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Conserved domains on  [gi|385251386|ref|NP_001245254|]
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protein SFI1 homolog isoform c [Homo sapiens]

Protein Classification

Sfi1 domain-containing protein( domain architecture ID 713344)

Sfi1 domain-containing protein similar to Homo sapiens coiled-coil domain-containing protein 191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sfi1 super family cl25835
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 328-786 3.51e-13

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


The actual alignment was detected with superfamily member pfam08457:

Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 73.87  E-value: 3.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   328 LRRAFTHWKHYMllcAEEAAQFEMAEEHhrhsqLLLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELW 405
Cdd:pfam08457   31 LTKAFTHWAQAA---SEEVERTSAARRH-----ILRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAW 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   406 LQYTQKRRykqLLQARADGHFQQRALPAAFHTWnrlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAE 485
Cdd:pfam08457   89 RRRTLQIR---VREEVAVQVYQENLLKRSFWKW----FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLRERE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   486 RMAILHAERQLLYRSWFMWHQQAAARHQEQ-----------------EWQTVA---------CAHHRHGRLKKAFCLWRE 539
Cdd:pfam08457  155 QEAEAKRKRLLLSSALQIWSERTEAVQAAEqeadsfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   540 SAQGLRtertgrvRAAEFHMAQLLRWAWSQWR---ECLALRG----------------AERQKLMRAdlHHQHSVLHRAL 600
Cdd:pfam08457  235 RARMSR-------QAREVDRARILRNAWTTWNdelRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVL 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   601 QAWVTyqgRVRSILREVAARESQH----NRQLLRGALRRWKENTMAR---------VDEAKKTFQASTHYR--------- 658
Cdd:pfam08457  306 STWVT---NTRDTRTRLLRHEEEFeehrNRKLLRSKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqkl 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   659 ---------RTICSKVLVQWREAVSVQMYYRQQEDCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHH 727
Cdd:pfam08457  383 ekwardarfYFLATRTLKKWRAATEESRRERRQDAYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNR 458

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   728 HRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLAQRLSRTCFRQWRQQLAA-RRQEQRAT 786
Cdd:pfam08457  459 LLEDAIELFDRWRERTAKRKQR---AEDADQFYAEQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 881-1074 7.91e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 7.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  881 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 960
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  961 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1040
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251386 1041 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1074
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
Sfi1 super family cl25835
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 78-516 3.71e-03

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


The actual alignment was detected with superfamily member pfam08457:

Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 41.51  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386    78 TRQGRLRELRIRFYYEQRLLRKVFEEWKeewwvfqheWKLCVR-ADCHYRYYLYNLMFQTWKTYVRQQQEMRNKyirAEV 156
Cdd:pfam08457   92 TLQIRVREEVAVQVYQENLLKRSFWKWF---------WEFCERrAPQWYDFRLKRRSLLTWLRKFRTLREREQE---AEA 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   157 HDAKQKMRQAWKSWLIYVvvrRTKLQMQTTALEFRQRIILRVWWSTWRQrlgQVRVSRALHASALKHRAlSLQVQAWSQW 236
Cdd:pfam08457  160 KRKRLLLSSALQIWSERT---EAVQAAEQEADSFRRRKLLRRALDEWRI---QARLEPALRQVSAKVDR-RILRSALSVW 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   237 REQLLYVQKEKQKVVSAVKHH--QHWQKRRFLKAWLEYLQVRRVKRQQNE--MAERF------HHVTVLQIYFCDWQQAW 306
Cdd:pfam08457  233 KLRARMSRQAREVDRARILRNawTTWNDELRCKALRERIDERLKLEALYKwvLEERLrlfqriREQRLKREVLSTWVTNT 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   307 ERRESLYAHHAQVEKLARKMAL-RRAFTHWKHYMLLCAE-EAAQFEMaeehhrHSQLLLHRFWNLWRSQIEQKKEREllp 384
Cdd:pfam08457  313 RDTRTRLLRHEEEFEEHRNRKLlRSKLLKWRDQLAEQRErEIAANEF------YAPRLLQEALDAWRERHQHVQKLE--- 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   385 llHAAWDHYRIALLCKCIELWLQYTQK--------------RRYKQLLQARADGHFQQRALPAAfhtwnrlwrwrhqenV 450
Cdd:pfam08457  384 --KWARDARFYFLATRTLKKWRAATEEsrrerrqdayaqvrRKVKINLARRALSKWRSKAAEVA---------------D 446

