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Conserved domains on  [gi|985801711|ref|NP_001306874|]
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glucose-6-phosphatase 3 isoform 4 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 38-141 4.25e-45

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member cd03381:

Pssm-ID: 469784  Cd Length: 235  Bit Score: 149.07  E-value: 4.25e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801711  38 LFLFYFPAAYYASRRVGIAVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQA-PAQVHQFPSSCETGPGSPSGHCM 116
Cdd:cd03381    1 LFLIVFPLCGHLSQSVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVHETDYYSNSsVPKIEQFPLTCETGPGSPSGHAM 80

                         90       100
                 ....*....|....*....|....*
gi 985801711 117 ITGAALWPIMTALSSQVATRARRRC 141
Cdd:cd03381   81 GTTAVLLVMVTALLSHLAGRKRSRF 105
 
Name Accession Description Interval E-value
PAP2_glucose_6_phosphatase cd03381
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts ...
 38-141 4.25e-45

PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an important control point in metabolism, and stands at the end of gluconeogenesis and the release of glucose from glycogen. Deficiency of glucose-6-phosphatase leads to von Gierke's disease.


Pssm-ID: 239476  Cd Length: 235  Bit Score: 149.07  E-value: 4.25e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801711  38 LFLFYFPAAYYASRRVGIAVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQA-PAQVHQFPSSCETGPGSPSGHCM 116
Cdd:cd03381    1 LFLIVFPLCGHLSQSVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVHETDYYSNSsVPKIEQFPLTCETGPGSPSGHAM 80

                         90       100
                 ....*....|....*....|....*
gi 985801711 117 ITGAALWPIMTALSSQVATRARRRC 141
Cdd:cd03381   81 GTTAVLLVMVTALLSHLAGRKRSRF 105
acidPPc smart00014
Acid phosphatase homologues;
58-145 3.96e-05

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 41.18  E-value: 3.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801711    58 LWISLITEWLNLIFKWFLFGDRPFWWvhesgyYSQAPAQVHQFPSSCETGPGSPSGHCMItGAALWPIMTALSSQVATRA 137
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFL------SIGDACCTPNFLLTLEAGYSFPSGHTAF-AFAFALFLLLYLPARAGRK 73


                   ....*...
gi 985801711   138 RRRCPGLA 145
Cdd:smart00014  74 LLIFLLLL 81
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 56-129 3.58e-04

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 38.94  E-value: 3.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985801711   56 AVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQAPAQVHQFPSscetgpgSPSGHCMITGAALWPIMTAL 129
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGYS-------FPSGHSATAFALALLLALLL 67
 
Name Accession Description Interval E-value
PAP2_glucose_6_phosphatase cd03381
PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts ...
 38-141 4.25e-45

PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an important control point in metabolism, and stands at the end of gluconeogenesis and the release of glucose from glycogen. Deficiency of glucose-6-phosphatase leads to von Gierke's disease.


Pssm-ID: 239476  Cd Length: 235  Bit Score: 149.07  E-value: 4.25e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801711  38 LFLFYFPAAYYASRRVGIAVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQA-PAQVHQFPSSCETGPGSPSGHCM 116
Cdd:cd03381    1 LFLIVFPLCGHLSQSVGIKLLWVAVIGDWLNLVFKWILFGQRPYWWVHETDYYSNSsVPKIEQFPLTCETGPGSPSGHAM 80

                         90       100
                 ....*....|....*....|....*
gi 985801711 117 ITGAALWPIMTALSSQVATRARRRC 141
Cdd:cd03381   81 GTTAVLLVMVTALLSHLAGRKRSRF 105
acidPPc smart00014
Acid phosphatase homologues;
58-145 3.96e-05

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 41.18  E-value: 3.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801711    58 LWISLITEWLNLIFKWFLFGDRPFWWvhesgyYSQAPAQVHQFPSSCETGPGSPSGHCMItGAALWPIMTALSSQVATRA 137
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFL------SIGDACCTPNFLLTLEAGYSFPSGHTAF-AFAFALFLLLYLPARAGRK 73


                   ....*...
gi 985801711   138 RRRCPGLA 145
Cdd:smart00014  74 LLIFLLLL 81
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 51-139 1.32e-04

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 40.14  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801711  51 RRVGIAVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYsqapaqvhQFPSSCETGPGSPSGHCMITGAALWPIMTALS 130
Cdd:cd01610    2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDG--------DPLLLTEGGYSFPSGHAAFAFALALFLALLLP 73


                 ....*....
gi 985801711 131 SQVATRARR 139
Cdd:cd01610   74 RRLLRLLLG 82
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 56-129 3.58e-04

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 38.94  E-value: 3.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985801711   56 AVLWISLITEWLNLIFKWFLFGDRPFWWVHESGYYSQAPAQVHQFPSscetgpgSPSGHCMITGAALWPIMTAL 129
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLPGLGYS-------FPSGHSATAFALALLLALLL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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