NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|756398326|ref|NP_001291900|]
View 

plakophilin-4 isoform e [Homo sapiens]

Protein Classification

Arm domain-containing protein( domain architecture ID 11997863)

Arm domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 559-598 1.98e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.61  E-value: 1.98e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 756398326  559 DNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 598
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 865-900 6.26e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.26e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 756398326   865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 900
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 603-644 6.77e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 756398326   603 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 644
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 232-347 1.77e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756398326  232 PSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLP--------AARAASPySQRPASPTAIRRIGSVTSRQTSNPNGPT 303
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSP-PQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 756398326  304 PQYQTTARV-GSPLTLTDAQTRVASPSQGQVGSSSPKRSGmTAVP 347
Cdd:PHA03247 2708 PEPAPHALVsATPLPPGPAAARQASPALPAAPAPPAVPAG-PATP 2751
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 559-598 1.98e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.61  E-value: 1.98e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 756398326  559 DNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 598
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 559-599 4.68e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 4.68e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 756398326   559 DNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 599
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 865-900 6.26e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.26e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 756398326   865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 900
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 603-644 6.77e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 756398326   603 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 644
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 603-644 2.27e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.14  E-value: 2.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 756398326  603 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 644
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 232-347 1.77e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756398326  232 PSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLP--------AARAASPySQRPASPTAIRRIGSVTSRQTSNPNGPT 303
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSP-PQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 756398326  304 PQYQTTARV-GSPLTLTDAQTRVASPSQGQVGSSSPKRSGmTAVP 347
Cdd:PHA03247 2708 PEPAPHALVsATPLPPGPAAARQASPALPAAPAPPAVPAG-PATP 2751
HEAT COG1413
HEAT repeat [General function prediction only];
526-648 2.27e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756398326 526 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevcrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 604
Cdd:COG1413   13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 756398326 605 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 648
Cdd:COG1413   75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 865-900 2.74e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 2.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 756398326  865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 900
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 530-644 8.34e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756398326  530 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVCrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 608
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 756398326  609 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 644
Cdd:PLN03200  136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 559-598 1.98e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.61  E-value: 1.98e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 756398326  559 DNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLV 598
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 559-599 4.68e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.43  E-value: 4.68e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 756398326   559 DNKVKMEVCRLGGIKHLVDLLDHRVLEVQKNACGALRNLVF 599
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 865-900 6.26e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.26e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 756398326   865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 900
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 603-644 6.77e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.77e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 756398326   603 TDENKIAMKNVGGIPALLRLLRKSiDAEVRELVTGVLWNLSS 644
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 603-644 2.27e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.14  E-value: 2.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 756398326  603 TDENKIAMKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSS 644
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 232-347 1.77e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756398326  232 PSRGSLRTSLGSGFGSPSVTDPRPLNPSAYSSTTLP--------AARAASPySQRPASPTAIRRIGSVTSRQTSNPNGPT 303
Cdd:PHA03247 2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSP-PQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 756398326  304 PQYQTTARV-GSPLTLTDAQTRVASPSQGQVGSSSPKRSGmTAVP 347
Cdd:PHA03247 2708 PEPAPHALVsATPLPPGPAAARQASPALPAAPAPPAVPAG-PATP 2751
HEAT COG1413
HEAT repeat [General function prediction only];
526-648 2.27e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756398326 526 RDPE-LPEVIHMLQHQFPSVQANAAAYLQHLcfGDNKVkmevcrlggIKHLVDLLDHRVLEVQKNACGALRNLvfgkstd 604
Cdd:COG1413   13 GDPAaVPALIAALADEDPDVRAAAARALGRL--GDPRA---------VPALLEALKDPDPEVRAAAAEALGRI------- 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 756398326 605 enkiamKNVGGIPALLRLLrKSIDAEVRELVTGVLWNLSSCDAV 648
Cdd:COG1413   75 ------GDPEAVPALIAAL-KDEDPEVRRAAAEALGRLGDPAAV 111
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 865-900 2.74e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 2.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 756398326  865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMA 900
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 530-644 8.34e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756398326  530 LPEVIHMLQHQFPSVQANAAAYLQHLCfGDNKVKMEVCrLGG-IKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDEnkI 608
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLC-KEEDLRVKVL-LGGcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDH--V 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 756398326  609 AMK---NVGGIPALLRLL--RKSIDAEVRELVTGVLWNLSS 644
Cdd:PLN03200  136 GSKifsTEGVVPSLWDQLqpGNKQDKVVEGLLTGALRNLCG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH