NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|557786217|ref|NP_001273574|]
View 

alpha-adducin isoform e [Homo sapiens]

Protein Classification

class II aldolase/adducin head domain-containing protein( domain architecture ID 842)

class II aldolase/adducin head domain-containing protein involved in catalyzing central steps of carbohydrate metabolism; it promotes carbon-carbon bond cleavage and stabilizes enolate intermediates using divalent cations

Gene Symbol:  ADD3
PubMed:  10581174

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Aldolase_II super family cl00214
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 145-391 2.49e-99

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


The actual alignment was detected with superfamily member PRK07044:

Pssm-ID: 469663  Cd Length: 252  Bit Score: 304.46  E-value: 2.49e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044  17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 225 SAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL-GEVAYHDYHGILVDEEEKVLIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044  95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLNPEKYKAKSRSPGSPVGEGtgsppkwqIGEQEFEALMRM 383
Cdd:PRK07044 174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAG--------AGELAWPALLRK 242

                        250
                 ....*....|
gi 557786217 384 LD--NLGYRT 391
Cdd:PRK07044 243 LDriDPGYRD 252
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 145-391 2.49e-99

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 304.46  E-value: 2.49e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044  17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 225 SAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL-GEVAYHDYHGILVDEEEKVLIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044  95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLNPEKYKAKSRSPGSPVGEGtgsppkwqIGEQEFEALMRM 383
Cdd:PRK07044 174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAG--------AGELAWPALLRK 242

                        250
                 ....*....|
gi 557786217 384 LD--NLGYRT 391
Cdd:PRK07044 243 LDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 142-352 1.25e-68

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 222.63  E-value: 1.25e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 142 EKLLRcKLAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIV--DRGSTNLGvnqa 219
Cdd:cd00398    1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSAR-DRDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETP---- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 220 gftLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL---GEVAYHDYHGILvDEEEKVLIQKNLG-PKSK 295
Cdd:cd00398   75 ---LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfPNSK 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 557786217 296 VLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGG--PDNLVLLNPEKYKAK 352
Cdd:cd00398  151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 145-341 7.05e-58

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 194.28  E-value: 7.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGstnlGVNQAGFTLH 224
Cdd:COG0235    6 LREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSSETPLH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 225 SAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPIS-PEAL-SLGEVAYHDYHGIlVDEEEKVLIQKNLGpKSKVLILRNH 302
Cdd:COG0235   80 LAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEqTEAAaFLGDVPVVPYAGP-GTEELAEAIAEALG-DRPAVLLRNH 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 557786217 303 GLVSVGESVEEAFYYIHNLVVACEIQVRTLAsAGGPDNL 341
Cdd:COG0235  158 GVVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 147-329 5.24e-56

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 188.14  E-value: 5.24e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217  147 CKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGstnLGVNqAGFTLHSA 226
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217  227 IYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL--GEVAYHDYHGiLVDEEEKVLIQKNLGPKSKVLILRNHGL 304
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 557786217  305 VSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 149-329 1.84e-53

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 181.68  E-value: 1.84e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217   149 LAAFYRLADLFGWSQLIYNHITTRVNsEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGSTnlGVNQAGFTLHSAIY 228
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217   229 AARPDVKCVVHIHTPAGAAVSAM--KCGLLPIS-PEALSLGEVAYHDYHGILVDEEEKV-LIQKNLGPK---SKVLILRN 301
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEqAAAFLGGEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 557786217   302 HGLVSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
 
Name Accession Description Interval E-value
PRK07044 PRK07044
aldolase II superfamily protein; Provisional
 145-391 2.49e-99

aldolase II superfamily protein; Provisional


Pssm-ID: 235916  Cd Length: 252  Bit Score: 304.46  E-value: 2.49e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrgSTNLGVNQAGFTLH 224
Cdd:PRK07044  17 ARVDLAAAYRLVALLGWDDLIYTHISARVPGEEHHFLINPYGLLFDEITASNLVKIDLDGNVVD--DSPYPVNPAGFTIH 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 225 SAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL-GEVAYHDYHGILVDEEEKVLIQKNLGPKsKVLILRNHG 303
Cdd:PRK07044  95 SAIHAARPDAHCVMHTHTTAGVAVSAQRDGLLPLSQHALQFyGRLAYHDYEGIALDLDEGERLVADLGDK-PAMLLRNHG 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 304 LVSVGESVEEAFYYIHNLVVACEIQVRTLaSAGGPdnLVLLNPEKYKAKSRSPGSPVGEGtgsppkwqIGEQEFEALMRM 383
Cdd:PRK07044 174 LLTVGRTVAEAFLLMYTLERACEIQVAAQ-AGGGE--LVLPPPEVAERTARQSLFDPGAG--------AGELAWPALLRK 242

                        250
                 ....*....|
gi 557786217 384 LD--NLGYRT 391
Cdd:PRK07044 243 LDriDPGYRD 252
Aldolase_II cd00398
Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes ...
 142-352 1.25e-68

Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). Class II enzymes are further divided into two sub-classes A and B. This family includes class II A aldolases and adducins which has not been ascribed any enzymatic function. Members of this class are primarily bacterial and eukaryotic in origin and include L-fuculose-1-phosphate, L-rhamnulose-1-phosphate aldolases and L-ribulose-5-phosphate 4-epimerases. They all share the ability to promote carbon-carbon bond cleavage and stabilize enolate intermediates using divalent cations.


Pssm-ID: 238232 [Multi-domain]  Cd Length: 209  Bit Score: 222.63  E-value: 1.25e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 142 EKLLRcKLAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIV--DRGSTNLGvnqa 219
Cdd:cd00398    1 EKLKR-KIIAACLLLDLYGWVTGTGGNVSAR-DRDRGYFLITPSGVDYEEMTASDLVVVDAQGKVVegKKPSSETP---- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 220 gftLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL---GEVAYHDYHGILvDEEEKVLIQKNLG-PKSK 295
Cdd:cd00398   75 ---LHLALYRARPDIGCIVHTHSTHATAVSQLKEGLIPAGHTACAVyftGDIPCTPYMTPE-TGEDEIGTQRALGfPNSK 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 557786217 296 VLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASAGG--PDNLVLLNPEKYKAK 352
Cdd:cd00398  151 AVLLRNHGLFAWGPTLDEAFHLAVVLEVAAEIQLKALSMGGQlpPISLELLNKEYLRKH 209
AraD COG0235
5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar ...
 145-341 7.05e-58

5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) [Amino acid transport and metabolism, Carbohydrate transport and metabolism]; 5-methylthioribulose/5-deoxyribulose/Fuculose 1-phosphate aldolase (methionine salvage, sugar degradation) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440005 [Multi-domain]  Cd Length: 208  Bit Score: 194.28  E-value: 7.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 145 LRCKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGstnlGVNQAGFTLH 224
Cdd:COG0235    6 LREELAAAGRRLARRGLVDGTAGNISVRL--DDDRFLITPSGVDFGELTPEDLVVVDLDGNVVEGD----LKPSSETPLH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 225 SAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPIS-PEAL-SLGEVAYHDYHGIlVDEEEKVLIQKNLGpKSKVLILRNH 302
Cdd:COG0235   80 LAIYRARPDVGAVVHTHSPYATALSALGEPLPPLEqTEAAaFLGDVPVVPYAGP-GTEELAEAIAEALG-DRPAVLLRNH 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 557786217 303 GLVSVGESVEEAFYYIHNLVVACEIQVRTLAsAGGPDNL 341
Cdd:COG0235  158 GVVVWGKDLAEAFDRAEVLEEAARIQLLALA-LGGPLVL 195
Aldolase_II pfam00596
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 147-329 5.24e-56

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 459862 [Multi-domain]  Cd Length: 178  Bit Score: 188.14  E-value: 5.24e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217  147 CKLAAFYRLADLFGWSQLIYNHITTRVnsEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGstnLGVNqAGFTLHSA 226
Cdd:pfam00596   1 EELAAAGRLLARRGLVEGTGGNISVRL--PGDGFLITPSGVDFGELTPEDLVVVDLDGNVVEGG---LKPS-SETPLHLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217  227 IYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL--GEVAYHDYHGiLVDEEEKVLIQKNLGPKSKVLILRNHGL 304
Cdd:pfam00596  75 IYRARPDAGAVVHTHSPYATALSLAKEGLPPITQEAADFlgGDIPIIPYYT-PGTEELGERIAEALGGDRKAVLLRNHGL 153

                         170       180
                  ....*....|....*....|....*
gi 557786217  305 VSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:pfam00596 154 LVWGKTLEEAFYLAEELERAAEIQL 178
Aldolase_II smart01007
Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and ...
 149-329 1.84e-53

Class II Aldolase and Adducin N-terminal domain; This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.


