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Conserved domains on  [gi|345091034|ref|NP_001230741|]
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voltage-dependent N-type calcium channel subunit alpha-1B isoform 2 [Homo sapiens]

Protein Classification

Ion_trans and Ca_chan_IQ domain-containing protein( domain architecture ID 13634006)

protein containing domains PRK12678, Ion_trans, GPHH, and Ca_chan_IQ

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1470-1719 1.65e-73

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 245.64  E-value: 1.65e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1470 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECVLKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1547
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1548 TDILVTEIaetNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1627
Cdd:pfam00520   81 ISLVLSSV---GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1628 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSnqacdeqanatECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1707
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVI 226

                          250
                   ....*....|..
gi 345091034  1708 MDNFEYLTRDSS 1719
Cdd:pfam00520  227 IDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 94-367 8.56e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.30  E-value: 8.56e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034    94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   250 HKacfpnstdaepvgdfpcgkeaparlcegdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 345091034   330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 481-720 9.11e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.71  E-value: 9.11e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   481 AQSFYWVVLCVVALNTLCVAMVHYNQP-RRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSV 558
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   559 FEVVWAAIkpGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 638
Cdd:pfam00520   81 ISLVLSSV--GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   639 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 716
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234


                   ....
gi 345091034   717 ELTK 720
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1150-1380 3.32e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 190.17  E-value: 3.32e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1150 RYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1229
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1230 ALVAFAFSGSKGkdINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFf 1309
Cdd:pfam00520   79 SLISLVLSSVGS--LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL- 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 345091034  1310 yctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1380
Cdd:pfam00520  156 ---------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1792-1869 5.28e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 145.81  E-value: 5.28e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 345091034  1792 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1869
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1728-1781 3.05e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 117.37  E-value: 3.05e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 345091034  1728 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1781
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PRK12678 super family cl36163
transcription termination factor Rho; Provisional
 831-988 2.26e-05

transcription termination factor Rho; Provisional


The actual alignment was detected with superfamily member PRK12678:

Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 49.52  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  831 GGKARPEAAEAPEGVDPPRRHHRHRdkdKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGP 910
Cdd:PRK12678   60 GGGAAAAAATPAAPAAAARRAARAA---AAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEA 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 345091034  911 GpeggrrhhRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPA 988
Cdd:PRK12678  137 A--------RRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRR 206
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 1901-2187 2.00e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 1901 QPAVLRGARVFLRQKSSTSLSNGGaiqnQESGikesvsWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSi 1980
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSES----SGCG------WGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS- 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 1981 TRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLcSTTPDRPPPSQASSHHHHHRchrrr 2060
Cdd:PHA03307  290 SPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP-GPSPSRSPSPSRPPPPADPS----- 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 2061 drkqRSLEKGPSLSADMDGAPSSAvgpglppgegptgcrrererrqergRSQERRQPSSSSSEKQRFYSCDRFGGREPPK 2140
Cdd:PHA03307  364 ----SPRKRPRPSRAPSSPAASAG-------------------------RPTRRRARAAVAGRARRRDATGRFPAGRPRP 414

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 345091034 2141 PKPSLSSHPTSPTAGQEPGphpqagsavgfpnttpccreTPSASPWP 2187
Cdd:PHA03307  415 SPLDAGAASGAFYARYPLL--------------------TPSGEPWP 441
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1470-1719 1.65e-73

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 245.64  E-value: 1.65e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1470 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECVLKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1547
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1548 TDILVTEIaetNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1627
Cdd:pfam00520   81 ISLVLSSV---GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1628 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSnqacdeqanatECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1707
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVI 226

                          250
                   ....*....|..
gi 345091034  1708 MDNFEYLTRDSS 1719
Cdd:pfam00520  227 IDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 94-367 8.56e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.30  E-value: 8.56e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034    94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   250 HKacfpnstdaepvgdfpcgkeaparlcegdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 345091034   330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 481-720 9.11e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.71  E-value: 9.11e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   481 AQSFYWVVLCVVALNTLCVAMVHYNQP-RRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSV 558
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   559 FEVVWAAIkpGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 638
Cdd:pfam00520   81 ISLVLSSV--GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   639 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 716
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234


                   ....
gi 345091034   717 ELTK 720
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1150-1380 3.32e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 190.17  E-value: 3.32e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1150 RYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1229
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1230 ALVAFAFSGSKGkdINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFf 1309
Cdd:pfam00520   79 SLISLVLSSVGS--LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL- 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 345091034  1310 yctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1380
Cdd:pfam00520  156 ---------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1792-1869 5.28e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 145.81  E-value: 5.28e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 345091034  1792 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1869
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1728-1781 3.05e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 117.37  E-value: 3.05e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 345091034  1728 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1781
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1847-1877 3.76e-11

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 59.54  E-value: 3.76e-11
                            10        20        30
                    ....*....|....*....|....*....|.
gi 345091034   1847 DEMTVGKVYAALMIFDFYKQNKTTRDQMQQA 1877
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 831-988 2.26e-05

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 49.52  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  831 GGKARPEAAEAPEGVDPPRRHHRHRdkdKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGP 910
Cdd:PRK12678   60 GGGAAAAAATPAAPAAAARRAARAA---AAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEA 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 345091034  911 GpeggrrhhRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPA 988
Cdd:PRK12678  137 A--------RRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRR 206
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1901-2187 2.00e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 1901 QPAVLRGARVFLRQKSSTSLSNGGaiqnQESGikesvsWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSi 1980
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSES----SGCG------WGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS- 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 1981 TRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLcSTTPDRPPPSQASSHHHHHRchrrr 2060
Cdd:PHA03307  290 SPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP-GPSPSRSPSPSRPPPPADPS----- 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 2061 drkqRSLEKGPSLSADMDGAPSSAvgpglppgegptgcrrererrqergRSQERRQPSSSSSEKQRFYSCDRFGGREPPK 2140
Cdd:PHA03307  364 ----SPRKRPRPSRAPSSPAASAG-------------------------RPTRRRARAAVAGRARRRDATGRFPAGRPRP 414

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 345091034 2141 PKPSLSSHPTSPTAGQEPGphpqagsavgfpnttpccreTPSASPWP 2187
Cdd:PHA03307  415 SPLDAGAASGAFYARYPLL--------------------TPSGEPWP 441
COG3903 COG3903
Predicted ATPase [General function prediction only];
769-991 8.37e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.54  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  769 EQRASQLRLQ----NLRASCEALYSEMDPEERLRFAT-------TRHLRPDMKTHLDRPLvvELGRDGARGPVGGKARPE 837
Cdd:COG3903   513 DQLAWLARLDaehdNLRAALRWALAHGDAELALRLAAalapfwfLRGLLREGRRWLERAL--AAAGEAAAALAAAAALAA 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  838 AAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEGGRR 917
Cdd:COG3903   591 AAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAA 670

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 345091034  918 HHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEA 991
Cdd:COG3903   671 AAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAAA 744
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1470-1719 1.65e-73

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 245.64  E-value: 1.65e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1470 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECVLKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1547
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1548 TDILVTEIaetNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD 1627
Cdd:pfam00520   81 ISLVLSSV---GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1628 DDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSnqacdeqanatECGSDFAYFYFVSFIFLCSFLMLNLFVAVI 1707
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVI 226

                          250
                   ....*....|..
gi 345091034  1708 MDNFEYLTRDSS 1719
Cdd:pfam00520  227 IDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 94-367 8.56e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.30  E-value: 8.56e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034    94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   250 HKacfpnstdaepvgdfpcgkeaparlcegdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 345091034   330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 481-720 9.11e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.71  E-value: 9.11e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   481 AQSFYWVVLCVVALNTLCVAMVHYNQP-RRLTTTLYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSV 558
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   559 FEVVWAAIkpGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 638
Cdd:pfam00520   81 ISLVLSSV--GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034   639 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 716
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234


