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Conserved domains on  [gi|969812446|ref|NP_001304977|]
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laminin subunit beta-4 isoform 3 precursor [Homo sapiens]

Protein Classification

Laminin_N and EGF_Lam domain-containing protein( domain architecture ID 11079853)

Laminin_N and EGF_Lam domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 4.15e-97

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 300.65  E-value: 4.15e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055   1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055  72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055 151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227


                  ...
gi 969812446  261 VRG 263
Cdd:pfam00055 228 VGG 230
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-503 2.86e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.99  E-value: 2.86e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 969812446 454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055    1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-549 7.09e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.83  E-value: 7.09e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 969812446 505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055    1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 395-452 9.47e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.44  E-value: 9.47e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 969812446  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053   1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 264-320 1.47e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 1.47e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446 264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055    1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 332-382 1.55e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.42  E-value: 1.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 969812446  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053   1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 4.15e-97

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 300.65  E-value: 4.15e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055   1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055  72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055 151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227


                  ...
gi 969812446  261 VRG 263
Cdd:pfam00055 228 VGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 23-263 1.73e-67

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 223.01  E-value: 1.73e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446    23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCILS-YLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136   2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLVgHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446   102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136  74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446   177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136 152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230


                   ....*...
gi 969812446   256 LYEMIVRG 263
Cdd:smart00136 231 ISDIAVGG 238
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-503 2.86e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.99  E-value: 2.86e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 969812446 454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055    1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-549 7.09e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.83  E-value: 7.09e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 969812446 505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055    1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 395-452 9.47e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.44  E-value: 9.47e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 969812446  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053   1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 455-508 4.22e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 58.52  E-value: 4.22e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 969812446  455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053   1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-549 1.18e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 1.18e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 969812446   506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180   1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 394-453 3.94e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 3.94e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446 394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055    1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-503 6.58e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.01  E-value: 6.58e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 969812446   455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180   1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
395-448 6.56e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 6.56e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 969812446   395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180   1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 264-320 1.47e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 1.47e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446 264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055    1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 506-544 5.85e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.58  E-value: 5.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 969812446  506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053   1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 332-382 1.55e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.42  E-value: 1.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 969812446  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053   1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 331-384 1.96e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 1.96e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 969812446 331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055    1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
332-382 3.71e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.53  E-value: 3.71e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 969812446   332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180   1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 265-323 9.48e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.41  E-value: 9.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 969812446  265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053   1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
291-313 1.95e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.60  E-value: 1.95e-04
                           10        20
                   ....*....|....*....|...
gi 969812446   291 VHGQCVCQHNTDGPNCERCKDFF 313
Cdd:smart00180  16 DTGQCECKPNVTGRRCDRCAPGY 38
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 4.15e-97

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 300.65  E-value: 4.15e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055   1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055  72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055 151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227


                  ...
gi 969812446  261 VRG 263
Cdd:pfam00055 228 VGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 23-263 1.73e-67

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 223.01  E-value: 1.73e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446    23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCILS-YLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136   2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLVgHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446   102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136  74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446   177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136 152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230


                   ....*...
gi 969812446   256 LYEMIVRG 263
Cdd:smart00136 231 ISDIAVGG 238
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 454-503 2.86e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 61.99  E-value: 2.86e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 969812446 454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055    1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 505-549 7.09e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.83  E-value: 7.09e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 969812446 505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055    1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 395-452 9.47e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.44  E-value: 9.47e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 969812446  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053   1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 455-508 4.22e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 58.52  E-value: 4.22e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 969812446  455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053   1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-549 1.18e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 56.94  E-value: 1.18e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 969812446   506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180   1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 394-453 3.94e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 3.94e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446 394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055    1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-503 6.58e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.01  E-value: 6.58e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 969812446   455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180   1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
395-448 6.56e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 6.56e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 969812446   395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180   1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 264-320 1.47e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.50  E-value: 1.47e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 969812446 264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055    1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 506-544 5.85e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.58  E-value: 5.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 969812446  506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053   1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 332-382 1.55e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 45.42  E-value: 1.55e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 969812446  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053   1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 331-384 1.96e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 1.96e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 969812446 331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055    1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
332-382 3.71e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.53  E-value: 3.71e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 969812446   332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180   1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 265-323 9.48e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 40.41  E-value: 9.48e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 969812446  265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053   1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
291-313 1.95e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.60  E-value: 1.95e-04
                           10        20
                   ....*....|....*....|...
gi 969812446   291 VHGQCVCQHNTDGPNCERCKDFF 313
Cdd:smart00180  16 DTGQCECKPNVTGRRCDRCAPGY 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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