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Conserved domains on  [gi|374429542|ref|NP_001243404|]
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sperm microtubule associated protein 2-like [Homo sapiens]

Protein Classification

THEG domain-containing protein( domain architecture ID 10633003)

THEG domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 404-463 6.94e-15

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 68.77  E-value: 6.94e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 374429542  404 WPVSYATTHSKASPRIQELANPnkRAPVRIVYYDPDV-FKTKPAALKAQCSQRIWELSQPL 463
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKP--KEPHDIYEPDRPVeWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 369-426 2.32e-13

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 64.53  E-value: 2.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 374429542  369 PVPPAAMIAKPSPRTIALAKSKSVHQDYLPDRDAHWPVSYATTHSKASPRIQELANPN 426
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 210-277 3.51e-12

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 61.06  E-value: 3.51e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 374429542  210 PVSQGALKAQLTKRLENLAQPKEVSCHYVPNRaqyyhscgreSVIWEITPPALFRQPSKRIQRLSQPN 277
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----------PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 329-390 4.09e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 49.51  E-value: 4.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 374429542  329 KISLSTLSAIATPRIIELAHPRIKLEGLCYERqrseLPIRPVPPAAMIAKPSPRTIALAKSK 390
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 303-350 1.23e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 45.66  E-value: 1.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 374429542  303 PSPRILQLSVAKGTDPNYHPSKKMQTKISLSTLSAIATPRIIELAHPR 350
Cdd:pfam14912  12 ASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 175-231 1.48e-03

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


:

Pssm-ID: 464368  Cd Length: 59  Bit Score: 36.80  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 374429542  175 KCFSSRKRTPNLSKPKkqwgtPDRKLFWGNQDPIRPVSQGALKAQLTKRLENLAQPK 231
Cdd:pfam14912   8 LKAKASPRLKELAKPK-----EPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
 
Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 404-463 6.94e-15

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 68.77  E-value: 6.94e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 374429542  404 WPVSYATTHSKASPRIQELANPnkRAPVRIVYYDPDV-FKTKPAALKAQCSQRIWELSQPL 463
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKP--KEPHDIYEPDRPVeWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 369-426 2.32e-13

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 64.53  E-value: 2.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 374429542  369 PVPPAAMIAKPSPRTIALAKSKSVHQDYLPDRDAHWPVSYATTHSKASPRIQELANPN 426
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 210-277 3.51e-12

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 61.06  E-value: 3.51e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 374429542  210 PVSQGALKAQLTKRLENLAQPKEVSCHYVPNRaqyyhscgreSVIWEITPPALFRQPSKRIQRLSQPN 277
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----------PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 329-390 4.09e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 49.51  E-value: 4.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 374429542  329 KISLSTLSAIATPRIIELAHPRIKLEGLCYERqrseLPIRPVPPAAMIAKPSPRTIALAKSK 390
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 303-350 1.23e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 45.66  E-value: 1.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 374429542  303 PSPRILQLSVAKGTDPNYHPSKKMQTKISLSTLSAIATPRIIELAHPR 350
Cdd:pfam14912  12 ASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 175-231 1.48e-03

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 36.80  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 374429542  175 KCFSSRKRTPNLSKPKkqwgtPDRKLFWGNQDPIRPVSQGALKAQLTKRLENLAQPK 231
Cdd:pfam14912   8 LKAKASPRLKELAKPK-----EPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
 
Name Accession Description Interval E-value
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 404-463 6.94e-15

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 68.77  E-value: 6.94e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 374429542  404 WPVSYATTHSKASPRIQELANPnkRAPVRIVYYDPDV-FKTKPAALKAQCSQRIWELSQPL 463
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKP--KEPHDIYEPDRPVeWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 369-426 2.32e-13

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 64.53  E-value: 2.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 374429542  369 PVPPAAMIAKPSPRTIALAKSKSVHQDYLPDRDAHWPVSYATTHSKASPRIQELANPN 426
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 210-277 3.51e-12

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 61.06  E-value: 3.51e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 374429542  210 PVSQGALKAQLTKRLENLAQPKEVSCHYVPNRaqyyhscgreSVIWEITPPALFRQPSKRIQRLSQPN 277
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----------PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 329-390 4.09e-08

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 49.51  E-value: 4.09e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 374429542  329 KISLSTLSAIATPRIIELAHPRIKLEGLCYERqrseLPIRPVPPAAMIAKPSPRTIALAKSK 390
Cdd:pfam14912   2 PVSRAALKAKASPRLKELAKPKEPHDIYEPDR----PVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 303-350 1.23e-06

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 45.66  E-value: 1.23e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 374429542  303 PSPRILQLSVAKGTDPNYHPSKKMQTKISLSTLSAIATPRIIELAHPR 350
Cdd:pfam14912  12 ASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 255-314 1.19e-05

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 42.57  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 374429542  255 WEITPPALFRQPSKRIQRLSQPNGFKRQCLLNRPFSDNSARDSLRiSDPSPRILQLSVAK 314
Cdd:pfam14912   1 WPVSRAALKAKASPRLKELAKPKEPHDIYEPDRPVEWKVSPAALK-AKPSPRIEELAKPK 59
THEG pfam14912
Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG ...
 175-231 1.48e-03

Testicular haploid expressed repeat; This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions. Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice.


Pssm-ID: 464368  Cd Length: 59  Bit Score: 36.80  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 374429542  175 KCFSSRKRTPNLSKPKkqwgtPDRKLFWGNQDPIRPVSQGALKAQLTKRLENLAQPK 231
Cdd:pfam14912   8 LKAKASPRLKELAKPK-----EPHDIYEPDRPVEWKVSPAALKAKPSPRIEELAKPK 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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