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Conserved domains on  [gi|809281445|ref|NP_001295036|]
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synphilin-1 isoform E [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNCAIP_SNCA_bd super family cl25051
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 146-189 6.29e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


The actual alignment was detected with superfamily member pfam16700:

Pssm-ID: 435527  Cd Length: 45  Bit Score: 65.91  E-value: 6.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 809281445  146 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 189
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-143 2.07e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  28 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 106
Cdd:COG0666  129 YNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEI 201

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 809281445 107 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 143
Cdd:COG0666  202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
 
Name Accession Description Interval E-value
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 146-189 6.29e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 65.91  E-value: 6.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 809281445  146 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 189
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-143 2.07e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  28 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 106
Cdd:COG0666  129 YNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEI 201

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 809281445 107 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 143
Cdd:COG0666  202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
28-121 1.29e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445   28 QNGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDqDGNSAVHVASQHGYLGCI 107
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 809281445  108 QTLVEYGANVTMQN 121
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-144 1.74e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  56 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 135
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                 ....*....
gi 809281445 136 HTLCSRYLV 144
Cdd:PHA02874 202 DYACIKLLI 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 90-119 9.30e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 9.30e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 809281445    90 DGNSAVHVASQHGYLGCIQTLVEYGANVTM 119
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 146-189 6.29e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 65.91  E-value: 6.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 809281445  146 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 189
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-143 2.07e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  28 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 106
Cdd:COG0666  129 YNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEI 201

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 809281445 107 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 143
Cdd:COG0666  202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-144 1.57e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  28 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 106
Cdd:COG0666   96 RNGDLEIVKLLL---EAGADVnARDKDGETPLHLAAYNGNLEIVKLLL----EAGADVNAQDNDGNTPLHLAAANGNLEI 168

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 809281445 107 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 144
Cdd:COG0666  169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
52-144 3.20e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 3.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  52 KDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSA 131
Cdd:COG0666   85 DGGNTLLHAAARNGDLEIVKLLL----EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                         90
                 ....*....|...
gi 809281445 132 ERQGHTLCSRYLV 144
Cdd:COG0666  161 AANGNLEIVKLLL 173
Ank_2 pfam12796
Ankyrin repeats (3 copies);
28-121 1.29e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445   28 QNGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDqDGNSAVHVASQHGYLGCI 107
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 809281445  108 QTLVEYGANVTMQN 121
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
58-144 1.59e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445   58 IHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYgANVTMQNHaGEKPSQSAERQGHT 137
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL----ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHL 74


                  ....*..
gi 809281445  138 LCSRYLV 144
Cdd:pfam12796  75 EIVKLLL 81
Ank_4 pfam13637
Ankyrin repeats (many copies);
56-111 5.10e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 5.10e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 809281445   56 SLIHYAGCYGQEKILLWLLQFmqeqGISLDEVDQDGNSAVHVASQHGYLGCIQTLV 111
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-143 2.09e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  28 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 106
Cdd:COG0666  162 ANGNLEIVKLLL---EAGADVnARDNDGETPLHLAAENGHLEIVKLLL----EAGADVNAKDNDGKTALDLAAENGNLEI 234

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 809281445 107 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 143
Cdd:COG0666  235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
91-144 7.17e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 7.17e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 809281445   91 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 144
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 56-144 1.74e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  56 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 135
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                 ....*....
gi 809281445 136 HTLCSRYLV 144
Cdd:PHA02874 202 DYACIKLLI 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
44-144 1.91e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.40  E-value: 1.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281445  44 AIAELSCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHA 123
Cdd:COG0666   44 LLALALADALGALLLLAAALAGDLLVALLLL----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                         90       100
                 ....*....|....*....|.
gi 809281445 124 GEKPSQSAERQGHTLCSRYLV 144
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLL 140
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 79-135 4.47e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 4.47e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 809281445  79 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 135
Cdd:PTZ00322 103 TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 90-119 9.30e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 9.30e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 809281445    90 DGNSAVHVASQHGYLGCIQTLVEYGANVTM 119
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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