Pssm-ID: 214970 [Multi-domain]  Cd Length: 185  Bit Score: 181.68  E-value: 1.84e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217   149 LAAFYRLADLFGWSQLIYNHITTRVNsEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDRGSTnlGVNQAGFTLHSAIY 228
Cdd:smart01007   1 LAAACRLLARRGLVEGTGGNISARVG-EEDLFLITPSGVDFGELTASDLVVVDLDGNVVEGGGG--PKPSSETPLHLAIY 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217   229 AARPDVKCVVHIHTPAGAAVSAM--KCGLLPIS-PEALSLGEVAYHDYHGILVDEEEKV-LIQKNLGPK---SKVLILRN 301
Cdd:smart01007  78 RARPDVGAVVHTHSPYATALAALgkPLPLLPTEqAAAFLGGEIPYAPYAGPGTELAEEGaELAEALAEAlpdRPAVLLRN 157

                          170       180
                   ....*....|....*....|....*...
gi 557786217   302 HGLVSVGESVEEAFYYIHNLVVACEIQV 329
Cdd:smart01007 158 HGLLVWGKTLEEAFDLAEELEEAAEIQL 185
PRK06661 PRK06661
hypothetical protein; Provisional
 149-334 9.02e-44

hypothetical protein; Provisional


Pssm-ID: 168637  Cd Length: 231  Bit Score: 156.92  E-value: 9.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 149 LAAFYRLADLFGWSQLIYNHITTRvNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrgSTNLGVNQAGFTLHSAIY 228
Cdd:PRK06661   7 LAAAYRIMAYLSLDDHTYTHLSAR-PKNADFYYIYPFGLRFEEVTTENLLKVSLDGQILE--GEEYQYNKTGYFIHGSIY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 229 AARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSLGE-VAYHDYHGILVDEE-EKVLIQKNLGpKSKVLILRNHGLVS 306
Cdd:PRK06661  84 KTRPDISAIFHYHTPASIAVSALKCGLLPISQWALHFYDrISYHNYNSLALDADkQSSRLVNDLK-QNYVMLLRNHGAIT 162

                        170       180
                 ....*....|....*....|....*...
gi 557786217 307 VGESVEEAFYYIHNLVVACEIQVRTLAS 334
Cdd:PRK06661 163 CGKTIHEAMFYTYHLEQACKTQCLLNST 190
PRK06208 PRK06208
class II aldolase/adducin family protein;
148-361 4.92e-42

class II aldolase/adducin family protein;


Pssm-ID: 235743  Cd Length: 274  Bit Score: 153.61  E-value: 4.92e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 148 KLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrgsTNLGVNQAGFTLHSAI 227
Cdd:PRK06208  46 RLAAAFRLFARFGFDEGLAGHITARDPELPDHFWVNPLGVHFSQIKVSDLLLVDHDGEVVE---GDRPLNRAAFAIHSAI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 228 YAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSLGE--VAYHDYHGILVDEEEKVLIQKNLGPKsKVLILRNHGLV 305
Cdd:PRK06208 123 HEARPDVVAAAHTHSTYGKAWSTLGRPLDPITQDACAFYEdhALFDDFTGVVVDTSEGRRIAAALGTH-KAVILQNHGLL 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 557786217 306 SVGESVEEA-FYYIhNLVVACEIQVrtLASAGGPdnLVLLNPEKYKAKSRSPGSPVG 361
Cdd:PRK06208 202 TVGPSVDAAaWWFI-ALERACQTQL--LAEAAGP--PQPIDHETARHTRSQVGSEYG 253
PRK06486 PRK06486
aldolase;
114-385 1.17e-26

aldolase;