                   ....
gi 345091034   717 ELTK 720
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1150-1380 3.32e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 190.17  E-value: 3.32e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1150 RYFEVVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1229
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1230 ALVAFAFSGSKGkdINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFf 1309
Cdd:pfam00520   79 SLISLVLSSVGS--LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL- 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 345091034  1310 yctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1380
Cdd:pfam00520  156 ---------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1792-1869 5.28e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 145.81  E-value: 5.28e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 345091034  1792 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1869
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1728-1781 3.05e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 117.37  E-value: 3.05e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 345091034  1728 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1781
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1847-1877 3.76e-11

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 59.54  E-value: 3.76e-11
                            10        20        30
                    ....*....|....*....|....*....|.
gi 345091034   1847 DEMTVGKVYAALMIFDFYKQNKTTRDQMQQA 1877
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1493-1712 4.61e-11

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 64.99  E-value: 4.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1493 YDAPYEYELMLkCLNI--VFTSMFSMECVLKIIAFGvLNYFRDAWNVFDFVTVLGSIT--------DILVTE-----IAE 1557
Cdd:pfam08016    2 YVTNRSLFILL-CEIVfvVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVlivlniyrDFLADRliksvEAS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1558 TNNFIN--------------LSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1623
Cdd:pfam08016   80 PVTFIDfdrvaqldnlyriiLAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGT 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  1624 ialdddtsinRHNNFRTFLQALMLLFRsatgeawheIMLSclsnqacDEQANATE-CGSDFAYFYFVSFIFLCSFLMLNL 1702
Cdd:pfam08016  160 ----------QAPNFSNFVKSILTLFR---------TILG-------DFGYNEIFsGNRVLGPLLFLTFVFLVIFILLNL 213

                          250
                   ....*....|
gi 345091034  1703 FVAVIMDNFE 1712
Cdd:pfam08016  214 FLAIINDSYV 223
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 831-988 2.26e-05

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 49.52  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  831 GGKARPEAAEAPEGVDPPRRHHRHRdkdKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGP 910
Cdd:PRK12678   60 GGGAAAAAATPAAPAAAARRAARAA---AAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEA 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 345091034  911 GpeggrrhhRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPA 988
Cdd:PRK12678  137 A--------RRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRR 206
PHA03169 PHA03169
hypothetical protein; Provisional
 820-984 2.39e-05

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 49.20  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  820 ELGRDGARGPVGGkARPEAAEAPEGVDPPRRhhrhRDKDKTPAAGDqdraeAPKAESGEPGARE-ERPRPHRSHSKEAAG 898
Cdd:PHA03169  154 SHNPSPNQQPSSF-LQPSHEDSPEEPEPPTS----EPEPDSPGPPQ-----SETPTSSPPPQSPpDEPGEPQSPTPQQAP 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  899 PPEARSERGrgpgpeggrrHHRRGSPEEAAEREPRRHRAHRHQ----DPSKECAGA-----KGERRARHRGgpRAgPREA 969
Cdd:PHA03169  224 SPNTQQAVE----------HEDEPTEPEREGPPFPGHRSHSYTvvgwKPSTRPGGVpklclRCTSHPSHRS--RL-PEGQ 290

