NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1007354568|ref|NP_001307991|]
View 

NAD-dependent protein deacylase sirtuin-6 isoform 7 [Homo sapiens]

Protein Classification

SIR2 family protein( domain architecture ID 1222)

SIR2 family protein similar to NAD-dependent deacetylase that catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose

PubMed:  7498786

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SIR2 super family cl00195
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 1-122 4.77e-52

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


The actual alignment was detected with superfamily member cd01410:

Pssm-ID: 444738  Cd Length: 206  Bit Score: 166.71  E-value: 4.77e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   1 MFVEECAKCKTQYVRDTVVGTMGLKATGRLCTvakarglrACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGT 80
Cdd:cd01410    93 MFIEVCKSCGPEYVRDDVVETRGDKETGRRCH--------ACGGILKDTIVDFGERLPPENWMGAAAAACRADLFLCLGT 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1007354568  81 SLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGY 122
Cdd:cd01410   165 SLQVTPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
 
Name Accession Description Interval E-value
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 1-122 4.77e-52

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 166.71  E-value: 4.77e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   1 MFVEECAKCKTQYVRDTVVGTMGLKATGRLCTvakarglrACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGT 80
Cdd:cd01410    93 MFIEVCKSCGPEYVRDDVVETRGDKETGRRCH--------ACGGILKDTIVDFGERLPPENWMGAAAAACRADLFLCLGT 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1007354568  81 SLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGY 122
Cdd:cd01410   165 SLQVTPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 6-134 1.79e-18

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 80.61  E-value: 1.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   6 CAKCKTQYVRDTVvgtmgLKATGRLCTvakarglrACRGELR-DTILdWEDSLPDRDLALADEASRNADLSITLGTSLQI 84
Cdd:PRK00481  125 CTKCGQTYDLDEY-----LKPEPPRCP--------KCGGILRpDVVL-FGEMLPELAIDEAYEALEEADLFIVIGTSLVV 190

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1007354568  85 RPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHL 134
Cdd:PRK00481  191 YPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEEL 240
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 6-132 6.83e-18

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 79.05  E-value: 6.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   6 CAKCKTQYVRDTVVGTMGLKaTGRLCtvakarglRACRGELR-DTILDwEDSLPDRDLALADEASRNADLSITLGTSLQI 84
Cdd:COG0846   126 CTKCGKRYDLEDVLEDLEGE-LPPRC--------PKCGGLLRpDVVWF-GEMLPEEALERALEALAEADLFLVIGTSLVV 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1007354568  85 RPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMK 132
Cdd:COG0846   196 YPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
 
Name Accession Description Interval E-value
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 1-122 4.77e-52

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 166.71  E-value: 4.77e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   1 MFVEECAKCKTQYVRDTVVGTMGLKATGRLCTvakarglrACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGT 80
Cdd:cd01410    93 MFIEVCKSCGPEYVRDDVVETRGDKETGRRCH--------ACGGILKDTIVDFGERLPPENWMGAAAAACRADLFLCLGT 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1007354568  81 SLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGY 122
Cdd:cd01410   165 SLQVTPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
SIR2-fam cd01407
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ...
 1-122 7.70e-33

SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.


Pssm-ID: 238698  Cd Length: 218  Bit Score: 118.06  E-value: 7.70e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   1 MFVEECAKCKTQYVRDTVVgTMGLKATGRLCTvakarglrACRGELRDTILDWEDSLPDRDLALADEASRnADLSITLGT 80
Cdd:cd01407   107 LFRVRCTKCGKEYPRDELQ-ADIDREEVPRCP--------KCGGLLRPDVVFFGESLPEELDEAAEALAK-ADLLLVIGT 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1007354568  81 SLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGY 122
Cdd:cd01407   177 SLQVYPAAGLPLYAPERGAPVVIINLEPTPADRKADLVILGD 218
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 1-121 3.71e-25

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 98.18  E-value: 3.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   1 MFVEECAKCKTQYVRDTVVGTMglkatgrlctvaKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGT 80
Cdd:cd00296   111 LDRVRCTSCGKEYPRDEVLERE------------KPPRCPKCGGLLRPDVVDFGEALPKEWFDRALEALLEADLVLVIGT 178

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1007354568  81 SLQIRPSGNLPLATKRRGGRLVIVNLQPTKHD--RHADLRIHG 121
Cdd:cd00296   179 SLTVYPAARLLLRAPERGAPVVIINREPTPADalKKADLVILG 221
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 6-134 1.79e-18

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 80.61  E-value: 1.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   6 CAKCKTQYVRDTVvgtmgLKATGRLCTvakarglrACRGELR-DTILdWEDSLPDRDLALADEASRNADLSITLGTSLQI 84
Cdd:PRK00481  125 CTKCGQTYDLDEY-----LKPEPPRCP--------KCGGILRpDVVL-FGEMLPELAIDEAYEALEEADLFIVIGTSLVV 190

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1007354568  85 RPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHL 134
Cdd:PRK00481  191 YPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEEL 240
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 6-132 6.83e-18

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 79.05  E-value: 6.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   6 CAKCKTQYVRDTVVGTMGLKaTGRLCtvakarglRACRGELR-DTILDwEDSLPDRDLALADEASRNADLSITLGTSLQI 84
Cdd:COG0846   126 CTKCGKRYDLEDVLEDLEGE-LPPRC--------PKCGGLLRpDVVWF-GEMLPEEALERALEALAEADLFLVIGTSLVV 195

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1007354568  85 RPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMK 132
Cdd:COG0846   196 YPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
SIR2_Af2 cd01413
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ...
 40-121 2.13e-16

SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.


Pssm-ID: 238704  Cd Length: 222  Bit Score: 74.71  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568  40 RACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRI 119
Cdd:cd01413   140 PKCGGIIRPDVVLFGEPLPQALLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADLVI 219


                  ..
gi 1007354568 120 HG 121
Cdd:cd01413   220 QD 221
PRK14138 PRK14138
NAD-dependent deacetylase; Provisional
 6-136 8.50e-16

NAD-dependent deacetylase; Provisional


Pssm-ID: 172627 [Multi-domain]  Cd Length: 244  Bit Score: 73.70  E-value: 8.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568   6 CAKCKTQYVRDTVVGTMGLKATGRLCTvakarglraCRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIR 85
Cdd:PRK14138  122 CVRCGKRYTVEDVIEKLEKSDVPRCDD---------CSGLIRPNIVFFGEALPQDALREAIRLSSKASLMIVMGSSLVVY 192

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1007354568  86 PSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGL 136
Cdd:PRK14138  193 PAAELPLITVRSGGKLVIVNLGETPLDDIATLKYNMDVVEFANRVMSEGGI 243
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
 41-131 7.42e-11

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 59.53  E-value: 7.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568  41 ACRGELRDTILDWEDSLPDrDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIH 120
Cdd:cd01412   135 KCGGLLRPGVVWFGESLPL-ALLEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFR 213

                          90
                  ....*....|.
gi 1007354568 121 GYVDEVMTRLM 131
Cdd:cd01412   214 GKAGEVLPALL 224
SIR2H cd01411
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ...
 42-124 3.43e-07

SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238702  Cd Length: 225  Bit Score: 49.29  E-value: 3.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568  42 CRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLpLATKRRGGRLVIVNLQPTKHDRHADLRIHG 121
Cdd:cd01411   142 CGGVIRPDIVLYEEMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGL-IDYRQAGANLIAINKEPTQLDSPATLVIKD 220


                  ...
gi 1007354568 122 YVD 124
Cdd:cd01411   221 AVK 223
PTZ00408 PTZ00408
NAD-dependent deacetylase; Provisional
 66-127 4.84e-04

NAD-dependent deacetylase; Provisional


Pssm-ID: 240405  Cd Length: 242  Bit Score: 40.19  E-value: 4.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568  66 DEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHG--------YVDEVM 127
Cdd:PTZ00408  167 ESVMSKTDLFVAVGTSGNVYPAAGFVGRAQFYGATTLELNLEEGTNYSQFDESIYGkasvivpaWVDRVL 236
IlvB COG0028
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ...
 65-141 2.42e-03

Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439799 [Multi-domain]  Cd Length: 548  Bit Score: 38.22  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1007354568  65 ADEASRNADLSITLGTSLQIRPSGNlpLATKRRGGRLVIVNLQPTKHDRH--ADLRIHGYVDEVMTRLMKHL---GLEIP 139
Cdd:COG0028   262 ANEALAEADLVLAVGARFDDRVTGN--WDEFAPDAKIIHIDIDPAEIGKNypVDLPIVGDAKAVLAALLEALeprADDRA 339


                  ..
gi 1007354568 140 AW 141
Cdd:COG0028   340 AW 341
PTZ00409 PTZ00409
Sir2 (Silent Information Regulator) protein; Provisional
 41-109 5.03e-03

Sir2 (Silent Information Regulator) protein; Provisional


Pssm-ID: 173599 [Multi-domain]  Cd Length: 271  Bit Score: 37.21  E-value: 5.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1007354568  41 ACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPT 109
Cdd:PTZ00409  169 PCGGIFKPNVILFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKKKKIVEVNISKT 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH