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Conserved domains on  [gi|385251390|ref|NP_001245256|]
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protein SFI1 homolog isoform e [Homo sapiens]

Protein Classification

Sfi1 domain-containing protein( domain architecture ID 713344)

Sfi1 domain-containing protein similar to Homo sapiens coiled-coil domain-containing protein 191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sfi1 super family cl25835
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 335-747 5.00e-09

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


The actual alignment was detected with superfamily member pfam08457:

Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 60.39  E-value: 5.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   335 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 412
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   413 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 488
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   489 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 544
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   545 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 603
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   604 GALRRWKENTMAR---------VDEAKKTFQVLVQWREavsvQMYYRQQEDCAIWEAQK-VLDRGCLRTW---------- 663
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRE----RHQHVQKLEKWARDARFyFLATRTLKKWraateesrre 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   664 ---------------------FQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 722
Cdd:pfam08457  413 rrqdayaqvrrkvkinlarraLSKWRSKAAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 385251390   723 QRLSRTCFRQWRQQLAA-RRQEQRAT 747
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 842-1035 6.98e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  842 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 921
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  922 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1001
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251390 1002 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1035
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 335-747 5.00e-09

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 60.39  E-value: 5.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   335 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 412
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   413 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 488
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   489 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 544
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   545 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 603
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   604 GALRRWKENTMAR---------VDEAKKTFQVLVQWREavsvQMYYRQQEDCAIWEAQK-VLDRGCLRTW---------- 663
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRE----RHQHVQKLEKWARDARFyFLATRTLKKWraateesrre 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   664 ---------------------FQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 722
Cdd:pfam08457  413 rrqdayaqvrrkvkinlarraLSKWRSKAAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 385251390   723 QRLSRTCFRQWRQQLAA-RRQEQRAT 747
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 PHA03247
large tegument protein UL36; Provisional
 842-1035 6.98e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  842 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 921
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  922 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1001
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251390 1002 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1035
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 826-1052 1.79e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   826 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 896
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   897 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 971
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   972 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1027
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 385251390  1028 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1052
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
COG3903 COG3903
Predicted ATPase [General function prediction only];
481-929 1.35e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 43.08  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  481 AAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQLLRWAWSQWRECLALRGAERQKLMRA 560
Cdd:COG3903   477 AAERLAEAGERAAARRRHADYYLALAERAAAELRGPDQLAWLARLDAEHDNLRAALRWALAHGDAELALRLAAALAPFWF 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  561 DLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALRRWKENTMARVDEAKKTFQVLVQWREAVSVQMYY 640
Cdd:COG3903   557 LRGLLREGRRWLERALAAAGEAAAALAAAAALAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAA 636

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  641 RQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQL 720
Cdd:COG3903   637 AAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAA 716

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  721 LAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWAFSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLL 800
Cdd:COG3903   717 AAAAAAAAAALLAAAAAAALAAAAAAAALALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAA 796

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  801 RFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLET 880
Cdd:COG3903   797 AAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAALAAALAAAAAAAAAAAAAAAAAAALAAALAAAAAAAAAAALAAAAAA 876

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 385251390  881 KRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQR 929
Cdd:COG3903   877 AAAAAAALLAAAAAAAAAAAAAAAAAAALAAAAAAAAAAALAAAAAAAA 925
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 335-747 5.00e-09

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 60.39  E-value: 5.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   335 LLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELWLQYTQKRRykqLLQARADGHFQQRALPAAFHTWn 412
Cdd:pfam08457   57 LRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAWRRRTLQIR---VREEVAVQVYQENLLKRSFWKW- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   413 rlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQ---- 488
Cdd:pfam08457  119 ---FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSERTEAVQAAEqead 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   489 -------------EWQTVA---------CAHHRHGRLKKAFCLWRESAQGLRtertgrvRAAEFHMAQLLRWAWSQWR-- 544
Cdd:pfam08457  189 sfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKLRARMSR-------QAREVDRARILRNAWTTWNde 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   545 -ECLALRG----------------AERQKLMRAdlHHQHSVLHRALQAWVTyqgRVRSILREVAARESQH----NRQLLR 603
Cdd:pfam08457  262 lRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVLSTWVT---NTRDTRTRLLRHEEEFeehrNRKLLR 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   604 GALRRWKENTMAR---------VDEAKKTFQVLVQWREavsvQMYYRQQEDCAIWEAQK-VLDRGCLRTW---------- 663
Cdd:pfam08457  337 SKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRE----RHQHVQKLEKWARDARFyFLATRTLKKWraateesrre 412

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   664 ---------------------FQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLA 722
Cdd:pfam08457  413 rrqdayaqvrrkvkinlarraLSKWRSKAAEVADLEQQADQLRQNRLLEDAIELFDRWRERTAKRKQR---AEDADQFYA 489

                          490       500
                   ....*....|....*....|....*.
gi 385251390   723 QRLSRTCFRQWRQQLAA-RRQEQRAT 747
Cdd:pfam08457  490 EQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 PHA03247
large tegument protein UL36; Provisional
 842-1035 6.98e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  842 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 921
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  922 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1001
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251390 1002 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1035
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
PHA03247 PHA03247
large tegument protein UL36; Provisional
 882-1052 1.05e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  882 RPQASRPLGAlGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQ-SQRPQKPQEHGLGMAQPAAPSLTRPFLAE----- 955
Cdd:PHA03247 2632 SPAANEPDPH-PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPptpep 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  956 APTALVPHSPLP----------GALSSAPGPKQPPTASTGPELLLLPLSSFMPCGA------AAPARVSAQRATPRDKPP 1019
Cdd:PHA03247 2711 APHALVSATPLPpgpaaarqasPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPpapappAAPAAGPPRRLTRPAVAS 2790

                         170       180       190
                  ....*....|....*....|....*....|...
gi 385251390 1020 VPSSLASVPDPHLLLPGDFSATRAGPGLSTAGS 1052
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
PHA03247 PHA03247
large tegument protein UL36; Provisional
 847-1078 1.43e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  847 PQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKRPQASRPLgalgrlAAEEPHALELntahsARKQPRRPH--FLLEP 924
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA------APARPPVRRL-----ARPAVSRSTesFALPP 2902

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  925 AQSQRPQKPQehglgmaqPAAPSLTRPfLAEAPTALVPHSPLPGAlssaPGPKQPPTASTGPELLLLPLSSFMPCGAAAP 1004
Cdd:PHA03247 2903 DQPERPPQPQ--------APPPPQPQP-QPPPPPQPQPPPPPPPR----PQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 385251390 1005 ARVSAQRA-TPRDKPPVPSSLASVPDPHlllpgdfsaTRAGPGLST-AGSLDLEAELEEIQQQLlhyqttKQNLWS 1078
Cdd:PHA03247 2970 GRVAVPRFrVPQPAPSREAPASSTPPLT---------GHSLSRVSSwASSLALHEETDPPPVSL------KQTLWP 3030
PHA03247 PHA03247
large tegument protein UL36; Provisional
 844-1031 3.64e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  844 GGKPQPLAAIAPSrkvtfegpllnriaaGAGDGTLETKRPqASRPLGAlgrlaaeephalelntahSARKQPRRPHFLLE 923
Cdd:PHA03247 2549 GDPPPPLPPAAPP---------------AAPDRSVPPPRP-APRPSEP------------------AVTSRARRPDAPPQ 2594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  924 PAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPH--SPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMpcGA 1001
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL--GR 2672

                         170       180       190
                  ....*....|....*....|....*....|
gi 385251390 1002 AAPARVSAQRATPRDKPPVPSSLASVPDPH 1031
Cdd:PHA03247 2673 AAQASSPPQRPRRRAARPTVGSLTSLADPP 2702
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 907-1130 4.10e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 4.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  907 TAHSARKQPRRPHFLLEPAQSQRPQKPQEH--GLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGAlSSAPGPKQPPTAST 984
Cdd:PRK07764  598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPapAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA-SDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  985 GPELLLLPLSSFMPCGAAAPARvSAQRATPRDKPPVPSSLASVPDPhlllPGDfSATRAGPGLSTAGSLDLEAELEEIQQ 1064
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADDPAAQP----PQA-AQGASAPSPAADDPVPLPPEPDDPPD 750

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 385251390 1065 QLLHYQTTKQNLWSCRRQASSLR-RWLELNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQR 1130
Cdd:PRK07764  751 PAGAPAQPPPPPAPAPAAAPAAApPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGAKK 817
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
846-1030 1.07e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  846 KPQPLAAIAPSRKVTfegPLLNRIAAGAGDGTletkrpQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPA 925
Cdd:PRK07003  411 APKAAAAAAATRAEA---PPAAPAPPATADRG------DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  926 QSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTAL-------VPHSPLPGALSSAPGPKQPPTASTGPELLL-------L 991
Cdd:PRK07003  482 SDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsredapaAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagM 561

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 385251390  992 PLSSFMPCGAAAPARVSAQRATPrDKPPVPSSLASVPDP 1030
Cdd:PRK07003  562 RVSSDRGARAAAAAKPAAAPAAA-PKPAAPRVAVQVPTP 599
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
842-1055 1.21e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.46  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  842 GRGGKPQPLAAIAPSRKVTFEGPllnRIAAGAGDGTLETKRPQASRPLGALgRLAAEEPHALELNTAhsarkqprrphfl 921
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAVPAPGA---RAAAAVGASAVPAVTAVTGAAGAAL-APKAAAAAAATRAEA------------- 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  922 lEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLP---GALSSAPGPKQPPTASTGPELLLLPLSSFMP 998
Cdd:PRK07003  426 -PPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPpadSGSASAPASDAPPDAAFEPAPRAAAPSAATP 504

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 385251390  999 CGAAAPARVSAQRATPRDKPP-VPSSLASVPDPhlllPGDFSATRAGpglSTAGSLDL 1055
Cdd:PRK07003  505 AAVPDARAPAAASREDAPAAAaPPAPEARPPTP----AAAAPAARAG---GAAAALDV 555
PHA03378 PHA03378
EBNA-3B; Provisional
 874-1049 1.31e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.68  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  874 GDGTLETKRPQASRPLGALGRLAAEEPHALELNTA---HSARKQPRR-PHFLLEPAQSQRPQKPqeHGLGMAQPAAPSLT 949
Cdd:PHA03378  607 EPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPItfnVLVFPTPHQpPQVEITPYKPTWTQIG--HIPYQPSPTGANTM 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  950 RPFLAeAPTALVPHSPLPGALS---SAPGPKQPPTASTGPellllplssfMPCGAAAPARVSAQRATPRDKPPvPSSLAS 1026
Cdd:PHA03378  685 LPIQW-APGTMQPPPRAPTPMRppaAPPGRAQRPAAATGR----------ARPPAAAPGRARPPAAAPGRARP-PAAAPG 752

                         170       180
                  ....*....|....*....|...
gi 385251390 1027 VPDPHLLLPGDFSATRAGPGLST 1049
Cdd:PHA03378  753 RARPPAAAPGRARPPAAAPGAPT 775
PHA03247 PHA03247
large tegument protein UL36; Provisional
 846-1053 2.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  846 KPQPLAAIAPSRkVTFEGPLLNRIAAGAGDGTLETKRPQASRP-LGALGRLA---------AEEPHALELNTAHSARKQP 915
Cdd:PHA03247 2649 PERPRDDPAPGR-VSRPRRARRLGRAAQASSPPQRPRRRAARPtVGSLTSLAdpppppptpEPAPHALVSATPLPPGPAA 2727

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  916 RRPHFLLEPAQSQRPQKPQehglGMAQPAAPS--LTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPL 993
Cdd:PHA03247 2728 ARQASPALPAAPAPPAVPA----GPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  994 SSFMPcgAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSatragPGLSTAGSL 1053
Cdd:PHA03247 2804 PADPP--AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP-----PSLPLGGSV 2856
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 424-786 3.06e-05

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 48.06  E-value: 3.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   424 LSARATRFHRETLEKQVFSLWRQKMFQHRENRLAERMAIlhaerqLLYRSWFMWHQQAAarhqeqEWQTvacaHHRHGRL 503
Cdd:pfam08457   18 LERRAARARDLYLLTKAFTHWAQAASEEVERTSAARRHI------LRKKYFNAWREITA------VNEL----KAQRFAL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   504 KKAFCLWRESAQGLRTErtgRVRAAEFHMAQLLRWAWSQWRECLALRGAER---QKLMR-------------------AD 561
Cdd:pfam08457   82 KRPLGAWRRRTLQIRVR---EEVAVQVYQENLLKRSFWKWFWEFCERRAPQwydFRLKRrslltwlrkfrtlrereqeAE 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   562 LHHQHSVLHRALQAWvtyQGRVRSILREVAARESQHNRQLLRGALRRWKENT---------MARVDEAKKTFqVLVQWRE 632
Cdd:pfam08457  159 AKRKRLLLSSALQIW---SERTEAVQAAEQEADSFRRRKLLRRALDEWRIQArlepalrqvSAKVDRRILRS-ALSVWKL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   633 AVSVQmyyRQQEDCAiweaqkvlDRGCLRTWFQRWWDCSRRSAQQ-----RLQLE-----------RAVQHHHRQ-LLLE 695
Cdd:pfam08457  235 RARMS---RQAREVD--------RARILRNAWTTWNDELRCKALRerideRLKLEalykwvleerlRLFQRIREQrLKRE 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   696 GLARWKTHHLQcVRKRLLHRQST--QLLAQRLSRTCFRQWRQQLAARRQEQRAtvrALWFWAFSLQAKVWATWLAfvlER 773
Cdd:pfam08457  304 VLSTWVTNTRD-TRTRLLRHEEEfeEHRNRKLLRSKLLKWRDQLAEQREREIA---ANEFYAPRLLQEALDAWRE---RH 376

                          410
                   ....*....|...
gi 385251390   774 RRKKARLQWALQA 786
Cdd:pfam08457  377 QHVQKLEKWARDA 389
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 826-1052 1.79e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   826 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 896
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   897 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 971
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390   972 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1027
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 385251390  1028 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1052
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
852-1043 7.38e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 7.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  852 AIAPSRKVTFEGPLLNRIA---AGAGDGTleTKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQ 928
Cdd:PRK12323  344 ALAPDEYAGFTMTLLRMLAfrpGQSGGGA--GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAA 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  929 RPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAA------ 1002
Cdd:PRK12323  422 APARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppwee 501

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 385251390 1003 APARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRA 1043
Cdd:PRK12323  502 LPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLA 542
COG3903 COG3903
Predicted ATPase [General function prediction only];
481-929 1.35e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 43.08  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  481 AAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQLLRWAWSQWRECLALRGAERQKLMRA 560
Cdd:COG3903   477 AAERLAEAGERAAARRRHADYYLALAERAAAELRGPDQLAWLARLDAEHDNLRAALRWALAHGDAELALRLAAALAPFWF 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  561 DLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALRRWKENTMARVDEAKKTFQVLVQWREAVSVQMYY 640
Cdd:COG3903   557 LRGLLREGRRWLERALAAAGEAAAALAAAAALAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAA 636

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  641 RQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQL 720
Cdd:COG3903   637 AAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAA 716

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  721 LAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWAFSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLL 800
Cdd:COG3903   717 AAAAAAAAAALLAAAAAAALAAAAAAAALALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAA 796

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  801 RFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLET 880
Cdd:COG3903   797 AAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAALAAALAAAAAAAAAAAAAAAAAAALAAALAAAAAAAAAAALAAAAAA 876

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 385251390  881 KRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQR 929
Cdd:COG3903   877 AAAAAAALLAAAAAAAAAAAAAAAAAAALAAAAAAAAAAALAAAAAAAA 925
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
298-767 1.39e-03

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 42.87  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  298 HRHSQLYFCFRALKDNVTHAHLQQIRRNLAHQQHGVTLLHRFWNLWRSQIEQKKERELLPLLHAAWDHYRIALLckciel 377
Cdd:COG5635   474 HRSFQEYLAARALVEELDEELLELLAEHLEDPRWREVLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALL------ 547

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  378 wlqyTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQKMFQHRENRLA 457
Cdd:COG5635   548 ----LALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLA 623

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  458 ERMAILHAERQLLYRSWFmWHQQAAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQLLR 537
Cdd:COG5635   624 LLLLLLLLLLAELLLLAL-LALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALA 702

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  538 WAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALRRWKENTMARV 617
Cdd:COG5635   703 LALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLL 782

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  618 DEAKKTFQVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGL 697
Cdd:COG5635   783 LALALLASLLLALLLLILLLVLLGSLLLLRLLDDLALLLLLALAAARLLLSSLALVALELARASLGASLVLLALLLATLL 862

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  698 ARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWAFSLQAKVWATWL 767
Cdd:COG5635   863 LLLLLLLALALALLSLLSLSSLALLSLLGLLLALSLLALLLLSLSLALAALLLAAREALTLDRLLSLASL 932
COG3899 COG3899
Predicted ATPase [General function prediction only];
368-835 1.63e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 42.92  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  368 IALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQK 447
Cdd:COG3899   725 LRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLG 804

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  448 MFQ--HRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERTGRV 525
Cdd:COG3899   805 DYEeaYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAAAAAA 884

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  526 RAAEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAAREsqhnrqlLRGA 605
Cdd:COG3899   885 ALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAA-------LAAA 957

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  606 LRRWKENTMARVDEAKKTFQVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAV 685
Cdd:COG3899   958 LALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALL 1037

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  686 QHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWAFSLQAKVWAT 765
Cdd:COG3899  1038 AAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALA 1117

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  766 WLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATL 835
Cdd:COG3899  1118 AALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAA 1187
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
847-1068 3.56e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  847 PQPLAAIAPSRKVTfEGPLLNRIAAGAGDGTLETKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRrPHFLLEPAQ 926
Cdd:PRK12323  383 AQPAPAAAAPAAAA-PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-PAPAAAPAA 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  927 SQRPQKPQEHGLGMA--------QPAAPSltrpflAEAPTALVPHSPLPGALSSaPGPKQPPTASTGPEllllpLSSFMP 998
Cdd:PRK12323  461 AARPAAAGPRPVAAAaaaaparaAPAAAP------APADDDPPPWEELPPEFAS-PAPAQPDAAPAGWV-----AESIPD 528

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 385251390  999 CGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRAGPgLSTAGSLDLEAEL--EEIQQQLLH 1068
Cdd:PRK12323  529 PATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD-MFDGDWPALAARLpvRGLAQQLAR 599
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 891-1028 6.46e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 6.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  891 ALGRLAAEEPHALELNTAHSARKQPRRPHfLLEPAQSQRPQKpqehglgmAQPAAPSLTRPFLAEAPTALVPHSPlPGAL 970
Cdd:PRK14951  357 VLLRLLAFKPAAAAEAAAPAEKKTPARPE-AAAPAAAPVAQA--------AAAPAPAAAPAAAASAPAAPPAAAP-PAPV 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385251390  971 SSAPGPKQPPTASTGPELLLLPLSSFM---PCGAAAPARVSAQRATPRDKPPVPSSLASVP 1028
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAqaaPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 941-1053 7.53e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251390  941 AQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPV 1020
Cdd:PRK14951  379 KTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPE 458

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 385251390 1021 PSSLA--SVPDPHLLLPGDFSATRAGPGLSTAGSL 1053
Cdd:PRK14951  459 TVAIPvrVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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