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Conserved domains on  [gi|1495460170|ref|NP_001353816|]
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glycosyltransferase 1 domain-containing protein 1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco4_Geo_Pelo super family cl45694
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 21-298 2.76e-55

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


The actual alignment was detected with superfamily member NF038229:

Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 182.49  E-value: 2.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  21 PATRSRPSAFGhrIPFGVIFGGTDVNEDANQaEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIaTT 100
Cdd:NF038229   69 RVWLELARALG--IPYLVTLTGTDVNEALDP-DRRPETLRVLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-EL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 101 PNAAFNWntflqrSEINQSADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAA 180
Cdd:NF038229  145 GGEPFPL------RELGLFDSDEFVFLLPAGLRPVKGVLFLLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRP 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 181 GVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRL 260
Cdd:NF038229  219 WARYLGEIPHDAMGALYRRADVVLNNSLFEGMANALLEAMALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQL 298

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1495460170 261 VSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKL 298
Cdd:NF038229  299 LQDPALRRRLGRPGRQLVRERYSPEREAEAYLRLYRAV 336
 
Name Accession Description Interval E-value
Glyco4_Geo_Pelo NF038229
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 21-298 2.76e-55

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 182.49  E-value: 2.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  21 PATRSRPSAFGhrIPFGVIFGGTDVNEDANQaEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIaTT 100
Cdd:NF038229   69 RVWLELARALG--IPYLVTLTGTDVNEALDP-DRRPETLRVLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-EL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 101 PNAAFNWntflqrSEINQSADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAA 180
Cdd:NF038229  145 GGEPFPL------RELGLFDSDEFVFLLPAGLRPVKGVLFLLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRP 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 181 GVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRL 260
Cdd:NF038229  219 WARYLGEIPHDAMGALYRRADVVLNNSLFEGMANALLEAMALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQL 298

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1495460170 261 VSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKL 298
Cdd:NF038229  299 LQDPALRRRLGRPGRQLVRERYSPEREAEAYLRLYRAV 336
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 16-296 4.13e-33

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 124.96  E-value: 4.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  16 CCGHTPATRSRPSAFGHRIPFGVIF-GGTDVNEDANQAEKNTVMGRVLEEARFA---VAFTESMKEMAQAQWPHAKGKVY 91
Cdd:cd03801    88 AHGLLAALLAALLALLLGAPLVVTLhGAEPGRLLLLLAAERRLLARAEALLRRAdavIAVSEALRDELRALGGIPPEKIV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  92 VQSQGIATTPNAAFnwntflQRSEINQSADNLhIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEvDPVFTRE 171
Cdd:cd03801   168 VIPNGVDLERFSPP------LRRKLGIPPDRP-VLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGGD-GPLRAEL 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 172 VKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS--N 249
Cdd:cd03801   240 EELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPpdD 319

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1495460170 250 PQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIR 296
Cdd:cd03801   320 VEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 132-276 9.27e-24

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 94.65  E-value: 9.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 132 LRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEG 211
Cdd:pfam00534  11 LEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEG 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1495460170 212 MSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGRE 276
Cdd:pfam00534  91 FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENARK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 193-298 1.93e-20

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 84.66  E-value: 1.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 193 LHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEI 270
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRLLEDPELRRRL 93

                          90       100
                  ....*....|....*....|....*...
gi 1495460170 271 VVNGREYVRMYHSWQVERDTYQQLIRKL 298
Cdd:COG0438    94 GEAARERAEERFSWEAIAERLLALYEEL 121
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
108-285 5.39e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 47.48  E-value: 5.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 108 NTFLQRSEINQSADNLHIFLlicGLRQVKDP--LYLVDAFSAWHQEEPNVHLVIVGpevDPVFTR-----EVKAKVKRAA 180
Cdd:PRK15484  179 PQPNLRQQLNISPDETVLLY---AGRISPDKgiLLLMQAFEKLATAHSNLKLVVVG---DPTASSkgekaAYQKKVLEAA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 181 ---GVRLI--GEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFV 254
Cdd:PRK15484  253 kriGDRCImlGGQPPEKMHNYYPLAdLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAEPMTSD 332

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1495460170 255 HLA---KRLVSDPALEkEIVVNGREYVRMYHSWQ 285
Cdd:PRK15484  333 SIIsdiNRTLADPELT-QIAEQAKDFVFSKYSWE 365
 
Name Accession Description Interval E-value
Glyco4_Geo_Pelo NF038229
GPMC system family 4 glycosyltransferase; Members of this family are family 4 ...
 21-298 2.76e-55

GPMC system family 4 glycosyltransferase; Members of this family are family 4 glycosyltransferases of the GPMC (Geobacter/Pelobacter Mystery Cassette) system, in which the most distinctive signature is the TIGR04442 protein family.


Pssm-ID: 439530 [Multi-domain]  Cd Length: 338  Bit Score: 182.49  E-value: 2.76e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  21 PATRSRPSAFGhrIPFGVIFGGTDVNEDANQaEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPHAKGKVYVQSQGIaTT 100
Cdd:NF038229   69 RVWLELARALG--IPYLVTLTGTDVNEALDP-DRRPETLRVLRGAAAIVAFNPLVRERLGQHLPPLAAKLVVIPQGV-EL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 101 PNAAFNWntflqrSEINQSADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAA 180
Cdd:NF038229  145 GGEPFPL------RELGLFDSDEFVFLLPAGLRPVKGVLFLLEMLAPLHAEDPRLRLAFAGPVLDEEYAAAFFAALARRP 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 181 GVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRL 260
Cdd:NF038229  219 WARYLGEIPHDAMGALYRRADVVLNNSLFEGMANALLEAMALGRPVLARDIPGNRSVVRPGVTGLLYRDEAEFLRQARQL 298

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1495460170 261 VSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKL 298
Cdd:NF038229  299 LQDPALRRRLGRPGRQLVRERYSPEREAEAYLRLYRAV 336
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 16-296 4.13e-33

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 124.96  E-value: 4.13e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  16 CCGHTPATRSRPSAFGHRIPFGVIF-GGTDVNEDANQAEKNTVMGRVLEEARFA---VAFTESMKEMAQAQWPHAKGKVY 91
Cdd:cd03801    88 AHGLLAALLAALLALLLGAPLVVTLhGAEPGRLLLLLAAERRLLARAEALLRRAdavIAVSEALRDELRALGGIPPEKIV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  92 VQSQGIATTPNAAFnwntflQRSEINQSADNLhIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEvDPVFTRE 171
Cdd:cd03801   168 VIPNGVDLERFSPP------LRRKLGIPPDRP-VLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGGD-GPLRAEL 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 172 VKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS--N 249
Cdd:cd03801   240 EELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPpdD 319

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1495460170 250 PQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIR 296
Cdd:cd03801   320 VEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 132-276 9.27e-24

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 94.65  E-value: 9.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 132 LRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEG 211
Cdd:pfam00534  11 LEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEG 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1495460170 212 MSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGRE 276
Cdd:pfam00534  91 FGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENARK 157
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 193-298 1.93e-20

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 84.66  E-value: 1.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 193 LHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEI 270
Cdd:COG0438    14 LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRLLEDPELRRRL 93

                          90       100
                  ....*....|....*....|....*...
gi 1495460170 271 VVNGREYVRMYHSWQVERDTYQQLIRKL 298
Cdd:COG0438    94 GEAARERAEERFSWEAIAERLLALYEEL 121
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 92-295 2.07e-19

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 87.03  E-value: 2.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  92 VQSQGIATTPNAAFNWNTFLQRSEINQSADNLHI-FLLICGLRQV-KDPLYLVDAFSAWHQEEPNVHLVIVG---PEVDP 166
Cdd:cd03809   159 VPPEKIVVIPLGVDPSFFPPESAAVLIAKYLLPEpYFLYVGTLEPrKNHERLLKAFALLKKQGGDLKLVIVGgkgWEDEE 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 167 VFTREVKAKVKRaaGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPgnaavVKHEVTG-- 244
Cdd:cd03809   239 LLDLVKKLGLGG--RVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNIS-----VLPEVAGda 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1495460170 245 -LLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYhSWQVerdTYQQLI 295
Cdd:cd03809   312 aLYFDplDPESIADAILRLLEDPSLREELIRKGLERAKKF-SWEK---TAEKTL 361
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
133-263 2.47e-18