Pssm-ID: 235814  Cd Length: 262  Bit Score: 109.42  E-value: 1.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 114 MA-ALNMSLGMVTPVNDLRGSDSIAYdkgeklLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEV 192
Cdd:PRK06486   1 MAhSLTTDSAPPAGNRPLLDSDAVAQ------ARVDLAACFRAAARHGLEEGICNHFSAVLPGHDDLFLVNPYGYAFSEI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 193 TASSLVKINLQGDIVD-RGStnlgVNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMK-CGLLPISPEALSL-GEVA 269
Cdd:PRK06486  75 TASDLLICDFDGNVLAgRGE----PEATAFFIHARIHRAIPRAKAAFHTHMPYATALSLTEgRPLTTLGQTALKFyGRTA 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 270 Y-HDYHGILVDEEEKVLIQKNLGPKSkVLILRNHGLVSVGESVEEAF---YYihnLVVACEIQVRTLaSAGGPdnLVLLN 345
Cdd:PRK06486 151 VdEDYNGLALDAAEGDRIARAMGDAD-IVFLKNHGVMVCGPRIAEAWddlYY---LERACEVQVLAM-STGRP--LVPVD 223

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 557786217 346 PEKYKAKSRspgspvgegtgsppKWQIGEQE-----FEALMRMLD 385
Cdd:PRK06486 224 PAIAAAVAR--------------QMREGDREsarlhLEALRRTLD 254
PRK07490 PRK07490
hypothetical protein; Provisional
 135-385 2.28e-20

hypothetical protein; Provisional


Pssm-ID: 236031 [Multi-domain]  Cd Length: 245  Bit Score: 90.93  E-value: 2.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 135 SIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKINlqGDIVDRGSTNL 214
Cdd:PRK07490   1 MTMALSDEEQIRVDLAAAFRWIARLGMHEAVANHFSAAVSADGKQFLLNPKWKHFSRIRASDLLLLD--ADDPSTAERPD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 215 GVNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCG-LLPISPE-ALSLGEVAYHDYHGILVDEEEKVLIQKNLGP 292
Cdd:PRK07490  79 VPDATAWAIHGQIHRRLPHARCVMHVHSVYATALACLADPtLPPIDQNtARFFNRVAVDTLYGGMALEEEGERLAGLLGD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 293 KSkVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLASaGGPdnLVLLNPEkykaksrspgspVGEGTGSppKWQ- 371
Cdd:PRK07490 159 KR-RLLMGNHGVLVTGDTVAEAFDDLYYFERACQTYITALST-GQP--LRVLSDA------------VAEKTAR--DWEd 220

                        250
                 ....*....|....*..
gi 557786217 372 ---IGEQEFEALMRMLD 385
Cdd:PRK07490 221 ypgFSRQHFAELKALLD 237
PRK07090 PRK07090
class II aldolase/adducin domain protein; Provisional
 145-338 3.56e-19

class II aldolase/adducin domain protein; Provisional


Pssm-ID: 180832  Cd Length: 260  Bit Score: 87.77  E-value: 3.56e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 145 LRCKLAAFYRLADLFGWSQLIYNHITTRvnSEQEH-FLIVPFGLLYSEVTASSLVKINLQGDIVD-RGSTNlGVNQagft 222
Cdd:PRK07090  31 LRQKLALTCRILFDAGHDSGLAGQITAR--AEAPGtYYTQRLGLGFDEITASNLLLVDEDLNVLDgEGMPN-PANR---- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 223 LHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALSL-GEVAY-HDYHGILVDEEEKVLIQKNLGPKSKVLiLR 300
Cdd:PRK07090 104 FHSWIYRARPDVNCIIHTHPPHVAALSMLEVPLVVSHMDTCPLyDDCAFlKDWPGVPVGNEEGEIISAALGDKRAIL-LS 182

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 557786217 301 NHGLVSVGESVEEAFYYIHNLVVACEIQVrtLASAGGP 338
Cdd:PRK07090 183 HHGQLVAGKSIEEACVLALLIERAARLQL--LAMAAGP 218
PRK08333 PRK08333
aldolase;
143-316 1.75e-13

aldolase;


Pssm-ID: 181393 [Multi-domain]  Cd Length: 184  Bit Score: 69.08  E-value: 1.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 143 KLLRCKLAAFYRLADLFGWSQLIYNHITTRVNseqEHFLIVPFGLLYSEVTASSLVKINLQGDIVD--RGSTNlgvnqag 220
Cdd:PRK08333   2 RNVKAQLVKYSKLAHERGLTAAFGGNLSIRVG---NLVFIKATGSVMDELTREQVAVIDLNGNQLSsvRPSSE------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 221 FTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLP-ISPEA-LSLGEVAYHDYHGI----LVDEEEKVLIQKNlgpks 294
Cdd:PRK08333  72 YRLHLAVYRNRPDVRAIAHLHPPYSIVASTLLEEELPiITPEAeLYLKKIPILPFRPAgsveLAEQVAEAMKEYD----- 146

                        170       180
                 ....*....|....*....|..
gi 557786217 295 kVLILRNHGLVSVGESVEEAFY 316
Cdd:PRK08333 147 -AVIMERHGIVTVGRSLREAFY 167
PRK06557 PRK06557
L-ribulose-5-phosphate 4-epimerase; Validated
 176-314 1.77e-12

L-ribulose-5-phosphate 4-epimerase; Validated


Pssm-ID: 235829 [Multi-domain]  Cd Length: 221  Bit Score: 67.34  E-value: 1.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 176 EQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrGSTNLGVNQAGftlHSAIYAARPDVKCVVHIHTPAGAAVSA----M 251
Cdd:PRK06557  41 GTDLVVIKPSGVSYDDLTPEDMVVVDLDGNVVE-GDLKPSSDTAS---HLYVYRHMPDVGGVVHTHSTYATAWAArgepI 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557786217 252 KCGLLPISPEAlsLGEVAYHDYHGILVDEEEKVLIQKNLGPKSKVLILRNHGLVSVGESVEEA 314
Cdd:PRK06557 117 PCVLTAMADEF--GGPIPVGPFALIGDEAIGKGIVETLKGGRSPAVLMQNHGVFTIGKDAEDA 177
PRK08130 PRK08130
putative aldolase; Validated
 179-316 8.45e-08

putative aldolase; Validated


Pssm-ID: 181241 [Multi-domain]  Cd Length: 213  Bit Score: 53.34  E-value: 8.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 179 HFLIVPFGLLYSEVTASSLVKINLQGDIV--DRGSTNLgvnqagfTLHSAIYAARPDVKCVVHIHTPAGAAVS------- 249
Cdd:PRK08130  38 GWLVTPTGSCLGRLDPARLSKVDADGNWLsgDKPSKEV-------PLHRAIYRNNPECGAVVHLHSTHLTALSclggldp 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 250 -----------AMKCGLLPISPealslgevayhdYH--GilvDEEEKVLIQKnLGPKSKVLILRNHGLVSVGESVEEAFY 316
Cdd:PRK08130 111 tnvlppftpyyVMRVGHVPLIP------------YYrpG---DPAIAEALAG-LAARYRAVLLANHGPVVWGSSLEAAVN 174
PRK06833 PRK06833
L-fuculose-phosphate aldolase;
174-338 4.09e-07

L-fuculose-phosphate aldolase;


Pssm-ID: 180717 [Multi-domain]  Cd Length: 214  Bit Score: 51.29  E-value: 4.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 174 NSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrGSTnlgVNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKC 253
Cdd:PRK06833  34 NREQGLMAITPSGIDYFEIKPEDIVIMDLDGKVVE-GER---KPSSELDMHLIFYRNREDINAIVHTHSPYATTLACLGW 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 254 GLLPISPE-ALSLGEVAYHDYHGI----LVDEEEKVLIQKnlgpksKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQ 328
Cdd:PRK06833 110 ELPAVHYLiAVAGPNVRCAEYATFgtkeLAENAFEAMEDR------RAVLLANHGLLAGANNLKNAFNIAEEIEFCAEIY 183

                        170
                 ....*....|
gi 557786217 329 VRTlASAGGP 338
Cdd:PRK06833 184 YQT-KSIGEP 192
PRK08087 PRK08087
L-fuculose-phosphate aldolase;
177-333 2.57e-06

L-fuculose-phosphate aldolase;


