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Conserved domains on  [gi|526252802|ref|NP_001268233|]
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inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
62-110 3.30e-13

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.14  E-value: 3.30e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 526252802   62 LWGMELGLLSMRRGELARFLFKPNYAYGTLGC-PPLIPPNTTVLFEIELL 110
Cdd:pfam00254  45 IPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPVIPPNATLVFEVELL 94
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
191-272 1.46e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526252802 191 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDInneLKKLASCY 270
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA---LNNLGLAL 86


                 ..
gi 526252802 271 RD 272
Cdd:COG0457   87 QA 88
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
62-110 3.30e-13

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.14  E-value: 3.30e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 526252802   62 LWGMELGLLSMRRGELARFLFKPNYAYGTLGC-PPLIPPNTTVLFEIELL 110
Cdd:pfam00254  45 IPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPVIPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 64-112 5.00e-11

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 58.65  E-value: 5.00e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 526252802  64 GMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDF 112
Cdd:COG0545   56 GWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNSTLVFEVELLDV 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
191-272 1.46e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526252802 191 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDInneLKKLASCY 270
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA---LNNLGLAL 86


                 ..
gi 526252802 271 RD 272
Cdd:COG0457   87 QA 88
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 58-111 3.60e-04

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 41.29  E-value: 3.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 526252802  58 LDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPlIPPNTTVLFEIELLD 111
Cdd:PRK10902 195 LDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPG-IPANSTLVFDVELLD 247
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
62-110 3.30e-13

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.14  E-value: 3.30e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 526252802   62 LWGMELGLLSMRRGELARFLFKPNYAYGTLGC-PPLIPPNTTVLFEIELL 110
Cdd:pfam00254  45 IPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPVIPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 64-112 5.00e-11

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 58.65  E-value: 5.00e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 526252802  64 GMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDF 112
Cdd:COG0545   56 GWDEGLQGMKVGGKRRLVIPPELAYGERGAGGVIPPNSTLVFEVELLDV 104
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
191-272 1.46e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526252802 191 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDInneLKKLASCY 270
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEA---LNNLGLAL 86


                 ..
gi 526252802 271 RD 272
Cdd:COG0457   87 QA 88
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
191-263 3.21e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 3.21e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 526252802 191 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNEL 263
Cdd:COG0457   44 ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 58-111 3.60e-04

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 41.29  E-value: 3.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 526252802  58 LDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPlIPPNTTVLFEIELLD 111
Cdd:PRK10902 195 LDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPG-IPANSTLVFDVELLD 247
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
191-263 4.42e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 4.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 526252802 191 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNEL 263
Cdd:COG0457   78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 148-259 4.26e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 38.44  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526252802 148 GNYLFRQNRFYDAkvrykrallllrrrsappeEQHLVEAAKL-----PVLLNLSFTYLKLDRPTIALCYGEQALIIDQKN 222
Cdd:COG3914  119 GNLLLALGRLEEA-------------------LAALRRALALnpdfaEAYLNLGEALRRLGRLEEAIAALRRALELDPDN 179

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 526252802 223 AKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDI 259
Cdd:COG3914  180 AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
180-258 5.27e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.53  E-value: 5.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526252802 180 EQHLVEAAKL-----PVLLNLSFTYLKLDRPTIALCYgEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQP 254
Cdd:COG3063   12 EEYYEKALELdpdnaDALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90


                 ....
gi 526252802 255 FNHD 258
Cdd:COG3063   91 SALR 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
191-279 6.18e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 37.29  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526252802 191 VLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCY 270
Cdd:COG0457  112 ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALA 191


                 ....*....
gi 526252802 271 RDYVDKEKE 279
Cdd:COG0457  192 AAEVLLALL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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