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Conserved domains on  [gi|429325228|ref|NP_001258822|]
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twist-related protein 2 [Homo sapiens]

Protein Classification

helix-loop-helix domain-containing protein( domain architecture ID 14444704)

helix-loop-helix (HLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
bHLH_TS_TWIST2 cd19700
basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar ...
51-132 2.17e-45

basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar proteins; TWIST2, also termed Class A basic helix-loop-helix protein 39 (bHLHa39), or Dermis-expressed protein 1, or Dermo-1, is a bHLH transcription factor that regulates the development of mesenchymal tissues and plays a critical role in embryogenesis. It binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C.


:

Pssm-ID: 381543 [Multi-domain]  Cd Length: 82  Bit Score: 143.39  E-value: 2.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  51 GKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKM 130
Cdd:cd19700    1 GKKSSPSSQSYEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKM 80

                 ..
gi 429325228 131 TS 132
Cdd:cd19700   81 TS 82
 
Name Accession Description Interval E-value
bHLH_TS_TWIST2 cd19700
basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar ...
51-132 2.17e-45

basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar proteins; TWIST2, also termed Class A basic helix-loop-helix protein 39 (bHLHa39), or Dermis-expressed protein 1, or Dermo-1, is a bHLH transcription factor that regulates the development of mesenchymal tissues and plays a critical role in embryogenesis. It binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C.


Pssm-ID: 381543 [Multi-domain]  Cd Length: 82  Bit Score: 143.39  E-value: 2.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  51 GKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKM 130
Cdd:cd19700    1 GKKSSPSSQSYEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKM 80

                 ..
gi 429325228 131 TS 132
Cdd:cd19700   81 TS 82
HLH pfam00010
Helix-loop-helix DNA-binding domain;
67-117 4.59e-16

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 67.87  E-value: 4.59e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 429325228   67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFL 117
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLPPDkKLSKAEILRLAIEYIKHL 52
HLH smart00353
helix loop helix domain;
72-123 1.18e-15

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 66.86  E-value: 1.18e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 429325228    72 NVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQS 123
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPKNkKLSKAEILRLAIEYIKSLQEELQK 53
 
Name Accession Description Interval E-value
bHLH_TS_TWIST2 cd19700
basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar ...
51-132 2.17e-45

basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar proteins; TWIST2, also termed Class A basic helix-loop-helix protein 39 (bHLHa39), or Dermis-expressed protein 1, or Dermo-1, is a bHLH transcription factor that regulates the development of mesenchymal tissues and plays a critical role in embryogenesis. It binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C.


Pssm-ID: 381543 [Multi-domain]  Cd Length: 82  Bit Score: 143.39  E-value: 2.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  51 GKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKM 130
Cdd:cd19700    1 GKKSSPSSQSYEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKM 80

                 ..
gi 429325228 131 TS 132
Cdd:cd19700   81 TS 82
bHLH_TS_TWIST1 cd11412
basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar ...
57-132 3.69e-44

basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar proteins; TWIST1, also termed Class A basic helix-loop-helix protein 38 (bHLHa38), or H-twist, is a bHLH transcriptional regulator that inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. It also represses expression of proinflammatory cytokines such as TNFA and IL1B. In addition, TWIST1 is involved in cancer development and progression.


Pssm-ID: 381418 [Multi-domain]  Cd Length: 77  Bit Score: 140.30  E-value: 3.69e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  57 SAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTS 132
Cdd:cd11412    2 SPQSFEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMAS 77
bHLH_TS_TWIST cd11464
basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST ...
67-125 2.23e-35

basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST family includes TWIST1 and TWIST2, which are highly homologous bHLH transcription factors that promote epithelial-mesenchymal transition (EMT) during development and tumor metastasis. They are involved in the negative regulation of cellular determination and in the differentiation of several lineages, including myogenesis, osteogenesis, and neurogenesis. TWIST factors express in broad partially-overlapping patterns during embryo development and dimerize with a broad sets of dimer partners that form numerous unique transcriptional complexes to regulate embryonic development.


Pssm-ID: 381470 [Multi-domain]  Cd Length: 59  Bit Score: 117.20  E-value: 2.23e-35
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDE 125
Cdd:cd11464    1 QRVLANVRERQRTQSLNEAFTSLRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLRSDE 59
bHLH_TS cd11390
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ...
68-121 1.75e-22

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.


Pssm-ID: 381396 [Multi-domain]  Cd Length: 55  Bit Score: 84.16  E-value: 1.75e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11390    1 RNAANARERRRMHDLNDAFEALRKVLPTVPPDkKLSKIETLRLAINYIAALSDLL 55
bHLH_TS_scleraxis_like cd11465
basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and ...
68-121 2.14e-18

basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and similar proteins; The family includes scleraxis and transcription factor 15 (TCF-15). Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons. TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381471 [Multi-domain]  Cd Length: 55  Bit Score: 73.99  E-value: 2.14e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11465    1 RQAANARERDRTHSVNSAFTALRTLIPTEPADrKLSKIETLRLASSYISHLATVL 55
bHLH_TS_HAND cd11466
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
68-121 1.33e-17

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein (HAND) family; The HAND family includes two bHLH transcription factors, HAND1 and HAND2. HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381472 [Multi-domain]  Cd Length: 56  Bit Score: 72.05  E-value: 1.33e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11466    2 RGSANKKERRRTQSINSAFADLRECIPNVPADtKLSKIKTLRLATSYIAYLMDVL 56
bHLH_TS_FERD3L_like cd19686
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas ...
67-121 1.63e-17

basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; The family corresponds to a group of bHLH transcription factors, including FERD3L and PTF1A. FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription. PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381529 [Multi-domain]  Cd Length: 56  Bit Score: 71.69  E-value: 1.63e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19686    1 QRQAANIRERKRMRSINDAFDGLRRHIPTFPYEKrLSKVDTLRLAIQYINFLTELL 56
bHLH_TS_HAND2 cd11471
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
67-127 3.45e-16

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins; HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is a bHLH transcription factor that is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.


Pssm-ID: 381477 [Multi-domain]  Cd Length: 62  Bit Score: 68.55  E-value: 3.45e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDEMD 127
Cdd:cd11471    1 RRGTANRKERRRTQSINSAFAELRECIPNVPADtKLSKIKTLRLATSYIAYLMDLLAKDDQN 62
HLH pfam00010
Helix-loop-helix DNA-binding domain;
67-117 4.59e-16

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 67.87  E-value: 4.59e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 429325228   67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFL 117
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLPPDkKLSKAEILRLAIEYIKHL 52
bHLH_TS_TAL2 cd19707
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 ...
66-125 5.62e-16

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 (TAL-2) and similar proteins; TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. It has been implicated in T-cell acute lymphoblastic leukemia.


Pssm-ID: 381550 [Multi-domain]  Cd Length: 61  Bit Score: 68.09  E-value: 5.62e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 429325228  66 SQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDE 125
Cdd:cd19707    1 TRKIFTNTRERWRQQNVNSAFAELRKLIPTHPPDkKLSKNEILRLAMKYINFLVKLLGDQG 61
bHLH_TS_PTF1A cd11417
basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha ...
67-121 6.42e-16

basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is a bHLH transcription factor implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation.


Pssm-ID: 381423 [Multi-domain]  Cd Length: 56  Bit Score: 67.56  E-value: 6.42e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11417    1 QRQAANLRERRRMQSINDAFEGLRSHIPTLPYEKrLSKVDTLRLAIGYINFLSELV 56
bHLH_TS_TCF15_paraxis cd11470
basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar ...
67-121 7.40e-16

basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar proteins; TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.


Pssm-ID: 381476 [Multi-domain]  Cd Length: 66  Bit Score: 67.80  E-value: 7.40e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11470    8 QRQAANARERDRTQSVNTAFTALRTLIPTEPVDrKLSKIETLRLASSYIAHLANVL 63
HLH smart00353
helix loop helix domain;
72-123 1.18e-15

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 66.86  E-value: 1.18e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 429325228    72 NVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQS 123
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPKNkKLSKAEILRLAIEYIKSLQEELQK 53
bHLH_TS_TAL_LYL cd11413
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ ...
67-125 4.01e-15

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family; The TAL/LYL family includes a group of bHLH transcription factors (TAL1, TAL2 and LYL1) implicated in T cell acute leukaemia. They act as mediators of T cell leukaemogenesis. TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor that plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381419 [Multi-domain]  Cd Length: 60  Bit Score: 65.55  E-value: 4.01e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDE 125
Cdd:cd11413    1 RRIFTNTRERWRQQNVNGAFAELRKLIPTHPPDkKLSKNEILRLAMKYIKFLEKILEDQE 60
bHLH_TS_FIGLA cd11422
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ...
68-122 3.76e-14

basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected.


Pssm-ID: 381428  Cd Length: 56  Bit Score: 63.14  E-value: 3.76e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd11422    1 RRVANARERERVRNLNSGFSKLRRIVPLIPRDrKPSKVDTLKGATEYIRLLQRILE 56
bHLH_TS_HAND1 cd18952
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ...
74-124 5.44e-14

basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 1 (HAND1) and similar proteins; HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), is a bHLH transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis.


Pssm-ID: 381522 [Multi-domain]  Cd Length: 60  Bit Score: 62.73  E-value: 5.44e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 429325228  74 RERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSD 124
Cdd:cd18952    9 KERRRTESINSAFAELRECIPNVPADtKLSKIKTLRLATSYIAYLMDVLAKD 60
bHLH_TS_FERD3L_NATO3 cd11415
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L) and similar proteins; ...
65-121 9.37e-14

basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L) and similar proteins; FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is a bHLH transcription factor expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription.


Pssm-ID: 381421 [Multi-domain]  Cd Length: 64  Bit Score: 62.06  E-value: 9.37e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11415    7 YAQRQAANIRERRRMFNLNEAFDKLRKKVPTFAYEKrLSRIETLRLAIVYISFMTDLL 64
bHLH_TS_scleraxis cd18951
basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also ...
67-121 1.35e-13

basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons.


Pssm-ID: 381521 [Multi-domain]  Cd Length: 68  Bit Score: 62.10  E-value: 1.35e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd18951    4 QRHTANARERDRTNSVNTAFTALRTLIPTEPADrKLSKIETLRLASSYISHLGNVL 59
bHLH_TS_LYL1 cd19705
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also ...
66-122 1.46e-13

basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.


Pssm-ID: 381548 [Multi-domain]  Cd Length: 65  Bit Score: 61.96  E-value: 1.46e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 429325228  66 SQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19705    5 ARRVFTNSRERWRQQNVNGAFAELRKLIPTHPPDkKLSKNEILRLAMKYIDFLVTLLR 62
bHLH_TS_taxi_Dei cd11431
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar ...
68-121 1.65e-13

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar proteins; Protein taxi, also termed protein delilah (Dei), is a bHLH transcription factor that is involved in regulation of cell adhesion and attachment that is expressed in specialized cells that provide anchoring sites to either muscles (tendon cells), or proprioceptors (chordotonal attachment cells) during embryonic development. It probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.


Pssm-ID: 381437 [Multi-domain]  Cd Length: 59  Bit Score: 61.29  E-value: 1.65e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLP----SDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11431    2 RKTANARERDRMREINDAFEALRRAVPEYPvagkDGKLTKITTLRLAMNYIKALTDLL 59
bHLH_TS_ceHLH13_like cd11416
basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein ...
67-124 2.72e-13

basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein 13 (HLH13) and similar proteins; Caenorhabditis elegans HLH13, also termed Fer3-like protein, or nephew of atonal 3, is a bHLH transcription factor that plays a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling).


Pssm-ID: 381422 [Multi-domain]  Cd Length: 63  Bit Score: 60.98  E-value: 2.72e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVLQSD 124
Cdd:cd11416    5 QRHAANIRERKRMLSINSAFEELRCHVPTFPYEKrLSKIDTLRLAIAYIALLRDILRSG 63
bHLH_TS_ASCL cd11418
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ...
72-121 3.95e-13

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381424 [Multi-domain]  Cd Length: 56  Bit Score: 60.31  E-value: 3.95e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11418    6 NERERRRVQAVNDAFDRLRQHVPYLKRRKkLSKVKTLRRAIEYIRHLQKLL 56
bHLH_TS_NeuroD cd11427
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) ...
68-121 5.82e-13

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) family; The NeuroD family includes NeuroD1, NeuroD2, NeuroD4 and NeuroD6. NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice. NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter. NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation. NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism.


Pssm-ID: 381433 [Multi-domain]  Cd Length: 55  Bit Score: 60.11  E-value: 5.82e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTL-PSDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11427    1 RVKANARERNRMHGLNDALDNLRKVVPCYsKTQKLSKIETLRLARNYIWALSEIL 55
bHLH_TS_TAL1 cd19706
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 ...
67-127 8.02e-13

basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins; TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-1 has been implicated in T-cell acute lymphoblastic leukemia. In common with other tissue-specific bHLH proteins, Tal heterodimerizes with ubiquitously-expressed members of the E2A family and form a DNA-binding complex with an E-box (CANNTG) to regulate transcription at its recognition site.


Pssm-ID: 381549 [Multi-domain]  Cd Length: 65  Bit Score: 60.05  E-value: 8.02e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDEMD 127
Cdd:cd19706    4 RRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDkKLSKNEILRLAMKYINFLAKLLNDQEEE 65
bHLH_TS_NGN cd11428
basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes ...
67-122 1.66e-12

basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes three neural-specific bHLH transcription factors, NGN1-3, which may function at neuroblast selection genes during the development of several neuronal lineages. NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis.


Pssm-ID: 381434 [Multi-domain]  Cd Length: 57  Bit Score: 58.99  E-value: 1.66e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd11428    1 RRLKANDRERNRMHNLNDALDALREVLPSFPDEtKLTKIETLRFAHNYIWALSETLK 57
bHLH_TS_dHLH3B_like cd19708
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein ...
67-122 2.20e-12

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein 3B (dHLH3B) and similar proteins; Drosophila HLH3B is an uncharacterized bHLH transcription factor that belongs to the T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family.


Pssm-ID: 381551 [Multi-domain]  Cd Length: 60  Bit Score: 58.75  E-value: 2.20e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19708    1 RRMFTNSRERWRQQNVNGAFAELRKLVPTHPPDkKLSKNEILRLAIKYIRLLSNVLE 57
bHLH_TS_NeuroD4_ATOH3 cd19721
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) ...
41-123 2.85e-12

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) and similar proteins; NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation.


Pssm-ID: 381564 [Multi-domain]  Cd Length: 87  Bit Score: 58.94  E-value: 2.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  41 EDGsPTPGKRG-KKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLP-SDKLSKIQTLKLAARYIDFLY 118
Cdd:cd19721    4 EDG-EKPKRRGpKKKKMTKARLERFRARRVKANARERSRMHGLNDALDNLRRVMPCYSkTQKLSKIETLRLARNYIWALS 82

                 ....*
gi 429325228 119 QVLQS 123
Cdd:cd19721   83 EVLET 87
bHLH_TS_HEN cd11414
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN ...
68-121 3.57e-12

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN family includes two neuron-specific bHLH transcription factors, HEN-1 (also known as Nhlh1 or bHLHa35 or NSCL-1) and HEN-2 (also known as Nhlh2 or bHLHa34 or NSCL-2). They may serve as DNA-binding protein that is involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381420  Cd Length: 57  Bit Score: 57.92  E-value: 3.57e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11414    3 RNAHATRERIRVEAFNSAFAQLRKLLPTLPPDkKLSKIEILRLAICYISYLNHVL 57
bHLH_TS_NGN3_ATOH5 cd19718
basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, ...
65-122 3.86e-12

basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis.


Pssm-ID: 381561 [Multi-domain]  Cd Length: 68  Bit Score: 58.12  E-value: 3.86e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19718    6 RNRRMKANDRERNRMHNLNSALDALRSVLPTFPDDaKLTKIETLRFAHNYIWALTETLR 64
bHLH_TS_NGN2_ATOH4 cd19717
basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, ...
65-122 5.45e-12

basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. It activates transcription by binding to the E box (5'-CANNTG-3').


Pssm-ID: 381560 [Multi-domain]  Cd Length: 69  Bit Score: 57.72  E-value: 5.45e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19717    8 KTRRVKANNRERNRMHNLNAALDSLREVLPTFPEDaKLTKIETLRFAHNYIWALSETLR 66
bHLH_TS_amos_like cd19715
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar ...
62-122 8.79e-12

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar proteins; Amos, also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein, is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381558 [Multi-domain]  Cd Length: 64  Bit Score: 57.15  E-value: 8.79e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  62 EELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19715    3 DVLKKRRLAANARERRRMNSLNVAFDKLRDVVPSLGDDrKLSKYETLQMAQSYITALKELLS 64
bHLH_TS_ATOH1 cd19713
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar ...
67-123 1.35e-11

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins; ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1).


Pssm-ID: 381556  Cd Length: 64  Bit Score: 56.50  E-value: 1.35e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQS 123
Cdd:cd19713    6 RRLAANARERRRMHGLNHAFDQLRNVIPSFNNDkKLSKYETLQMAQIYINALSELLQG 63
bHLH_TS_musculin cd19703
basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also ...
65-128 2.13e-11

basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. Musculin heterodimerizes with products of the E2A gene.


Pssm-ID: 381546 [Multi-domain]  Cd Length: 66  Bit Score: 56.31  E-value: 2.13e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDEMDN 128
Cdd:cd19703    2 QSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDtKLSKLDTLRLASSYIAHLRQLLQEDRYEN 66
bHLH_TS_ATOH1_like cd11430
basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar ...
68-121 2.78e-11

basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar proteins; The family includes ATOH1 and ATOH7. ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. The family also includes protein Amos (also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein). It is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system.


Pssm-ID: 381436 [Multi-domain]  Cd Length: 56  Bit Score: 55.52  E-value: 2.78e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11430    2 RLAANARERRRMNGLNRAFDQLRSVVPSIGNDkKLSKYETLQMAQIYIETLSELL 56
bHLH_TS_musculin_like cd11423
basic helix-loop-helix (bHLH) domain found in musculin, transcription factor 21 (TCF-21) and ...
67-121 2.83e-11

basic helix-loop-helix (bHLH) domain found in musculin, transcription factor 21 (TCF-21) and similar proteins; The family includes two bHLH transcription factors, musculin and transcription factor 21 (TCF-21). Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. TCF-21, also termed capsulin, or Class A basic helix-loop-helix protein 23 (bHLHa23), or epicardin, or podocyte-expressed 1 (Pod-1), is a bHLH transcription factor expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. It may play a role in the specification or differentiation of one or more subsets of epicardial cell types.


Pssm-ID: 381429 [Multi-domain]  Cd Length: 56  Bit Score: 55.59  E-value: 2.83e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11423    1 QRNAANARERARMRVLSKAFSRLKTTLPWVPPDtKLSKLDTLRLAASYIAHLRQIL 56
bHLH_TS_MIST1 cd19711
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
67-117 3.59e-11

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) and similar proteins; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription.


Pssm-ID: 381554  Cd Length: 62  Bit Score: 55.49  E-value: 3.59e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFL 117
Cdd:cd19711    1 RRLESNERERQRMHKLNNAFQALREVIPHVRAEkKLSKIETLTLAKNYIKSL 52
bHLH_TS_ATOH8 cd11421
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar ...
65-125 1.27e-10

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar proteins; ATOH8, also termed Class A basic helix-loop-helix protein 21 (bHLHa21), or helix-loop-helix protein hATH-6 (hATH6), is a bHLH shear-stress-responsive transcription factor expressed in activated satellite cells and proliferating myoblasts of human skeletal muscle tissue. It regulates endothelial cell proliferation, migration and tube-like structures formation. ATOH8 binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins.


Pssm-ID: 381427 [Multi-domain]  Cd Length: 68  Bit Score: 54.36  E-value: 1.27e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDE 125
Cdd:cd11421    6 RQRRIEANARERTRVHTISAAFEALRKAVPSYSYNqKLSKLAILRIACSYILALARLADLDY 67
bHLH_TS_NGN1_NeuroD3 cd19716
basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, ...
65-122 1.30e-10

basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. It activates transcription by binding to the E box (5'-CANNTG-3').


Pssm-ID: 381559 [Multi-domain]  Cd Length: 77  Bit Score: 54.65  E-value: 1.30e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19716   15 KSRRVKANDRERNRMHNLNAALDELRSVLPSFPDDtKLTKIETLRFAHNYIWALSETLR 73
bHLH_TS_ATOH7 cd19714
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar ...
60-125 1.74e-10

basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins; ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells.


Pssm-ID: 381557 [Multi-domain]  Cd Length: 69  Bit Score: 53.80  E-value: 1.74e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 429325228  60 SFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDE 125
Cdd:cd19714    1 RLESAARRRLAANARERRRMQGLNTAFDRLRKVVPQWGQDkKLSKYETLQMALSYIMALTRILAEAE 67
bHLH_TS_Mesp_like cd11425
basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, ...
67-122 1.79e-10

basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis. The family also includes mesogenin-1 (Msgn1) and similar proteins. Msgn1, also termed paraxial mesoderm-specific mesogenin1, or pMesogenin1 (pMsgn1), is a bHLH transcription factor required for maturation and segmentation of paraxial mesoderm. It may regulate the expression of T-box transcription factors essential for mesoderm formation and differentiation.


Pssm-ID: 381431 [Multi-domain]  Cd Length: 59  Bit Score: 53.65  E-value: 1.79e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPT--LPSDK-LSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd11425    1 QRQLANERERLRMRTLADALGELRQHLPPsvAPKGKrLSKIQTLKYAIRYIGYLGNVLQ 59
bHLH_TS_TCF21_capsulin cd19704
basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar ...
65-125 2.06e-10

basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar proteins; TCF-21, also termed capsulin, or Class A basic helix-loop-helix protein 23 (bHLHa23), or epicardin, or podocyte-expressed 1 (Pod-1), is a bHLH transcription factor expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. It may play a role in the specification or differentiation of one or more subsets of epicardial cell types.


Pssm-ID: 381547 [Multi-domain]  Cd Length: 64  Bit Score: 53.67  E-value: 2.06e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQSDE 125
Cdd:cd19704    2 QVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDtKLSKLDTLRLASSYIAHLRQILANDK 63
bHLH_TS_MIST1_like cd11426
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ...
67-121 2.53e-10

basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) family; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription. The family also includes Drosophila melanogaster protein dimmed and similar proteins. Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.


Pssm-ID: 381432  Cd Length: 56  Bit Score: 52.98  E-value: 2.53e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11426    1 RRLESNERERLRMHQLNDAFQALREVIPHVRSErKLSKIETLTLAKNYIKSLTNMI 56
bHLH_TS_dimmed_like cd19712
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and ...
67-121 2.55e-10

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and similar proteins; Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila.


Pssm-ID: 381555 [Multi-domain]  Cd Length: 60  Bit Score: 53.26  E-value: 2.55e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19712    1 RRLESNERERMRMHSLNDAFQGLREVIPHVNAErKLSKIETLTLAKNYIKALTNVI 56
bHLH_TS_NeuroD6_ATOH2 cd19722
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) ...
61-122 2.77e-10

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins; NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism.


Pssm-ID: 381565 [Multi-domain]  Cd Length: 70  Bit Score: 53.50  E-value: 2.77e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 429325228  61 FEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLP-SDKLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19722    8 MERVKVRRQEANARERNRMHGLNDALDSLRKVVPCYSkTQKLSKIETLRLAKNYIWALSEILR 70
bHLH_TS_HEN1 cd19701
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar ...
65-122 7.98e-10

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar proteins; HEN-1, also termed nescient helix-loop-helix 1 (Nhlh1), or Class A basic helix-loop-helix protein 35 (bHLHa35), or nescient helix loop helix 1 (NSCL-1), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381544 [Multi-domain]  Cd Length: 72  Bit Score: 52.35  E-value: 7.98e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19701   14 AKYRTAHATRERIRVEAFNVAFAELRKLLPTLPPDkKLSKIEILRLAICYISYLNHVLD 72
bHLH_TS_ASCL3_like cd19724
basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and ...
72-121 8.41e-10

basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and similar proteins; This subfamily includes three ASCL family of transcription factors, ASCL-3, ASCL-4 and ASCL-5. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, may be involved in skin development. ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that is close related to ASCL-3 and ASCL-4.


Pssm-ID: 381567  Cd Length: 56  Bit Score: 51.53  E-value: 8.41e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19724    6 NERERQRVRCVNEGYARLRRHLPLENKDKrLSKVETLRAAIRYIKHLQELL 56
bHLH_TS_NeuroD2 cd19720
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) ...
41-123 9.24e-10

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins; NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter.