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 385251386   451 LSARATRFHRETLEK---QVFSLWRQKMFQHRENrlAERMAILHAErQLLYRSWFMWHQQAAARHQEQE 516
Cdd:pfam08457  447 LEQQADQLRQNRLLEdaiELFDRWRERTAKRKQR--AEDADQFYAE-QLLRSYLARWRERLRELRELEQ 512
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 328-786 3.51e-13

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 73.87  E-value: 3.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   328 LRRAFTHWKHYMllcAEEAAQFEMAEEHhrhsqLLLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELW 405
Cdd:pfam08457   31 LTKAFTHWAQAA---SEEVERTSAARRH-----ILRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAW 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   406 LQYTQKRRykqLLQARADGHFQQRALPAAFHTWnrlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAE 485
Cdd:pfam08457   89 RRRTLQIR---VREEVAVQVYQENLLKRSFWKW----FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLRERE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   486 RMAILHAERQLLYRSWFMWHQQAAARHQEQ-----------------EWQTVA---------CAHHRHGRLKKAFCLWRE 539
Cdd:pfam08457  155 QEAEAKRKRLLLSSALQIWSERTEAVQAAEqeadsfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   540 SAQGLRtertgrvRAAEFHMAQLLRWAWSQWR---ECLALRG----------------AERQKLMRAdlHHQHSVLHRAL 600
Cdd:pfam08457  235 RARMSR-------QAREVDRARILRNAWTTWNdelRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVL 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   601 QAWVTyqgRVRSILREVAARESQH----NRQLLRGALRRWKENTMAR---------VDEAKKTFQASTHYR--------- 658
Cdd:pfam08457  306 STWVT---NTRDTRTRLLRHEEEFeehrNRKLLRSKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqkl 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   659 ---------RTICSKVLVQWREAVSVQMYYRQQEDCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHH 727
Cdd:pfam08457  383 ekwardarfYFLATRTLKKWRAATEESRRERRQDAYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNR 458

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   728 HRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLAQRLSRTCFRQWRQQLAA-RRQEQRAT 786
Cdd:pfam08457  459 LLEDAIELFDRWRERTAKRKQR---AEDADQFYAEQLLRSYLARWRERLRElRELEQDAD 515
PHA03247 PHA03247
large tegument protein UL36; Provisional
 881-1074 7.91e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 7.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  881 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 960
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  961 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1040
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251386 1041 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1074
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 865-1091 2.59e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 2.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   865 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 935
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   936 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 1010
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  1011 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1066
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 385251386  1067 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1091
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
COG3899 COG3899
Predicted ATPase [General function prediction only];
395-921 1.18e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 43.31  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  395 IALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQK 474
Cdd:COG3899   725 LRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLG 804

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  475 MFQhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVacahhrHGRLKKAFCLWRESAQGLRTERTGRVRA 554
Cdd:COG3899   805 DYE-EAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREA------LELLREALEAGLETGDAALALLALAAAA 877

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  555 AEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALR 634
Cdd:COG3899   878 AAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAA 957

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  635 RWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSA 714
Cdd:COG3899   958 LALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALL 1037

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  715 QQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWA 794
Cdd:COG3899  1038 AAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALA 1117

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  795 FSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATL 874
Cdd:COG3899  1118 AALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALLA 1197

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 385251386  875 WKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKR 921
Cdd:COG3899  1198 ALLALAARLAALLALALLALEAAALLLLLLLAALALAAALLALRLLA 1244
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 78-516 3.71e-03

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 41.51  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386    78 TRQGRLRELRIRFYYEQRLLRKVFEEWKeewwvfqheWKLCVR-ADCHYRYYLYNLMFQTWKTYVRQQQEMRNKyirAEV 156
Cdd:pfam08457   92 TLQIRVREEVAVQVYQENLLKRSFWKWF---------WEFCERrAPQWYDFRLKRRSLLTWLRKFRTLREREQE---AEA 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   157 HDAKQKMRQAWKSWLIYVvvrRTKLQMQTTALEFRQRIILRVWWSTWRQrlgQVRVSRALHASALKHRAlSLQVQAWSQW 236
Cdd:pfam08457  160 KRKRLLLSSALQIWSERT---EAVQAAEQEADSFRRRKLLRRALDEWRI---QARLEPALRQVSAKVDR-RILRSALSVW 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   237 REQLLYVQKEKQKVVSAVKHH--QHWQKRRFLKAWLEYLQVRRVKRQQNE--MAERF------HHVTVLQIYFCDWQQAW 306
Cdd:pfam08457  233 KLRARMSRQAREVDRARILRNawTTWNDELRCKALRERIDERLKLEALYKwvLEERLrlfqriREQRLKREVLSTWVTNT 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   307 ERRESLYAHHAQVEKLARKMAL-RRAFTHWKHYMLLCAE-EAAQFEMaeehhrHSQLLLHRFWNLWRSQIEQKKEREllp 384
Cdd:pfam08457  313 RDTRTRLLRHEEEFEEHRNRKLlRSKLLKWRDQLAEQRErEIAANEF------YAPRLLQEALDAWRERHQHVQKLE--- 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   385 llHAAWDHYRIALLCKCIELWLQYTQK--------------RRYKQLLQARADGHFQQRALPAAfhtwnrlwrwrhqenV 450
Cdd:pfam08457  384 --KWARDARFYFLATRTLKKWRAATEEsrrerrqdayaqvrRKVKINLARRALSKWRSKAAEVA---------------D 446

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 385251386   451 LSARATRFHRETLEK---QVFSLWRQKMFQHRENrlAERMAILHAErQLLYRSWFMWHQQAAARHQEQE 516
Cdd:pfam08457  447 LEQQADQLRQNRLLEdaiELFDRWRERTAKRKQR--AEDADQFYAE-QLLRSYLARWRERLRELRELEQ 512
 
Name Accession Description Interval E-value
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 328-786 3.51e-13

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 73.87  E-value: 3.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   328 LRRAFTHWKHYMllcAEEAAQFEMAEEHhrhsqLLLHRFWNLWRSQieqkkerellpllHAAWD--HYRIALlCKCIELW 405
Cdd:pfam08457   31 LTKAFTHWAQAA---SEEVERTSAARRH-----ILRKKYFNAWREI-------------TAVNElkAQRFAL-KRPLGAW 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   406 LQYTQKRRykqLLQARADGHFQQRALPAAFHTWnrlwRWRHQENvlsaRATRFHRETLEKQVFSLWRQKMfqhRENRLAE 485
Cdd:pfam08457   89 RRRTLQIR---VREEVAVQVYQENLLKRSFWKW----FWEFCER----RAPQWYDFRLKRRSLLTWLRKF---RTLRERE 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   486 RMAILHAERQLLYRSWFMWHQQAAARHQEQ-----------------EWQTVA---------CAHHRHGRLKKAFCLWRE 539
Cdd:pfam08457  155 QEAEAKRKRLLLSSALQIWSERTEAVQAAEqeadsfrrrkllrraldEWRIQArlepalrqvSAKVDRRILRSALSVWKL 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   540 SAQGLRtertgrvRAAEFHMAQLLRWAWSQWR---ECLALRG----------------AERQKLMRAdlHHQHSVLHRAL 600
Cdd:pfam08457  235 RARMSR-------QAREVDRARILRNAWTTWNdelRCKALREriderlklealykwvlEERLRLFQR--IREQRLKREVL 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   601 QAWVTyqgRVRSILREVAARESQH----NRQLLRGALRRWKENTMAR---------VDEAKKTFQASTHYR--------- 658
Cdd:pfam08457  306 STWVT---NTRDTRTRLLRHEEEFeehrNRKLLRSKLLKWRDQLAEQrereiaaneFYAPRLLQEALDAWRerhqhvqkl 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   659 ---------RTICSKVLVQWREAVSVQMYYRQQEDCA-IWEAQKV-LDRGCLRTWFQRwwdcSRRSAQQRLQLERAVQHH 727
Cdd:pfam08457  383 ekwardarfYFLATRTLKKWRAATEESRRERRQDAYAqVRRKVKInLARRALSKWRSK----AAEVADLEQQADQLRQNR 458

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   728 HRQLLLEGLARWKTHHLQCVRKrllHRQSTQLLAQRLSRTCFRQWRQQLAA-RRQEQRAT 786
Cdd:pfam08457  459 LLEDAIELFDRWRERTAKRKQR---AEDADQFYAEQLLRSYLARWRERLRElRELEQDAD 515
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 192-775 3.42e-08

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 57.69  E-value: 3.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   192 QRIILRVWWSTWRQRLGQVRVSRALhasALKHRALSLQVQAWSQWREQLLYVQKEKQKVVSAvkhhqhwqKRRFLKAWLE 271
Cdd:pfam08457   77 QRFALKRPLGAWRRRTLQIRVREEV---AVQVYQENLLKRSFWKWFWEFCERRAPQWYDFRL--------KRRSLLTWLR 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   272 YLqvrRVKRQQNEMAERFHHVTVLQIYFCDWQQaweRRESLYAHHAQVEKLARKMALRRAFTHWKHYMLLCAEEAAQFEM 351
Cdd:pfam08457  146 KF---RTLREREQEAEAKRKRLLLSSALQIWSE---RTEAVQAAEQEADSFRRRKLLRRALDEWRIQARLEPALRQVSAK 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   352 AEEHHRHSQLLLhrfWNLWRSQIEQKKERELLPLLHAAWDHYRIALLCKcielwlqytqkrrykqLLQARADghfqQRAL 431
Cdd:pfam08457  220 VDRRILRSALSV---WKLRARMSRQAREVDRARILRNAWTTWNDELRCK----------------ALRERID----ERLK 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   432 PAAFHTWnrlwrwrhqenVLSARA---TRFHRETLEKQVFSLWRQKMFQHRENRLAermailhaerqllyrswfmwHQQA 508
Cdd:pfam08457  277 LEALYKW-----------VLEERLrlfQRIREQRLKREVLSTWVTNTRDTRTRLLR--------------------HEEE 325

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   509 AARHQEQEwqtvacahhrhgRLKKAFCLWRESaqgLRTERTGRVRAAEFHMAQLLRWAWSQWREclalRGAERQKLMR-A 587
Cdd:pfam08457  326 FEEHRNRK------------LLRSKLLKWRDQ---LAEQREREIAANEFYAPRLLQEALDAWRE----RHQHVQKLEKwA 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   588 DLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQ--LLRGALRRWKENTMARVDEAKKTFQASTHYRRTICSKV 665
Cdd:pfam08457  387 RDARFYFLATRTLKKWRAATEESRRERRQDAYAQVRRKVKinLARRALSKWRSKAAEVADLEQQADQLRQNRLLEDAIEL 466

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   666 LVQWREAVSVQMyyRQQEDCAIWEAQKVLDRgCLRTWFQRWWDCsrrsaqqRLQLERAVQHHHRQLLLEGLARWKTHHLQ 745
Cdd:pfam08457  467 FDRWRERTAKRK--QRAEDADQFYAEQLLRS-YLARWRERLREL-------RELEQDADAYRREHTLGQAAAALRKWSLR 536

                          570       580       590
                   ....*....|....*....|....*....|...
gi 385251386   746 CVRKRLLHRQSTQLLAQ---RLSRTCFRQWRQQ 775
Cdd:pfam08457  537 LFQIRSREETADALRERnlrKHLRNMLRHWLQK 569
PHA03247 PHA03247
large tegument protein UL36; Provisional
 881-1074 7.91e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 7.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  881 GRGGKPQPLAAIAPSrkvtfegpllnriAAGAGDGTLETKRPQASRPLGAlgrlAAEEPHALELNTAHSARKQPRRPHFL 960
Cdd:PHA03247 2728 ARQASPALPAAPAPP-------------AVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVAS 2790

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  961 LEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTAstgpellllplssfmPCGA 1040
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---------------LGGS 2855

                         170       180       190
                  ....*....|....*....|....*....|....
gi 385251386 1041 AAPARVSAQRATPRDKPPVPSSLASVPDPHLLLP 1074
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARP 2889
PHA03247 PHA03247
large tegument protein UL36; Provisional
 921-1091 1.11e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  921 RPQASRPLGAlGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQ-SQRPQKPQEHGLGMAQPAAPSLTRPFLAE----- 994
Cdd:PHA03247 2632 SPAANEPDPH-PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQaSSPPQRPRRRAARPTVGSLTSLADPPPPPptpep 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  995 APTALVPHSPLP----------GALSSAPGPKQPPTASTGPELLLLPLSSFMPCGA------AAPARVSAQRATPRDKPP 1058
Cdd:PHA03247 2711 APHALVSATPLPpgpaaarqasPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPpapappAAPAAGPPRRLTRPAVAS 2790

                         170       180       190
                  ....*....|....*....|....*....|...
gi 385251386 1059 VPSSLASVPDPHLLLPGDFSATRAGPGLSTAGS 1091
Cdd:PHA03247 2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823
PHA03247 PHA03247
large tegument protein UL36; Provisional
 886-1117 1.62e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  886 PQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKRPQASRPLgalgrlAAEEPHALELntahsARKQPRRPH--FLLEP 963
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA------APARPPVRRL-----ARPAVSRSTesFALPP 2902

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  964 AQSQRPQKPQehglgmaqPAAPSLTRPfLAEAPTALVPHSPLPGAlssaPGPKQPPTASTGPELLLLPLSSFMPCGAAAP 1043
Cdd:PHA03247 2903 DQPERPPQPQ--------APPPPQPQP-QPPPPPQPQPPPPPPPR----PQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 385251386 1044 ARVSAQRA-TPRDKPPVPSSLASVPDPHlllpgdfsaTRAGPGLST-AGSLDLEAELEEIQQQLlhyqttKQNLWS 1117
Cdd:PHA03247 2970 GRVAVPRFrVPQPAPSREAPASSTPPLT---------GHSLSRVSSwASSLALHEETDPPPVSL------KQTLWP 3030
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 946-1169 3.82e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 3.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  946 TAHSARKQPRRPHFLLEPAQSQRPQKPQEH--GLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGAlSSAPGPKQPPTAST 1023
Cdd:PRK07764  598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPapAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA-SDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386 1024 GPELLLLPLSSFMPCGAAAPARvSAQRATPRDKPPVPSSLASVPDPhlllPGDfSATRAGPGLSTAGSLDLEAELEEIQQ 1103
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADDPAAQP----PQA-AQGASAPSPAADDPVPLPPEPDDPPD 750

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 385251386 1104 QLLHYQTTKQNLWSCRRQASSLR-RWLELNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQR 1169
Cdd:PRK07764  751 PAGAPAQPPPPPAPAPAAAPAAApPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGAKK 817
PHA03247 PHA03247
large tegument protein UL36; Provisional
 883-1070 3.95e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 3.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  883 GGKPQPLAAIAPSrkvtfegpllnriaaGAGDGTLETKRPqASRPLGAlgrlaaeephalelntahSARKQPRRPHFLLE 962
Cdd:PHA03247 2549 GDPPPPLPPAAPP---------------AAPDRSVPPPRP-APRPSEP------------------AVTSRARRPDAPPQ 2594

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  963 PAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPH--SPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMpcGA 1040
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAanEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRL--GR 2672

                         170       180       190
                  ....*....|....*....|....*....|
gi 385251386 1041 AAPARVSAQRATPRDKPPVPSSLASVPDPH 1070
Cdd:PHA03247 2673 AAQASSPPQRPRRRAARPTVGSLTSLADPP 2702
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
885-1069 1.02e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  885 KPQPLAAIAPSRKVTfegPLLNRIAAGAGDGTletkrpQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPA 964
Cdd:PRK07003  411 APKAAAAAAATRAEA---PPAAPAPPATADRG------DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA 481

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  965 QSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTAL-------VPHSPLPGALSSAPGPKQPPTASTGPELLL-------L 1030
Cdd:PRK07003  482 SDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAsredapaAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagM 561

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 385251386 1031 PLSSFMPCGAAAPARVSAQRATPrDKPPVPSSLASVPDP 1069
Cdd:PRK07003  562 RVSSDRGARAAAAAKPAAAPAAA-PKPAAPRVAVQVPTP 599
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
881-1094 1.12e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  881 GRGGKPQPLAAIAPSRKVTFEGPllnRIAAGAGDGTLETKRPQASRPLGALgRLAAEEPHALELNTAhsarkqprrphfl 960
Cdd:PRK07003  363 TGGGAPGGGVPARVAGAVPAPGA---RAAAAVGASAVPAVTAVTGAAGAAL-APKAAAAAAATRAEA------------- 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  961 lEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLP---GALSSAPGPKQPPTASTGPELLLLPLSSFMP 1037
Cdd:PRK07003  426 -PPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPpadSGSASAPASDAPPDAAFEPAPRAAAPSAATP 504

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 385251386 1038 CGAAAPARVSAQRATPRDKPP-VPSSLASVPDPhlllPGDFSATRAGpglSTAGSLDL 1094
Cdd:PRK07003  505 AAVPDARAPAAASREDAPAAAaPPAPEARPPTP----AAAAPAARAG---GAAAALDV 555
PHA03378 PHA03378
EBNA-3B; Provisional
 913-1088 1.43e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.68  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  913 GDGTLETKRPQASRPLGALGRLAAEEPHALELNTA---HSARKQPRR-PHFLLEPAQSQRPQKPqeHGLGMAQPAAPSLT 988
Cdd:PHA03378  607 EPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPItfnVLVFPTPHQpPQVEITPYKPTWTQIG--HIPYQPSPTGANTM 684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  989 RPFLAeAPTALVPHSPLPGALS---SAPGPKQPPTASTGPellllplssfMPCGAAAPARVSAQRATPRDKPPvPSSLAS 1065
Cdd:PHA03378  685 LPIQW-APGTMQPPPRAPTPMRppaAPPGRAQRPAAATGR----------ARPPAAAPGRARPPAAAPGRARP-PAAAPG 752

                         170       180
                  ....*....|....*....|...
gi 385251386 1066 VPDPHLLLPGDFSATRAGPGLST 1088
Cdd:PHA03378  753 RARPPAAAPGRARPPAAAPGAPT 775
PHA03247 PHA03247
large tegument protein UL36; Provisional
 885-1092 2.72e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  885 KPQPLAAIAPSRkVTFEGPLLNRIAAGAGDGTLETKRPQASRP-LGALGRLA---------AEEPHALELNTAHSARKQP 954
Cdd:PHA03247 2649 PERPRDDPAPGR-VSRPRRARRLGRAAQASSPPQRPRRRAARPtVGSLTSLAdpppppptpEPAPHALVSATPLPPGPAA 2727

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  955 RRPHFLLEPAQSQRPQKPQehglGMAQPAAPS--LTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPL 1032
Cdd:PHA03247 2728 ARQASPALPAAPAPPAVPA----GPATPGGPArpARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386 1033 SSFMPcgAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSatragPGLSTAGSL 1092
Cdd:PHA03247 2804 PADPP--AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP-----PSLPLGGSV 2856
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 865-1091 2.59e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.53  E-value: 2.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   865 HRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEgPLLNRIAAGAG--------DGTLETKRPQASRPLGALGRLA- 935
Cdd:pfam03154  228 HTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQ-PLPQPSLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSq 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   936 AEEPHALELNTAHSARKQPRRPhfllePAQSQ--RPQKPQEHGLgmaqPAAPsLTRPFLAEAPTALVPHSPLPGALS--- 1010
Cdd:pfam03154  307 SQVPPGPSPAAPGQSQQRIHTP-----PSQSQlqSQQPPREQPL----PPAP-LSMPHIKPPPTTPIPQLPNPQSHKhpp 376

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  1011 --SAPGPKQ---------------------PPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPR-DKPPVPSSLASV 1066
Cdd:pfam03154  377 hlSGPSPFQmnsnlppppalkplsslsthhPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPaASHPPTSGLHQV 456

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 385251386  1067 PD-----PHLLLPGD-----------FSATRAGPGLSTAGS 1091
Cdd:pfam03154  457 PSqspfpQHPFVPGGpppitppsgppTSTSSAMPGIQPPSS 497
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
891-1082 6.81e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 6.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  891 AIAPSRKVTFEGPLLNRIA---AGAGDGTleTKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQ 967
Cdd:PRK12323  344 ALAPDEYAGFTMTLLRMLAfrpGQSGGGA--GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAA 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  968 RPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAA------ 1041
Cdd:PRK12323  422 APARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppwee 501

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 385251386 1042 APARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRA 1082
Cdd:PRK12323  502 LPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLA 542
COG3899 COG3899
Predicted ATPase [General function prediction only];
395-921 1.18e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 43.31  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  395 IALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQK 474
Cdd:COG3899   725 LRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLLLG 804

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  475 MFQhRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVacahhrHGRLKKAFCLWRESAQGLRTERTGRVRA 554
Cdd:COG3899   805 DYE-EAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREA------LELLREALEAGLETGDAALALLALAAAA 877

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  555 AEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALR 634
Cdd:COG3899   878 AAAAAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELARLAAAAAAAAALALAAAAAAAAAAALAAAAAAAALAAA 957

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  635 RWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSA 714
Cdd:COG3899   958 LALAAAAAAAAAAALAAAAAAAAAAAAAAAAAALEAAAAALLALLAAAAAAAAAAAALAAALLAAALAALAAAAAAAALL 1037

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  715 QQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWA 794
Cdd:COG3899  1038 AAAAALALLAALAAAAAAAAAAAALAAAAALLAAAAAAAAAAAAAAAAAALAAALAAAALAAAAAAALALAAALAALALA 1117

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  795 FSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATL 874
Cdd:COG3899  1118 AALAALALAAAARAAAALLLLAAALALALAALLLLAALLLALALLLLALAALALAAALAALAAALLAAAAAAAAAAALLA 1197

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 385251386  875 WKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKR 921
Cdd:COG3899  1198 ALLALAARLAALLALALLALEAAALLLLLLLAALALAAALLALRLLA 1244
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
886-1107 3.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  886 PQPLAAIAPSRKVTfEGPLLNRIAAGAGDGTLETKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRrPHFLLEPAQ 965
Cdd:PRK12323  383 AQPAPAAAAPAAAA-PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-PAPAAAPAA 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  966 SQRPQKPQEHGLGMA--------QPAAPSltrpflAEAPTALVPHSPLPGALSSaPGPKQPPTASTGPEllllpLSSFMP 1037
Cdd:PRK12323  461 AARPAAAGPRPVAAAaaaaparaAPAAAP------APADDDPPPWEELPPEFAS-PAPAQPDAAPAGWV-----AESIPD 528

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 385251386 1038 CGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRAGPgLSTAGSLDLEAEL--EEIQQQLLH 1107
Cdd:PRK12323  529 PATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD-MFDGDWPALAARLpvRGLAQQLAR 599
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 78-516 3.71e-03

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 41.51  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386    78 TRQGRLRELRIRFYYEQRLLRKVFEEWKeewwvfqheWKLCVR-ADCHYRYYLYNLMFQTWKTYVRQQQEMRNKyirAEV 156
Cdd:pfam08457   92 TLQIRVREEVAVQVYQENLLKRSFWKWF---------WEFCERrAPQWYDFRLKRRSLLTWLRKFRTLREREQE---AEA 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   157 HDAKQKMRQAWKSWLIYVvvrRTKLQMQTTALEFRQRIILRVWWSTWRQrlgQVRVSRALHASALKHRAlSLQVQAWSQW 236
Cdd:pfam08457  160 KRKRLLLSSALQIWSERT---EAVQAAEQEADSFRRRKLLRRALDEWRI---QARLEPALRQVSAKVDR-RILRSALSVW 232

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   237 REQLLYVQKEKQKVVSAVKHH--QHWQKRRFLKAWLEYLQVRRVKRQQNE--MAERF------HHVTVLQIYFCDWQQAW 306
Cdd:pfam08457  233 KLRARMSRQAREVDRARILRNawTTWNDELRCKALRERIDERLKLEALYKwvLEERLrlfqriREQRLKREVLSTWVTNT 312

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   307 ERRESLYAHHAQVEKLARKMAL-RRAFTHWKHYMLLCAE-EAAQFEMaeehhrHSQLLLHRFWNLWRSQIEQKKEREllp 384
Cdd:pfam08457  313 RDTRTRLLRHEEEFEEHRNRKLlRSKLLKWRDQLAEQRErEIAANEF------YAPRLLQEALDAWRERHQHVQKLE--- 383

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   385 llHAAWDHYRIALLCKCIELWLQYTQK--------------RRYKQLLQARADGHFQQRALPAAfhtwnrlwrwrhqenV 450
Cdd:pfam08457  384 --KWARDARFYFLATRTLKKWRAATEEsrrerrqdayaqvrRKVKINLARRALSKWRSKAAEVA---------------D 446

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 385251386   451 LSARATRFHRETLEK---QVFSLWRQKMFQHRENrlAERMAILHAErQLLYRSWFMWHQQAAARHQEQE 516
Cdd:pfam08457  447 LEQQADQLRQNRLLEdaiELFDRWRERTAKRKQR--AEDADQFYAE-QLLRSYLARWRERLRELRELEQ 512
Sfi1 pfam08457
Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a ...
 96-659 4.19e-03

Sfi1 spindle body protein; This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins which are present in microtubule-organizing centres.


Pssm-ID: 430007 [Multi-domain]  Cd Length: 570  Bit Score: 41.13  E-value: 4.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386    96 LLRKVFEEWKEEwwvfqhewklcvradchyryylynlmfqtwktyvrqqqemrnkyiraevhdakqkmrqawkswliyVV 175
Cdd:pfam08457   57 LRKKYFNAWREI------------------------------------------------------------------TA 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   176 VRRTKLqmqttalefrQRIILRVWWSTWRQRLGQVRVSRALhasALKHRALSLQVQAWSQWREQLLYVQKEKQKVVSAvk 255
Cdd:pfam08457   71 VNELKA----------QRFALKRPLGAWRRRTLQIRVREEV---AVQVYQENLLKRSFWKWFWEFCERRAPQWYDFRL-- 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   256 hhqhwqKRRFLKAWLEYLqvrRVKRQQNEMAERFHHVTVLQIYFCDWQQaweRRESLYAHHAQVEKLARKMALRRAFTHW 335
Cdd:pfam08457  136 ------KRRSLLTWLRKF---RTLREREQEAEAKRKRLLLSSALQIWSE---RTEAVQAAEQEADSFRRRKLLRRALDEW 203

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   336 KHYMLLCAEEAAQFEMAEEHHRHSQLLLhrfWNLWRSQIEQKKERELLPLLHAAWDHYRIALLCKcieLWLQYTQKRR-- 413
Cdd:pfam08457  204 RIQARLEPALRQVSAKVDRRILRSALSV---WKLRARMSRQAREVDRARILRNAWTTWNDELRCK---ALRERIDERLkl 277

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   414 ---YKQLLQARA---DGHFQQRALPAAFHTW------NRLWRWRHQEnvlsaRATRFHRETLEKQVFSLWRQKMfqhREN 481
Cdd:pfam08457  278 ealYKWVLEERLrlfQRIREQRLKREVLSTWvtntrdTRTRLLRHEE-----EFEEHRNRKLLRSKLLKWRDQL---AEQ 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   482 RLAERMAILHAERQLLYRSWFMWHQQaaaRHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERtgrvRAAEFHMAQ 561
Cdd:pfam08457  350 REREIAANEFYAPRLLQEALDAWRER---HQHVQKLEKWARDARFYFLATRTLKKWRAATEESRRER----RQDAYAQVR 422

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386   562 ------LLRWAWSQWREclalRGAERQKLMR-ADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALR 634
Cdd:pfam08457  423 rkvkinLARRALSKWRS----KAAEVADLEQqADQLRQNRLLEDAIELFDRWRERTAKRKQRAEDADQFYAEQLLRSYLA 498

                          570       580
                   ....*....|....*....|....*
gi 385251386   635 RWkentMARVDEAKKTFQASTHYRR 659
Cdd:pfam08457  499 RW----RERLRELRELEQDADAYRR 519
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 930-1067 5.85e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  930 ALGRLAAEEPHALELNTAHSARKQPRRPHfLLEPAQSQRPQKpqehglgmAQPAAPSLTRPFLAEAPTALVPHSPlPGAL 1009
Cdd:PRK14951  357 VLLRLLAFKPAAAAEAAAPAEKKTPARPE-AAAPAAAPVAQA--------AAAPAPAAAPAAAASAPAAPPAAAP-PAPV 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385251386 1010 SSAPGPKQPPTASTGPELLLLPLSSFM---PCGAAAPARVSAQRATPRDKPPVPSSLASVP 1067
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAqaaPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 980-1092 7.43e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.47  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385251386  980 AQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPV 1059
Cdd:PRK14951  379 KTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPE 458

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 385251386 1060 PSSLA--SVPDPHLLLPGDFSATRAGPGLSTAGSL 1092
Cdd:PRK14951  459 TVAIPvrVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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