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Conserved domains on  [gi|974005297|ref|NP_001305717|]
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cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2 precursor [Homo sapiens]

Protein Classification

cytochrome c oxidase subunit IV family protein( domain architecture ID 10097092)

cytochrome c oxidase subunit IV (COXIV) family protein such as mammalian cytochrome c oxidase subunit IV (COXIV) and yeast subunit cytochrome c oxidase polypeptide Vb (also known as Cox5bp), which are components of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_c_Oxidase_IV cd00922
Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 26-126 5.96e-44

Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit IV is the largest of the nuclear-encoded subunits. It binds ATP at the matrix side, leading to an allosteric inhibition of enzyme activity at high intramitochondrial ATP/ADP ratios. In mammals, subunit IV has a lung-specific isoform and a ubiquitously expressed isoform.


:

Pssm-ID: 238462  Cd Length: 136  Bit Score: 140.87  E-value: 5.96e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005297  26 SVVKSEDFSLPAYMDRRDHPLPEVAHVKhLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVG 105
Cdd:cd00922    1 EVVGYGANSLPTYADIPDRPLPMIRFRE-LSAEIKALREKEKGDWKQLTLEEKKALYRISFGETGPEMNAPTGEWKTVFG 79

                         90       100
                 ....*....|....*....|.
gi 974005297 106 GAMFFIGFTALVIMWQKHYAL 126
Cdd:cd00922   80 GVLAFIGITGVIFGLQRAFVY 100
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_IV cd00922
Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 26-126 5.96e-44

Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit IV is the largest of the nuclear-encoded subunits. It binds ATP at the matrix side, leading to an allosteric inhibition of enzyme activity at high intramitochondrial ATP/ADP ratios. In mammals, subunit IV has a lung-specific isoform and a ubiquitously expressed isoform.


Pssm-ID: 238462  Cd Length: 136  Bit Score: 140.87  E-value: 5.96e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005297  26 SVVKSEDFSLPAYMDRRDHPLPEVAHVKhLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVG 105
Cdd:cd00922    1 EVVGYGANSLPTYADIPDRPLPMIRFRE-LSAEIKALREKEKGDWKQLTLEEKKALYRISFGETGPEMNAPTGEWKTVFG 79

                         90       100
                 ....*....|....*....|.
gi 974005297 106 GAMFFIGFTALVIMWQKHYAL 126
Cdd:cd00922   80 GVLAFIGITGVIFGLQRAFVY 100
COX4 pfam02936
Cytochrome c oxidase subunit IV; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 32-101 6.06e-24

Cytochrome c oxidase subunit IV; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit IV. The Dictyostelium member of this family is called COX VI. The yeast protein Swiss:P53077 appears to be the yeast COX IV subunit.


Pssm-ID: 460755  Cd Length: 100  Bit Score: 88.79  E-value: 6.06e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005297   32 DFSLPAYMDRRDHPLPEVaHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRG-SNEWK 101
Cdd:pfam02936   1 ANSNPTYADRWENPPPDI-RFREQTELQKALREKEKGDWKELSLEEKKALYRISFGQTGPPLPHTmTKEWQ 70
 
Name Accession Description Interval E-value
Cyt_c_Oxidase_IV cd00922
Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the ...
 26-126 5.96e-44

Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit IV is the largest of the nuclear-encoded subunits. It binds ATP at the matrix side, leading to an allosteric inhibition of enzyme activity at high intramitochondrial ATP/ADP ratios. In mammals, subunit IV has a lung-specific isoform and a ubiquitously expressed isoform.


Pssm-ID: 238462  Cd Length: 136  Bit Score: 140.87  E-value: 5.96e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005297  26 SVVKSEDFSLPAYMDRRDHPLPEVAHVKhLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVG 105
Cdd:cd00922    1 EVVGYGANSLPTYADIPDRPLPMIRFRE-LSAEIKALREKEKGDWKQLTLEEKKALYRISFGETGPEMNAPTGEWKTVFG 79

                         90       100
                 ....*....|....*....|.
gi 974005297 106 GAMFFIGFTALVIMWQKHYAL 126
Cdd:cd00922   80 GVLAFIGITGVIFGLQRAFVY 100
COX4 pfam02936
Cytochrome c oxidase subunit IV; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 32-101 6.06e-24

Cytochrome c oxidase subunit IV; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit IV. The Dictyostelium member of this family is called COX VI. The yeast protein Swiss:P53077 appears to be the yeast COX IV subunit.


Pssm-ID: 460755  Cd Length: 100  Bit Score: 88.79  E-value: 6.06e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005297   32 DFSLPAYMDRRDHPLPEVaHVKHLSASQKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRG-SNEWK 101
Cdd:pfam02936   1 ANSNPTYADRWENPPPDI-RFREQTELQKALREKEKGDWKELSLEEKKALYRISFGQTGPPLPHTmTKEWQ 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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