Pssm-ID: 181226 [Multi-domain]  Cd Length: 215  Bit Score: 48.97  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 177 QEHFLIVPFGLLYSEVTASSLVKINlqgdivDRGSTNLG-VNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGL 255
Cdd:PRK08087  35 QDGMLITPTGIPYEKLTESHIVFVD------GNGKHEEGkLPSSEWRFHMAAYQTRPDANAVVHNHAVHCTAVSILNRPI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 256 --------------LPISPEAlSLG--EVAYHDYHGIlvdeeekvliqknlgPKSKVLILRNHGLVSVGESVEEAFYYIH 319
Cdd:PRK08087 109 paihymiaaaggnsIPCAPYA-TFGtrELSEHVALAL---------------KNRKATLLQHHGLIACEVNLEKALWLAH 172

                        170
                 ....*....|....
gi 557786217 320 NLVVACEIQVRTLA 333
Cdd:PRK08087 173 EVEVLAQLYLKTLA 186
araD PRK13145
L-ribulose-5-phosphate 4-epimerase; Provisional
 173-323 3.86e-05

L-ribulose-5-phosphate 4-epimerase; Provisional


Pssm-ID: 183870 [Multi-domain]  Cd Length: 234  Bit Score: 45.59  E-value: 3.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 173 VNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVDrGSTNlgvNQAGFTLHSAIYAARPDVKCVVHIHTPAGA----AV 248
Cdd:PRK13145  33 VCRELGRIVIKPSGVDYDELTPENMVVTDLDGNVVE-GDLN---PSSDLPTHVELYKAWPEVGGIVHTHSTEAVgwaqAG 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 249 SAMKC----------GLLPISpEALSLGEV--AYHDYHGILVDEEEKvliQKNLGPKS-KVLILRNHGLVSVGESVEEAF 315
Cdd:PRK13145 109 RDIPFygtthadyfyGPIPCA-RSLTKDEVngAYEKETGSVIIEEFE---KRGLDPMAvPGIVVRNHGPFTWGKNPEQAV 184


                 ....*...
gi 557786217 316 YyiHNLVV 323
Cdd:PRK13145 185 Y--HSVVL 190
sgaE PRK12348
L-ribulose-5-phosphate 4-epimerase; Reviewed
 173-327 4.22e-05

L-ribulose-5-phosphate 4-epimerase; Reviewed


Pssm-ID: 183460  Cd Length: 228  Bit Score: 45.18  E-value: 4.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 173 VNSEQEHFLIVPFGLLYSEVTASSLVKINLQGDIVD---RGSTNLGVnqagftlHSAIYAARPDVKCVVHIHTP------ 243
Cdd:PRK12348  31 IDRERGLVVIKPSGVAYETMKADDMVVVDMSGKVVEgeyRPSSDTAT-------HLELYRRYPSLGGIVHTHSThatawa 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 244 -AGAAVSAMKC-------GLLPISpEALSLGEVAyHDYHgilvDEEEKVLIQkNLGPKSKV----LILRNHGLVSVGESV 311
Cdd:PRK12348 104 qAGLAIPALGTthadyffGDIPCT-RGLSEEEVQ-GEYE----LNTGKVIIE-TLGNAEPLhtpgIVVYQHGPFAWGKDA 176

                        170
                 ....*....|....*.
gi 557786217 312 EEAfyyIHNLVVACEI 327
Cdd:PRK12348 177 HDA---VHNAVVMEEV 189
PRK08660 PRK08660
aldolase;
224-327 7.83e-03

aldolase;


Pssm-ID: 181527 [Multi-domain]  Cd Length: 181  Bit Score: 38.01  E-value: 7.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786217 224 HSAIYAaRPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALS-LGE--VAYHDYHGILVDEEEKVLIQKNlgpksKVLILR 300
Cdd:PRK08660  72 HRAIYR-RTSAKAIVHAHPPYAVALSLLEDEIVPLDSEGLYfLGTipVVGGDIGSGELAENVARALSEH-----KGVVVR 145

                         90       100
                 ....*....|....*....|....*..
gi 557786217 301 NHGLVSVGESVEEAFYYIHNLVVACEI 327
Cdd:PRK08660 146 GHGTFAIGKTLEEAYIYTSQLEHSCKV 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH