NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1800417187|ref|NP_001364968|]
View 

sorting nexin-25 isoform 8 [Homo sapiens]

Protein Classification

PXA domain-containing protein( domain architecture ID 10490349)

PXA domain-containing protein similar to Homo sapiens sorting nexin-25 that negatively regulates TGF-beta signaling by enhancing the receptor degradation through lysosome pathway

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PXA pfam02194
PXA domain; This domain is associated with PX domains pfam00787.
 166-321 4.26e-16

PXA domain; This domain is associated with PX domains pfam00787.


:

Pssm-ID: 460484  Cd Length: 181  Bit Score: 76.12  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187 166 DKALKEVFDYSYRDYILSWYGNLSRDEG---QLYHLLLEdfweIARQLHHRLSHVDVVKVVCNDVVRTLLTHF------- 235
Cdd:pfam02194   5 DAALDELIDLIIRDFVQSWYSKISSDPEfpnEVRQTLRH----ALRELSQRLRKVDLASLLLSRLLPLLTSHLedyrkae 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187 236 ----------CDLKAANARHEEQPRPFVLHACLRNSDD---EVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKV 302
Cdd:pfam02194  81 eavrgkklneLDLALASKYLALKPHPALSPVLLSSSQSreaEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACLV 160

                         170
                  ....*....|....*....
gi 1800417187 303 LKPVVELLSNPDYINQMLL 321
Cdd:pfam02194 161 LLPVINKLSDPDFINELIV 179
 
Name Accession Description Interval E-value
PXA pfam02194
PXA domain; This domain is associated with PX domains pfam00787.
 166-321 4.26e-16

PXA domain; This domain is associated with PX domains pfam00787.


Pssm-ID: 460484  Cd Length: 181  Bit Score: 76.12  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187 166 DKALKEVFDYSYRDYILSWYGNLSRDEG---QLYHLLLEdfweIARQLHHRLSHVDVVKVVCNDVVRTLLTHF------- 235
Cdd:pfam02194   5 DAALDELIDLIIRDFVQSWYSKISSDPEfpnEVRQTLRH----ALRELSQRLRKVDLASLLLSRLLPLLTSHLedyrkae 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187 236 ----------CDLKAANARHEEQPRPFVLHACLRNSDD---EVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKV 302
Cdd:pfam02194  81 eavrgkklneLDLALASKYLALKPHPALSPVLLSSSQSreaEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACLV 160

                         170
                  ....*....|....*....
gi 1800417187 303 LKPVVELLSNPDYINQMLL 321
Cdd:pfam02194 161 LLPVINKLSDPDFINELIV 179
PXA smart00313
Domain associated with PX domains; unpubl. observations
 165-321 2.72e-14

Domain associated with PX domains; unpubl. observations


Pssm-ID: 214611  Cd Length: 176  Bit Score: 70.91  E-value: 2.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187  165 MDKALKEVFDYSYRDYILSWYGNLSRDEGqlyhLLLEDFWE---IARQLHHRLSHVDVVKVVCNDVVRTLLTHFCDLKAA 241
Cdd:smart00313   4 LEEPLQLLISKIIRDYVQGWYKGVSEDPS----FLREIEQTleyILRQLYRRLSRQDSAHLILYEILKNLISTITNALEA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187  242 NARH----------EEQPRPFVLHACLRNSDDEVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLS 311
Cdd:smart00313  80 VLRFaspqipsteiDLQYAETAIHKALSSPSNELTYRRQLVEMLLKFLLPEDSLCSRLHRCLLREVLAMQVILPLITHLS 159

                          170
                   ....*....|
gi 1800417187  312 NPDYINQMLL 321
Cdd:smart00313 160 DPDTINLCII 169
 
Name Accession Description Interval E-value
PXA pfam02194
PXA domain; This domain is associated with PX domains pfam00787.
 166-321 4.26e-16

PXA domain; This domain is associated with PX domains pfam00787.


Pssm-ID: 460484  Cd Length: 181  Bit Score: 76.12  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187 166 DKALKEVFDYSYRDYILSWYGNLSRDEG---QLYHLLLEdfweIARQLHHRLSHVDVVKVVCNDVVRTLLTHF------- 235
Cdd:pfam02194   5 DAALDELIDLIIRDFVQSWYSKISSDPEfpnEVRQTLRH----ALRELSQRLRKVDLASLLLSRLLPLLTSHLedyrkae 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187 236 ----------CDLKAANARHEEQPRPFVLHACLRNSDD---EVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKV 302
Cdd:pfam02194  81 eavrgkklneLDLALASKYLALKPHPALSPVLLSSSQSreaEQKYLRLLVDGLLPLLLPPEDLESRPVRVLVREILACLV 160

                         170
                  ....*....|....*....
gi 1800417187 303 LKPVVELLSNPDYINQMLL 321
Cdd:pfam02194 161 LLPVINKLSDPDFINELIV 179
PXA smart00313
Domain associated with PX domains; unpubl. observations
 165-321 2.72e-14

Domain associated with PX domains; unpubl. observations


Pssm-ID: 214611  Cd Length: 176  Bit Score: 70.91  E-value: 2.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187  165 MDKALKEVFDYSYRDYILSWYGNLSRDEGqlyhLLLEDFWE---IARQLHHRLSHVDVVKVVCNDVVRTLLTHFCDLKAA 241
Cdd:smart00313   4 LEEPLQLLISKIIRDYVQGWYKGVSEDPS----FLREIEQTleyILRQLYRRLSRQDSAHLILYEILKNLISTITNALEA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1800417187  242 NARH----------EEQPRPFVLHACLRNSDDEVRFLQTCSRVLVFCLLPSKDVQSLSLRIMLAEILTTKVLKPVVELLS 311
Cdd:smart00313  80 VLRFaspqipsteiDLQYAETAIHKALSSPSNELTYRRQLVEMLLKFLLPEDSLCSRLHRCLLREVLAMQVILPLITHLS 159

                          170
                   ....*....|
gi 1800417187  312 NPDYINQMLL 321
Cdd:smart00313 160 DPDTINLCII 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH