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Conserved domains on  [gi|1483834838|ref|NP_001353267|]
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coiled-coil domain-containing protein 14 isoform 4 [Homo sapiens]

Protein Classification

CCDC14 domain-containing protein( domain architecture ID 12172588)

CCDC14 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CCDC14 pfam15254
Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing ...
1-610 0e+00

Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing protein 14 (CCDC14) is a domain of unknown function. This family of proteins is found in eukaryotes. Proteins in this family are typically between 301 and 912 amino acids in length.


:

Pssm-ID: 464594  Cd Length: 857  Bit Score: 1018.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838   1 MYSPIIYQALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQT 80
Cdd:pfam15254 105 MYSPIIYQALCEHVQTQMSLMNNLASKNSPNGIPAVPCHTVSGSESQATTASNYGLPTSTPVLSPQHPACPLVVHSEVQT 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  81 DGNSQFASQGKTVSATCT-DVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFR 159
Cdd:pfam15254 185 DSDNQFASQGGTTSVNCTmDVPRNSFSASPGVPCSLPQTDAPAIPTFQQLSLANGILPQQQQLKEADLLKCIQTHLSLLQ 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 160 SHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLG 239
Cdd:pfam15254 265 SHEKDNHPDSQTCQSPTQLQPAFLATNEEKCAREQIEETTSEGKDLNLHVVDIKPVKDVQKAKNVNQTAEKVRTVKYLLG 344
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 240 ELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVD 319
Cdd:pfam15254 345 ELKALVADQEDSEVLRLITEVEACVSLLPAVSGNTNIQAEIALALQPLRSENAQLRRQLRILNQQLREQEKTEKTSGSGD 424
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 320 CNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELE 399
Cdd:pfam15254 425 CNLELFSLQSLNMSLQNQLQESLKSQELLQSKNEELLKVIENQKEENKKLTKIFKEKEQTLLENKQQFDIETTRVKIELE 504
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 400 EALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTR-------------------------------------- 441
Cdd:pfam15254 505 EALVNMKSFQFKLEAAEKENQILGITLRQRDAEVTRLRELTRtlqgsmakllsdlsmdtarpkpgnnltksllniydkql 584
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838     --------------------------------------------------------------------------------
Cdd:pfam15254 585 qhdpapahtsimsylkkletnhsfthseplstikneetiepnrpyenvlpskgpqhsntrameevsapgiisalskqdsd 664
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 442 -------------------------STPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICsSSTKEAE 496
Cdd:pfam15254 665 tesetttliedehnldetiyipfarSTSKKKSPLSKRLSPQPQISVATKQLDSGSGLSVSEQENKLCAPKVC-SSKKEAE 743
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 497 DAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFST 576
Cdd:pfam15254 744 DAPEKLSRTADTEDKQLLKKIKEAIGKIPAAAEDPEEQAACHGPSACQSGHVQVKGSSVSDSSFLNSDLMSDWSISSFST 823
                         730       740       750
                  ....*....|....*....|....*....|....
gi 1483834838 577 FTSRDEQDFRNGLAALDANIARLQKSLRTGLLEK 610
Cdd:pfam15254 824 FTSRDEQDFRNGLAALDANIARLQKSLRSGLLEK 857
 
Name Accession Description Interval E-value
CCDC14 pfam15254
Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing ...
1-610 0e+00

Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing protein 14 (CCDC14) is a domain of unknown function. This family of proteins is found in eukaryotes. Proteins in this family are typically between 301 and 912 amino acids in length.


Pssm-ID: 464594  Cd Length: 857  Bit Score: 1018.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838   1 MYSPIIYQALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQT 80
Cdd:pfam15254 105 MYSPIIYQALCEHVQTQMSLMNNLASKNSPNGIPAVPCHTVSGSESQATTASNYGLPTSTPVLSPQHPACPLVVHSEVQT 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  81 DGNSQFASQGKTVSATCT-DVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFR 159
Cdd:pfam15254 185 DSDNQFASQGGTTSVNCTmDVPRNSFSASPGVPCSLPQTDAPAIPTFQQLSLANGILPQQQQLKEADLLKCIQTHLSLLQ 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 160 SHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLG 239
Cdd:pfam15254 265 SHEKDNHPDSQTCQSPTQLQPAFLATNEEKCAREQIEETTSEGKDLNLHVVDIKPVKDVQKAKNVNQTAEKVRTVKYLLG 344
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 240 ELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVD 319
Cdd:pfam15254 345 ELKALVADQEDSEVLRLITEVEACVSLLPAVSGNTNIQAEIALALQPLRSENAQLRRQLRILNQQLREQEKTEKTSGSGD 424
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 320 CNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELE 399
Cdd:pfam15254 425 CNLELFSLQSLNMSLQNQLQESLKSQELLQSKNEELLKVIENQKEENKKLTKIFKEKEQTLLENKQQFDIETTRVKIELE 504
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 400 EALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTR-------------------------------------- 441
Cdd:pfam15254 505 EALVNMKSFQFKLEAAEKENQILGITLRQRDAEVTRLRELTRtlqgsmakllsdlsmdtarpkpgnnltksllniydkql 584
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838     --------------------------------------------------------------------------------
Cdd:pfam15254 585 qhdpapahtsimsylkkletnhsfthseplstikneetiepnrpyenvlpskgpqhsntrameevsapgiisalskqdsd 664
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 442 -------------------------STPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICsSSTKEAE 496
Cdd:pfam15254 665 tesetttliedehnldetiyipfarSTSKKKSPLSKRLSPQPQISVATKQLDSGSGLSVSEQENKLCAPKVC-SSKKEAE 743
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 497 DAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFST 576
Cdd:pfam15254 744 DAPEKLSRTADTEDKQLLKKIKEAIGKIPAAAEDPEEQAACHGPSACQSGHVQVKGSSVSDSSFLNSDLMSDWSISSFST 823
                         730       740       750
                  ....*....|....*....|....*....|....
gi 1483834838 577 FTSRDEQDFRNGLAALDANIARLQKSLRTGLLEK 610
Cdd:pfam15254 824 FTSRDEQDFRNGLAALDANIARLQKSLRSGLLEK 857
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
181-442 1.52e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 181 AFLATNEEKCAREQIREATSERKDLNIHVRdtktvkdvQKAKNVNKTAEKvriIKYLLGELKALvaEQEDSEIQRLITEM 260
Cdd:COG4942     8 ALLLALAAAAQADAAAEAEAELEQLQQEIA--------ELEKELAALKKE---EKALLKQLAAL--ERRIAALARRIRAL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 261 EACISvlptvsgntDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKtqkpSGAVDCNLELFSLQSLNmslqnqleE 340
Cdd:COG4942    75 EQELA---------ALEAELAELEKEIAELRAELEAQKEELAELLRALYR----LGRQPPLALLLSPEDFL--------D 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 341 SLKSQELLQSKNEELLKVIENQKdenkkfssifkdKDQTILENKQQydiEITRIKIELEEALVNVKSSQFKLETAEKENQ 420
Cdd:COG4942   134 AVRRLQYLKYLAPARREQAEELR------------ADLAELAALRA---ELEAERAELEALLAELEEERAALEALKAERQ 198
                         250       260
                  ....*....|....*....|...
gi 1483834838 421 ILGITLRQR-DAEVTRLRELTRS 442
Cdd:COG4942   199 KLLARLEKElAELAAELAELQQE 221
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
183-455 2.18e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  183 LATNEEKCAR--EQIREATSERKDLNIHVRD-TKTVKDVQKAKNvnktaEKVRIIKYLLGELKALVAEQEDSEIQRLITE 259
Cdd:TIGR02168  679 IEELEEKIEEleEKIAELEKALAELRKELEElEEELEQLRKELE-----ELSRQISALRKDLARLEAEVEQLEERIAQLS 753
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  260 MEacisvlptvsgNTDIQVEIALAMQPLRSENAQLRRQLRILnQQLREQQKTQKpsgavdcnLELFSLQSLNMSLQNQLE 339
Cdd:TIGR02168  754 KE-----------LTELEAEIEELEERLEEAEEELAEAEAEI-EELEAQIEQLK--------EELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  340 ESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQ---YDIEITRIKIELEEALVNVKSSQFKLETAE 416
Cdd:TIGR02168  814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEieeLEELIEELESELEALLNERASLEEALALLR 893
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1483834838  417 KENQILGITLRQRDAEVTRLRELTRSTPEKKSPLSKRLS 455
Cdd:TIGR02168  894 SELEELSEELRELESKRSELRRELEELREKLAQLELRLE 932
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
218-442 1.52e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  218 VQKAKNVNKTAEKVRIIKYLLGELKalvaeQEDSEIQRLITEMEACISVLPTVSG------NTDIQVEIA--------LA 283
Cdd:PRK10929   119 LEKSRQAQQEQDRAREISDSLSQLP-----QQQTEARRQLNEIERRLQTLGTPNTplaqaqLTALQAESAalkalvdeLE 193
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  284 MQPLRSENAQLRRQLRILNQQLREQQKtqkpsgavdcNLELFSLQS-LNMSLQNQLEESLKSQELLQSKNEELLKVIENQ 362
Cdd:PRK10929   194 LAQLSANNRQELARLRSELAKKRSQQL----------DAYLQALRNqLNSQRQREAERALESTELLAEQSGDLPKSIVAQ 263
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  363 KDENKKFSSIFKDKDQTI-LENKQQYdiEITRIKIELEEALVNVKssqfklETAE--KENQILGITLRqrdAEVTRLREL 439
Cdd:PRK10929   264 FKINRELSQALNQQAQRMdLIASQQR--QAASQTLQVRQALNTLR------EQSQwlGVSNALGEALR---AQVARLPEM 332

                   ...
gi 1483834838  440 TRS 442
Cdd:PRK10929   333 PKP 335
 
Name Accession Description Interval E-value
CCDC14 pfam15254
Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing ...
1-610 0e+00

Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing protein 14 (CCDC14) is a domain of unknown function. This family of proteins is found in eukaryotes. Proteins in this family are typically between 301 and 912 amino acids in length.


Pssm-ID: 464594  Cd Length: 857  Bit Score: 1018.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838   1 MYSPIIYQALCEHVQTQMSLMNDLTSKNIPNGIPAVPCHAPSHSESQATPHSSYGLCTSTPVWSLQRPPCPPKVHSEVQT 80
Cdd:pfam15254 105 MYSPIIYQALCEHVQTQMSLMNNLASKNSPNGIPAVPCHTVSGSESQATTASNYGLPTSTPVLSPQHPACPLVVHSEVQT 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  81 DGNSQFASQGKTVSATCT-DVLRNSFNTSPGVPCSLPKTDISAIPTLQQLGLVNGILPQQGIHKETDLLKCIQTYLSLFR 159
Cdd:pfam15254 185 DSDNQFASQGGTTSVNCTmDVPRNSFSASPGVPCSLPQTDAPAIPTFQQLSLANGILPQQQQLKEADLLKCIQTHLSLLQ 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 160 SHGKETHLDSQTHRSPTQSQPAFLATNEEKCAREQIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIIKYLLG 239
Cdd:pfam15254 265 SHEKDNHPDSQTCQSPTQLQPAFLATNEEKCAREQIEETTSEGKDLNLHVVDIKPVKDVQKAKNVNQTAEKVRTVKYLLG 344
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 240 ELKALVAEQEDSEIQRLITEMEACISVLPTVSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKPSGAVD 319
Cdd:pfam15254 345 ELKALVADQEDSEVLRLITEVEACVSLLPAVSGNTNIQAEIALALQPLRSENAQLRRQLRILNQQLREQEKTEKTSGSGD 424
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 320 CNLELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQYDIEITRIKIELE 399
Cdd:pfam15254 425 CNLELFSLQSLNMSLQNQLQESLKSQELLQSKNEELLKVIENQKEENKKLTKIFKEKEQTLLENKQQFDIETTRVKIELE 504
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 400 EALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTR-------------------------------------- 441
Cdd:pfam15254 505 EALVNMKSFQFKLEAAEKENQILGITLRQRDAEVTRLRELTRtlqgsmakllsdlsmdtarpkpgnnltksllniydkql 584
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838     --------------------------------------------------------------------------------
Cdd:pfam15254 585 qhdpapahtsimsylkkletnhsfthseplstikneetiepnrpyenvlpskgpqhsntrameevsapgiisalskqdsd 664
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 442 -------------------------STPEKKSPLSKRLSPQPQIRAATTQLVSNSGLAVSGKENKLCTPVICsSSTKEAE 496
Cdd:pfam15254 665 tesetttliedehnldetiyipfarSTSKKKSPLSKRLSPQPQISVATKQLDSGSGLSVSEQENKLCAPKVC-SSKKEAE 743
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 497 DAPEKLSRASDMKDTQLLKKIKEAIGKIPAATKEPEEQTACHGPSGCLSNSLQVKGNTVCDGSVFTSDLMSDWSISSFST 576
Cdd:pfam15254 744 DAPEKLSRTADTEDKQLLKKIKEAIGKIPAAAEDPEEQAACHGPSACQSGHVQVKGSSVSDSSFLNSDLMSDWSISSFST 823
                         730       740       750
                  ....*....|....*....|....*....|....
gi 1483834838 577 FTSRDEQDFRNGLAALDANIARLQKSLRTGLLEK 610
