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Conserved domains on  [gi|1015809804|ref|NP_001309091|]
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transcription factor 12 isoform a [Homo sapiens]

Protein Classification

basic helix-loop-helix domain-containing protein( domain architecture ID 14441779)

basic helix-loop-helix (bHLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
bHLH_E-protein_TCF4_E2-2 cd18945
basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar ...
595-679 1.07e-50

basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins; TCF-4, also termed E2-2, or Class B basic helix-loop-helix protein 19 (bHLHb19), or immunoglobulin transcription factor 2 (ITF-2), or SL3-3 enhancer factor 2 (SEF-2), is a bHLH transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. It is involved in the initiation of neuronal differentiation.


:

Pssm-ID: 381515  Cd Length: 85  Bit Score: 171.11  E-value: 1.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809804 595 KIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRRE 674
Cdd:cd18945     1 KAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRRE 80

                  ....*
gi 1015809804 675 EEKVS 679
Cdd:cd18945    81 EEKVS 85
 
Name Accession Description Interval E-value
bHLH_E-protein_TCF4_E2-2 cd18945
basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar ...
595-679 1.07e-50

basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins; TCF-4, also termed E2-2, or Class B basic helix-loop-helix protein 19 (bHLHb19), or immunoglobulin transcription factor 2 (ITF-2), or SL3-3 enhancer factor 2 (SEF-2), is a bHLH transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. It is involved in the initiation of neuronal differentiation.


Pssm-ID: 381515  Cd Length: 85  Bit Score: 171.11  E-value: 1.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809804 595 KIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRRE 674
Cdd:cd18945     1 KAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRRE 80

                  ....*
gi 1015809804 675 EEKVS 679
Cdd:cd18945    81 EEKVS 85
HLH smart00353
helix loop helix domain;
607-660 5.81e-13

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 63.78  E-value: 5.81e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809804  607 NARERLRVRDINEAFKELGRMCQLHLKSEKPqTKLLILHQAVAVILSLEQQVRE 660
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPKNKKL-SKAEILRLAIEYIKSLQEELQK 53
HLH pfam00010
Helix-loop-helix DNA-binding domain;
602-655 1.09e-10

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 57.08  E-value: 1.09e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015809804 602 RRMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSLE 655
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDEL-RELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
 
Name Accession Description Interval E-value
bHLH_E-protein_TCF4_E2-2 cd18945
basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar ...
595-679 1.07e-50

basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins; TCF-4, also termed E2-2, or Class B basic helix-loop-helix protein 19 (bHLHb19), or immunoglobulin transcription factor 2 (ITF-2), or SL3-3 enhancer factor 2 (SEF-2), is a bHLH transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. It is involved in the initiation of neuronal differentiation.


Pssm-ID: 381515  Cd Length: 85  Bit Score: 171.11  E-value: 1.07e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809804 595 KIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRRE 674
Cdd:cd18945     1 KAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRRE 80

                  ....*
gi 1015809804 675 EEKVS 679
Cdd:cd18945    81 EEKVS 85
bHLH_E-protein_TCF12_HEB cd18946
basic helix-loop-helix (bHLH) domain found in transcription factor 12 (TCF-12) and similar ...
602-684 1.05e-48

basic helix-loop-helix (bHLH) domain found in transcription factor 12 (TCF-12) and similar proteins; TCF-12, also termed HEB, or Class B basic helix-loop-helix protein 20 (bHLHb20), or DNA-binding protein HTF4, or E-box-binding protein, or transcription factor HTF-4, is a bHLH transcription factor that is involved in the initiation of neuronal differentiation.


Pssm-ID: 381516  Cd Length: 83  Bit Score: 165.67  E-value: 1.05e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809804 602 RRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAV 681
Cdd:cd18946     1 RRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAV 80

                  ...
gi 1015809804 682 SAE 684
Cdd:cd18946    81 SAE 83
bHLH_E-protein_E2A_TCF3 cd18944
basic helix-loop-helix (bHLH) domain found in transcription factor E2-alpha (E2A) and similar ...
601-674 3.02e-47

basic helix-loop-helix (bHLH) domain found in transcription factor E2-alpha (E2A) and similar proteins; E2A, also termed Class B basic helix-loop-helix protein 21 (bHLHb21), or immunoglobulin enhancer-binding factor E12/E47, or immunoglobulin transcription factor 1, or Kappa-E2-binding factor, or transcription factor 3 (TCF-3), or transcription factor ITF-1, is a bHLH transcriptional regulator involved in the initiation of neuronal differentiation.


Pssm-ID: 381514  Cd Length: 74  Bit Score: 161.35  E-value: 3.02e-47
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1015809804 601 ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRRE 674
Cdd:cd18944     1 ERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQAVSVILNLEQQVRERNLNPKAACLKRRE 74
bHLH_E-protein_E47-like cd18943
basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins; ...
593-666 3.10e-42

basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins; E47 is a class I bHLH transcriptional regulator that forms heterodimers with class II bHLH proteins to regulate distinct differentiation pathways. Its homodimers regulate B lymphocytes development.


Pssm-ID: 381513  Cd Length: 74  Bit Score: 147.50  E-value: 3.10e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1015809804 593 EQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPK 666
Cdd:cd18943     1 EEKDLRDRERRMANNARERVRVRDINEAFKELGRMCQMHLKSDKAQTKLIILQQAVQVILGLEQQVRERNLNPK 74
bHLH_E-protein_Da_like cd11467
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein daughterless (Da) ...
601-670 1.39e-33

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein daughterless (Da) and similar proteins; Da is a nuclear bHLH transcription factor that is a sole E protein ortholog essential for both neurogenesis and sex determination in Drosophila. Da is expressed in a broad range of tissues and is involved in diverse developmental processes such as oogenesis, sex determination and neurogenesis depending on its bHLH-binding partners. Da and achaete-scute complex (AS-C) form heterodimers that act as transcriptional activators of neural cell fates and are involved in sex determination.


Pssm-ID: 381473  Cd Length: 70  Bit Score: 122.83  E-value: 1.39e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809804 601 ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACL 670
Cdd:cd11467     1 ERRQANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAACL 70
bHLH_E-protein cd11420
basic helix-loop-helix (bHLH) domain found in E proteins family; The E proteins family ...
610-656 3.48e-30

basic helix-loop-helix (bHLH) domain found in E proteins family; The E proteins family corresponds to class I bHLH proteins, which are widely expressed within the immune system and on which the majority of this chapter will be focused. Members in this family include E2A (also referred to as TCF-3), E47, TCF-12 (also referred to as HEB), and TCF-4 (also referred to as E2-2) in vertebrates, as well as the E protein ortholog, Daughterless (Da), from Drosophila melanogaster. E-proteins are expressed broadly and in certain complexes they are restricted to specific cell types. E-proteins homodimerize and heterodimerize with the tissue specific bHLH factors to bind DNA and regulate transcription and differentiation of cells during development. The activity of the E-proteins is regulated by two main mechanisms: first, the relative concentrations of E-proteins, tissue specific bHLH factors, and the Id proteins, and second, covalent modification.


Pssm-ID: 381426  Cd Length: 47  Bit Score: 112.50  E-value: 3.48e-30
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1015809804 610 ERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQ 656
Cdd:cd11420     1 ERIRVRDINEAFKELGRMCQLHLKSDKPQTKLLILHQAVSVITSLEQ 47
HLH smart00353
helix loop helix domain;
607-660 5.81e-13

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 63.78  E-value: 5.81e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809804  607 NARERLRVRDINEAFKELGRMCQLHLKSEKPqTKLLILHQAVAVILSLEQQVRE 660
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPKNKKL-SKAEILRLAIEYIKSLQEELQK 53
HLH pfam00010
Helix-loop-helix DNA-binding domain;
602-655 1.09e-10

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 57.08  E-value: 1.09e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015809804 602 RRMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSLE 655
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDEL-RELLPTLPPDKKLSKAEILRLAIEYIKHLQ 53
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
603-656 5.04e-08

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 49.88  E-value: 5.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1015809804 603 RMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSLEQ 656
Cdd:cd11390     1 RNAANARERRRMHDLNDAFEAL-RKVLPTVPPDKKLSKIETLRLAINYIAALSD 53
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
610-656 1.17e-06

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 45.59  E-value: 1.17e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1015809804 610 ERLRVRDINEAFKELGRMCQLHLKSEKPqTKLLILHQAVAVILSLEQ 656
Cdd:cd00083     1 ERRRRDKINDAFEELKRLLPELPDSKKL-SKASILQKAVEYIRELQS 46
bHLH_TS_FIGLA cd11422
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ...
602-656 3.06e-06

basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.


