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Conserved domains on  [gi|1020159027|ref|NP_001310240|]
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purine-rich element-binding protein gamma isoform A [Homo sapiens]

Protein Classification

Pur family transcription activator( domain architecture ID 12058637)

Pur family transcription activator such as Pur-alpha (PurA), Pur-beta (PurB), and Pur-gamma (PurG), which bind preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 57-321 1.72e-124

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


:

Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 356.45  E-value: 1.72e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027  57 IQELASKRVDIQKKRFYLDVKQSSRGRFLKIAEVWIGRgrqdniRKSKLTLSLSVAAELKDCLGDFIEHYAHLGlkghRQ 136
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGG------RKSRITLSMSVAAEFKDELSKFSDHYAQLG----PS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027 137 EHGHSKEQGsrrrqkhsapsppvsvgseehpHSVLKTDYIERDNRKYYLDLKENQRGRFLRIRQTMMRGtgmigyfgHSL 216
Cdd:pfam04845  71 NGEHLPEDG----------------------SSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMRG--------NPR 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027 217 GQEQTIVLPAQGMIEFRDALVQLIEDYGEGDieerrgGDDDPLELPEGTSFRVDNKRFYFDVGSNKYGIFLKVSEVRPPY 296
Cdd:pfam04845 121 GQRQQIALPAQGMIEFRDALTDLIEDYGEGD------ENDIPQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNY 194

                         250       260
                  ....*....|....*....|....*
gi 1020159027 297 RNTITVPFKAWTRFGENFIKYEEEM 321
Cdd:pfam04845 195 RNSITVPEKAWTRFRDIFDKYIEKM 219
 
Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 57-321 1.72e-124

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 356.45  E-value: 1.72e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027  57 IQELASKRVDIQKKRFYLDVKQSSRGRFLKIAEVWIGRgrqdniRKSKLTLSLSVAAELKDCLGDFIEHYAHLGlkghRQ 136
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGG------RKSRITLSMSVAAEFKDELSKFSDHYAQLG----PS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027 137 EHGHSKEQGsrrrqkhsapsppvsvgseehpHSVLKTDYIERDNRKYYLDLKENQRGRFLRIRQTMMRGtgmigyfgHSL 216
Cdd:pfam04845  71 NGEHLPEDG----------------------SSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMRG--------NPR 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027 217 GQEQTIVLPAQGMIEFRDALVQLIEDYGEGDieerrgGDDDPLELPEGTSFRVDNKRFYFDVGSNKYGIFLKVSEVRPPY 296
Cdd:pfam04845 121 GQRQQIALPAQGMIEFRDALTDLIEDYGEGD------ENDIPQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNY 194

                         250       260
                  ....*....|....*....|....*
gi 1020159027 297 RNTITVPFKAWTRFGENFIKYEEEM 321
Cdd:pfam04845 195 RNSITVPEKAWTRFRDIFDKYIEKM 219
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 171-244 4.99e-18

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 76.88  E-value: 4.99e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020159027  171 LKTDYIERDNRKYYLDLKENQRGRFLRIRQTMMRgtgmigyfghslGQEQTIVLPAQGMIEFRDALVQLIEDYG 244
Cdd:smart00712   2 LASKKLTVENKRFYFDVKENRRGRFLRISEVKNN------------GGRSSITVPEQGAAEFRDALTKLIEKYG 63
 
Name Accession Description Interval E-value
PurA pfam04845
PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.
 57-321 1.72e-124

PurA ssDNA and RNA-binding protein; This family represents most of the length of the protein.


Pssm-ID: 282672 [Multi-domain]  Cd Length: 219  Bit Score: 356.45  E-value: 1.72e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027  57 IQELASKRVDIQKKRFYLDVKQSSRGRFLKIAEVWIGRgrqdniRKSKLTLSLSVAAELKDCLGDFIEHYAHLGlkghRQ 136
Cdd:pfam04845   1 EQELASKRLDIQNKRFYLDVKQNTRGRFIKIAEVGAGG------RKSRITLSMSVAAEFKDELSKFSDHYAQLG----PS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027 137 EHGHSKEQGsrrrqkhsapsppvsvgseehpHSVLKTDYIERDNRKYYLDLKENQRGRFLRIRQTMMRGtgmigyfgHSL 216
Cdd:pfam04845  71 NGEHLPEDG----------------------SSLLKSETLVRDNRKYYLDLKENQRGRFLRIAQTPMRG--------NPR 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1020159027 217 GQEQTIVLPAQGMIEFRDALVQLIEDYGEGDieerrgGDDDPLELPEGTSFRVDNKRFYFDVGSNKYGIFLKVSEVRPPY 296
Cdd:pfam04845 121 GQRQQIALPAQGMIEFRDALTDLIEDYGEGD------ENDIPQELPEGTSLTVDNKRFYFDVGSNKRGVFLRISEVKPNY 194

                         250       260
                  ....*....|....*....|....*
gi 1020159027 297 RNTITVPFKAWTRFGENFIKYEEEM 321
Cdd:pfam04845 195 RNSITVPEKAWTRFRDIFDKYIEKM 219
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 171-244 4.99e-18

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 76.88  E-value: 4.99e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1020159027  171 LKTDYIERDNRKYYLDLKENQRGRFLRIRQTMMRgtgmigyfghslGQEQTIVLPAQGMIEFRDALVQLIEDYG 244
Cdd:smart00712   2 LASKKLTVENKRFYFDVKENRRGRFLRISEVKNN------------GGRSSITVPEQGAAEFRDALTKLIEKYG 63
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 261-321 1.98e-16

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 72.64  E-value: 1.98e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1020159027  261 LPEGTSFRVDNKRFYFDVGSNKYGIFLKVSEVRP-PYRNTITVPFKAWTRFGENFIKYEEEM 321
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNnGGRSSITVPEQGAAEFRDALTKLIEKY 62
PUR smart00712
DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes ...
 59-127 3.92e-16

DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria;


Pssm-ID: 197840 [Multi-domain]  Cd Length: 63  Bit Score: 71.87  E-value: 3.92e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1020159027   59 ELASKRVDIQKKRFYLDVKQSSRGRFLKIAEVWIGRGRqdnirkSKLTLSLSVAAELKDCLGDFIEHYA 127
Cdd:smart00712   1 ELASKKLTVENKRFYFDVKENRRGRFLRISEVKNNGGR------SSITVPEQGAAEFRDALTKLIEKYG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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