Cdd:pfam15254 824 FTSRDEQDFRNGLAALDANIARLQKSLRSGLLEK 857
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
181-442 1.52e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 181 AFLATNEEKCAREQIREATSERKDLNIHVRdtktvkdvQKAKNVNKTAEKvriIKYLLGELKALvaEQEDSEIQRLITEM 260
Cdd:COG4942     8 ALLLALAAAAQADAAAEAEAELEQLQQEIA--------ELEKELAALKKE---EKALLKQLAAL--ERRIAALARRIRAL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 261 EACISvlptvsgntDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQKtqkpSGAVDCNLELFSLQSLNmslqnqleE 340
Cdd:COG4942    75 EQELA---------ALEAELAELEKEIAELRAELEAQKEELAELLRALYR----LGRQPPLALLLSPEDFL--------D 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 341 SLKSQELLQSKNEELLKVIENQKdenkkfssifkdKDQTILENKQQydiEITRIKIELEEALVNVKSSQFKLETAEKENQ 420
Cdd:COG4942   134 AVRRLQYLKYLAPARREQAEELR------------ADLAELAALRA---ELEAERAELEALLAELEEERAALEALKAERQ 198
                         250       260
                  ....*....|....*....|...
gi 1483834838 421 ILGITLRQR-DAEVTRLRELTRS 442
Cdd:COG4942   199 KLLARLEKElAELAAELAELQQE 221
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
183-455 2.18e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.74  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  183 LATNEEKCAR--EQIREATSERKDLNIHVRD-TKTVKDVQKAKNvnktaEKVRIIKYLLGELKALVAEQEDSEIQRLITE 259
Cdd:TIGR02168  679 IEELEEKIEEleEKIAELEKALAELRKELEElEEELEQLRKELE-----ELSRQISALRKDLARLEAEVEQLEERIAQLS 753
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  260 MEacisvlptvsgNTDIQVEIALAMQPLRSENAQLRRQLRILnQQLREQQKTQKpsgavdcnLELFSLQSLNMSLQNQLE 339
Cdd:TIGR02168  754 KE-----------LTELEAEIEELEERLEEAEEELAEAEAEI-EELEAQIEQLK--------EELKALREALDELRAELT 813
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  340 ESLKSQELLQSKNEELLKVIENQKDENKKFSSIFKDKDQTILENKQQ---YDIEITRIKIELEEALVNVKSSQFKLETAE 416
Cdd:TIGR02168  814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEieeLEELIEELESELEALLNERASLEEALALLR 893
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1483834838  417 KENQILGITLRQRDAEVTRLRELTRSTPEKKSPLSKRLS 455
Cdd:TIGR02168  894 SELEELSEELRELESKRSELRRELEELREKLAQLELRLE 932
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
218-442 1.52e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  218 VQKAKNVNKTAEKVRIIKYLLGELKalvaeQEDSEIQRLITEMEACISVLPTVSG------NTDIQVEIA--------LA 283
Cdd:PRK10929   119 LEKSRQAQQEQDRAREISDSLSQLP-----QQQTEARRQLNEIERRLQTLGTPNTplaqaqLTALQAESAalkalvdeLE 193
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  284 MQPLRSENAQLRRQLRILNQQLREQQKtqkpsgavdcNLELFSLQS-LNMSLQNQLEESLKSQELLQSKNEELLKVIENQ 362
Cdd:PRK10929   194 LAQLSANNRQELARLRSELAKKRSQQL----------DAYLQALRNqLNSQRQREAERALESTELLAEQSGDLPKSIVAQ 263
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  363 KDENKKFSSIFKDKDQTI-LENKQQYdiEITRIKIELEEALVNVKssqfklETAE--KENQILGITLRqrdAEVTRLREL 439
Cdd:PRK10929   264 FKINRELSQALNQQAQRMdLIASQQR--QAASQTLQVRQALNTLR------EQSQwlGVSNALGEALR---AQVARLPEM 332

                   ...
gi 1483834838  440 TRS 442
Cdd:PRK10929   333 PKP 335
HAUS-augmin3 pfam14932
HAUS augmin-like complex subunit 3; This domain is subunit three of the augmin complex found ...
270-381 2.32e-03

HAUS augmin-like complex subunit 3; This domain is subunit three of the augmin complex found from Drosophila to humans. The HAUS-augmin complex is made up of eight subunits. The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity.


Pssm-ID: 464384 [Multi-domain]  Cd Length: 261  Bit Score: 39.99  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 270 VSGNTDIQVEIALAMQPLRSENAQLRRQLRILNQQLREQQktqkpSGAVDCNLELFSLQSLNMSLQNQLEEslkSQELLQ 349
Cdd:pfam14932  69 VEALEESLEEIREATEDLEAELQELQKTKQLKINRLNKLQ-----AQASSLSQGLRALVAEEEEAAKQLEE---LQEELA 140
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1483834838 350 SKNEELLKVIENQKDENKKFSSIFKDKDQTIL 381
Cdd:pfam14932 141 ALNAKTNNVLQSLQSEVKELASFFSASEPPVF 172
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
226-455 4.93e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.04  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  226 KTAEKVRIIK---------YLLGELKALVAEQEdsEIQRLITEMEacisvlptvsgntDIQVEIALAMQPLRSENAQLRR 296
Cdd:TIGR02168  210 EKAERYKELKaelrelelaLLVLRLEELREELE--ELQEELKEAE-------------EELEELTAELQELEEKLEELRL 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838  297 QLRILNQQLREQQKtqkpsgavdcnlELFSLQSLNMSLQNQLEESLKSQELLQSKNEELLKVIEnqKDENKkfssifKDK 376
Cdd:TIGR02168  275 EVSELEEEIEELQK------------ELYALANEISRLEQQKQILRERLANLERQLEELEAQLE--ELESK------LDE 334
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1483834838  377 DQTILenkqqydieiTRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEVTRLRELTRSTPEKKSPLSKRLS 455
Cdd:TIGR02168  335 LAEEL----------AELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIE 403
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
194-443 5.38e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 194 QIREATSERKDLNIHVRDTKTVKDVQKAKNVNKTAEKVRIikyllgELKALVAEQEDSEIQRLITEMEACISvlptvsgn 273
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEEL------RLELEELELELEEAQAEEYELLAELA-------- 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 274 tdiqvEIALAMQPLRSENAQLRRQLRILNQQLREQQKTQKpsgavdcnlelfslqslnmSLQNQLEESLKSQELLQSKNE 353
Cdd:COG1196   299 -----RLEQDIARLEERRRELEERLEELEEELAELEEELE-------------------ELEEELEELEEELEEAEEELE 354
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1483834838 354 ELLKVIENQKDENKKFSSIFKDKDQTILENKQQYdIEITRIKIELEEALVNVKSSQFKLETAEKENQILGITLRQRDAEV 433
Cdd:COG1196   355 EAEAELAEAEEALLEAEAELAEAEEELEELAEEL-LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433
                         250
                  ....*....|
gi 1483834838 434 TRLRELTRST 443
Cdd:COG1196   434 EEEEEEEEEA 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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