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 79.48  E-value: 2.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 133 RQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDpvftREVKAKVKR-AAGVRLIGemPQEDLHAVVKNCFAVVNSSVSEG 211
Cdd:pfam13692  12 PNVKGVDYLLEAVPLLRKRDNDVRLVIVGDGPE----EELEELAAGlEDRVIFTG--FVEDLAELLAAADVFVLPSLYEG 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1495460170 212 MSAAILEAMDLEVPVLARNIPGNAAVVkHEVTGLLFS--NPQEFVHLAKRLVSD 263
Cdd:pfam13692  86 FGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLVPpgDPEALAEAILRLLED 138
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 136-283 2.74e-18

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 83.80  E-value: 2.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 136 KDPLYLVDAFSAWHQEEPNVHLVIVGP-EVDPvfTREVKAKVKRAAG-VRLIGEMpqEDLHAVVKNCFAVVNSSVSEGMS 213
Cdd:cd03808   202 KGIDELIEAAKILKKKGPNVRFLLVGDgELEN--PSEILIEKLGLEGrIEFLGFR--SDVPELLAESDVFVLPSYREGLP 277

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1495460170 214 AAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFsNPQEFVHLAK---RLVSDPALEKEIVVNGREYVRMYHS 283
Cdd:cd03808   278 RSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLV-PPGDVEALADaieKLIEDPELRKEMGEAARKRVEEKFD 349
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 34-260 6.49e-18

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 82.81  E-value: 6.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  34 IPFGVIFGGTDVNEDANQAEKNTVMGRVLEEARFAVAFTESMKEMAQAQWPhAKGKVYVQSQGIATtpnaafnwNTFLQR 113
Cdd:cd03798   120 VPYVVTEHGSDINVFPPRSLLRKLLRWALRRAARVIAVSKALAEELVALGV-PRDRVDVIPNGVDP--------ARFQPE 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 114 SEINQSADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQEDL 193
Cdd:cd03798   191 DRGLGLPLDAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQV 270

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1495460170 194 HAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSnPQEFVHLAKRL 260
Cdd:cd03798   271 PAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVP-PGDADALAAAL 336
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 25-294 6.41e-15

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 74.28  E-value: 6.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  25 SRPSAFGHRIPfGVIFGGTDVNEDANQaeknTVMGRVLEEARF-----AVAFTESMKEMAQAQWpHAKGKVYVQSQGIAT 99
Cdd:cd03807    94 GGLAAKLAGGV-KVIWSVRSSNIPQRL----TRLVRKLCLLLSkfspaTVANSSAVAEFHQEQG-YAKNKIVVIYNGIDL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 100 TpnaAFNwNTFLQRSEINQS---ADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVdpvfTREVKAKV 176
Cdd:cd03807   168 F---KLS-PDDASRARARRRlglAEDRRVIGIVGRLHPVKDHSDLLRAAALLVETHPDLRLLLVGRGP----ERPNLERL 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 177 KRAAG----VRLIGEmpQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKhEVTGLLFS--NP 250
Cdd:cd03807   240 LLELGledrVHLLGE--RSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVD-DGTGFLVPagDP 316

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1495460170 251 QEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQL 294
Cdd:cd03807   317 QALADAIRALLEDPEKRARLGRAARERIANEFSIDAMVRRYETL 360
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 125-247 1.15e-14

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 72.05  E-value: 1.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 125 IFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGPEVDPVFTREVKAKVKRAAGVRLIGEMPQ-EDLHAVVKNCFAV 203
Cdd:cd01635   112 DKVSVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDdEVLELLLAAADVF 191

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1495460170 204 VNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF 247
Cdd:cd01635   192 VLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 97-249 7.42e-14

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 70.85  E-value: 7.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  97 IATTPNAaFNWNTFLQRSEINQSADNLHIFLLIC-G-LRQVKDPLYLVDAFSAWHQEEPNVHLVIVG--PEvdpvftREV 172
Cdd:cd03811   161 IEVIYNP-IDIDRIRALAKEPILNEPEDGPVILAvGrLDPQKGHDLLIEAFAKLRKKYPDVKLVILGdgPL------REE 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 173 KAKVKRAAG----VRLIGEmpQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS 248
Cdd:cd03811   234 LEKLAKELGlaerVIFLGF--QSNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVP 311


