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Conserved domains on  [gi|952977807|ref|NP_001304024|]
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N-alpha-acetyltransferase 60 isoform d [Homo sapiens]

Protein Classification

N-acetyltransferase( domain architecture ID 11418877)

N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  9175471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 27-106 2.11e-15

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 67.76  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807  27 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVL 106
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDALV 86
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 27-106 2.11e-15

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 67.76  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807  27 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVL 106
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDALV 86
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-90 2.35e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.91  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807   12 IHKEDGDILA----SNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYEN 87
Cdd:pfam00583  37 VAEEDGELVGfaslSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWA---RERGCERIFLEVAADNLAAIALYEK 113


                  ...
gi 952977807   88 RDF 90
Cdd:pfam00583 114 LGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 31-101 8.49e-08

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 48.48  E-value: 8.49e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 952977807   31 AYILSLGVVKEFRKHGIGSLLLESLKDHISTTAqdhCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYS 101
Cdd:TIGR01575  55 AHILNIAVKPEYQGQGIGRALLRELIDEAKGRG---VNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYYP 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 19-73 1.15e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.41  E-value: 1.15e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 952977807  19 ILASNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLH 73
Cdd:cd04301   14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA---RERGAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 35-86 8.36e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 34.90  E-value: 8.36e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 952977807  35 SLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYE 86
Cdd:PRK03624  73 YLAVHPDFRGRGIGRALVARLEKKL---IARGCPKINLQVREDNDAVLGFYE 121
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 27-106 2.11e-15

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 67.76  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807  27 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVL 106
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDALV 86
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-90 2.35e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.91  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807   12 IHKEDGDILA----SNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYEN 87
Cdd:pfam00583  37 VAEEDGELVGfaslSIIDDEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWA---RERGCERIFLEVAADNLAAIALYEK 113


                  ...
gi 952977807   88 RDF 90
Cdd:pfam00583 114 LGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-108 3.46e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 53.07  E-value: 3.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807   2 IVAEiknrtkihkEDGDILA-------SNFSVDTQVAYIlSLGVVKEFRKHGIGSLLLESLKDHistTAQDHCKAIYLHV 74
Cdd:COG1247   55 LVAE---------EDGEVVGfaslgpfRPRPAYRGTAEE-SIYVDPDARGRGIGRALLEALIER---ARARGYRRLVAVV 121

                         90       100       110
                 ....*....|....*....|....*....|....
gi 952977807  75 LTTNNTAINFYENRDFKQHHYLPYYYSIRGVLKD 108
Cdd:COG1247  122 LADNEASIALYEKLGFEEVGTLPEVGFKFGRWLD 155
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 27-98 1.95e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 50.38  E-value: 1.95e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 952977807  27 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHisttAQDH-CKAIYLHvltTNNTAINFYENRDFKQ--HHYLPY 98
Cdd:COG1246   49 DEDLAELRSLAVHPDYRGRGIGRRLLEALLAE----ARELgLKRLFLL---TTSAAIHFYEKLGFEEidKEDLPY 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 30-99 1.99e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 50.44  E-value: 1.99e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807  30 VAYILSLGVVKEFRKHGIGSLLLESLkdhISTTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYY 99
Cdd:COG0454   58 VLELKRLYVLPEYRGKGIGKALLEAL---LEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERYVAY 124
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 27-92 2.40e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 48.99  E-value: 2.40e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 952977807   27 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttaqdHCKAIYLHVLTTNNTAINFYENRDFKQ 92
Cdd:pfam13508  25 DEGALAELRLAVHPEYRGQGIGRALLEAAEAAA------KEGGIKLLELETTNRAAAFYEKLGFEE 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 31-101 8.49e-08

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 48.48  E-value: 8.49e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 952977807   31 AYILSLGVVKEFRKHGIGSLLLESLKDHISTTAqdhCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYS 101
Cdd:TIGR01575  55 AHILNIAVKPEYQGQGIGRALLRELIDEAKGRG---VNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYYP 122
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
30-99 1.06e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 44.51  E-value: 1.06e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807  30 VAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYY 99
Cdd:COG3393   15 VAEISGVYTHPEYRGRGLASALVAALAREA---LARGARTPFLYVDADNPAARRLYERLGFRPVGEYATV 81
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
2-91 1.78e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 45.46  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977807   2 IVAEiknrtkihkEDGDILAS------NFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHistTAQDHCKAIYLHvl 75
Cdd:COG3153   42 LVAE---------DDGEIVGHvalspvDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEA---ARERGARAVVLL-- 107

                         90
                 ....*....|....*.
gi 952977807  76 tTNNTAINFYENRDFK 91
Cdd:COG3153  108 -GDPSLLPFYERFGFR 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 19-73 1.15e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.41  E-value: 1.15e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 952977807  19 ILASNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLH 73
Cdd:cd04301   14 ASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEA---RERGAKRLRLE 65
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
38-93 1.84e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 39.40  E-value: 1.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 952977807  38 VVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTtnnTAINFYENRDFKQH 93
Cdd:COG2153   66 VLPEYRGQGLGRALMEAAIEEA---RERGARRIVLSAQA---HAVGFYEKLGFVPV 115
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 29-86 1.98e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 38.46  E-value: 1.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 952977807   29 QVAYILSLGVVKEFRKHGIGSLLLESLKDHISTTAQDhckaIYLHVLTTNNTAINFYE 86
Cdd:pfam08445  20 PGGELGALQTLPEHRRRGLGSRLVAALARGIAERGIT----PFAVVVAGNTPSRRLYE 73
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 32-93 1.98e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 36.48  E-value: 1.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 952977807   32 YILSLGVVKEFRKHGIGSLLLESLKDHISttaQDHCKAIYLhVLTTNNTAINFYENRDFKQH 93
Cdd:pfam13673  53 HISLLFVDPDYQGQGIGKALLEAVEDYAE---KDGIKLSEL-TVNASPYAVPFYEKLGFRAT 110
PRK03624 PRK03624
putative acetyltransferase; Provisional
 35-86 8.36e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 34.90  E-value: 8.36e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 952977807  35 SLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYE 86
Cdd:PRK03624  73 YLAVHPDFRGRGIGRALVARLEKKL---IARGCPKINLQVREDNDAVLGFYE 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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