|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-724 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1364.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 3 KGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEW 82
Cdd:cd00764 41 EGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFREREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 83 SDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHC 162
Cdd:cd00764 121 PSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTDMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHC 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 163 GYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTR 242
Cdd:cd00764 201 GYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRSRGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 243 VTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALK 322
Cdd:cd00764 281 VTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAA 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 323 LRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEA 401
Cdd:cd00764 361 LRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVEL 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 402 GWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSN 481
Cdd:cd00764 441 GWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSN 520
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 482 NVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEH 561
Cdd:cd00764 521 NVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEH 600
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 562 LVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKI 641
Cdd:cd00764 601 LTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKL 680
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 642 KESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTdFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHIT 721
Cdd:cd00764 681 KENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT-FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVT 759
|
...
gi 1236486008 722 RKR 724
Cdd:cd00764 760 RGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
4-705 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1130.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWS 83
Cdd:TIGR02478 39 GYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRERPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 84 DLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCG 163
Cdd:TIGR02478 119 SLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMTIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 164 YLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRV 243
Cdd:TIGR02478 199 YLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRI 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 244 TVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKL 323
Cdd:TIGR02478 279 TVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRL 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 324 RGRSFMNNWEVYKLLA---HVRPPVSKSGSH-TVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIE 399
Cdd:TIGR02478 359 RGREFAENLETFLFLSipdDDKKLVPSEASRlRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVR 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 400 EAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATV 479
Cdd:TIGR02478 439 ELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATI 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 480 SNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANV 559
Cdd:TIGR02478 519 SNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDI 598
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 560 EHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSG 639
Cdd:TIGR02478 599 EHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEE 678
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1236486008 640 KIKESYRNGRIFANtPDSGCVLGMRKRALVFQPVA-ELKDQTDFEHRIPKEQWWLKLRPILKILAKY 705
Cdd:TIGR02478 679 KIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVKqLLANETDFEHRRPKNQWWLQLRPLVRILAGR 744
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-333 |
3.29e-166 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 481.41 E-value: 3.29e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWS 83
Cdd:cd00363 39 GYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 84 DllsdlqkagkitdeeatKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCG 163
Cdd:cd00363 117 S-----------------KYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 164 YLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRV 243
Cdd:cd00363 180 DIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGKRHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 244 TVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVtkamdekkfdeALKL 323
Cdd:cd00363 260 TVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLNENQVVRHPLTEAVNMTKRV-----------GVDL 328
|
330
....*....|
gi 1236486008 324 RGRSFMNNWE 333
Cdd:cd00363 329 EGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
4-271 |
2.24e-117 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 353.57 E-value: 2.24e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWS 83
Cdd:pfam00365 38 GYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEGREKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 84 dllsdlqkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCG 163
Cdd:pfam00365 116 ----------------------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 164 YLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRLNIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRV 243
Cdd:pfam00365 174 WLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRFSIIVVAEGASD-------GEFLAKLIEEGTGIETRV 242
|
250 260
....*....|....*....|....*...
gi 1236486008 244 TVLGHVQRGGTPSAFDRILGSRMGVEAV 271
Cdd:pfam00365 243 TVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
353-635 |
7.40e-106 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 323.91 E-value: 7.40e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 353 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 429
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEgre 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 430 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 509
Cdd:pfam00365 82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 510 AAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLvQKMKTTVkrgLVLRNEKCNenyTTDF 589
