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Conserved domains on  [gi|929524276|ref|NP_001300921|]
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insulin-like growth factor-binding protein 2 isoform c [Homo sapiens]

Protein Classification

TY domain-containing protein( domain architecture ID 11082431)

TY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 61-140 1.90e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 74.26  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929524276   61 CQQELDQVLERISTMRLPDergplehlySLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 140
Cdd:pfam00086   1 CERERARALEQAASGRPAS---------GLYIPNCDEDGFYKPVQC----HGSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 61-140 1.90e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 74.26  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929524276   61 CQQELDQVLERISTMRLPDergplehlySLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 140
Cdd:pfam00086   1 CERERARALEQAASGRPAS---------GLYIPNCDEDGFYKPVQC----HGSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 60-140 3.24e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 71.34  E-value: 3.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929524276  60 PCQQELDQVLERIstmrlpdergPLEHLYSLHIPNCDKHGLYNLKQCKMSLngqrGECWCVNPNtGKLIQGAPTIRGDPE 139
Cdd:cd00191    1 PCERERASALESL----------AGPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPN 65


                 .
gi 929524276 140 C 140
Cdd:cd00191   66 C 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 92-141 2.46e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 60.47  E-value: 2.46e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 929524276    92 IPNCDKHGLYNLKQCkmslNGQRGECWCVNPnTGKLIQGAPTIRGDPECH 141
Cdd:smart00211   1 IPQCDEDGNYEPVQC----DGSSGQCWCVDA-TGREIPGTRTEGGDPDCP 45
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 61-140 1.90e-18

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 74.26  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929524276   61 CQQELDQVLERISTMRLPDergplehlySLHIPNCDKHGLYNLKQCkmslNGQRGECWCVNPNtGKLIQGAPTIRGDPEC 140
Cdd:pfam00086   1 CERERARALEQAASGRPAS---------GLYIPNCDEDGFYKPVQC----HGSTGYCWCVDPE-GQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 60-140 3.24e-17

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 71.34  E-value: 3.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929524276  60 PCQQELDQVLERIstmrlpdergPLEHLYSLHIPNCDKHGLYNLKQCKMSLngqrGECWCVNPNtGKLIQGAPTIRGDPE 139
Cdd:cd00191    1 PCERERASALESL----------AGPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPD-GEEIPGTRTRGGPPN 65


                 .
gi 929524276 140 C 140
Cdd:cd00191   66 C 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 92-141 2.46e-13

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 60.47  E-value: 2.46e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 929524276    92 IPNCDKHGLYNLKQCkmslNGQRGECWCVNPnTGKLIQGAPTIRGDPECH 141
Cdd:smart00211   1 IPQCDEDGNYEPVQC----DGSSGQCWCVDA-TGREIPGTRTEGGDPDCP 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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