cd Length: 245 Bit Score: 81.78 E-value: 9.47e-18
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| Name | Accession | Description | Interval | E-value | ||||
| EHN | pfam06441 | Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ... |
48-124 | 2.66e-32 | ||||
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561. Pssm-ID: 461913 Cd Length: 106 Bit Score: 117.18 E-value: 2.66e-32
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| Abhydrolase_1 | pfam00561 | alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. |
121-328 | 9.47e-18 | ||||
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. Pssm-ID: 395444 [Multi-domain] Cd Length: 245 Bit Score: 81.78 E-value: 9.47e-18
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| Name | Accession | Description | Interval | E-value | ||||
| EHN | pfam06441 | Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ... |
48-124 | 2.66e-32 | ||||
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561. Pssm-ID: 461913 Cd Length: 106 Bit Score: 117.18 E-value: 2.66e-32
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| Abhydrolase_1 | pfam00561 | alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. |
121-328 | 9.47e-18 | ||||
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. Pssm-ID: 395444 [Multi-domain] Cd Length: 245 Bit Score: 81.78 E-value: 9.47e-18
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| Blast search parameters | ||||
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