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFS---IIVVAEGAS---DGEF 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1236486008 590 IFNLYsEEGKGIfDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 635
Cdd:pfam00365 228 LAKLI-EEGTGI-ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
4-313 |
1.94e-104 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 322.79 E-value: 1.94e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsews 83
Cdd:COG0205 40 GYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTEEGREKALENLKKLGIDALVVIGGDGSLDGAA------- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 84 dllsdlqkagKITDEEAtkssyLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCG 163
Cdd:COG0205 111 ----------KLAEEYG-----IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 164 YLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPI---------------TSED 228
Cdd:COG0205 176 WLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 229 IKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDtpaCVVSLSGNQAVRLPLMECVQVTKDV 308
Cdd:COG0205 253 LAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPV 329
|
....*
gi 1236486008 309 TKAMD 313
Cdd:COG0205 330 DPDSP 334
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
4-321 |
4.07e-102 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 315.87 E-value: 4.07e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsews 83
Cdd:PRK03202 40 GYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRAKAIENLKKLGIDALVVIGGDGSYMGAK------- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 84 dLLSDLQkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCG 163
Cdd:PRK03202 111 -RLTEHG---------------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 164 YLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGSRLNIIIVAEGAIDKngkpitsEDIKNLVVKRLGYDTRV 243
Cdd:PRK03202 175 DLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGKKHAIIVVAEGVMPA-------EELAKEIEERTGLETRV 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1236486008 244 TVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacVVSLSGNQAVRLPLMECVQVTKdvtkamdeKKFDEAL 321
Cdd:PRK03202 245 TVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNNKIVHVPIEEAVENMK--------HPFDKDL 311
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
3-300 |
6.14e-86 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 273.07 E-value: 6.14e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 3 KGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsew 82
Cdd:TIGR02482 37 RGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVREKAVENLKKLGIEGLVVIGGDGSYTGA------- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 83 sdllSDLQKAGKItdeeatkssylNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHC 162
Cdd:TIGR02482 108 ----QKLYEEGGI-----------PVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 163 GYLALVTSLSCGADWVFIPECPPDDDweeHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKpitseDIKNLVVKRLGYDTR 242
Cdd:TIGR02482 173 GDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKHSIIIVAEGNIVGSAK-----EVAKKIEEKTGIETR 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1236486008 243 VTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacVVSLSGNQAVRLPLME 300
Cdd:TIGR02482 245 VTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MIGIQNNKIVTHPIEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-312 |
5.25e-79 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 255.41 E-value: 5.25e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsews 83
Cdd:cd00763 39 GYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEGQAKAIEQLKKHGIDALVVIGGDGSYMGAM------- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 84 dllsdlqkagKITDEEatkssyLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCG 163
Cdd:cd00763 110 ----------RLTEHG------FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 164 YLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGSRLNIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRV 243
Cdd:cd00763 174 DIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGKKHAIVVVAEGVYD-------VDELAKEIEEATGFETRA 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1236486008 244 TVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGtpdTPACVVSLSGNQAVRLPLMECVQVTKDVTKAM 312
Cdd:cd00763 244 TVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLAVGIQNEQLVHHDIIDAIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
4-302 |
1.21e-68 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 228.34 E-value: 1.21e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGgDHIKEATWESVSMMLQLGGTVIGSARCKDFR-EREGRLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsew 82
Cdd:TIGR02483 39 GWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyEEDGDDKIVANLKELGLDALIAIGGDGTLGIA------- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 83 sdllSDLQKAGkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHC 162
Cdd:TIGR02483 111 ----RRLADKG------------LPVVGVPKTIDNDLEATDYTFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 163 GYLALVTSLSCGADWVFIPECPPddDWEEhLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKN----------- 231
Cdd:TIGR02483 175 GWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGKRFAIVVVAEGAKPKGGEMVVQEGVKDafghvrlggig 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1236486008 232 -----LVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacVVSLSGNQAVRLPLMECV 302
Cdd:TIGR02483 252 nwlaeEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVAAVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
352-701 |
4.30e-53 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 186.82 E-value: 4.30e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 352 TVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKS---F 428
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTeegR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 429 EQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 508
Cdd:COG0205 83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 509 SAAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLqanVEHLVQKMKTTVKRGLV-----LRNEKCNE 583
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIvvaegAGDEDGEA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 584 NYTTD-FIFNLYSEEGKGI-----------FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNW-MSGKikesyrngri 650
Cdd:COG0205 233 VLEADtDAFGHVRLGGIGEylakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELlLEGK---------- 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1236486008 651 fantpdSGCVLGMRKRALVFQPVAELKDQtdfEHRIPKEQWWLKLRPILKI 701
Cdd:COG0205 303 ------TGVMVGIRRGEIVLVPLEEVANK---EKPVDPDSPLIQLARELGI 344
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
353-633 |
7.17e-53 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 186.35 E-value: 7.17e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 353 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQIS 432
Cdd:cd00363 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 433 A---NITKFNIQGLVIIGGFEAYTGGLELmegRKQFDELCIPFVVI--PATVSNNVPGSDFSVGADTALNTICTTCDRIK 507
Cdd:cd00363 83 KaaeNLKKHGIDALVVIGGDGSYTGADLL---TEEWPSKYQGFNVIglPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 508 QSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDlqanVEHLVQKMKTTVKRG----LVLRNEKcne 583
Cdd:cd00363 160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG--- 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1236486008 584 nyTTDFIFNLYSEEG-------KGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 633
Cdd:cd00363 232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEA 286
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
353-633 |
2.37e-51 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 181.43 E-value: 2.37e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 353 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 429
Cdd:PRK03202 4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgra 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 430 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRkqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 509
Cdd:PRK03202 84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 510 AAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEK-CNENYTTD 588
Cdd:PRK03202 157 AS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAK 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1236486008 589 FIfnlyseEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 633
Cdd:PRK03202 233 EI------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
353-633 |
6.98e-50 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 177.22 E-value: 6.98e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 353 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRtLPKKSFEQIS 432
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 433 A----NITKFNIQGLVIIGGFEAYTGGLELMEgrkqfdeLCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 508
Cdd:cd00763 82 AkaieQLKKHGIDALVVIGGDGSYMGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 509 SAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEKCnenYTTD 588
Cdd:cd00763 155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1236486008 589 FIFNLYSEEGKgiFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 633
Cdd:cd00763 228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
4-308 |
1.38e-47 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 172.18 E-value: 1.38e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKD----------FREREGRLRAAYNlvKRGITNLCVIGGDGSLT 73
Cdd:PRK14071 44 ATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKGDpfafpmpdgsLRDRSQEIIDGYH--SLGLDALIGIGGDGSLA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 74 gadtfrsewsdLLSDLQKAGKItdeeatkssylNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTF 153
Cdd:PRK14071 122 -----------ILRRLAQQGGI-----------NLVGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVM 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 154 VLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSED----- 228
Cdd:PRK14071 180 ILEVMGRDAGHIALAAGIAGGADVILIPEIPYT---LENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalged 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 229 --------IKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTpacVVSLSGNQAVRLPLME 300
Cdd:PRK14071 257 ryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAE 333
|
....*...
gi 1236486008 301 CVQVTKDV 308
Cdd:PRK14071 334 AIATYRAV 341
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
351-680 |
1.65e-44 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 170.98 E-value: 1.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 351 HTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQ--IEEAGWSYVGGWTGQGGSKLGTKRTlpkKSF 428
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGdnIEEAQWEDVRGILSLGGTIIGTARC---KEF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 429 EQ------ISANITKFNIQGLVIIGGFEAYTG---------GL--ELM-------EGRKQFDELCIpfVVIPATVSNNVP 484
Cdd:TIGR02478 78 RErpgrlkAARNLVSNGIDALVVIGGDGSLTGadlfreewpSLleELVdtgkitaEQAEEHRHLTI--VGLVGSIDNDMC 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 485 GSDFSVGADTALNTICTTCDRIkQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTI--RDLQANVEHL 562
Cdd:TIGR02478 156 GTDMTIGADSALHRICEAIDAI-SSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEgwEDQLCHKLKR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 563 VQKM---KTTVKRGLVLRNEKCNEnYTTDFIFNLYSEEGKgiFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNwmsg 639
Cdd:TIGR02478 235 NRKAgkrKTIVIVAEGAIDRDLNP-ITSEDVKDVLVERLG--LDTRITVLGHVQRGGAPSAFDRILATRQGVEAVL---- 307
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1236486008 640 kikesyrngRIFANTPDS-GCVLGMRKRALVFQPVAELKDQT 680
Cdd:TIGR02478 308 ---------AVLESTPETpSPVISLRGNKIVRKPLVEAVAQT 340
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
353-675 |
4.52e-38 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 151.90 E-value: 4.52e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 353 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKG--QIEEAGWSYVGGWTGQGGSKLGTKRTlpkKSFE- 429
Cdd:cd00764 6 IAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARC---KEFRe 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 430 -----QISANITKFNIQGLVIIGGFEAYTGG----------LELMEGRKQFDE--------LCIPFVVipATVSNNVPGS 486
Cdd:cd00764 83 regrlQAAYNLIQRGITNLCVIGGDGSLTGAdlfrsewpslLEELVKDGKITEeevakyqhLNIVGMV--GSIDNDFCGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 487 DFSVGADTALNTICTTCDRIkQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTiRDLQanvEHLVQKM 566
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAI-TTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPE-DGWE---DQMCRRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 567 KTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI------FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNwmsgk 640
Cdd:cd00764 236 SEHRSRGKRLNIIIVAEGAIDDQLKPITSEDVKDLvverlgLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVM----- 310
|
330 340 350
....*....|....*....|....*....|....*.
gi 1236486008 641 ikesyrngRIFANTPDS-GCVLGMRKRALVFQPVAE 675
Cdd:cd00764 311 --------ALLEATPDTpACVVSLNGNKAVRLPLME 338
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
4-298 |
1.08e-19 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 92.62 E-value: 1.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGGDH-IKEATWESVSMMLQLGGTVIGSARckdfrereGRLRAAY---NLVKRGITNLCVIGGDGSLTGadtfr 79
Cdd:PRK06830 121 GYQGLIPRYGHdPVELTPEVVADIHEFGGTILGSSR--------GPQDPEEivdTLERMNINILFVIGGDGTLRG----- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 80 sewsdllsdlqkAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVL-EVM 158
Cdd:PRK06830 188 ------------ASAIAEEIERRGLKISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLM 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 159 GRHCGYLALVTSLSCG-ADWVFIPECPPDDDWE----EHLCRRLSEtrtRGSRlnIIIVAEGA----IDKNGKpitSEDI 229
Cdd:PRK06830 256 GRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPngllAALEKRLAE---RGHA--VIVVAEGAgqelFDDTGE---TDAS 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 230 KNLVVKRLGYDTRVTVLGHVQRGGTP-----------------SAFDRILGSRMGVEAVMALLEGTPDtpaCVVSLSGNQ 292
Cdd:PRK06830 328 GNPKLGDIGLFLKDRIKEYFKARGIPinlkyidpsyiirsvpaNANDSVYCGFLGQNAVHAAMAGKTG---MVVGRWNNR 404
|
....*.
gi 1236486008 293 AVRLPL 298
Cdd:PRK06830 405 FVHLPI 410
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
4-228 |
1.02e-18 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 89.72 E-value: 1.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVDGgDHIKeATWESVSMMLQLGGTVIGSARCKDFRERegrlrAAYNLVKRGITNLCVIGGDGSLTGADtfrsews 83
Cdd:PTZ00286 128 GYKGLYKE-DWIK-LDPKDVKTIHRLGGTILGSSRGGFDPKV-----MVDTLIRHGINILFTLGGDGTHRGAL------- 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 84 dllsdlqkagKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTF-VLEVMGRHC 162
Cdd:PTZ00286 194 ----------AIYKELRRRKLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDS 263
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1236486008 163 GYLALVTSLSCG-ADWVFIPEcppdDDWEEHLCRRLSETRTRGSRLNIIIVAEGAID--KNGKPITSED 228
Cdd:PTZ00286 264 GFIALHASVASAdVNVCLIPE----FDIPLEGVLEYIEQRLQKKGHCVIVVAEGAGQslKDADLDLGTD 328
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
353-635 |
6.79e-18 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 85.89 E-value: 6.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 353 VAVMNVGAPAAGMNAAVRSTVRIGLIQ-GNRVLVVHDGFEGLAKG--QIEEAGWSYVGGWTGQGGSKLGTKR-------- 421
Cdd:PRK14071 7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpfafp 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 422 ----TLPKKSfEQISANITKFNIQGLVIIGGfeayTGGLELMegRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALN 497
Cdd:PRK14071 87 mpdgSLRDRS-QEIIDGYHSLGLDALIGIGG----DGSLAIL--RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 498 TICTTCDRIKQSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIrdlqanvEHLVQKMKTTVKRG---- 573
Cdd:PRK14071 160 IATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfc 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1236486008 574 LVLRNEKC----NENYTTDFIF--NLYSEEGKGIFD---------SRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 635
Cdd:PRK14071 232 LVVVSEAVrteeGEQVTKTQALgeDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAAVD 308
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
66-277 |
1.22e-16 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 82.99 E-value: 1.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 66 IGGDGSltgADTfrsewsdllsdlqkAGKITdEEATKSSY-LNIVGLVGSIDNDFCGTDMTIGTDSALHRI----MEI-- 138
Cdd:PRK14072 110 NGGNDS---MDT--------------ALKVS-QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIatsvLEAal 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 139 -VDAITTTaqshQRTFVLEVMGRHCGYLALVTSLSC-----GADWVFIPECPPDDDweehlcRRLSETRTRGSRLN--II 210
Cdd:PRK14072 172 dVAAMANT----SKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFDEE------KFLADVRAIVKRYGycVV 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 211 IVAEGAIDKNGKPI----TSED-------------IKNLVVKRLGYDTRVTVLGHVQR--GGTPSAFDRILGSRMGVEAV 271
Cdd:PRK14072 242 VVSEGIRDADGKFIaeagLAEDafghaqlggvapvLANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAV 321
|
....*.
