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Conserved domains on  [gi|1379048653|ref|NP_001349448|]
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rab proteins geranylgeranyltransferase component A 1 isoform c [Homo sapiens]

Protein Classification

Rossmann-fold NAD(P)-binding domain-containing protein( domain architecture ID 229380)

Rossmann-fold NAD(P)-binding domain-containing protein may function as an oxidoreductase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
77-394 5.10e-42

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member COG5044:

Pssm-ID: 473865  Cd Length: 434  Bit Score: 155.33  E-value: 5.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653  77 RRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCME 156
Cdd:COG5044    71 RDLNIDLIPKFLFANSELLKILIETGVTEYLEFKQISGSFLYRPGKIYKVPYNEAEIFTSPLLSLFEKRRVMRFLKWVSN 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 157 YEKYPDEYKGY-EEITFYEYL-KTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGE 234
Cdd:COG5044   151 YAEQKSTLQELyESKDTMEFLfEKFGLSGATEEFIGHGIALSLDLDIPAREALERILRYMRSFGDYGKSPYLYPRYGLGE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 235 LPQCFCRMCAVFGGIYCLRhsvQCLVVDKESRKcKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYRQISRAVLITDRS 314
Cdd:COG5044   231 LSQGFARSSAVYGGTYMLN---QAIDEINETKD-VETVDKGSLTQKAGKIISSPTYFREDSKSVGQFYRIIRAICILLVH 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 315 VLKTDSDQQISILTVPAEEPG-TFAVRVIELCSSTMTCMKGTYLVHLTCTSSKTAREDLESVVQKLFVPYTE-MEIENEQ 392
Cdd:COG5044   307 PVPFTTGLDSLQIIFPPFSLKrKNDIQVAGLGSGSEVCPEGYYLAYISTIDETPTPEDEILAALELLGPSVEkFVDVEEI 386

                  ..
gi 1379048653 393 VE 394
Cdd:COG5044   387 YQ 388
 
Name Accession Description Interval E-value
MRS6 COG5044
RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational ...
77-394 5.10e-42

RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227377  Cd Length: 434  Bit Score: 155.33  E-value: 5.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653  77 RRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCME 156
Cdd:COG5044    71 RDLNIDLIPKFLFANSELLKILIETGVTEYLEFKQISGSFLYRPGKIYKVPYNEAEIFTSPLLSLFEKRRVMRFLKWVSN 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 157 YEKYPDEYKGY-EEITFYEYL-KTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGE 234
Cdd:COG5044   151 YAEQKSTLQELyESKDTMEFLfEKFGLSGATEEFIGHGIALSLDLDIPAREALERILRYMRSFGDYGKSPYLYPRYGLGE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 235 LPQCFCRMCAVFGGIYCLRhsvQCLVVDKESRKcKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYRQISRAVLITDRS 314
Cdd:COG5044   231 LSQGFARSSAVYGGTYMLN---QAIDEINETKD-VETVDKGSLTQKAGKIISSPTYFREDSKSVGQFYRIIRAICILLVH 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 315 VLKTDSDQQISILTVPAEEPG-TFAVRVIELCSSTMTCMKGTYLVHLTCTSSKTAREDLESVVQKLFVPYTE-MEIENEQ 392
Cdd:COG5044   307 PVPFTTGLDSLQIIFPPFSLKrKNDIQVAGLGSGSEVCPEGYYLAYISTIDETPTPEDEILAALELLGPSVEkFVDVEEI 386

                  ..
gi 1379048653 393 VE 394
Cdd:COG5044   387 YQ 388
PTZ00363 PTZ00363
rab-GDP dissociation inhibitor; Provisional
75-358 2.09e-35

rab-GDP dissociation inhibitor; Provisional


Pssm-ID: 185577  Cd Length: 443  Bit Score: 137.04  E-value: 2.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653  75 EGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFR-EGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTF 153
Cdd:PTZ00363   67 RNRDWNVDLIPKFIMASGELVKILLHTDVTRYLEFKVIDGSYVYQkEGKIHKVPATDMEALSSPLMGFFEKNRCKNFLQY 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 154 CMEYE-KYPDEYKGY--EEITFYEYLKTQKLTPNLQYIVMHSIAMTSETA---SSTIDGLKATKNFLHCLGRYGNTPFLF 227
Cdd:PTZ00363  147 VSNYDeNDPETHKGLnlKTMTMAQLYKKFGLEDNTIDFVGHAVALYTNDDylnKPAIETVMRIKLYMDSLSRYGKSPFIY 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 228 PLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKaiIDQFGQRIISEHFLVED-SYFPEnmcsRVQYR-QIS 305
Cdd:PTZ00363  227 PLYGLGGLPQAFSRLCAIYGGTYMLNTPVDEVVFDENGKVCG--VKSEGGEVAKCKLVICDpSYFPD----KVKKVgKVI 300
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379048653 306 RAVLITDRSVLKTDSDQQISILtVPAEEPG-TFAVRVIELCSSTMTCMKGTYLV 358
Cdd:PTZ00363  301 RCICILNHPIPNTNNANSCQII-IPQKQLGrKNDIYIMLVSSNHGVCPKGKYIA 353
GDI pfam00996
GDP dissociation inhibitor;
75-357 3.04e-34

GDP dissociation inhibitor;