Pssm-ID: 381563 [Multi-domain]  Cd Length: 93  Bit Score: 52.76  E-value: 9.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  41 EDGSPTPGKRG-KKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLP-SDKLSKIQTLKLAARYIDFLY 118
Cdd:cd19720    8 EADGERPKKRGpKKRKMTKARLERSKLRRQKANARERNRMHDLNSALDNLRKVVPCYSkTQKLSKIETLRLAKNYIWALS 87

                 ....*
gi 429325228 119 QVLQS 123
Cdd:cd19720   88 EILRS 92
bHLH_TS_NeuroD1 cd19719
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) ...
41-123 1.25e-09

basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) and similar proteins; NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice.


Pssm-ID: 381562  Cd Length: 86  Bit Score: 52.10  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  41 EDGSPTPGKRG-KKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLP-SDKLSKIQTLKLAARYIDFLY 118
Cdd:cd19719    1 EDDDQKPKRRGpKKKKMTKARLERFKMRRMKANARERNRMHGLNAALDNLRKVVPCYSkTQKLSKIETLRLAKNYIWALS 80

                 ....*
gi 429325228 119 QVLQS 123
Cdd:cd19719   81 EILRS 85
bHLH_TS_OLIG cd11429
basic helix-loop-helix (bHLH) domain found in Oligodendrocyte lineage genes (OLIG) family of ...
68-123 6.62e-09

basic helix-loop-helix (bHLH) domain found in Oligodendrocyte lineage genes (OLIG) family of transcription factors; The OLIG family includes three bHLH transcription factors, Oligo1-3, which are expressed in both the developing and mature central nervous system. Oligo1 and Oligo2 are expressed in a nervous tissue-specific manner, but Oligo3 is found mainly in non-neural tissues. Oligo (also known as Olig) have key roles in the specification of motor neurons, dorsal interneurons, and oligodendrocytes. Oligo1, also termed Class B basic helix-loop-helix protein 6 (bHLHb6), or Class E basic helix-loop-helix protein 21 (bHLHe21), promotes formation and maturation of oligodendrocytes, especially within the brain. Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube. Oligo3, also termed Class B basic helix-loop-helix protein 7 (bHLHb7), or Class E basic helix-loop-helix protein 20 (bHLHe20), is expressed in the ventricular zone of the dorsal alar plate of the hindbrain and involved in regulating the development of dorsal and ventral spinal cord. It may determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. This family also includes two OLIG-related bHLH transcription factors, bHLHe22 and bHLHe23. bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is a neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types. bHLHe23, also termed Class B basic helix-loop-helix protein 4 (bHLHb4), is expressed in rod bipolar cells and is required for rod bipolar cell maturation. bHLHe23 have roles in spinal interneuron differentiation by mechanisms linked to the Notch signaling pathway. It modulates the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types.


Pssm-ID: 381435  Cd Length: 61  Bit Score: 49.34  E-value: 6.62e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD---KLSKIQTLKLAARYIDFLYQVLQS 123
Cdd:cd11429    1 RLKINSRERKRMHDLNSALDGLRSVMPYAQGPsvrKLSKIATLLLARNYILMLTQALEE 59
bHLH_TS_TCF23_OUT cd19709
basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar ...
74-121 7.51e-09

basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins; TCF-23, also termed Class A basic helix-loop-helix protein 24 (bHLHa24), is a bHLH transcription factor that is essential for progesterone-dependent decidualization. The mouse homolog is also called ovary, uterus and testis protein (OUT), which is expressed predominantly in the reproductive organs such as the uterus, ovary and testis. It shows an Id-like inhibitory activity and functions as a negative regulator of bHLH factors through the formation of a functionally inactive heterodimeric complex. OUT inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers, but lacks DNA binding activity. OUT is involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. It also plays a role in the inhibition of myogenesis. Unlike typical bHLH factors, OUT proteins do not bind E-box (CANNTG) or N-box DNA sequences and inhibit DNA binding of homo- and heterodimers consisting of E12 and MyoD in gel mobility shift assays.


Pssm-ID: 381552  Cd Length: 56  Bit Score: 49.33  E-value: 7.51e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 429325228  74 RERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19709    7 RERSRVRTLRQAFLALQAALPSVPPDtKLSKLDVLVLATSYIAHLTRTL 55
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
66-114 1.01e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 48.85  E-value: 1.01e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 429325228  66 SQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYI 114
Cdd:cd11419    3 IRREIANSNERRRMQSINAGFQSLRTLLPHCDGEKLSKAAILQQTAEYI 51
bHLH_TS_bHLHe22_like cd11468
basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein bHLHe22, ...
68-126 1.42e-08

basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein bHLHe22, bHLHe23 and similar proteins; The family includes two OLIG-related bHLH transcription factors, bHLHe22 and bHLHe23. bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is a neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types. bHLHe23, also termed Class B basic helix-loop-helix protein 4 (bHLHb4), is expressed in rod bipolar cells and is required for rod bipolar cell maturation. bHLHe23 have roles in spinal interneuron differentiation by mechanisms linked to the Notch signaling pathway. It modulates the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types.


Pssm-ID: 381474  Cd Length: 62  Bit Score: 48.68  E-value: 1.42e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD---KLSKIQTLKLAARYIdfLYQVLQSDEM 126
Cdd:cd11468    1 RLSINARERRRMHDLNDALDDLRAVIPYAHSPsvrKLSKIATLLLAKNYI--LMQARAIEEL 60
bHLH_TS_HEN2 cd19702
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar ...
74-121 1.43e-08

basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar proteins; HEN-2, also termed nescient helix-loop-helix 2 (Nhlh2), or Class A basic helix-loop-helix protein 34 (bHLHa34), or nescient helix loop helix 2 (NSCL-2), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.


Pssm-ID: 381545 [Multi-domain]  Cd Length: 73  Bit Score: 48.93  E-value: 1.43e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 429325228  74 RERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19702   23 RERIRVEAFNLAFAELRKLLPTLPPDkKLSKIEILRLAICYISYLNHVL 71
bHLH_TS_OUT cd11424
basic helix-loop-helix (bHLH) domain found in ovary, uterus and testis protein (OUT) family; ...
74-121 2.59e-08

basic helix-loop-helix (bHLH) domain found in ovary, uterus and testis protein (OUT) family; The OUT family includes transcription factor 23 (TCF-23), transcription factor 24 (TCF-24) and similar proteins. TCF-23, also termed Class A basic helix-loop-helix protein 24 (bHLHa24), is a bHLH transcription factor that is essential for progesterone-dependent decidualization. The mouse homolog is also called ovary, uterus and testis protein (OUT), which is expressed predominantly in the reproductive organs such as the uterus, ovary and testis. It shows an Id-like inhibitory activity and functions as a negative regulator of bHLH factors through the formation of a functionally inactive heterodimeric complex. OUT inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers, but lacks DNA binding activity. OUT is involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. It also plays a role in the inhibition of myogenesis. Unlike typical bHLH factors, OUT proteins do not bind E-box (CANNTG) or N-box DNA sequences and inhibit DNA binding of homo- and heterodimers consisting of E12 and MyoD in gel mobility shift assays. TCF-24 is an uncharacterized bHLH transcription factor that shows high sequence similarity with TCF-23.


Pssm-ID: 381430  Cd Length: 55  Bit Score: 47.90  E-value: 2.59e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 429325228  74 RERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11424    7 RERSRVRTLRTAFQSLQRALPAVPPDtKLSKLDVLLLASRYIAHLTRKL 55
bHLH_TS_ASCL5 cd19747
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and ...
72-121 3.25e-08

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and similar proteins; ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that belongs to AS-C (achaete, scute, lethal of scute, and asense) family.


Pssm-ID: 381590  Cd Length: 61  Bit Score: 47.69  E-value: 3.25e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19747   11 NERERQRVKCVNEGYARLRDHLPGAMAEKrLSKVETLRAAIRYIKYLQDLL 61
bHLH_TS_TCF24 cd19710
basic helix-loop-helix (bHLH) domain found in transcription factor 24 (TCF-24) and similar ...
74-121 6.34e-08

basic helix-loop-helix (bHLH) domain found in transcription factor 24 (TCF-24) and similar proteins; TCF-24 is an uncharacterized bHLH transcription factor that shows high sequence similarity with TCF-23.


Pssm-ID: 381553  Cd Length: 56  Bit Score: 46.85  E-value: 6.34e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 429325228  74 RERQRTQSLNEAFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19710    8 RERSRVQTLRSAFLELQRTLPSVPPDtKLSKLDVLVLATTYIAHLMRTL 56
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
75-117 8.41e-08

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 46.36  E-value: 8.41e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 429325228  75 ERQRTQSLNEAFAALRKIIPTLP-SDKLSKIQTLKLAARYIDFL 117
Cdd:cd00083    1 ERRRRDKINDAFEELKRLLPELPdSKKLSKASILQKAVEYIREL 44
bHLH_TS_ASCL3 cd19745
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and ...
72-121 1.08e-07

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and similar proteins; ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis.


Pssm-ID: 381588  Cd Length: 59  Bit Score: 46.39  E-value: 1.08e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19745    9 NERERQRVKCVNEGYAKLRRHLPQEYSEKrLSKVETLRAAIKYIKHLQSVL 59
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
67-117 3.36e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 45.62  E-value: 3.36e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPS-DKLSKIQTLKLAARYIDFL 117
Cdd:cd11400    1 KRRLHNVLERQRRNDLKNSFEKLRDLVPELADnEKASKVVILKKATEYIKQL 52
bHLH_TS_ASCL1_like cd19723
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
72-121 4.15e-07

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins, achaete-scute-like proteins, ASCL1-2, and similar proteins; This subfamily includes Drosophila melanogaster AS-C proteins and two ASCL family of transcription factors, ASCL-1 and ASCL-2. Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381566  Cd Length: 56  Bit Score: 44.75  E-value: 4.15e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLP-SDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19723    6 NERERNRVKLVNLGFATLREHVPNGRaNKKMSKVETLRSAVEYIRQLQQLL 56
bHLH_TS_bHLHe22_bHLHb5 cd18954
basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 ...
68-126 7.60e-07

basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins; bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is an OLIG-related bHLH neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types.


Pssm-ID: 381524  Cd Length: 70  Bit Score: 44.55  E-value: 7.60e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSD---KLSKIQTLKLAARYIdfLYQVLQSDEM 126
Cdd:cd18954    2 RLNINARERRRMHDLNDALDELRAVIPYAHSPsvrKLSKIATLLLAKNYI--LMQANALEEM 61
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
67-128 1.00e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 43.88  E-value: 1.00e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDN 128
Cdd:cd11406    1 KRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILKKATEYIQYMRRKNHTHQQDI 62
bHLH_TS_dAS-C_like cd19744
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ...
72-121 1.02e-06

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins and similar proteins; Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.


Pssm-ID: 381587 [Multi-domain]  Cd Length: 67  Bit Score: 44.12  E-value: 1.02e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTL------------PSDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19744    6 NARERNRVKQVNNGFAILRQHIPQSviedltagggrgKSKKLSKVDTLRMAVEYIRRLQKLL 67
bHLH_TS_OLIG1 cd18942
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 1 (Oligo1) ...
62-122 2.36e-06

basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 1 (Oligo1) and similar proteins; Oligo1, also termed Class B basic helix-loop-helix protein 6 (bHLHb6), or Class E basic helix-loop-helix protein 21 (bHLHe21), is a bHLH transcription factor that promotes formation and maturation of oligodendrocytes, especially within the brain.


Pssm-ID: 381512  Cd Length: 75  Bit Score: 43.06  E-value: 2.36e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  62 EELQSQRILANVRERQRTQSLNEAFAALRKII--------PTLPSDKLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd18942    1 EEQQQLRRKINSRERKRMQDLNLAMDALREVIlpysaahcQSSPGRKLSKIATLLLARNYILLLGSSLQ 69
bHLH_TS_ASCL4 cd19746
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and ...
72-122 2.40e-06

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and similar proteins; ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, is a bHLH transcriptional regulator that may be involved in skin development.


Pssm-ID: 381589  Cd Length: 64  Bit Score: 43.10  E-value: 2.40e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd19746   13 NERERQRVRCVNEGYARLREHLPQELADKrLSKVETLRAAIDYIKHLQELLE 64
bHLH_TS_MYOD1_Myf3 cd18936
basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and ...
67-122 3.44e-06

basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins; MYOD1, also termed Class C basic helix-loop-helix protein 1 (bHLHc1), or myogenic factor 3 (Myf-3), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with Myf-5 and MYOG, MYOD1 co-occupies muscle-specific gene promoter core region during myogenesis.


Pssm-ID: 381506  Cd Length: 61  Bit Score: 42.35  E-value: 3.44e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd18936    6 RRKAATMRERRRLSKVNEAFETLKRCTSTNPNQRLPKVEILRNAIRYIESLQALLR 61
bHLH_TS_OLIG2_like cd19725
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factors, Oligo2, ...
68-126 5.26e-06

basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factors, Oligo2, Oligo3 and similar proteins; The family includes two bHLH transcription factors, Oligo2 and Oligo3. Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube. Oligo3, also termed Class B basic helix-loop-helix protein 7 (bHLHb7), or Class E basic helix-loop-helix protein 20 (bHLHe20), is expressed in the ventricular zone of the dorsal alar plate of the hindbrain and involved in regulating the development of dorsal and ventral spinal cord. It may determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.


Pssm-ID: 381568  Cd Length: 63  Bit Score: 41.84  E-value: 5.26e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTL--PS-DKLSKIQTLKLAARYIDFLYQVLqsDEM 126
Cdd:cd19725    2 RLKINSRERKRMHDLNSALDGLREVMPYAhgPSvRKLSKIATLLLARNYILMLTNSL--EEM 61
bHLH_TS_ASCL2_Mash2 cd19743
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and ...
72-121 6.19e-06

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and similar proteins; ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves.


Pssm-ID: 381586  Cd Length: 64  Bit Score: 41.88  E-value: 6.19e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTL-PSDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19743    8 NERERNRVKLVNLGFAALRQHVPQGgASKKMSKVETLRSAVEYIRALQRLL 58
bHLH_TS_bHLHa9 cd18912
basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) ...
65-121 7.99e-06

basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) and similar proteins; bHLHa9, also termed Class F basic helix-loop-helix factor 42 (bHLHf42), is a bHLH transcription factor that plays an essential role in limb development.


Pssm-ID: 381482  Cd Length: 63  Bit Score: 41.47  E-value: 7.99e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 429325228  65 QSQRILANVRERQRTQSLNEAFAALRKIIP-TLPSDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd18912    6 KARRVAANVRERKRILDYNQAFNALRLALKhDLGGKRLSKIATLRRAINRISALSLFL 63
bHLH_TS_MRF cd11411
basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs ...
67-121 9.82e-06

basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs are a family of muscle-specific bHLH transcription proteins (MyoD, Myf5, Mrf4 and MyoG) that plays an essential role in regulating skeletal muscle development and growth. MRFs are capable of binding to E-box motifs as a heterodimer with E-proteins to regulate transcription expression.


Pssm-ID: 381417  Cd Length: 56  Bit Score: 40.98  E-value: 9.82e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd11411    2 RRKAATMRERRRLKKVNEAFEALKRCTSANPNQRLPKVEILRNAIEYIESLQDLL 56
bHLH_TS_Myf5 cd18937
basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; ...
67-122 1.25e-05

basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; Myf-5, also termed Class C basic helix-loop-helix protein 2 (bHLHc2), is a nuclear bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle specification and differentiation. It also acts as an RNA-binding protein which enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis.


Pssm-ID: 381507  Cd Length: 64  Bit Score: 40.89  E-value: 1.25e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd18937    2 RRKAATMRERRRLKKVNQAFETLKRCTTSNPNQRLPKVEILRNAIRYIESLQDLLR 57
bHLH_TS_ASCL1_Mash1 cd19742
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and ...
72-127 1.90e-05

basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins; ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system.


Pssm-ID: 381585  Cd Length: 71  Bit Score: 40.89  E-value: 1.90e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLPSDK-LSKIQTLKLAARYIDFLYQVLqsDEMD 127
Cdd:cd19742   10 NERERNRVKLVNMGFATLREHVPNGAANKkMSKVETLRSAVEYIRALQQLL--DEHD 64
bHLH_TS_MRF4_Myf6 cd18934
basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and ...
67-123 2.32e-05

basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and similar proteins; MRF4, also termed Class C basic helix-loop-helix protein 4 (bHLHc4), or myogenic factor 6 (Myf-6), is a bHLH transcription factor associated with myogenesis. It plays a role in skeletal muscle differentiation.


Pssm-ID: 381504  Cd Length: 64  Bit Score: 40.43  E-value: 2.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQS 123
Cdd:cd18934    2 RRKAATLRERRRLKKINEAFEALKRRTVPNPNQRLPKVEILRSAINYIEKLQDLLHS 58
bHLH_TS_bHLHe23_bHLHb4 cd18953
basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 23 ...
62-126 2.42e-05

basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 23 (bHLHe23) and similar proteins; bHLHe23, also termed Class B basic helix-loop-helix protein 4 (bHLHb4), is an OLIG-related bHLH transcription factor that is expressed in rod bipolar cells and is required for rod bipolar cell maturation. bHLHe23 have roles in spinal interneuron differentiation by mechanisms linked to the Notch signaling pathway. It modulates the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types.


Pssm-ID: 381523  Cd Length: 81  Bit Score: 40.81  E-value: 2.42e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 429325228  62 EELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSD---KLSKIQTLKLAARYIdfLYQVLQSDEM 126
Cdd:cd18953    2 KEQRSLRLSINARERRRMHDLNDALDGLRSVIPYAHSPsvrKLSKIATLLLAKNYI--LMQAQALEEM 67
bHLH_TS_MYOG_Myf4 cd18935
basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also ...
67-123 5.89e-05

basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also termed Class C basic helix-loop-helix protein 3 (bHLHc3), or myogenic factor 4 (Myf-4), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy.


Pssm-ID: 381505  Cd Length: 59  Bit Score: 39.25  E-value: 5.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQS 123
Cdd:cd18935    2 RRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSS 58
bHLH_TS_dMYOD_like cd19699
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination ...
67-121 7.06e-05

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination protein (dMYOD) and similar proteins; dMYOD, also termed protein nautilus, or Myd, may play an important role in the early development of muscle in Drosophila.


Pssm-ID: 381542  Cd Length: 56  Bit Score: 38.67  E-value: 7.06e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVL 121
Cdd:cd19699    2 RRKAATMRERRRLRKVNEAFEVLKRRTCPNPNQRLPKVEILRNAIEYIESLEDLL 56
bHLH_TS_OLIG2 cd18940
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) ...
63-122 9.22e-05

basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins; Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is a bHLH transcription factor that is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube.


Pssm-ID: 381510  Cd Length: 85  Bit Score: 39.24  E-value: 9.22e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 429325228  63 ELQSQRILANVRERQRTQSLNEAFAALRKIIPTL--PS-DKLSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd18940   11 ELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAhgPSvRKLSKIATLLLARNYILMLTNSLE 73
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
67-130 9.48e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 38.82  E-value: 9.48e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 429325228  67 QRILANVR-ERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVL-----QSDEMDNKM 130
Cdd:cd11404    1 QRRLNHVRsEKKRRELIKKGYDELCALVPGLDPQKRTKADILQKAADWIQELKEENekleeQLDELKEAA 70
bHLH_TS_OLIG3 cd18941
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 3 (Oligo3) ...
62-126 1.27e-04

basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 3 (Oligo3) and similar proteins; Oligo3, also termed Class B basic helix-loop-helix protein 7 (bHLHb7), or Class E basic helix-loop-helix protein 20 (bHLHe20), is a bHLH transcription factor that is expressed in the ventricular zone of the dorsal alar plate of the hindbrain and involved in regulating the development of dorsal and ventral spinal cord. It may determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.


Pssm-ID: 381511  Cd Length: 81  Bit Score: 38.81  E-value: 1.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 429325228  62 EELQSQRILANVRERQRTQSLNEAFAALRKIIPTL--PS-DKLSKIQTLKLAARYIDFLYQVLqsDEM 126
Cdd:cd18941   11 QDLQQLRLKINGRERKRMHDLNLAMDGLREVMPYAhgPSvRKLSKIATLLLARNYILMLTSSL--EEM 76
bHLH_TS_Mesp cd18938
basic helix-loop-helix (bHLH) domain found in the mesoderm posterior protein (Mesp) family; ...
67-128 2.18e-04

basic helix-loop-helix (bHLH) domain found in the mesoderm posterior protein (Mesp) family; Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis.


Pssm-ID: 381508 [Multi-domain]  Cd Length: 65  Bit Score: 37.57  E-value: 2.18e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIP--TLPSDK-LSKIQTLKLAARYIDFLYQVLQSDEMDN 128
Cdd:cd18938    1 QRQSASEREKLRMRDLAKALHNLRRYLPpsVAPAGQsLTKIETLRLTIRYISHLSAQLGLSEESL 65
bHLH_TS_Msgn1 cd18939
basic helix-loop-helix (bHLH) domain found in mesogenin-1 (Msgn1) and similar proteins; Msgn1, ...
67-122 2.19e-04

basic helix-loop-helix (bHLH) domain found in mesogenin-1 (Msgn1) and similar proteins; Msgn1, also termed paraxial mesoderm-specific mesogenin1, or pMesogenin1 (pMsgn1), is a bHLH transcription factor required for maturation and segmentation of paraxial mesoderm. It may regulate the expression of T-box transcription factors essential for mesoderm formation and differentiation.


Pssm-ID: 381509  Cd Length: 66  Bit Score: 37.58  E-value: 2.19e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 429325228  67 QRILANVRERQRTQSLNEAFAALRKIIPTLPSDK---LSKIQTLKLAARYIDFLYQVLQ 122
Cdd:cd18939    8 RRRKASEREKLRMRTLAEALHTLRNYLPPVYSQRgqpLTKIQTLKCTIQYISELSGLLN 66
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
68-117 2.80e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 37.25  E-value: 2.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFL 117
Cdd:cd19682    1 RLRHKKRERERRSELRELFDKLKQLLGLDSDEKASKLAVLTEAIEEIQQL 50
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
72-123 6.24e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 36.01  E-value: 6.24e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPtlPSDKLSKIQTLKLAARYIDFLYQVLQS 123
Cdd:cd11393    2 SIAERKRREKINERIRALRSLVP--NGGKTDKASILDEAIEYIKFLQEQVKV 51
bHLH_AtAIB_like cd11449
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE ...
75-129 4.24e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AIB and MYC proteins (MYC2, MYC3 and MYC4). AIB, also termed AtbHLH17, or EN 35, is a transcription activator that regulates positively abscisic acid (ABA) response. MYC2, also termed protein jasmonate insensitive 1, or R-homologous Arabidopsis protein 1 (RAP-1), or AtbHLH6, or EN 38, or Z-box binding factor 1 protein, is a transcriptional activator involved in abscisic acid (ABA), jasmonic acid (JA), and light signaling pathways. MYC3, also termed protein altered tryptophan regulation 2, or AtbHLH5, or transcription factor ATR2, or EN 36, is a transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. MYC4, also termed AtbHLH4, or EN 37, is a transcription factor involved in jasmonic acid (JA) gene regulation. MYC2, together with MYC3 and MYC4, controls additively subsets of JA-dependent responses.


Pssm-ID: 381455 [Multi-domain]  Cd Length: 78  Bit Score: 34.29  E-value: 4.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 429325228  75 ERQRTQSLNEAFAALRKIIPTLpsDKLSKIQTLKLAARYIDFLYQVLQSDEMDNK 129
Cdd:cd11449   13 ERQRREKLNQRFYALRAVVPNV--SKMDKASLLGDAISYINELKSKVQDMETEKK 65
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
68-124 5.50e-03

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 33.48  E-value: 5.50e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 429325228  68 RILANVRERQRTQSLNEAFAALRKIIPtLPSDKLSKIQTLKLAARYIDFLYQVLQSD 124
Cdd:cd19683    3 RERHNAKERQRRERIKIACDQLRKLVP-GCSRKTDKATVFEFTVAYIKFLREKLGDS 58
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
72-129 9.69e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 33.46  E-value: 9.69e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 429325228  72 NVRERQRTQSLNEAFAALRKIIPTLPSD----------------KLSKIQTLKLAARYIDFLYQVLQSDEMDNK 129
Cdd:cd11395    8 NAIEKRYRSNLNTKIERLRDAIPSLRSPegksddgglgglapttKLSKATILTKAIEYIRHLEQENERLEEENE 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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