gi 1236486008 272 MALLEG 277
Cdd:PRK14072 322 EYALAG 327
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
1-308 |
2.62e-13 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 72.54 E-value: 2.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 1 MPKGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARckdfrereGRLRAAY---NLVKRGITNLCVIGGDGSLTGADT 77
Cdd:PLN02884 90 IPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSR--------GGAKTSDivdSIEARGINMLFVLGGNGTHAGANA 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 78 frsewsdllsdlqkagkITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTF-VLE 156
Cdd:PLN02884 162 -----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIgLVK 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 157 VMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWEEHLCRRLSE-TRTRGSrlNIIIVAEGAIDKNGKPITSEDIK-NLV 233
Cdd:PLN02884 225 LMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHlIETKGS--AVVCVAEGAGQDLLQKTNATDASgNPV 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 234 VKRLGYDTRVTVLGHVQRGGTPS-----------------AFDRILGSRMGVEAVMALLEGtpdTPACVVSLSGNQAVRL 296
Cdd:PLN02884 303 LGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAVHGAFAG---FSGITVGICNTHYVYL 379
|
330
....*....|..
gi 1236486008 297 PLMECVQVTKDV 308
Cdd:PLN02884 380 PIPEVIAYPRRV 391
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
4-216 |
1.07e-12 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 70.42 E-value: 1.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 4 GYQGLVdGGDHIK--EATWESVSMMLQLGGTVIGSARCK-----D------FREREGRLR-AAYNLVKRGITNLCVIGGD 69
Cdd:PRK06555 44 GYQGLL-LGDSIEitPAVRANAGLLHRYGGSPIGNSRVKltnvaDcvkrglVKEGENPLKvAAERLAADGVDILHTIGGD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 70 GSLTGAdtfrsewSDLLSDLQKAGkitdeeatkssY-LNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQS 148
Cdd:PRK06555 123 DTNTTA-------ADLAAYLAENG-----------YdLTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 149 HQRTFVL-EVMGRHCGYLALVTS-----------------LSCGA---DWVFIPECPPDDDWEehlCRRLSETRTRGSRL 207
Cdd:PRK06555 185 NPRMLIIhEVMGRNCGWLTAATArayrewldrqeyvpgfgLSAERwdiHAVYLPEMAFDLEAE---AERLKAVMDEVGNV 261
|
....*....
gi 1236486008 208 NiIIVAEGA 216
Cdd:PRK06555 262 N-IFLSEGA 269
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
30-216 |
4.06e-09 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 59.76 E-value: 4.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 30 GGTVIGSARCKdfrerEGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEwsdllsdLQKAG-KITdeeatkssylnI 108
Cdd:PLN02564 152 GGTILGTSRGG-----HDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEE-------IRRRGlKVA-----------V 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 109 VGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSL-SCGADWVFIPECPPD 186
Cdd:PLN02564 209 AGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLaSRDVDCCLIPESPFY 288
|
170 180 190
....*....|....*....|....*....|....
gi 1236486008 187 DDWE----EHLCRRLSEtrtrgSRLNIIIVAEGA 216
Cdd:PLN02564 289 LEGKgglfEFIEKRLKE-----NGHMVIVVAEGA 317
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
352-531 |
4.94e-08 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 56.20 E-value: 4.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 352 TVAVMNVGAPAAGMNAAVRSTVRIGLI--QGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTlpKKSFE 429
Cdd:PTZ00286 89 KAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG--GFDPK 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 430 QISANITKFNIQGLVIIGGFEAYTGGLELM-EGRKQfdELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 508
Cdd:PTZ00286 167 VMVDTLIRHGINILFTLGGDGTHRGALAIYkELRRR--KLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244
|
170 180
....*....|....*....|...
gi 1236486008 509 SAAGTKRRVFIIETMGGYCGYLA 531
Cdd:PTZ00286 245 EAKSAKNGVGIVKLMGRDSGFIA 267
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
16-218 |
3.34e-03 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 41.11 E-value: 3.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 16 KEATWESVSMMLQLGG-TVIGSARCKdfREREGRLRAAYNLV-KRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQKag 93
Cdd:PTZ00468 153 RELTEDDINGILNQGGfNIICSGRHK--IETEEQMRASLEICeKLKLHGLVVIGGDDSNTNAA--------VLAEYFK-- 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 94 kitdeeaTKSSYLNIVGLVGSIDNDFCG--TDMTIGTDSAL----HRIMEIVDAITTtaqSHQRTFVLEVMGRHCGYLAL 167
Cdd:PTZ00468 221 -------RNSSSTVVVGCPKTIDGDLKNevIETSFGYDTAVktysEQIGSIMDAIKT---EGYGYYFVRLMGRSASHITL 290
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236486008 168 VTSLSCGADWVFIPECPPD---------DDWEEHLCRRLSetrtRGSRLNIIIVAEGAID 218
Cdd:PTZ00468 291 ECGLQTRANMILIGEEIKEenrslmsivDEIVEMILKRDS----LGKKHGIVLLPEGLIE 346
|
|
| |