Pssm-ID: 381428  Cd Length: 56  Bit Score: 44.65  E-value: 3.06e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809804 602 RRMANnARERLRVRDINEAFKELGRMCQLHLKSEKPqTKLLILHQAVAVILSLEQ 656
Cdd:cd11422     1 RRVAN-ARERERVRNLNSGFSKLRRIVPLIPRDRKP-SKVDTLKGATEYIRLLQR 53
bHLH_TS_taxi_Dei cd11431
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar ...
602-656 8.78e-06

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar proteins; Protein taxi, also termed protein delilah (Dei), is a bHLH transcription factor that is involved in regulation of cell adhesion and attachment that is expressed in specialized cells that provide anchoring sites to either muscles (tendon cells), or proprioceptors (chordotonal attachment cells) during embryonic development. It probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.


Pssm-ID: 381437 [Multi-domain]  Cd Length: 59  Bit Score: 43.57  E-value: 8.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809804 602 RRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQ--TKLLILHQAVAVILSLEQ 656
Cdd:cd11431     1 RRKTANARERDRMREINDAFEALRRAVPEYPVAGKDGklTKITTLRLAMNYIKALTD 57
bHLH_TS_bHLHa9 cd18912
basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) ...
598-654 8.93e-06

basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) and similar proteins; bHLHa9, also termed Class F basic helix-loop-helix factor 42 (bHLHf42), is a bHLH transcription factor that plays an essential role in limb development.


Pssm-ID: 381482  Cd Length: 63  Bit Score: 43.78  E-value: 8.93e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809804 598 REKERRMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSL 654
Cdd:cd18912     4 RSKARRVAANVRERKRILDYNQAFNAL-RLALKHDLGGKRLSKIATLRRAINRISAL 59
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
600-660 1.57e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 43.07  E-value: 1.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1015809804 600 KERRMANNARERLRVRDINEAFKELgRMCQLHLKSEKpQTKLLILHQAVAVILSLEQQVRE 660
Cdd:cd11419     2 RIRREIANSNERRRMQSINAGFQSL-RTLLPHCDGEK-LSKAAILQQTAEYIFSLEQEKTR 60
bHLH_TS_ATOH8 cd11421
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar ...
600-656 3.90e-05

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar proteins; ATOH8, also termed Class A basic helix-loop-helix protein 21 (bHLHa21), or helix-loop-helix protein hATH-6 (hATH6), is a bHLH shear-stress-responsive transcription factor expressed in activated satellite cells and proliferating myoblasts of human skeletal muscle tissue. It regulates endothelial cell proliferation, migration and tube-like structures formation. ATOH8 binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins.


Pssm-ID: 381427 [Multi-domain]  Cd Length: 68  Bit Score: 42.04  E-value: 3.90e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809804 600 KERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKpQTKLLILHQAVAVILSLEQ 656
Cdd:cd11421     6 RQRRIEANARERTRVHTISAAFEALRKAVPSYSYNQK-LSKLAILRIACSYILALAR 61
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
600-657 6.13e-05

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 41.05  E-value: 6.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1015809804 600 KERRmanNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQ 657
Cdd:cd11418     2 VARR---NERERRRVQAVNDAFDRL-RQHVPYLKRRKKLSKVKTLRRAIEYIRHLQKL 55
bHLH_TS_MIST1_like cd11426
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
602-654 7.76e-05

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) family; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription. The family also includes Drosophila melanogaster protein dimmed and similar proteins. Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.


Pssm-ID: 381432  Cd Length: 56  Bit Score: 41.04  E-value: 7.76e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1015809804 602 RRMANNARERLRVRDINEAFKELGRMCQlHLKSEKPQTKLLILHQAVAVILSL 654
Cdd:cd11426     1 RRLESNERERLRMHQLNDAFQALREVIP-HVRSERKLSKIETLTLAKNYIKSL 52
bHLH_TS_Myf5 cd18937
basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; ...
601-661 1.84e-04

basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; Myf-5, also termed Class C basic helix-loop-helix protein 2 (bHLHc2), is a nuclear bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle specification and differentiation. It also acts as an RNA-binding protein which enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.


