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Conserved domains on  [gi|1401585302|ref|NP_001351224|]
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transportin-1 isoform 4 [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
67-717 6.30e-19

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 92.31  E-value: 6.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302  67 SEGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSDVLDRPLNIMIPKFLQFFKH 143
Cdd:COG5215   113 MAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APEDLIQMSNVILFAIVMGALK 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 144 SSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPEVRKNVCRALVMLLEVRMDR 207
Cdd:COG5215   188 NETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEELQHAAFGCLNKIMMLYYKF 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 208 LLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDII--LLKGDVEEDe 284
Cdd:COG5215   256 MQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLSLLEKQG- 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 285 tiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLANVYRDELLPHILPLLKELL 364
Cdd:COG5215   335 --EDYYGD-------------------------------------DWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNI 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 365 FHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA-HWVVSQPPDTYLKPLMTE 442
Cdd:COG5215   376 RSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHLVLEVSA 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 443 LLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLL--ILYDAIGTL----AD 508
Cdd:COG5215   456 SLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTLilicPD 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 509 SVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNN 585
Cdd:COG5215   534 AVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILESTKPTT 613

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 586 AQPDQYEApdkdfmivaldlLSGLAEGLGGNIEQLVarSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIA 665
Cdd:COG5215   614 AFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIYAD 679

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1401585302 666 DFM---------PILGTNLNPEFISVcnnatwaIGEISIQMGIEMQPYIPMVLHQLVEIIN 717
Cdd:COG5215   680 VLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
67-717 6.30e-19

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 92.31  E-value: 6.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302  67 SEGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSDVLDRPLNIMIPKFLQFFKH 143
Cdd:COG5215   113 MAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APEDLIQMSNVILFAIVMGALK 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 144 SSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPEVRKNVCRALVMLLEVRMDR 207
Cdd:COG5215   188 NETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEELQHAAFGCLNKIMMLYYKF 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 208 LLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDII--LLKGDVEEDe 284
Cdd:COG5215   256 MQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLSLLEKQG- 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 285 tiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLANVYRDELLPHILPLLKELL 364
Cdd:COG5215   335 --EDYYGD-------------------------------------DWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNI 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 365 FHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA-HWVVSQPPDTYLKPLMTE 442
Cdd:COG5215   376 RSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHLVLEVSA 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 443 LLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLL--ILYDAIGTL----AD 508
Cdd:COG5215   456 SLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTLilicPD 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 509 SVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNN 585
Cdd:COG5215   534 AVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILESTKPTT 613

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 586 AQPDQYEApdkdfmivaldlLSGLAEGLGGNIEQLVarSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIA 665
Cdd:COG5215   614 AFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIYAD 679

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1401585302 666 DFM---------PILGTNLNPEFISVcnnatwaIGEISIQMGIEMQPYIPMVLHQLVEIIN 717
Cdd:COG5215   680 VLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 369-423 4.03e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.39  E-value: 4.03e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1401585302 369 WVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 423
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
67-717 6.30e-19

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 92.31  E-value: 6.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302  67 SEGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSDVLDRPLNIMIPKFLQFFKH 143
Cdd:COG5215   113 MAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APEDLIQMSNVILFAIVMGALK 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 144 SSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPEVRKNVCRALVMLLEVRMDR 207
Cdd:COG5215   188 NETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEELQHAAFGCLNKIMMLYYKF 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 208 LLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDII--LLKGDVEEDe 284
Cdd:COG5215   256 MQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFARAAVADVLpeLLSLLEKQG- 334

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 285 tiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLANVYRDELLPHILPLLKELL 364
Cdd:COG5215   335 --EDYYGD-------------------------------------DWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNI 375

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 365 FHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA-HWVVSQPPDTYLKPLMTE 442
Cdd:COG5215   376 RSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIAdHVAMIISPCGHLVLEVSA 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 443 LLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLL--ILYDAIGTL----AD 508
Cdd:COG5215   456 SLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNESNLrvSLFSALGTLilicPD 533

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 509 SVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNN 585
Cdd:COG5215   534 AVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDVEDQLMELFIRILESTKPTT 613

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 586 AQPDQYEApdkdfmivaldlLSGLAEGLGGNIEQLVarSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIA 665
Cdd:COG5215   614 AFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAVGLVGDLANTLGTDFNIYAD 679

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1401585302 666 DFM---------PILGTNLNPEFISVcnnatwaIGEISIQMGIEMQPYIPMVLHQLVEIIN 717
Cdd:COG5215   680 VLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 369-423 4.03e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.39  E-value: 4.03e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1401585302 369 WVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 423
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
338-482 1.61e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 338 AAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITC 417
Cdd:COG1413     3 RAAARALGRLGDPA----AVPALIAALADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAA 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1401585302 418 WTLSRYAHWVVSqppdtylkPLMTELLKrilDSNKRVQEAACSAFATLEEEactELVPYLAYILD 482
Cdd:COG1413    69 EALGRIGDPEAV--------PALIAALK---DEDPEVRRAAAEALGRLGDP---AAVPALLEALK 119
HEAT COG1413
HEAT repeat [General function prediction only];
79-236 2.71e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.70  E-value: 2.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302  79 GELQNwPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAeildsdvldrplnimIPKFLQFFKHSSPKIRSHAVACVNQ 158
Cdd:COG1413    10 GRLGD-PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1401585302 159 fiISRTQAlmlhidsfIENLFALAGDEEPEVRKNVCRALVMLLEVRmdrllphmhnIVEYMLQRTQDQDENVALEACE 236
Cdd:COG1413    74 --IGDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
HEAT COG1413
HEAT repeat [General function prediction only];
329-465 1.37e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.39  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 329 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDK 408
Cdd:COG1413    28 EDPDVR---AAAARALGRLGDPR----AVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDE 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1401585302 409 KALVRSITCWTLSRYAhwvvsqppDTYLKPLMTELLKrilDSNKRVQEAACSAFATL 465
Cdd:COG1413    91 DPEVRRAAAEALGRLG--------DPAAVPALLEALK---DPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
329-424 2.02e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 329 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDK 408
Cdd:COG1413    59 PDPEVR---AAAAEALGRIGDPE----AVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDP 121

                          90
                  ....*....|....*.
gi 1401585302 409 KALVRSITCWTLSRYA 424
Cdd:COG1413   122 DWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
371-541 1.51e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 39.61  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 371 VKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITCWTLSRYAHwvvsqppDTYLKPLMtELLKrilDS 450
Cdd:COG1413     1 VRRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLGD-------PRAVPALL-EALK---DP 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 451 NKRVQEAACSAFATL-EEEACTELVPYLayildtlvfafskyQHKNLLILYDAIGTLAdsvghHLNKPEYIqmlmPPLIQ 529
Cdd:COG1413    60 DPEVRAAAAEALGRIgDPEAVPALIAAL--------------KDEDPEVRRAAAEALG-----RLGDPAAV----PALLE 116

                         170
                  ....*....|..
gi 1401585302 530 kwnMLKDEDKDL 541
Cdd:COG1413   117 ---ALKDPDWEV 125
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 329-421 2.31e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.70  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 329 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCL-SD 407
Cdd:pfam13646  12 PDPEVR---AAAIRALGRIGDPE----AVPALLELLKDEDPAVRRAAAEALGKIGD----------PEALPALLELLrDD 74

                          90
                  ....*....|....
gi 1401585302 408 KKALVRSITCWTLS 421
Cdd:pfam13646  75 DDDVVRAAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 357-463 2.70e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.70  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585302 357 LPLLKELLFHHE-WVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITCWTLSRYahwvvsQPPDTY 435
Cdd:pfam13646   1 LPALLQALLRDPdPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKI------GDPEAL 64

                          90       100
                  ....*....|....*....|....*...
gi 1401585302 436 lkPLMTELLKRilDSNKRVQEAACSAFA 463
Cdd:pfam13646  65 --PALLELLRD--DDDDVVRAAAAEALA 88
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 146-197 4.15e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 4.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1401585302 146 PKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRAL 197
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 187-235 5.69e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 5.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1401585302 187 PEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEAC 235
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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