Pssm-ID: 395792  Cd Length: 436  Bit Score: 133.70  E-value: 3.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653  75 EGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFC 154
Cdd:pfam00996  67 RDRDWNVDLIPKFLMANGNLVKILIHTDVTRYLEFKVVEGSYVYKKGKIHKVPANDMEALSSPLMGLFEKRRARKFLEYV 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 155 MEY-EKYPDEYKGYE--EITFYEYLKTQKLTPNLQYIVMHSIAMTSETA---SSTIDGLKATKNFLHCLGRYGNTPFLFP 228
Cdd:pfam00996 147 QNYdEDDPKTHKGLDpdKLTMLEVYKKFGLGQNTIDFIGHALALYRDDDylkQPALETVERIKLYAESLARYGKSPYLYP 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 229 LYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKaiIDQFGQRIISEHFLVEDSYFPENMCSRvqyRQISRAV 308
Cdd:pfam00996 227 LYGLGELPQGFARLSAIYGGTYMLNKPVDEVVYDEDGKVVG--VKSGGEVAKCKQVICDPSYFPEKVRKV---GRVIRAI 301
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379048653 309 LITDRSVLKTDSDQQISILtVPAEEPGTFAVRVIELCSSTM-TCMKGTYL 357
Cdd:pfam00996 302 CILSHPIPNTDDANSVQII-IPQNQLGRKSDIYVALVSYAHnVAAKGKYI 350
 
Name Accession Description Interval E-value
MRS6 COG5044
RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational ...
77-394 5.10e-42

RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227377  Cd Length: 434  Bit Score: 155.33  E-value: 5.10e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653  77 RRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCME 156
Cdd:COG5044    71 RDLNIDLIPKFLFANSELLKILIETGVTEYLEFKQISGSFLYRPGKIYKVPYNEAEIFTSPLLSLFEKRRVMRFLKWVSN 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 157 YEKYPDEYKGY-EEITFYEYL-KTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGE 234
Cdd:COG5044   151 YAEQKSTLQELyESKDTMEFLfEKFGLSGATEEFIGHGIALSLDLDIPAREALERILRYMRSFGDYGKSPYLYPRYGLGE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 235 LPQCFCRMCAVFGGIYCLRhsvQCLVVDKESRKcKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYRQISRAVLITDRS 314
Cdd:COG5044   231 LSQGFARSSAVYGGTYMLN---QAIDEINETKD-VETVDKGSLTQKAGKIISSPTYFREDSKSVGQFYRIIRAICILLVH 306
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 315 VLKTDSDQQISILTVPAEEPG-TFAVRVIELCSSTMTCMKGTYLVHLTCTSSKTAREDLESVVQKLFVPYTE-MEIENEQ 392
Cdd:COG5044   307 PVPFTTGLDSLQIIFPPFSLKrKNDIQVAGLGSGSEVCPEGYYLAYISTIDETPTPEDEILAALELLGPSVEkFVDVEEI 386

                  ..
gi 1379048653 393 VE 394
Cdd:COG5044   387 YQ 388
PTZ00363 PTZ00363
rab-GDP dissociation inhibitor; Provisional
75-358 2.09e-35

rab-GDP dissociation inhibitor; Provisional


Pssm-ID: 185577  Cd Length: 443  Bit Score: 137.04  E-value: 2.09e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653  75 EGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFR-EGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTF 153
Cdd:PTZ00363   67 RNRDWNVDLIPKFIMASGELVKILLHTDVTRYLEFKVIDGSYVYQkEGKIHKVPATDMEALSSPLMGFFEKNRCKNFLQY 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 154 CMEYE-KYPDEYKGY--EEITFYEYLKTQKLTPNLQYIVMHSIAMTSETA---SSTIDGLKATKNFLHCLGRYGNTPFLF 227
Cdd:PTZ00363  147 VSNYDeNDPETHKGLnlKTMTMAQLYKKFGLEDNTIDFVGHAVALYTNDDylnKPAIETVMRIKLYMDSLSRYGKSPFIY 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 228 PLYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKaiIDQFGQRIISEHFLVED-SYFPEnmcsRVQYR-QIS 305
Cdd:PTZ00363  227 PLYGLGGLPQAFSRLCAIYGGTYMLNTPVDEVVFDENGKVCG--VKSEGGEVAKCKLVICDpSYFPD----KVKKVgKVI 300
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379048653 306 RAVLITDRSVLKTDSDQQISILtVPAEEPG-TFAVRVIELCSSTMTCMKGTYLV 358
Cdd:PTZ00363  301 RCICILNHPIPNTNNANSCQII-IPQKQLGrKNDIYIMLVSSNHGVCPKGKYIA 353
GDI pfam00996
GDP dissociation inhibitor;
75-357 3.04e-34

GDP dissociation inhibitor;


Pssm-ID: 395792  Cd Length: 436  Bit Score: 133.70  E-value: 3.04e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653  75 EGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFC 154
Cdd:pfam00996  67 RDRDWNVDLIPKFLMANGNLVKILIHTDVTRYLEFKVVEGSYVYKKGKIHKVPANDMEALSSPLMGLFEKRRARKFLEYV 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 155 MEY-EKYPDEYKGYE--EITFYEYLKTQKLTPNLQYIVMHSIAMTSETA---SSTIDGLKATKNFLHCLGRYGNTPFLFP 228
Cdd:pfam00996 147 QNYdEDDPKTHKGLDpdKLTMLEVYKKFGLGQNTIDFIGHALALYRDDDylkQPALETVERIKLYAESLARYGKSPYLYP 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048653 229 LYGQGELPQCFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKaiIDQFGQRIISEHFLVEDSYFPENMCSRvqyRQISRAV 308
Cdd:pfam00996 227 LYGLGELPQGFARLSAIYGGTYMLNKPVDEVVYDEDGKVVG--VKSGGEVAKCKQVICDPSYFPEKVRKV---GRVIRAI 301
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1379048653 309 LITDRSVLKTDSDQQISILtVPAEEPGTFAVRVIELCSSTM-TCMKGTYL 357
Cdd:pfam00996 302 CILSHPIPNTDDANSVQII-IPQNQLGRKSDIYVALVSYAHnVAAKGKYI 350
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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