NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1384071975|ref|NP_001349726|]
View 

zinc fingers and homeoboxes protein 2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 106-158 8.01e-23

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


:

Pssm-ID: 465737  Cd Length: 53  Bit Score: 92.01  E-value: 8.01e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384071975 106 LNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIET 158
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 444-496 1.26e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.64  E-value: 1.26e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384071975 444 RKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQR 496
Cdd:cd00086     5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 635-684 8.58e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 55.33  E-value: 8.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384071975 635 KSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:cd00086     7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 537-582 4.00e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.02  E-value: 4.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1384071975  537 TQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRK 582
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRA 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 272-321 4.30e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.85  E-value: 4.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384071975 272 DTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISW 321
Cdd:cd00086    10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 106-158 8.01e-23

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 92.01  E-value: 8.01e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384071975 106 LNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIET 158
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 444-496 1.26e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.64  E-value: 1.26e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384071975 444 RKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQR 496
Cdd:cd00086     5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 445-494 4.55e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 55.72  E-value: 4.55e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1384071975  445 KKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRC 494
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 635-684 8.58e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 55.33  E-value: 8.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384071975 635 KSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:cd00086     7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 634-684 2.27e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.79  E-value: 2.27e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1384071975  634 AKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 537-582 4.00e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.02  E-value: 4.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1384071975  537 TQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRK 582
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRA 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 536-582 5.09e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.02  E-value: 5.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1384071975 536 KTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRK 582
Cdd:cd00086     7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRA 53
Homeodomain pfam00046
Homeodomain;
444-496 2.53e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.49  E-value: 2.53e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384071975 444 RKK----TKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQR 496
Cdd:pfam00046   1 RRKrttfTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 272-321 4.30e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.85  E-value: 4.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384071975 272 DTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISW 321
Cdd:cd00086    10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 279-317 8.50e-05

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 41.08  E-value: 8.50e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1384071975  279 NSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKH 317
Cdd:smart00389  18 KEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
Homeodomain pfam00046
Homeodomain;
537-581 9.90e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.56  E-value: 9.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1384071975 537 TQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERR 581
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
Homeodomain pfam00046
Homeodomain;
636-680 1.30e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.48  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1384071975 636 SQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKeNR 680
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQ-NR 51
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
426-491 9.54e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 37.80  E-value: 9.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384071975 426 VPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHR 491
Cdd:COG5576    38 EMKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKR 103
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 106-158 8.01e-23

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 92.01  E-value: 8.01e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384071975 106 LNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIET 158
Cdd:pfam18387   1 ADPSFVCVECGFLAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 444-496 1.26e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 57.64  E-value: 1.26e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384071975 444 RKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQR 496
Cdd:cd00086     5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 445-494 4.55e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 55.72  E-value: 4.55e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1384071975  445 KKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRC 494
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 635-684 8.58e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 55.33  E-value: 8.58e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384071975 635 KSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:cd00086     7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 634-684 2.27e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.79  E-value: 2.27e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1384071975  634 AKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLK 684
Cdd:smart00389   7 SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 537-582 4.00e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.02  E-value: 4.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1384071975  537 TQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRK 582
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRA 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 536-582 5.09e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.02  E-value: 5.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1384071975 536 KTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRK 582
Cdd:cd00086     7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRA 53
Homeodomain pfam00046
Homeodomain;
444-496 2.53e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.49  E-value: 2.53e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384071975 444 RKK----TKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQR 496
Cdd:pfam00046   1 RRKrttfTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 272-321 4.30e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.85  E-value: 4.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384071975 272 DTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISW 321
Cdd:cd00086    10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 279-317 8.50e-05

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 41.08  E-value: 8.50e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1384071975  279 NSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKH 317
Cdd:smart00389  18 KEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
Homeodomain pfam00046
Homeodomain;
537-581 9.90e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.56  E-value: 9.90e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1384071975 537 TQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERR 581
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRR 52
Homeodomain pfam00046
Homeodomain;
636-680 1.30e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.48  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1384071975 636 SQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKeNR 680
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQ-NR 51
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 653-676 8.62e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 34.80  E-value: 8.62e-03
                          10        20
                  ....*....|....*....|....
gi 1384071975 653 PTPQEYDQLAAKTGLVRTEIVRWF 676
Cdd:pfam05920  10 PSEEEKAELAKETGLSRKQISNWF 33
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
426-491 9.54e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 37.80  E-value: 9.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384071975 426 VPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHR 491
Cdd:COG5576    38 EMKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH