Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat ...
492-582
8.00e-33
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins.
The actual alignment was detected with superfamily member pfam14654:
Pssm-ID: 434100 Cd Length: 91 Bit Score: 121.16 E-value: 8.00e-33
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
122-177
2.52e-07
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
:
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 48.09 E-value: 2.52e-07
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat ...
492-582
8.00e-33
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins.
Pssm-ID: 434100 Cd Length: 91 Bit Score: 121.16 E-value: 8.00e-33
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
122-177
2.52e-07
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 48.09 E-value: 2.52e-07
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
32-98
5.01e-04
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 38.84 E-value: 5.01e-04
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
27-251
3.40e-03
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.
Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 40.37 E-value: 3.40e-03
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat ...
492-582
8.00e-33
Mucin, catalytic, TM and cytoplasmic tail region; This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins.
Pssm-ID: 434100 Cd Length: 91 Bit Score: 121.16 E-value: 8.00e-33
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
122-177
2.52e-07
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 48.09 E-value: 2.52e-07
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
115-172
3.53e-05
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 41.92 E-value: 3.53e-05
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
76-157
1.04e-04
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 40.77 E-value: 1.04e-04
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
32-98
5.01e-04
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 38.84 E-value: 5.01e-04
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
19-83
2.21e-03
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 36.92 E-value: 2.21e-03
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
27-251
3.40e-03
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.
Pssm-ID: 468206 [Multi-domain] Cd Length: 1122 Bit Score: 40.37 E-value: 3.40e-03
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is ...
331-387
4.45e-03
Tandem-repeating region of mucin, epiglycanin-like; The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).
Pssm-ID: 461702 [Multi-domain] Cd Length: 68 Bit Score: 36.15 E-value: 4.45e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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