                  .
gi 1495460170 249 N 249
Cdd:cd03811   312 D 312
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 132-285 1.03e-13

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 70.73  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 132 LRQVKDPLYLVDAFSAWHQEEPNVHLVIVG-----PEVDPVFTREVKAKVKRAAG-VRLIGEMPQEDLHAVVKNCFAVVN 205
Cdd:cd03800   229 LDPRKGIDTLVRAFAQLPELRELANLVLVGgpsddPLSMDREELAELAEELGLIDrVRFPGRVSRDDLPELYRAADVFVV 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 206 SSVSE--GMSAaiLEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMY 281
Cdd:cd03800   309 PSLYEpfGLTA--IEAMACGTPVVATAVGGLQDIVRDGRTGLLVDphDPEALAAALRRLLDDPALWQRLSRAGLERARAH 386


                  ....
gi 1495460170 282 HSWQ 285
Cdd:cd03800   387 YTWE 390
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 141-294 8.69e-13

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 68.07  E-value: 8.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 141 LVDAFsAWHQEEPNVHLVIVG--PEvdpvfTREVKAKVKR---AAGVRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAA 215
Cdd:cd03817   219 LLRAF-AELKKEPNIKLVIVGdgPE-----REELKELARElglADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLV 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 216 ILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF-SNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQL 294
Cdd:cd03817   293 YLEAMAAGLPVVAAKDPAASELVEDGENGFLFePNDETLAEKLLHLRENLELLRKLSKNAEISAREFAFAKSVEKLYEEV 372
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 136-279 7.56e-12

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 65.03  E-value: 7.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 136 KDPLYLVDAFSAWHQEEPNVHLVIVG-PEVDPVFTREVKAKVKRAAGV-RLIGEM----PQEDLHAVVKNCFAVVNSSVS 209
Cdd:cd03792   210 KDPLGVIDAYKLFKRRAEEPQLVICGhGAVDDPEGSVVYEEVMEYAGDdHDIHVLrlppSDQEINALQRAATVVLQLSTR 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 210 EGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVR 279
Cdd:cd03792   290 EGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAVRILRLLTDPELRRKMGLAAREHVR 359
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 141-291 1.72e-10

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 61.20  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 141 LVDAFSAwHQEEPNVHLVIVGPEVDPvftREVKAKVKRA--AGVRLIGEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAI- 216
Cdd:cd03794   235 LLEAAER-LKRRPDIRFLFVGDGDEK---ERLKELAKARglDNVTFLGRVPKEEVPELLSAAdVGLVPLKDNPANRGSSp 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 217 ---LEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHSWQVERDTY 291
Cdd:cd03794   311 sklFEYMAAGKPILASDDGGSDLAVEINGCGLVVepGDPEALADAILELLDDPELRRAMGENGRELAEEKFSREKLADRL 390
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 126-281 8.23e-10

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 58.91  E-value: 8.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 126 FLLICG-LRQVKDPLYLVDAFSAWHqEEPNVHLVIVGpevDPVFTREVKAKVKRAAG---VRLIGemPQEDLHAVVKNCF 201
Cdd:cd03819   184 VVGYVGrLSPEKGWLLLVDAAAELK-DEPDFRLLVAG---DGPERDEIRRLVERLGLrdrVTFTG--FREDVPAALAASD 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 202 AVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQ--EFVHLAKRLVSDPALEKEIV---VNGRE 276
Cdd:cd03819   258 VVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPPGDaeALADAIRAAKLLPEAREKLQaaaALTEA 337


                  ....*
gi 1495460170 277 YVRMY 281
Cdd:cd03819   338 VRELL 342
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 140-282 3.89e-09

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 57.08  E-value: 3.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 140 YLVDAFSAWHQEEPNVHLVIVGpevDPVFTREVKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSV------SEGMS 213
Cdd:cd05844   206 VLIEAFRRLAARHPTARLVIAG---DGPLRPALQALAAALGRVRFLGALPHAEVQDWMRRAEIFCLPSVtaasgdSEGLG 282

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1495460170 214 AAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSnPQEFVHLAKR---LVSDPALEKEIVVNGREYVRMYH 282
Cdd:cd05844   283 IVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVP-EGDVDALADAlqaLLADRALADRMGGAARAFVCEQF 353
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 136-280 1.51e-08

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 55.07  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 136 KDPLYLVDAFSAWHQEEPNVHLVIVGPEvDPVFTREVKAKVKRAAG--VRLIGEMPQEDLHAVVK--NCFavVNSSVSEG 211
Cdd:cd03821   217 KGLDLLIRAARKLAEQGRDWHLVIAGPD-DGAYPAFLQLQSSLGLGdrVTFTGPLYGEAKWALYAsaDLF--VLPSYSEN 293

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1495460170 212 MSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRM 280
Cdd:cd03821   294 FGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEALRDPADRKRLGEMARRARQV 362
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 133-279 2.93e-08

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 54.28  E-value: 2.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 133 RQVKDPLYLVDAFsAWHQEEPNVHLVIVG--PEVDPVFTREVKAKVKRAagVRLIGEmpQEDLHAVVKNCFAVVNSSVSE 210
Cdd:cd04962   206 RPVKRIDDVVRVF-ARVRRKIPAKLLLVGdgPERVPAEELARELGVEDR--VLFLGK--QDDVEELLSIADLFLLPSEKE 280

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1495460170 211 GMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVR 279
Cdd:cd04962   281 SFGLAALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDvgDVDAMAKSALSILEDDELYNRMGRAARKRAA 351
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 106-276 4.56e-08

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 53.82  E-value: 4.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 106 NWNTfLQRSEINQSADNLHIFLLICGLRQVKDPLYLVDAfsawhQEEPNVHLVIVG--PEVDPVFTREVKAKVKRaagVR 183
Cdd:cd03795   175 NIPR-VDFENIKREKKGKKIFLFIGRLVYYKGLDYLIEA-----AQYLNYPIVIGGegPLKPDLEAQIELNLLDN---VK 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 184 LIGEMPQEDLHAVVKNCFAVVNSSV--SEGMSAAILEAMDLEVPVLARNIP-GNAAVVKHEVTGLLF--SNPQEFVHLAK 258
Cdd:cd03795   246 FLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVLLEAMMCGKPVISTNIGtGVPYVNNNGETGLVVppKDPDALAEAID 325

                         170
                  ....*....|....*...
gi 1495460170 259 RLVSDPALEKEIVVNGRE 276
Cdd:cd03795   326 KLLSDEELRESYGENAKK 343
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 182-276 1.73e-07

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 52.08  E-value: 1.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 182 VRLIGEMPQEDLHAVVK-NCFAV-VNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSN---PQEFVHL 256
Cdd:cd04946   285 VNFTGEVSNKEVKQLYKeNDVDVfVNVSESEGIPVSIMEAISFGIPVIATNVGGTREIVENETNGLLLDKdptPNEIVSS 364

                          90       100
                  ....*....|....*....|
gi 1495460170 257 AKRLVSDPALEKEIVVNGRE 276
Cdd:cd04946   365 IMKFYLDGGDYKTMKISARE 384
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 121-278 1.96e-07

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 51.68  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 121 DNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVGpevDPVFTREVKAKVKR---AAGVRLIGEMPQEDLHAVV 197
Cdd:cd04951   186 NDEFVILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAG---DGPLRNELERLICNlnlVDRVILLGQISNISEYYNA 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 198 KNCFavVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREY 277
Cdd:cd04951   263 ADLF--VLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVVPVSDPQLLAEKIKEIFDMSDEERDILGNKNEY 340


                  .
gi 1495460170 278 V 278
Cdd:cd04951   341 I 341
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 75-298 3.04e-07

