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Conserved domains on  [gi|548962166|ref|NP_001271430|]
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cytosolic Fe-S cluster assembly factor NUBP2 isoform 2 [Homo sapiens]

Protein Classification

Mrp/NBP35 family ATP-binding protein( domain architecture ID 10566257)

MRP (Multiple Resistance and pH adaptation)/NBP35 (Nucleotide-binding protein 35) family ATP-binding protein, similar to the yeast cytosolic iron-sulfur (Fe-S) assembly factors, NBP35 and CFD1 (also called NUBP1/NUBP2 in higher eukaryotes), which functions as a heterotetrameric complex to assemble nascent Fe-S clusters and transfer them to apoprotein targets

Gene Ontology:  GO:0005524|GO:0016887|GO:0046872
PubMed:  11916378

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-203 6.85e-105

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


:

Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 302.06  E-value: 6.85e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166    1 MLGAQGRAVHQCDRGWAPVFLDreqSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDE 80
Cdd:pfam10609  50 MLGLEGERPEQSDGGIIPVEAH---GIKVMSIGFLLPDEDDAVIWRGPMKSGAIKQFLTDVDWGELDYLIIDLPPGTGDE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   81 HMATIEALrpyqPL-GALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAG 159
Cdd:pfam10609 127 QLTLAQLL----PLtGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFGKGGGEKLAEELG 202

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 548962166  160 VPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKIL 203
Cdd:pfam10609 203 VPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-203 6.85e-105

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 302.06  E-value: 6.85e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166    1 MLGAQGRAVHQCDRGWAPVFLDreqSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDE 80
Cdd:pfam10609  50 MLGLEGERPEQSDGGIIPVEAH---GIKVMSIGFLLPDEDDAVIWRGPMKSGAIKQFLTDVDWGELDYLIIDLPPGTGDE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   81 HMATIEALrpyqPL-GALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAG 159
Cdd:pfam10609 127 QLTLAQLL----PLtGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFGKGGGEKLAEELG 202

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 548962166  160 VPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKIL 203
Cdd:pfam10609 203 VPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 1-173 3.41e-92

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 268.60  E-value: 3.41e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   1 MLGAQGRAVHQCDRGWAPVFLDreqSISLMSVGFLLEkPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDE 80
Cdd:cd02037   47 LLGVEGKPLHQSEEGIVPVEVG---GIKVMSIGFLLP-EDDAVIWRGPMKSGAIKQFLKDVDWGELDYLIIDLPPGTGDE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  81 HMATIEALRPYqplGALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAGV 160
Cdd:cd02037  123 HLSLVQLIPID---GAVVVTTPQEVSLIDVRKAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIFGKGGGEKLAEELGV 199

                        170
                 ....*....|...
gi 548962166 161 PFLGSVPLDPALM 173
Cdd:cd02037  200 PFLGKIPLDPELA 212
MrpORP NF041136
iron-sulfur cluster carrier protein MrpORP;
1-206 4.45e-86

iron-sulfur cluster carrier protein MrpORP;


Pssm-ID: 469059 [Multi-domain]  Cd Length: 365  Bit Score: 258.59  E-value: 4.45e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   1 MLGAQGRAVHQCDRGWAPVFLDreQSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDE 80
Cdd:NF041136  52 LLGLEGKRLGSEDEGILPVEYS--DNLKVMSIGFLLENRDDAVIWRGPVKMGVIKQFLSDVEWGDLDYLIIDSPPGTGDE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  81 HMATIEALrpyqPL-GALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAG 159
Cdd:NF041136 130 PLSVAQLI----PDaGAVIVTTPQELALADVRKSINFCRKLNIPILGIVENMSGFVCPHCGKEIDIFKSGGGEKLAEEMG 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 548962166 160 VPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKILDAT 206
Cdd:NF041136 206 VPFLGRIPIDPEIVEAGDAGRPFVLDYAWSPAAKALEKIVDPILELL 252
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
31-179 6.61e-32

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 118.61  E-value: 6.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  31 SVGFLLEkPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDEHMaTIEALRPYQplGALVVTTPQAVSVGDV 110
Cdd:PRK11670 182 SIGYLVT-DDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQL-TLAQNIPVT--GAVVVTTPQDIALIDA 257

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548962166 111 RRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAGVPFLGSVPLDPALMRTLEEG 179
Cdd:PRK11670 258 KKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDRG 326
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 27-138 3.53e-18

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 80.62  E-value: 3.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  27 ISLMSVGFLLEKPDEAVVwrgpkkNALIKQFVSDVAwGELDYLVVDTPPGTSDEHMATIealrpyQPL--GALVVTTPQA 104
Cdd:COG0489  170 LDVLPAGPLPPNPSELLA------SKRLKQLLEELR-GRYDYVIIDTPPGLGVADATLL------ASLvdGVLLVVRPGK 236

                         90       100       110
                 ....*....|....*....|....*....|....
gi 548962166 105 VSVGDVRRELTFCRKTGLRVMGIVENMsgfTCPH 138
Cdd:COG0489  237 TALDDVRKALEMLEKAGVPVLGVVLNM---VCPK 267
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-203 6.85e-105

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 302.06  E-value: 6.85e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166    1 MLGAQGRAVHQCDRGWAPVFLDreqSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDE 80
Cdd:pfam10609  50 MLGLEGERPEQSDGGIIPVEAH---GIKVMSIGFLLPDEDDAVIWRGPMKSGAIKQFLTDVDWGELDYLIIDLPPGTGDE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   81 HMATIEALrpyqPL-GALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAG 159
Cdd:pfam10609 127 QLTLAQLL----PLtGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFGKGGGEKLAEELG 202

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 548962166  160 VPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKIL 203
Cdd:pfam10609 203 VPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 1-173 3.41e-92

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 268.60  E-value: 3.41e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   1 MLGAQGRAVHQCDRGWAPVFLDreqSISLMSVGFLLEkPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDE 80
Cdd:cd02037   47 LLGVEGKPLHQSEEGIVPVEVG---GIKVMSIGFLLP-EDDAVIWRGPMKSGAIKQFLKDVDWGELDYLIIDLPPGTGDE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  81 HMATIEALRPYqplGALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAGV 160
Cdd:cd02037  123 HLSLVQLIPID---GAVVVTTPQEVSLIDVRKAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIFGKGGGEKLAEELGV 199

                        170
                 ....*....|...
gi 548962166 161 PFLGSVPLDPALM 173
Cdd:cd02037  200 PFLGKIPLDPELA 212
MrpORP NF041136
iron-sulfur cluster carrier protein MrpORP;
1-206 4.45e-86

iron-sulfur cluster carrier protein MrpORP;


Pssm-ID: 469059 [Multi-domain]  Cd Length: 365  Bit Score: 258.59  E-value: 4.45e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   1 MLGAQGRAVHQCDRGWAPVFLDreQSISLMSVGFLLEKPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDE 80
Cdd:NF041136  52 LLGLEGKRLGSEDEGILPVEYS--DNLKVMSIGFLLENRDDAVIWRGPVKMGVIKQFLSDVEWGDLDYLIIDSPPGTGDE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  81 HMATIEALrpyqPL-GALVVTTPQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAG 159
Cdd:NF041136 130 PLSVAQLI----PDaGAVIVTTPQELALADVRKSINFCRKLNIPILGIVENMSGFVCPHCGKEIDIFKSGGGEKLAEEMG 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 548962166 160 VPFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKILDAT 206
Cdd:NF041136 206 VPFLGRIPIDPEIVEAGDAGRPFVLDYAWSPAAKALEKIVDPILELL 252
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
31-179 6.61e-32

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 118.61  E-value: 6.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  31 SVGFLLEkPDEAVVWRGPKKNALIKQFVSDVAWGELDYLVVDTPPGTSDEHMaTIEALRPYQplGALVVTTPQAVSVGDV 110
Cdd:PRK11670 182 SIGYLVT-DDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQL-TLAQNIPVT--GAVVVTTPQDIALIDA 257

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548962166 111 RRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVFSRGGGEELAQLAGVPFLGSVPLDPALMRTLEEG 179
Cdd:PRK11670 258 KKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDRG 326
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 27-138 3.53e-18

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 80.62  E-value: 3.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  27 ISLMSVGFLLEKPDEAVVwrgpkkNALIKQFVSDVAwGELDYLVVDTPPGTSDEHMATIealrpyQPL--GALVVTTPQA 104
Cdd:COG0489  170 LDVLPAGPLPPNPSELLA------SKRLKQLLEELR-GRYDYVIIDTPPGLGVADATLL------ASLvdGVLLVVRPGK 236

                         90       100       110
                 ....*....|....*....|....*....|....
gi 548962166 105 VSVGDVRRELTFCRKTGLRVMGIVENMsgfTCPH 138
Cdd:COG0489  237 TALDDVRKALEMLEKAGVPVLGVVLNM---VCPK 267
FlhG COG0455
MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell ...
 64-205 1.15e-13

MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440223 [Multi-domain]  Cd Length: 230  Bit Score: 67.22  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  64 GELDYLVVDTPPGTSDEHMATIEAlrpyqplgA---LVVTTPQAVSVGDVRRELTFCRKT-GLRVMGIVENMsgftcphc 139
Cdd:COG0455   92 RFYDVVLVDTGAGISDSVLLFLAA--------AdevVVVTTPEPTSITDAYALLKLLRRRlGVRRAGVVVNR-------- 155

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548962166 140 tectsVFSRGGGEELA-QLAGV---------PFLGSVPLDPALMRTLEEGHDFIQEFPGSPAFAALTSIAQKILDA 205
Cdd:COG0455  156 -----VRSEAEARDVFeRLEQVaerflgvrlRVLGVIPEDPAVREAVRRGRPLVLAAPDSPAARAIRELAARLAGW 226
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 42-182 1.88e-08

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 52.73  E-value: 1.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166   42 AVVWRGPKKNALIKQFVSDVAwGELDYLVVDTPPGTsdeHMATIEALRPYQplGALVVTTPQAVSVGDVRRELTFCRKTG 121
Cdd:pfam01656  95 EKELLGPRKEERLREALEALK-EDYDYVIIDGAPGL---GELLRNALIAAD--YVIIPLEPEVILVEDAKRLGGVIAALV 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548962166  122 -------LRVMGIVENMSGftcphctectsvfSRGGGEELAQ-----LAGVPFLGSVPLDPALMRTLEEGHDF 182
Cdd:pfam01656 169 ggyallgLKIIGVVLNKVD-------------GDNHGKLLKEaleelLRGLPVLGVIPRDEAVAEAPARGLPV 228
FlhG-like cd02038
MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) ...
 49-191 3.55e-06

MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.


Pssm-ID: 349758 [Multi-domain]  Cd Length: 230  Bit Score: 46.02  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  49 KKNALIKQFVSDVAwgELDYLVVDTPPGTSDEhmaTIEALRPYQPLgaLVVTTPQAVSVGD--------VRRELtfcrKT 120
Cdd:cd02038   96 QKAKLIEELSSLES--NYDYLLIDTGAGISRN---VLDFLLAADEV--IVVTTPEPTSITDayalikvlSRRGG----KK 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166 121 GLRVmgiVENMsgftcphctectsVFSRGGGEELAQ-LAGV---------PFLGSVPLDPALMRTLEEGHDFIQEFPGSP 190
Cdd:cd02038  165 NFRL---IVNM-------------ARSPKEGRATFErLKKVakrfldinlDFVGFIPYDQSVRRAVRSQKPFVLLFPNSK 228


                 .
gi 548962166 191 A 191
Cdd:cd02038  229 A 229
CooC COG3640
CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, ...
 51-202 1.31e-05

CO dehydrogenase nickel-insertion accessory protein CooC1 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442857 [Multi-domain]  Cd Length: 249  Bit Score: 44.39  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  51 NALIKQFVSDVAWGELDYLVVDTPPGTsdEHMA--TIE---ALrpyqplgaLVVTTPQAVSVGDVRRELTFCRKTGLRVM 125
Cdd:COG3640  117 NALLRALLNHLVLGNYEYVVVDMEAGI--EHLGrgTAEgvdLL--------LVVSEPSRRSIETARRIKELAEELGIKKI 186

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 548962166 126 GIVENMsgftcphctectsVFSRGGGEELAQLAGVPFLGSVPLDPALMRtLEEGHDFIQEFPGSPAFAALTSIAQKI 202
Cdd:COG3640  187 YLVGNK-------------VREEEDEEFLRELLGLELLGFIPYDEEVRE-ADLEGKPLLDLPDSPAVAAVEEIAEKL 249
MinD cd02036
septum site-determining protein MinD; Septum site-determining protein MinD is part of the ...
 23-202 1.02e-04

septum site-determining protein MinD; Septum site-determining protein MinD is part of the operon MinCDE that determines the site of the formation of a septum at mid-cell, an important part of bacterial cell division. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal role, selecting the mid-cell over other sites through the activation and regulation of MinC and MinE. MinD is a membrane-associated ATPase, related to nitrogenase iron protein.


Pssm-ID: 349756 [Multi-domain]  Cd Length: 236  Bit Score: 41.80  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166  23 REQSISLMSVGFLLEKpDEAvvwrGPKKnalIKQFVSDVAwGELDYLVVDTPPGT-SDEHMATIEALRpyqplgALVVTT 101
Cdd:cd02036   77 RWENLYLLPASQTRDK-DAL----TPEK---LEELVKELK-DSFDFILIDSPAGIeSGFINAIAPADE------AIIVTN 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548962166 102 PQAVSVGDVRRELTFCRKTGLRVMGIVENMSGFTCPHCTECTSVfsrgggEELAQLAGVPFLGSVPLDPALMRTLEEGHD 181
Cdd:cd02036  142 PEISSVRDADRVIGLLESKGIVNIGLIVNRYRPEMVKSGDMLSV------EDIQEILGIPLLGVIPEDPEVIVATNRGEP 215

                        170       180
                 ....*....|....*....|.
gi 548962166 182 FIQEFPGSPAFAALTSIAQKI 202
Cdd:cd02036  216 LVLYKPNSLAAKAFENIARRL 236
SIMIBI cd01983
SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal ...
 67-131 1.62e-03

SIMIBI (signal recognition particle, MinD and BioD)-class NTPases; SIMIBI (after signal recognition particle, MinD, and BioD), consists of signal recognition particle (SRP) GTPases, the assemblage of MinD-like ATPases, which are involved in protein localization, chromosome partitioning, and membrane transport, and a group of metabolic enzymes with kinase or related phosphate transferase activity. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349751 [Multi-domain]  Cd Length: 107  Bit Score: 36.64  E-value: 1.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 548962166  67 DYLVVDTPPGTSDE--HMATIEALRPYQPLGALVVTTPQAVSVGDVRRELTFCR--KTGLRVMGIVENM 131
Cdd:cd01983   39 DYVLIDGGGGLETGllLGTIVALLALKKADEVIVVVDPELGSLLEAVKLLLALLllGIGIRPDGIVLNK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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