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Conserved domains on  [gi|1746322666|ref|NP_001361238|]
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syntaxin-binding protein 1 isoform e [Homo sapiens]

Protein Classification

Sec1 family protein( domain architecture ID 10469995)

Sec1 family protein such as syntaxin-binding proteins, which participate in the regulation of synaptic vesicle docking and fusion, and vacuolar protein sorting-associated protein 33A/33B/45, which play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network

CATH:  3.40.50.1910
PubMed:  8769846|15642380
SCOP:  4002933

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
15-566 4.46e-151

Sec1 family;


:

Pssm-ID: 460020  Cd Length: 506  Bit Score: 444.07  E-value: 4.46e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  15 KVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPtAKYRAAHVFFTD 94
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADFISSR-PKYKSYHIFFTS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  95 SCPDALFNELVKSraAKVIKTLTEINIAFLPYESQVYSLDSA---DSFQSFYSPHKAQMKNPILERLAEQIATLCATLKE 171
Cdd:pfam00995  80 RLSRELLEGLAEG--DEVVKKVKEINLDFIPLESDLFSLNDPelpLYFPSYYLDLNDPVWLDELDRIAKGLLSVCLTLGE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 172 YPAVRYRGEykdnalLAQLIQDKL-DAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY 250
Cdd:pfam00995 158 IPIIRYKGP------AAEMVAKKLaDKLRDKIDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALVHDLLGILKLNR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 251 KYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS--KRMNTGEKTTMRDLSQMLKKMPQYQKELS 328
Cdd:pfam00995 232 VTLETGGKEEEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKnkETRKTKGIASIADLKDFVAKLPELQEEKR 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 329 KYSTHLHLAEDCMKHYQGTV-DKLCRVEQDLAMGTDaegEKIKD-PMRAIVPiLLDANVSTYDKIRIILLYIFLKNGITE 406
Cdd:pfam00995 312 KLSLHTNLAEELLKIIKKRKlDELLELEQDLATGED---SKQKDkLIEELIA-LLDADVSPLDKLRLLLLYSLTENGKSK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 407 ENLNKLIQHAQIppedseiitnmahlgvpivtdstlrrrskperkeriseqtyqLSRWTPIIKDIMEDTIEDKLDTKHYP 486
Cdd:pfam00995 388 ELEDLKRELLQA------------------------------------------IYGYVPLLTRLVEALIKGGLLSSEFP 425
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 487 YISTRSSASF-STTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAyEVTQANGKWEVLIGSTHILTPQKLL 565
Cdd:pfam00995 426 SLKPPDPLGAdLSGSVSARSKSGASSGGSRRSSFRQRVIVFVVGGVTYSEIRAL-RELAKKKNKEIIIGSTSILNPNSFL 504

                  .
gi 1746322666 566 D 566
Cdd:pfam00995 505 E 505
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
15-566 4.46e-151

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 444.07  E-value: 4.46e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  15 KVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPtAKYRAAHVFFTD 94
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADFISSR-PKYKSYHIFFTS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  95 SCPDALFNELVKSraAKVIKTLTEINIAFLPYESQVYSLDSA---DSFQSFYSPHKAQMKNPILERLAEQIATLCATLKE 171
Cdd:pfam00995  80 RLSRELLEGLAEG--DEVVKKVKEINLDFIPLESDLFSLNDPelpLYFPSYYLDLNDPVWLDELDRIAKGLLSVCLTLGE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 172 YPAVRYRGEykdnalLAQLIQDKL-DAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY 250
Cdd:pfam00995 158 IPIIRYKGP------AAEMVAKKLaDKLRDKIDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALVHDLLGILKLNR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 251 KYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS--KRMNTGEKTTMRDLSQMLKKMPQYQKELS 328
Cdd:pfam00995 232 VTLETGGKEEEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKnkETRKTKGIASIADLKDFVAKLPELQEEKR 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 329 KYSTHLHLAEDCMKHYQGTV-DKLCRVEQDLAMGTDaegEKIKD-PMRAIVPiLLDANVSTYDKIRIILLYIFLKNGITE 406
Cdd:pfam00995 312 KLSLHTNLAEELLKIIKKRKlDELLELEQDLATGED---SKQKDkLIEELIA-LLDADVSPLDKLRLLLLYSLTENGKSK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 407 ENLNKLIQHAQIppedseiitnmahlgvpivtdstlrrrskperkeriseqtyqLSRWTPIIKDIMEDTIEDKLDTKHYP 486
Cdd:pfam00995 388 ELEDLKRELLQA------------------------------------------IYGYVPLLTRLVEALIKGGLLSSEFP 425
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 487 YISTRSSASF-STTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAyEVTQANGKWEVLIGSTHILTPQKLL 565
Cdd:pfam00995 426 SLKPPDPLGAdLSGSVSARSKSGASSGGSRRSSFRQRVIVFVVGGVTYSEIRAL-RELAKKKNKEIIIGSTSILNPNSFL 504

                  .
gi 1746322666 566 D 566
Cdd:pfam00995 505 E 505
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
3-571 4.46e-74

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 246.95  E-value: 4.46e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666   3 DVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPt 82
Cdd:COG5158    14 DEIFLVQPANIWKVLLLDKDTTSILSSLITTSELLEHGITLVDLIENKREPISDLPAIYFVRPTKENIDLILEDLEQWD- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  83 AKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPIlerlAEQI 162
Cdd:COG5158    93 PFYLNYHISFLNTVTESLLELLAESGVFEKILSVYEIYLDFFVLESDLFSLNLPESFLESSLPSTTEALIKI----VNGL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 163 ATLCATLKEYPAVRYRGEyKDNALLAQL----IQDKLDAYKaDDPTMGEGPdkaRSQLLILDRGFDPSSPVLHELTFQAM 238
Cdd:COG5158   169 FSLCVSLGRIPIIRYSGG-KNAEHMAKKlsdeIRNELSINF-DGVVSKNPL---RPILIILDRSLDPITPLLHQWTYQAM 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 239 SYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSS-SKRMNTGEKTTMRDLSQML 317
Cdd:COG5158   244 LHDLLGINNNIVTIPSSSVNGPEKKFSLSDKDDPFWNDNKFLNFGEVGEKLKKLAKELKTkAQLRHKENAKSVNDIKEFV 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 318 KKMPQYQKELSKYSTHLHLAEDCMKHYQ-GTVDKLCRVEQDLAmGTDAEGEKIKDpmraiVPILLDANVSTYDKIRIILL 396
Cdd:COG5158   324 DKLPELQKRSRSLNKHLTLASELLKVVEeRYLDDFSEIEQNLS-TGNDVKSDISD-----LIELLESGVEEDDKLRLLIL 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 397 YIFLKNGIT-EENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRrrsKPERKERIS----EQTYQLSRWTPIIKDI 471
Cdd:COG5158   398 YSLTKDGLIkDIDELRLLRIQGYGIEALNFFQRLKELGFLTLKDSKTI---SLKRGDKDSlfqwFNTYSLSREHQGVPDL 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 472 MeDTIEDKL-DTKHYPYIStRSSASFSTTAVSARYGHW---HKNKAPGEYRSGP-RLIIFILGGVSLNEMRCAYEVTQAN 546
Cdd:COG5158   475 E-NVYSGLIpLKKDIPIDL-LVRRLFEPLKSSQQQSLRlsrPKGRSRSNKKIPQqRILVFVIGGVTYEELRVLYELNESQ 552
                         570       580
                  ....*....|....*....|....*
gi 1746322666 547 GKWEVLIGSTHILTPQKLLDTLKKL 571
Cdd:COG5158   553 NSVRIIYGSTEILTPAEFLDEVKRL 577
 
Name Accession Description Interval E-value
Sec1 pfam00995
Sec1 family;
15-566 4.46e-151

Sec1 family;


Pssm-ID: 460020  Cd Length: 506  Bit Score: 444.07  E-value: 4.46e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  15 KVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPtAKYRAAHVFFTD 94
Cdd:pfam00995   1 KVLVLDKETLKILSSVLTVSDLLEEGVTLVEKIEKLREPLPDVPAIYFVRPTKENIDRIAADFISSR-PKYKSYHIFFTS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  95 SCPDALFNELVKSraAKVIKTLTEINIAFLPYESQVYSLDSA---DSFQSFYSPHKAQMKNPILERLAEQIATLCATLKE 171
Cdd:pfam00995  80 RLSRELLEGLAEG--DEVVKKVKEINLDFIPLESDLFSLNDPelpLYFPSYYLDLNDPVWLDELDRIAKGLLSVCLTLGE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 172 YPAVRYRGEykdnalLAQLIQDKL-DAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVY 250
Cdd:pfam00995 158 IPIIRYKGP------AAEMVAKKLaDKLRDKIDSFAKLSSDSRPVLIILDRSVDLVTPLLHQWTYQALVHDLLGILKLNR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 251 KYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSS--KRMNTGEKTTMRDLSQMLKKMPQYQKELS 328
Cdd:pfam00995 232 VTLETGGKEEEKKVELLDSSDPFWVENRHLHFADVGEKLKKKLKEYKAKnkETRKTKGIASIADLKDFVAKLPELQEEKR 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 329 KYSTHLHLAEDCMKHYQGTV-DKLCRVEQDLAMGTDaegEKIKD-PMRAIVPiLLDANVSTYDKIRIILLYIFLKNGITE 406
Cdd:pfam00995 312 KLSLHTNLAEELLKIIKKRKlDELLELEQDLATGED---SKQKDkLIEELIA-LLDADVSPLDKLRLLLLYSLTENGKSK 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 407 ENLNKLIQHAQIppedseiitnmahlgvpivtdstlrrrskperkeriseqtyqLSRWTPIIKDIMEDTIEDKLDTKHYP 486
Cdd:pfam00995 388 ELEDLKRELLQA------------------------------------------IYGYVPLLTRLVEALIKGGLLSSEFP 425
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 487 YISTRSSASF-STTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAyEVTQANGKWEVLIGSTHILTPQKLL 565
Cdd:pfam00995 426 SLKPPDPLGAdLSGSVSARSKSGASSGGSRRSSFRQRVIVFVVGGVTYSEIRAL-RELAKKKNKEIIIGSTSILNPNSFL 504

                  .
gi 1746322666 566 D 566
Cdd:pfam00995 505 E 505
SEC1 COG5158
Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular ...
3-571 4.46e-74

Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion];


Pssm-ID: 227487  Cd Length: 582  Bit Score: 246.95  E-value: 4.46e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666   3 DVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPt 82
Cdd:COG5158    14 DEIFLVQPANIWKVLLLDKDTTSILSSLITTSELLEHGITLVDLIENKREPISDLPAIYFVRPTKENIDLILEDLEQWD- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666  83 AKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPIlerlAEQI 162
Cdd:COG5158    93 PFYLNYHISFLNTVTESLLELLAESGVFEKILSVYEIYLDFFVLESDLFSLNLPESFLESSLPSTTEALIKI----VNGL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 163 ATLCATLKEYPAVRYRGEyKDNALLAQL----IQDKLDAYKaDDPTMGEGPdkaRSQLLILDRGFDPSSPVLHELTFQAM 238
Cdd:COG5158   169 FSLCVSLGRIPIIRYSGG-KNAEHMAKKlsdeIRNELSINF-DGVVSKNPL---RPILIILDRSLDPITPLLHQWTYQAM 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 239 SYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSS-SKRMNTGEKTTMRDLSQML 317
Cdd:COG5158   244 LHDLLGINNNIVTIPSSSVNGPEKKFSLSDKDDPFWNDNKFLNFGEVGEKLKKLAKELKTkAQLRHKENAKSVNDIKEFV 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 318 KKMPQYQKELSKYSTHLHLAEDCMKHYQ-GTVDKLCRVEQDLAmGTDAEGEKIKDpmraiVPILLDANVSTYDKIRIILL 396
Cdd:COG5158   324 DKLPELQKRSRSLNKHLTLASELLKVVEeRYLDDFSEIEQNLS-TGNDVKSDISD-----LIELLESGVEEDDKLRLLIL 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 397 YIFLKNGIT-EENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRrrsKPERKERIS----EQTYQLSRWTPIIKDI 471
Cdd:COG5158   398 YSLTKDGLIkDIDELRLLRIQGYGIEALNFFQRLKELGFLTLKDSKTI---SLKRGDKDSlfqwFNTYSLSREHQGVPDL 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1746322666 472 MeDTIEDKL-DTKHYPYIStRSSASFSTTAVSARYGHW---HKNKAPGEYRSGP-RLIIFILGGVSLNEMRCAYEVTQAN 546
Cdd:COG5158   475 E-NVYSGLIpLKKDIPIDL-LVRRLFEPLKSSQQQSLRlsrPKGRSRSNKKIPQqRILVFVIGGVTYEELRVLYELNESQ 552
                         570       580
                  ....*....|....*....|....*
gi 1746322666 547 GKWEVLIGSTHILTPQKLLDTLKKL 571
Cdd:COG5158   553 NSVRIIYGSTEILTPAEFLDEVKRL 577
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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