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 51.18  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170  75 MKEMAQAQWPHAKGKVYVQSQGIATTPNAAFNwntflqrSEINQSADNL--HIFLLICGLRQVKDPL----YLVDAFSAW 148
Cdd:cd03825   148 LADMVRRSPLLKGLPVVVIPNGIDTEIFAPVD-------KAKARKRLGIpqDKKVILFGAESVTKPRkgfdELIEALKLL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 149 HQEePNVHLVIVGPevDPVFTreVKAKVKraagVRLIGEM-PQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVL 227
Cdd:cd03825   221 ATK-DDLLLVVFGK--NDPQI--VILPFD----IISLGYIdDDEQLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVV 291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1495460170 228 ARNIPGNAAVVKHEVTGLLfSNPQEFVHLA---KRLVSDPALEKEIVVNGREYVRMYHSWQVERDTYQQLIRKL 298
Cdd:cd03825   292 AFDTGGSPEIVQHGVTGYL-VPPGDVQALAeaiEWLLANPKERESLGERARALAENHFDQRVQAQRYLELYKDL 364
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
108-285 5.39e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 47.48  E-value: 5.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 108 NTFLQRSEINQSADNLHIFLlicGLRQVKDP--LYLVDAFSAWHQEEPNVHLVIVGpevDPVFTR-----EVKAKVKRAA 180
Cdd:PRK15484  179 PQPNLRQQLNISPDETVLLY---AGRISPDKgiLLLMQAFEKLATAHSNLKLVVVG---DPTASSkgekaAYQKKVLEAA 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 181 ---GVRLI--GEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFV 254
Cdd:PRK15484  253 kriGDRCImlGGQPPEKMHNYYPLAdLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAEPMTSD 332

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1495460170 255 HLA---KRLVSDPALEkEIVVNGREYVRMYHSWQ 285
Cdd:PRK15484  333 SIIsdiNRTLADPELT-QIAEQAKDFVFSKYSWE 365
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 106-282 6.48e-06

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 46.85  E-value: 6.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 106 NWNTFLqrSEINQSADNLHIFLLICGLRQVKDPLYLVDAFSAWHQEEPNVHLVIVG--PEvdpvftREVKAKVKRAAG-- 181
Cdd:cd03820   166 NPLSFP--SEEPSTNLKSKRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGdgPE------REELEKLIDKLGle 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 182 --VRLIGemPQEDLHAVVKNCFAVVNSSVSEGMSAAILEAMDLEVPVLARNIP-GNAAVVKHEVTGLLFsNPQEFVHLAK 258
Cdd:cd03820   238 drVKLLG--PTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCPtGPSEIIEDGENGLLV-PNGDVDALAE 314

                         170       180
                  ....*....|....*....|....*..
gi 1495460170 259 ---RLVSDPALEKEIVVNGREYVRMYH 282
Cdd:cd03820   315 allRLMEDEELRKKMGKNARKNAERFS 341
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 141-296 9.32e-06

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 46.55  E-value: 9.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 141 LVDAFSawHQEEPNVHLVIVGpevDPVFTREVKAKVKRaaGVRLIGEMPQEDLHAVVKNC-FAVVNSSVSEGMSAAILEA 219
Cdd:cd03823   209 LVEAFK--RLPREDIELVIAG---HGPLSDERQIEGGR--RIAFLGRVPTDDIKDFYEKIdVLVVPSIWPEPFGLVVREA 281

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1495460170 220 MDLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREyvRMYHSWQVERdtYQQLIR 296
Cdd:cd03823   282 IAAGLPVIASDLGGIAELIQPGVNGLLFApgDAEDLAAAMRRLLTDPALLERLRAGAEP--PRSTESQAEE--YLKLYR 356
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
203-285 1.22e-05

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 42.98  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 203 VVNSSVSEGMSAA-ILEAMDLEVPVLARNIPGNAAVVKHEVTGLLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMY 281
Cdd:pfam13524   2 VLNPSRRPDSPNMrVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYLLEHPEERRAIAAAGRERVLAE 81


                  ....
gi 1495460170 282 HSWQ 285
Cdd:pfam13524  82 HTYA 85
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 135-294 1.69e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 46.17  E-value: 1.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 135 VKDPLYLVDAFSAWHQEEPNVHLVIVGPEV-DPVFTREVKAKVKRAAG---VRLIGEM------PQEDLhavvkncfaVV 204
Cdd:cd03813   305 IKDVKTFIRAFKLVRRAMPDAEGWLIGPEDeDPEYAQECKRLVASLGLenkVKFLGFQnikeyyPKLGL---------LV 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 205 NSSVSEGMSAAILEAMDLEVPVLA------RNIPGNAAVVKHEvTGLLF--SNPQEFVHLAKRLVSDPALEKEIVVNGRE 276
Cdd:cd03813   376 LTSISEGQPLVILEAMASGVPVVAtdvgscRELIYGADDALGQ-AGLVVppADPEALAEALIKLLRDPELRQAFGEAGRK 454

