NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|665821167|ref|NP_001287880|]
View 

zinc finger protein 91 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-55 2.72e-22

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 91.11  E-value: 2.72e-22
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665821167     13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIC 55
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-676 1.59e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 90.14  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  288 KPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKAFKRLSTLTKHK 365
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  366 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRFHTREKPFKCKEcgkAFIWS 442
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  443 STLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKA 522
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  523 FKQFSTLTTHKIIH-------AGKKLYKCEECGKAFNHSSSLSTHK--IIHTGE--KSYKCEE--CGKAFLWSSTLRRHK 589
Cdd:COG5048   264 SLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  590 RIHTGEKPYKC--EECGKAFSHSSALAKHKRI--HTGEKPYKCKE-----CGKAFSNSSTLANHKITHTEEKP--YKCKE 658
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410
                  ....*....|....*...
gi 665821167  659 CDKTFKRLSTLTKHKIIH 676
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
596-1037 1.19e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  596 KPYKCEECGKAFSHSSALAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKTFKRLSTLTKHK 673
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  674 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRIHTREKPFKCKEcgkAFIWS 750
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  751 STLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTgekpykckecgkafkhSSALAKHKIIHAGEKLYKCEecgka 830
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS----------------SSSLPLTTNSQLSPKSLLSQ----- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  831 fNQSSNLTTHKIIHTKEKPSKSeECDKAFIWSS----TLTEHKRIHTRektYKCEECGKAFSQPSHLTTHKRM--HTGE- 903
Cdd:COG5048   244 -SPSSLSSSDSSSSASESPRSS-LPTASSQSSSpnesDSSSEKGFSLP---IKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  904 -KPYKCEE--CGKAFSQSSTLTTHKIIHTGEKPYKC--EECGKAFRKSST-----LTEHKIIHTGEKPYKCE--ECGKAF 971
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665821167  972 SQSSTLTRHTRMHTGEKP--YKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHK 1037
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1043-1122 4.54e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167 1043 EKPYKCE--ECGKAFSQSSTLTRHkRLHtgekpykcGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNH 1120
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 665821167 1121 KK 1122
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-273 4.34e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.34e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   249 LTRHKRIHTGEKPYKCEECGKAFSH 273
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-55 2.72e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 91.11  E-value: 2.72e-22
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665821167     13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIC 55
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 7.31e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 7.31e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665821167    12 LLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLG 53
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-676 1.59e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 90.14  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  288 KPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKAFKRLSTLTKHK 365
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  366 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRFHTREKPFKCKEcgkAFIWS 442
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  443 STLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKA 522
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  523 FKQFSTLTTHKIIH-------AGKKLYKCEECGKAFNHSSSLSTHK--IIHTGE--KSYKCEE--CGKAFLWSSTLRRHK 589
Cdd:COG5048   264 SLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  590 RIHTGEKPYKC--EECGKAFSHSSALAKHKRI--HTGEKPYKCKE-----CGKAFSNSSTLANHKITHTEEKP--YKCKE 658
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410
                  ....*....|....*...
gi 665821167  659 CDKTFKRLSTLTKHKIIH 676
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIH 441
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 4.21e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 4.21e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 665821167   13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFL 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
596-1037 1.19e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  596 KPYKCEECGKAFSHSSALAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKTFKRLSTLTKHK 673
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  674 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRIHTREKPFKCKEcgkAFIWS 750
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  751 STLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTgekpykckecgkafkhSSALAKHKIIHAGEKLYKCEecgka 830
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS----------------SSSLPLTTNSQLSPKSLLSQ----- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  831 fNQSSNLTTHKIIHTKEKPSKSeECDKAFIWSS----TLTEHKRIHTRektYKCEECGKAFSQPSHLTTHKRM--HTGE- 903
Cdd:COG5048   244 -SPSSLSSSDSSSSASESPRSS-LPTASSQSSSpnesDSSSEKGFSLP---IKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  904 -KPYKCEE--CGKAFSQSSTLTTHKIIHTGEKPYKC--EECGKAFRKSST-----LTEHKIIHTGEKPYKCE--ECGKAF 971
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665821167  972 SQSSTLTRHTRMHTGEKP--YKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHK 1037
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1043-1122 4.54e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167 1043 EKPYKCE--ECGKAFSQSSTLTRHkRLHtgekpykcGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNH 1120
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 665821167 1121 KK 1122
Cdd:COG5189   418 RK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
585-609 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.24e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   585 LRRHKRIHTGEKPYKCEECGKAFSH 609
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-273 4.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.34e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   249 LTRHKRIHTGEKPYKCEECGKAFSH 273
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
753-777 4.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.51e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   753 LTRHKRIHTGEKPYKCEECGKAFSR 777
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1061-1084 3.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.76e-03
                           10        20
                   ....*....|....*....|....
gi 665821167  1061 LTRHKRLHTGEKPYKCGECGKAFK 1084
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 652-700 4.84e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 4.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 665821167  652 KPYkCKECDKTFKRLSTLtkhkIIHAGEKLYKCEECGKAFNRSSNLTIH 700
Cdd:cd20908     1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-55 2.72e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 91.11  E-value: 2.72e-22
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 665821167     13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLGIC 55
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 7.31e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 7.31e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 665821167    12 LLTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFLG 53
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-676 1.59e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 90.14  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  288 KPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKAFKRLSTLTKHK 365
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  366 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRFHTREKPFKCKEcgkAFIWS 442
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  443 STLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKA 522
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  523 FKQFSTLTTHKIIH-------AGKKLYKCEECGKAFNHSSSLSTHK--IIHTGE--KSYKCEE--CGKAFLWSSTLRRHK 589
Cdd:COG5048   264 SLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  590 RIHTGEKPYKC--EECGKAFSHSSALAKHKRI--HTGEKPYKCKE-----CGKAFSNSSTLANHKITHTEEKP--YKCKE 658
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPynCKNPP 423

                         410
                  ....*....|....*...
gi 665821167  659 CDKTFKRLSTLTKHKIIH 676
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIH 441
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-52 4.21e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 4.21e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 665821167   13 LTFRDVAIEFSPEEWQCLDTAQQNLYRNVMLENYRNLAFL 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
596-1037 1.19e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 87.44  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  596 KPYKCEECGKAFSHSSALAKHKRIHTGEKPYKC--KECGKAFSNSSTLANHKITHTEEKPYKCkeCDKTFKRLSTLTKHK 673
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  674 IIHAGEKLYKCE-ECGKAFNRSSNLTIHKFIHTGEKPYKCEEcgKAFNWSSSLTKH--KRIHTREKPFKCKEcgkAFIWS 750
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPL--PGNNSSSVNTPQsnSLHPPLPANSLSKD---PSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  751 STLTRHKRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTgekpykckecgkafkhSSALAKHKIIHAGEKLYKCEecgka 830
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS----------------SSSLPLTTNSQLSPKSLLSQ----- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  831 fNQSSNLTTHKIIHTKEKPSKSeECDKAFIWSS----TLTEHKRIHTRektYKCEECGKAFSQPSHLTTHKRM--HTGE- 903
Cdd:COG5048   244 -SPSSLSSSDSSSSASESPRSS-LPTASSQSSSpnesDSSSEKGFSLP---IKSKQCNISFSRSSPLTRHLRSvnHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  904 -KPYKCEE--CGKAFSQSSTLTTHKIIHTGEKPYKC--EECGKAFRKSST-----LTEHKIIHTGEKPYKCE--ECGKAF 971
Cdd:COG5048   319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665821167  972 SQSSTLTRHTRMHTGEKP--YKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFISSSTLNGHK 1037
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
708-1122 1.90e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.67  E-value: 1.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  708 KPYKCEECGKAFNWSSSLTKHKRIHTREKPFKC--KECGKAFIWSSTLTRHKRIHTGEKPYkcEECGKAFSRSSTLTKHK 785
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  786 TIHTGEKP-YKCKECGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHKIIHTKEKPSKSEEcdkAFIWSST 864
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKD---PSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  865 LTEHKRIHTREKTYKCEECGKAFSQPSHLTTHKRMHTgEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFR 944
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  945 KSSTLTEHKIIHTGE-------KPYKCEECGKAFSQSSTLTRHTRM--HTGE--KPYKCEE--CGKAFNRSSKLTTHKII 1011
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167 1012 HTGEKPYKC--EECGKAFISSSTLNGHKRIHTR-----EKPYKCE--ECGKAFSQSSTLTRHKRLHTGEKPY--KCGECG 1080
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 665821167 1081 KAFKESSALTKHKIIHTGEKPYKCEKCGKaFNQSSILTNHKK 1122
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
680-1065 8.24e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.67  E-value: 8.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  680 KLYKCEECGKAFNRSSNLTIHKFIHTGEKPYKC--EECGKAFNWSSSLTKHKRIHTREKPFKC-KECGKAFIWSSTLTRH 756
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  757 KRIHTGEKPYKCEECGKAFSRSSTLTKHKTIHTGEKPYKCKEC-GKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSS 835
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  836 NLTTHKIIHTKEKPSKS---------EECDKAFIWSSTLTEHKRIHTREKTYK------------CEECG------KAFS 888
Cdd:COG5048   192 VSTSIPSSSENSPLSSSysipssssdQNLENSSSSLPLTTNSQLSPKSLLSQSpsslsssdssssASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  889 QPSHLTTHKRMHTG-EKPYKCEECGKAFSQSSTLTTHK--IIHTGE--KPYKCEE--CGKAFRKSSTLTEHKIIHTGEKP 961
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  962 YKC--EECGKAFSQSST--LTRHTRMHTGEKPYKCEE-----CGKAFNRSSKLTTHKIIHTGEKPY--KCEECGKAFISS 1030
Cdd:COG5048   352 AKEklLNSSSKFSPLLNnePPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 665821167 1031 STLNGHKRIHTREKPYKCEECGKAFSQSSTLTRHK 1065
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
539-925 4.09e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 4.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  539 KKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKC--EECGKAFLWSSTLRRHKRIHTGEKPYkcEECGKAFSHSSALAKH 616
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  617 KRIHTGEKP-YKCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKTFKRLSTL--TKHKIIHAGEKLYKCEECGKAFNR 693
Cdd:COG5048   109 SLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsNSLHPPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  694 SSNLT-----IHKFIHTG-----------------EKPYKCEECGKAFNWSSSLTKHKRIHTREKPFKCKECGKAFIWSS 751
Cdd:COG5048   189 SSNVStsipsSSENSPLSssysipssssdqnlensSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  752 TLTRHKRIHTGE-------KPYKCEECGKAFSRSSTLTKHK--TIHTGE--KPYKCKE--CGKAFKHSSALAKHKIIHAG 818
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  819 EKLYKC--EECGKAFNQSSN------LTTHKIIHTKEKPSKSEECDKAFIWS-STLTEHKRIHTREKT--YKCEECGKAF 887
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSNSCIRNFKRdSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 665821167  888 SQPSHLTTHKRMHTGEKPYKCEECGKAFSQSSTLTTHK 925
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-565 2.20e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 2.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  203 DKPYKCEECGKAFKQLSTLTTHKIICAKEKIYKC--EECGKAFLWSSTLTRHKRIHTGEKPYKCE-ECGKAFSHSSTLAK 279
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  280 HKRIHTGEKPYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEEKPykckeCDKAFKRLS 359
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL-----SKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  360 TLTKHKIIHAGEKLYKCEECGKA------------FNRSSNLTIHKFIHTGEKPYKCE---------------ECGKAFN 412
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  413 WSSSLTKHKRFHT-------REKPFKCKECGKAFIWSSTLTRHKR--IHTGE--KPYKCEE--CGKAFRQSSTLTKHKII 479
Cdd:COG5048   266 PTASSQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  480 HTG--EKPYKFEECGKAFRQSLTLNKHKIIHSREKPYKCKE-------CGKAFKQFSTLTTHKIIHAGK--KLYKCEECG 548
Cdd:COG5048   346 HTSisPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFrpYNCKNPPCS 425

                         410
                  ....*....|....*..
gi 665821167  549 KAFNHSSSLSTHKIIHT 565
Cdd:COG5048   426 KSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-477 2.12e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  288 KPYKCEECGKAFSRSSTLAKHKR--IHTGE--KPYKCKE--CGKAFSNSSTLANHKITHTEEKPYKCK--ECDKAFKRLS 359
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  360 TLTKHKIIHageklykceecgkafNRSSNLTIHKFIHTGEKpykceeCGKAFNWSSSLTKHKRFHTREKP--FKCKECGK 437
Cdd:COG5048   368 NNEPPQSLQ---------------QYKDLKNDKKSETLSNS------CIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 665821167  438 AFIWSSTLTRHKRIHTGEKPYKCEECGKAFRQSSTLTKHK 477
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 245-365 3.75e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.87  E-value: 3.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  245 WSSTLTRHKRIHTGEKPYKCEECGKAFSHSSTL---AKHKRIHT-GEKPYKCE--ECGKAFSRSSTLAKHKrihtgekpy 318
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 665821167  319 KCKECGKAFSNSSTLANHKITHTEEKPYKCKECDKAFKRLSTLTKHK 365
Cdd:COG5189   372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 1043-1122 4.54e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.49  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167 1043 EKPYKCE--ECGKAFSQSSTLTRHkRLHtgekpykcGECGKAFKESSALTKHKIIHTGEKPYKCEKCGKAFNQSSILTNH 1120
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ..
gi 665821167 1121 KK 1122
Cdd:COG5189   418 RK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 581-673 1.32e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.95  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  581 WSSTLRRHKRIHTGEKPYKCEECGKAFSHSSAL---AKHKRIHT-GEKPYKCK--ECGKAFSNSSTLANHK-------IT 647
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKL 380

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 665821167  648 H------------TEEKPYKCKECDKTFKRLSTLTKHK 673
Cdd:COG5189   381 HenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 454-533 4.94e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  454 GEKPYKCE--ECGKAFRQSSTLTKHKiihtgekpyKFEECGKAFRQSLTLNKHKIIHSREKPYKCKECGKAFKQFSTLTT 531
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 665821167  532 HK 533
Cdd:COG5189   417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
834-1125 8.05e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  834 SSNLTTHKIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTYKC--EECGKAFSQPSHLTTHKRMHTGEKPYkcEEC 911
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  912 GKAFSQSSTLTTHKIIHTGEKPYKCE-----ECGKAFRKSSTLTEHKIIHTGEKPYK-CEECGKAFSQSS---------- 975
Cdd:COG5048    96 KSLPLSNSKASSSSLSSSSSNSNDNNllsshSLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNslhpplpans 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  976 ---------TLTRHTRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAF----ISSSTLNGHKRIHTR 1042
Cdd:COG5048   176 lskdpssnlSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167 1043 EKPYKCEECGKafSQSSTLTRHKRLHTGE-----KPYKCGECGKAFKESSALTKHK--IIHTGE--KPYKC--EKCGKAF 1111
Cdd:COG5048   256 SASESPRSSLP--TASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLF 333

                         330
                  ....*....|....
gi 665821167 1112 NQSSILTNHKKIHT 1125
Cdd:COG5048   334 SRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
585-609 1.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.24e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   585 LRRHKRIHTGEKPYKCEECGKAFSH 609
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 861-985 1.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  861 WSSTLTEHKRIHTREKTYKCEECGKAFSQPSHLT--THKRMH--TGEKPYKCE--ECGKAFSQSSTLTTHKiihtgekpy 934
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNidTPSRMLkvKDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 665821167  935 KCEECGKAFRKSSTLTEHKIIHTGEKPYKCEECGKAFSQSSTLTRHtRMHT 985
Cdd:COG5189   372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
249-273 4.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.34e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   249 LTRHKRIHTGEKPYKCEECGKAFSH 273
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
753-777 4.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 4.51e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   753 LTRHKRIHTGEKPYKCEECGKAFSR 777
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
445-469 5.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.88e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   445 LTRHKRIHTGEKPYKCEECGKAFRQ 469
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
977-1001 7.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.23e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   977 LTRHTRMHTGEKPYKCEECGKAFNR 1001
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
612-637 7.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 7.37e-04
                           10        20
                   ....*....|....*....|....*.
gi 665821167   612 ALAKHKRIHTGEKPYKCKECGKAFSN 637
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 721-841 7.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  721 WSSSLTKHKRIHTREKPFKCKECGKAFIWSSTL---TRHKRIHT-GEKPYKCE--ECGKAFSRSSTLTKHKtihtgekpy 794
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM--------- 371