Pssm-ID: 381507  Cd Length: 64  Bit Score: 40.12  E-value: 1.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1015809804 601 ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPqtKLLILHQAVAVILSLEQQVRER 661
Cdd:cd18937     1 DRRKAATMRERRRLKKVNQAFETLKRCTTSNPNQRLP--KVEILRNAIRYIESLQDLLREQ 59
bHLH_TS_ATOH7 cd19714
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar ...
595-654 2.65e-04

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins; ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells.


Pssm-ID: 381557 [Multi-domain]  Cd Length: 69  Bit Score: 39.93  E-value: 2.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809804 595 KIEREKERRMANNARERLRVRDINEAFKELGRMCQlHLKSEKPQTKLLILHQAVAVILSL 654
Cdd:cd19714     1 RLESAARRRLAANARERRRMQGLNTAFDRLRKVVP-QWGQDKKLSKYETLQMALSYIMAL 59
bHLH_TS_NeuroD2 cd19720
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) ...
595-659 3.15e-04

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins; NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter.


Pssm-ID: 381563 [Multi-domain]  Cd Length: 93  Bit Score: 40.44  E-value: 3.15e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1015809804 595 KIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKpQTKLLILHQAVAVILSLEQQVR 659
Cdd:cd19720    28 RLERSKLRRQKANARERNRMHDLNSALDNLRKVVPCYSKTQK-LSKIETLRLAKNYIWALSEILR 91
bHLH_TS_NeuroD6_ATOH2 cd19722
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) ...
593-659 4.02e-04

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins; NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism.


Pssm-ID: 381565 [Multi-domain]  Cd Length: 70  Bit Score: 39.25  E-value: 4.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809804 593 EQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKpQTKLLILHQAVAVILSLEQQVR 659
Cdd:cd19722     5 KARMERVKVRRQEANARERNRMHGLNDALDSLRKVVPCYSKTQK-LSKIETLRLAKNYIWALSEILR 70
bHLH_TS_dMYOD_like cd19699
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination ...
601-656 7.15e-04

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination protein (dMYOD) and similar proteins; dMYOD, also termed protein nautilus, or Myd, may play an important role in the early development of muscle in Drosophila.


Pssm-ID: 381542  Cd Length: 56  Bit Score: 38.29  E-value: 7.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809804 601 ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPqtKLLILHQAVAVILSLEQ 656
Cdd:cd19699     1 DRRKAATMRERRRLRKVNEAFEVLKRRTCPNPNQRLP--KVEILRNAIEYIESLED 54
bHLH_TS_ATOH1 cd19713
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar ...
599-656 8.96e-04

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins; ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1).


Pssm-ID: 381556  Cd Length: 64  Bit Score: 38.01  E-value: 8.96e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1015809804 599 EKERRMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSLEQ 656
Cdd:cd19713     3 QKQRRLAANARERRRMHGLNHAFDQL-RNVIPSFNNDKKLSKYETLQMAQIYINALSE 59
bHLH_TS_FERD3L_like cd19686
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas ...
601-651 1.00e-03

basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; The family corresponds to a group of bHLH transcription factors, including FERD3L and PTF1A. FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription. PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381529 [Multi-domain]  Cd Length: 56  Bit Score: 37.79  E-value: 1.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1015809804 601 ERRMANNaRERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVI 651
Cdd:cd19686     1 QRQAANI-RERKRMRSINDAFDGL-RRHIPTFPYEKRLSKVDTLRLAIQYI 49
bHLH_TS_MIST1 cd19711
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
602-654 1.17e-03

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) and similar proteins; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription.


Pssm-ID: 381554  Cd Length: 62  Bit Score: 37.77  E-value: 1.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1015809804 602 RRMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSL 654
Cdd:cd19711     1 RRLESNERERQRMHKLNNAFQAL-REVIPHVRAEKKLSKIETLTLAKNYIKSL 52
bHLH_TS_NeuroD4_ATOH3 cd19721
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) ...
595-636 1.19e-03

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) and similar proteins; NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation.


Pssm-ID: 381564 [Multi-domain]  Cd Length: 87  Bit Score: 38.52  E-value: 1.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1015809804 595 KIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEK 636
Cdd:cd19721    23 RLERFRARRVKANARERSRMHGLNDALDNLRRVMPCYSKTQK 64
bHLH_TS_NeuroD1 cd19719
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) ...
586-659 2.08e-03

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) and similar proteins; NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice.


Pssm-ID: 381562  Cd Length: 86  Bit Score: 37.85  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809804 586 EDEDLNPEQK-----------IEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKpQTKLLILHQAVAVILSL 654
Cdd:cd19719     1 EDDDQKPKRRgpkkkkmtkarLERFKMRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQK-LSKIETLRLAKNYIWAL 79

                  ....*
gi 1015809804 655 EQQVR 659
Cdd:cd19719    80 SEILR 84
bHLH_TS_dHLH3B_like cd19708
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein ...
602-659 2.71e-03

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein 3B (dHLH3B) and similar proteins; Drosophila HLH3B is an uncharacterized bHLH transcription factor that belongs to the T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family.


Pssm-ID: 381551 [Multi-domain]  Cd Length: 60  Bit Score: 36.79  E-value: 2.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1015809804 602 RRMANNARERLRVRDINEAFKELGRMCQLHlKSEKPQTKLLILHQAVAVILSLEQQVR 659
Cdd:cd19708     1 RRMFTNSRERWRQQNVNGAFAELRKLVPTH-PPDKKLSKNEILRLAIKYIRLLSNVLE 57
bHLH_TS_ATOH1_like cd11430
basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar ...
602-656 2.99e-03

basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar proteins; The family includes ATOH1 and ATOH7. ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. The family also includes protein Amos (also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein). It is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381436 [Multi-domain]  Cd Length: 56  Bit Score: 36.26  E-value: 2.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809804 602 RRMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSLEQ 656
Cdd:cd11430     1 RRLAANARERRRMNGLNRAFDQL-RSVVPSIGNDKKLSKYETLQMAQIYIETLSE 54
bHLH_TS_MRF cd11411
basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs ...
601-655 2.99e-03

basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs are a family of muscle-specific bHLH transcription proteins (MyoD, Myf5, Mrf4 and MyoG) that plays an essential role in regulating skeletal muscle development and growth. MRFs are capable of binding to E-box motifs as a heterodimer with E-proteins to regulate transcription expression.


Pssm-ID: 381417  Cd Length: 56  Bit Score: 36.36  E-value: 2.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809804 601 ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPqtKLLILHQAVAVILSLE 655
Cdd:cd11411     1 DRRKAATMRERRRLKKVNEAFEALKRCTSANPNQRLP--KVEILRNAIEYIESLQ 53
bHLH_TS_dimmed_like cd19712
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and ...
602-654 3.09e-03

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and similar proteins; Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.


Pssm-ID: 381555 [Multi-domain]  Cd Length: 60  Bit Score: 36.31  E-value: 3.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1015809804 602 RRMANNARERLRVRDINEAFKELgRMCQLHLKSEKPQTKLLILHQAVAVILSL 654
Cdd:cd19712     1 RRLESNERERMRMHSLNDAFQGL-REVIPHVNAERKLSKIETLTLAKNYIKAL 52
bHLH_TS_MYOD1_Myf3 cd18936
basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and ...
601-659 5.01e-03

basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins; MYOD1, also termed Class C basic helix-loop-helix protein 1 (bHLHc1), or myogenic factor 3 (Myf-3), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with Myf-5 and MYOG, MYOD1 co-occupies muscle-specific gene promoter core region during myogenesis.


Pssm-ID: 381506  Cd Length: 61  Bit Score: 35.81  E-value: 5.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809804 601 ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPqtKLLILHQAVAVILSLEQQVR 659
Cdd:cd18936     5 DRRKAATMRERRRLSKVNEAFETLKRCTSTNPNQRLP--KVEILRNAIRYIESLQALLR 61
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
606-660 7.32e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 35.31  E-value: 7.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809804 606 NNARERLRvRD-INEAFKELGRM---CQLHLKSEKPqTKLLILHQAVAVILSLEQQVRE 660
Cdd:cd11387     2 HNAVERRR-RDnINEKIQELGSLvppSRLETKDLKP-NKGSILSKAVEYIRELQNQNQE 58
bHLH_TS_amos_like cd19715
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar ...
600-624 8.49e-03

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar proteins; Amos, also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein, is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381558 [Multi-domain]  Cd Length: 64  Bit Score: 35.19  E-value: 8.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1015809804 600 KERRMANNARERLRVRDINEAFKEL 624
Cdd:cd19715     6 KKRRLAANARERRRMNSLNVAFDKL 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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