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Conserved domains on  [gi|544186065|ref|NP_001269653|]
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lipid droplet-associated hydrolase isoform f [Homo sapiens]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 51-120 2.00e-22

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member pfam10230:

Pssm-ID: 473884  Cd Length: 261  Bit Score: 88.50  E-value: 2.00e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544186065   51 PGERKSLDSNAQEIKDIYGLNGQIEHKLAFLRTHVP----KDMKLVLIGHSIGSYFTLQMLKRVPELP-----LMLPTL 120
Cdd:pfam10230  41 AGHSLEDRNDAKENGRVFSLQDQIEHKIDFIRAFLPansdKDVKLILIGHSIGAYIALEVLKRLSERGiikcvLLFPTI 119
 
Name Accession Description Interval E-value
LIDHydrolase pfam10230
Lipid-droplet associated hydrolase; This family of proteins is conserved from plants to humans. ...
 51-120 2.00e-22

Lipid-droplet associated hydrolase; This family of proteins is conserved from plants to humans. The function is as a lipid-droplet hydrolase. Human LDAH plays a role in cholesterol homeostasis.


Pssm-ID: 370901  Cd Length: 261  Bit Score: 88.50  E-value: 2.00e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544186065   51 PGERKSLDSNAQEIKDIYGLNGQIEHKLAFLRTHVP----KDMKLVLIGHSIGSYFTLQMLKRVPELP-----LMLPTL 120
Cdd:pfam10230  41 AGHSLEDRNDAKENGRVFSLQDQIEHKIDFIRAFLPansdKDVKLILIGHSIGAYIALEVLKRLSERGiikcvLLFPTI 119
 
Name Accession Description Interval E-value
LIDHydrolase pfam10230
Lipid-droplet associated hydrolase; This family of proteins is conserved from plants to humans. ...
 51-120 2.00e-22

Lipid-droplet associated hydrolase; This family of proteins is conserved from plants to humans. The function is as a lipid-droplet hydrolase. Human LDAH plays a role in cholesterol homeostasis.


Pssm-ID: 370901  Cd Length: 261  Bit Score: 88.50  E-value: 2.00e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544186065   51 PGERKSLDSNAQEIKDIYGLNGQIEHKLAFLRTHVP----KDMKLVLIGHSIGSYFTLQMLKRVPELP-----LMLPTL 120
Cdd:pfam10230  41 AGHSLEDRNDAKENGRVFSLQDQIEHKIDFIRAFLPansdKDVKLILIGHSIGAYIALEVLKRLSERGiikcvLLFPTI 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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