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 665821167  795 KCKECGKAFKHSSALAKHKIIHAGEKLYKCEECGKAFNQSSNLTTHK 841
Cdd:COG5189   372 LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
892-917 8.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 8.37e-04
                           10        20
                   ....*....|....*....|....*.
gi 665821167   892 HLTTHKRMHTGEKPYKCEECGKAFSQ 917
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-301 9.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 9.70e-04
                           10        20
                   ....*....|....*....|....*
gi 665821167   277 LAKHKRIHTGEKPYKCEECGKAFSR 301
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-329 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.02e-03
                           10        20
                   ....*....|....*....|....*
gi 665821167   305 LAKHKRIHTGEKPYKCKECGKAFSN 329
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 314-393 1.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  314 GEKPYKCK--ECGKAFSNSSTLANHKItHTEEKPYKCKECDKafkrlstlTKHKIIHAGEKLYKCEECGKAFNRSSNLTI 391
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 665821167  392 HK 393
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 958-1037 1.90e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  958 GEKPYKCE--ECGKAFSQSSTLTRHtRMHTgekpykceECGKAFNRSSKLTTHKIIHTGEKPYKCEECGKAFissSTLNG 1035
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY---KNLNG 413


                  ..
gi 665821167 1036 HK 1037
Cdd:COG5189   414 LK 415
zf-H2C2_2 pfam13465
Zinc-finger double domain;
781-805 3.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 3.12e-03
                           10        20
                   ....*....|....*....|....*
gi 665821167   781 LTKHKTIHTGEKPYKCKECGKAFKH 805
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1016-1127 3.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167 1016 KPYKCEECGKAFISSSTLNGHKRIHTREKPYKC--EECGKAFSQSSTLTRHKRLHTGEKPYKCgeCGKAFKESSALTKHK 1093
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 665821167 1094 IIHTGEKPYKCEKC-GKAFNQSSILTNHKKIHTIT 1127
Cdd:COG5048   110 LSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSIS 144
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1061-1084 3.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.76e-03
                           10        20
                   ....*....|....*....|....
gi 665821167  1061 LTRHKRLHTGEKPYKCGECGKAFK 1084
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-506 4.23e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  289 PYKCEECGKAFSRSSTLAKHKRIHTGEKPYKCKECGKAFSNSSTLANHKITHTEE-------KPYKCKECDKAFKRLSTL 361
Cdd:COG5048   226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPL 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  362 TKHK--IIHAGEKLYKCEE----CGKAFNRSSNLTIHKFIHTGEKPYKCEEC-------GKAFNWSSSLTKHKRFHTREK 428
Cdd:COG5048   306 TRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDK 385

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821167  429 PFKC--KECGKAFIWSSTLTRHKRIHTGEKPY--KCEECGKAFRQSSTLTKHKIIHTgEKPYKFEECGKAFRQSLTLNKH 504
Cdd:COG5048   386 KSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464


                  ..
gi 665821167  505 KI 506
Cdd:COG5048   465 GK 466
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 652-700 4.84e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 4.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 665821167  652 KPYkCKECDKTFKRLSTLtkhkIIHAGEKLYKCEECGKAFNRSSNLTIH 700
Cdd:cd20908     1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1088-1113 4.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.86e-03
                           10        20
                   ....*....|....*....|....*.
gi 665821167  1088 ALTKHKIIHTGEKPYKCEKCGKAFNQ 1113
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
949-973 5.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 5.10e-03
                           10        20
                   ....*....|....*....|....*
gi 665821167   949 LTEHKIIHTGEKPYKCEECGKAFSQ 973
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-357 8.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 8.42e-03
                           10        20
                   ....*....|....*....|....*
gi 665821167   333 LANHKITHTEEKPYKCKECDKAFKR 357
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
724-747 8.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 8.76e-03
                           10        20
                   ....*....|....*....|....
gi 665821167   724 SLTKHKRIHTREKPFKCKECGKAF 747
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH