interleukin-33 isoform a precursor [Homo sapiens]
Protein Classification
beta-trefoil_IL33 domain-containing protein( domain architecture ID 10633426)
beta-trefoil_IL33 domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| IL33 | pfam15095 | Interleukin 33; |
5-268 | 3.26e-155 | |||||
Interleukin 33; : Pssm-ID: 434452 Cd Length: 266 Bit Score: 432.73 E-value: 3.26e-155
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| Name | Accession | Description | Interval | E-value | |||||
| IL33 | pfam15095 | Interleukin 33; |
5-268 | 3.26e-155 | |||||
Interleukin 33; Pssm-ID: 434452 Cd Length: 266 Bit Score: 432.73 E-value: 3.26e-155
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| beta-trefoil_IL33 | cd23299 | beta-trefoil domain found in interleukin-33 (IL-33) and similar proteins; IL-33, also called ... |
118-268 | 1.20e-92 | |||||
beta-trefoil domain found in interleukin-33 (IL-33) and similar proteins; IL-33, also called interleukin-1 family member 11, or IL-1F11, or nuclear factor from high endothelial venules (NF-HEV), acts as cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. It is involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. It is also involved in activation of mast cells, basophils, eosinophils, and natural killer cells. It acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. IL-33 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466781 Cd Length: 153 Bit Score: 270.10 E-value: 1.20e-92
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| Name | Accession | Description | Interval | E-value | |||||
| IL33 | pfam15095 | Interleukin 33; |
5-268 | 3.26e-155 | |||||
Interleukin 33; Pssm-ID: 434452 Cd Length: 266 Bit Score: 432.73 E-value: 3.26e-155
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| beta-trefoil_IL33 | cd23299 | beta-trefoil domain found in interleukin-33 (IL-33) and similar proteins; IL-33, also called ... |
118-268 | 1.20e-92 | |||||
beta-trefoil domain found in interleukin-33 (IL-33) and similar proteins; IL-33, also called interleukin-1 family member 11, or IL-1F11, or nuclear factor from high endothelial venules (NF-HEV), acts as cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. It is involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. It is also involved in activation of mast cells, basophils, eosinophils, and natural killer cells. It acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. IL-33 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466781 Cd Length: 153 Bit Score: 270.10 E-value: 1.20e-92
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| beta-trefoil_IL1 | cd00100 | beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ... |
120-267 | 2.44e-17 | |||||
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466776 Cd Length: 145 Bit Score: 76.59 E-value: 2.44e-17
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| beta-trefoil_ABD_ABFB-like | cd23265 | Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family ... |
225-258 | 7.86e-03 | |||||
Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family includes alpha-L-arabinofuranosidase B (ABF B)-like proteins and otogelin-like proteins. Alpha-L-arabinofuranosidase (EC 3.2.1.55), also called ABF, or non-reducing end alpha-L-arabinofuranosidase, or arabinofuranosidase, or arabinosidase, is involved in the degradation of arabinoxylan, a major component of plant hemicellulose. It can hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan. ABF belongs to the glycosyl hydrolase 54 family. Hungateiclostridium thermocellum anti-sigma-I factor RsgI5 shows high sequence similarity with ABF B. It negatively regulates SigI5 activity through direct interaction. The OTOG subfamily includes otogelin (OTOG) and otogelin-like protein (OTOGL). OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in OTOG or OTOGL genes may cause hearing loss. Members of the ABFB family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD binds two arabinose molecules in the beta and gamma subdomains. Pssm-ID: 467807 Cd Length: 135 Bit Score: 35.72 E-value: 7.86e-03
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