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Conserved domains on  [gi|541862109|ref|NP_001269396|]
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WAP four-disulfide core domain protein 1 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WAP super family cl00156
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 82-108 6.38e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


The actual alignment was detected with superfamily member cd00199:

Pssm-ID: 469631 [Multi-domain]  Cd Length: 60  Bit Score: 37.04  E-value: 6.38e-04
                         10        20
                 ....*....|....*....|....*..
gi 541862109  82 RCQADSECPRHRRCCYNGCAYACLEAV 108
Cdd:cd00199   34 RCSSDSDCPGDKKCCENGCGKSCLTPV 60
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 82-108 6.38e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 37.04  E-value: 6.38e-04
                         10        20
                 ....*....|....*....|....*..
gi 541862109  82 RCQADSECPRHRRCCYNGCAYACLEAV 108
Cdd:cd00199   34 RCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP smart00217
Four-disulfide core domains;
82-108 2.99e-03

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 34.65  E-value: 2.99e-03
                           10        20
                   ....*....|....*....|....*..
gi 541862109    82 RCQADSECPRHRRCCYNGCAYACLEAV 108
Cdd:smart00217  21 KCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 82-107 7.41e-03

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 33.55  E-value: 7.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 541862109   82 RCQADSECPRHRRCCYNGCAYACLEA 107
Cdd:pfam00095  17 CCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Name Accession Description Interval E-value
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 82-108 6.38e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 37.04  E-value: 6.38e-04
                         10        20
                 ....*....|....*....|....*..
gi 541862109  82 RCQADSECPRHRRCCYNGCAYACLEAV 108
Cdd:cd00199   34 RCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP smart00217
Four-disulfide core domains;
82-108 2.99e-03

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 34.65  E-value: 2.99e-03
                           10        20
                   ....*....|....*....|....*..
gi 541862109    82 RCQADSECPRHRRCCYNGCAYACLEAV 108
Cdd:smart00217  21 KCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 82-107 7.41e-03

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 33.55  E-value: 7.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 541862109   82 RCQADSECPRHRRCCYNGCAYACLEA 107
Cdd:pfam00095  17 CCSSDDDCPGRQKCCSNGCGSVCVPP 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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