                         170
                  ....*....|....*...
gi 1495460170 277 YVRMYHSWQVERDTYQQL 294
Cdd:cd03813   455 RVEKYYTLEGMIDSYRKL 472
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 154-298 4.05e-05

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 44.59  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 154 NVHLVIVGPEVDPVFTREvKAKVKRAAGVRLIGEMPQEDLHAVVKNCFAVVNSSV-SEGMSAAILEAMDLEVPVLARNIP 232
Cdd:cd03802   195 GLPLKIAGKVRDEDYFYY-LQEPLPGPRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRG 273

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1495460170 233 GNAAVVKHEVTGLLFSNPQEFVHLAKRLvsdPALEKEIVvngREYVRMYHSWQVERDTYQQLIRKL 298
Cdd:cd03802   274 GLPEVIQHGETGFLVDSVEEMAEAIANI---DRIDRAAC---RRYAEDRFSAARMADRYEALYRKV 333
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 182-278 1.24e-04

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 43.21  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 182 VRLIGEMPQEDLHAVVKNCFAVVNSSVS------EGMSAAILEAMDLEVPVLARNIPGNAAVVKHEVTGLLF--SNPQEF 253
Cdd:cd03799   233 VKLLGWKPQEEIIEILDEADIFIAPSVTaadgdqDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVpeRDAEAI 312

                          90       100
                  ....*....|....*....|....*
gi 1495460170 254 VHLAKRLVSDPALEKEIVVNGREYV 278
Cdd:cd03799   313 AEKLTYLIEHPAIWPEMGKAGRARV 337
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
245-299 6.09e-04

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 40.68  E-value: 6.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1495460170 245 LLFSNPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYHswqverdTYQQLIRKLE 299
Cdd:COG4641   249 LVFRDGEELAEKLRYLLADPEERRAIAEAGRRRVLAEH-------TYAHRARELL 296
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 217-278 7.56e-04

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 40.65  E-value: 7.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1495460170 217 LEAMDLEVPVLARNIPGNAAVVKHEVTGLLF-SNPQEFVHLAKRLVSDPALEKEIVVNGREYV 278
Cdd:cd03805   317 LEAMYAGKPVIACNSGGPLETVVEGVTGFLCePTPEAFAEAMLKLANDPDLADRMGAAGRKRV 379
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 141-284 1.62e-03

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 39.58  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 141 LVDAFSAWHQEEPnVHLVIVG--PEvdpvftrevkAKVKRAAG--VRLIGEMPQEDLHAVVKNCFAVVNSSVSEGMSAAI 216
Cdd:cd03814   216 LLDADLPLAASPP-VRLVVVGdgPA----------RAELEARGpdVIFTGFLTGEELARAYASADVFVFPSRTETFGLVV 284

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 217 LEAMDLEVPVLARNIPGNAAVVKHEVTGLLFS--NPQEFVHLAKRLVSDPALEKEIVVNGREYVRMYhSW 284
Cdd:cd03814   285 LEAMASGLPVVAADAGGPRDIVRPGGTGALVEpgDAAAFAAALRALLEDPELRRRMAARARAEAERY-SW 353
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 140-296 1.75e-03

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 39.68  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 140 YLVDAFSAWHQEEPNVHLVIVGpEVDPVFTREVKAKVKRAAGVRLIGEM---------PQEDLHAVVKNCFAVVNS--SV 208
Cdd:cd03822   204 ILLEALPELKAEFPDVRLVIAG-ELHPSLARYEGERYRKAAIEELGLQDhvdfhnnflPEEEVPRYISAADVVVLPylNT 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1495460170 209 SEGMSAAILEAMDLEVPVLARNIPGNAAVVkHEVTGLLFsnPQEFVH----LAKRLVSDPALEKEIVVNGREYVRMYhSW 284
Cdd:cd03822   283 EQSSSGTLSYAIACGKPVISTPLRHAEELL-ADGRGVLV--PFDDPSaiaeAILRLLEDDERRQAIAERAYAYARAM-TW 358

                         170
                  ....*....|..
gi 1495460170 285 QVERDTYQQLIR 296
Cdd:cd03822   359 ESIADRYLRLFN 370
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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