                         170
                  ....*....|....*
gi 345091034  970 ESGEEPARRHRARHK 984
Cdd:PHA03169  291 QSEDKVPRKYQARRR 305
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 754-982 1.22e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 47.21  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  754 IAARQQNSAKARSVWEQRASQLRLQNLRASCEAlysemdpeERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGK 833
Cdd:PRK12678   55 IKEARGGGAAAAAATPAAPAAAARRAARAAAAA--------RQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQ 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  834 ARPEAAEAPEGVDPPRRHhRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPE 913
Cdd:PRK12678  127 ARERRERGEAARRGAARK-AGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDR 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 345091034  914 GgrrhhRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRAR 982
Cdd:PRK12678  206 R-----DRREQGDRREERGRRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDGEGRGGRRGRRFRDR 269
dnaA PRK14086
chromosomal replication initiator protein DnaA;
794-977 1.51e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 47.13  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  794 EERLRFATTRHLrpdmKTHLDRPLVVELGRDGARGPVGGKAR-PEAAEAPEGVDPPRR----HHRHRDKDKTPAAGDQD- 867
Cdd:PRK14086   63 EGRLAPIISETL----SRELGRPIRIAITVDPSAGEPAPPPPhARRTSEPELPRPGRRpyegYGGPRADDRPPGLPRQDq 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  868 RAEAPKA-----ESGEPGAReerPRPHRSHSKEA--AGPPEA---RSERGRGPGPEGGRRHHRRGSPEEAAEREPRrHRA 937
Cdd:PRK14086  139 LPTARPAypayqQRPEPGAW---PRAADDYGWQQqrLGFPPRapyASPASYAPEQERDREPYDAGRPEYDQRRRDY-DHP 214

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 345091034  938 HRHQDPSKecagakGERRARHRGGPRAGPREAESGEEPAR 977
Cdd:PRK14086  215 RPDWDRPR------RDRTDRPEPPPGAGHVHRGGPGPPER 248
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 823-989 1.98e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 46.44  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  823 RDGARGPVGGKARPEAAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEA 902
Cdd:PRK12678   83 AAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEARADAAE 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  903 RSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREA--ESGEEPARRHR 980
Cdd:PRK12678  163 RTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRrrRRDRRDARGDD 242


                  ....*....
gi 345091034  981 ARHKAQPAH 989
Cdd:PRK12678  243 NREDRGDRD 251
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 822-981 1.97e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  822 GRDGARGPVGGKARPEAAEAPEGVDP--PRRHHRHRDKDKTPAAGDQDRAEAPKAESGEP--GAREERPRPHRSHSKEAA 897
Cdd:PHA03307  228 AADDAGASSSDSSSSESSGCGWGPENecPLPRPAPITLPTRIWEASGWNGPSSRPGPASSssSPRERSPSPSPSSPGSGP 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  898 GPPEARSERGRGPGPEGGRRHHRRGSP---EEAAEREPRRHRAHRHQDPSKECAGAKgeRRARHRGGPRAGPREAESGEE 974
Cdd:PHA03307  308 APSSPRASSSSSSSRESSSSSTSSSSEssrGAAVSPGPSPSRSPSPSRPPPPADPSS--PRKRPRPSRAPSSPAASAGRP 385


                  ....*..
gi 345091034  975 PARRHRA 981
Cdd:PHA03307  386 TRRRARA 392
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1901-2187 2.00e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 1901 QPAVLRGARVFLRQKSSTSLSNGGaiqnQESGikesvsWGTQRTQDAPHEARPPLERGHSTEIPVGRSGALAVDVQMQSi 1980
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSES----SGCG------WGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS- 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 1981 TRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLcSTTPDRPPPSQASSHHHHHRchrrr 2060
Cdd:PHA03307  290 SPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSP-GPSPSRSPSPSRPPPPADPS----- 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034 2061 drkqRSLEKGPSLSADMDGAPSSAvgpglppgegptgcrrererrqergRSQERRQPSSSSSEKQRFYSCDRFGGREPPK 2140
Cdd:PHA03307  364 ----SPRKRPRPSRAPSSPAASAG-------------------------RPTRRRARAAVAGRARRRDATGRFPAGRPRP 414

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 345091034 2141 PKPSLSSHPTSPTAGQEPGphpqagsavgfpnttpccreTPSASPWP 2187
Cdd:PHA03307  415 SPLDAGAASGAFYARYPLL--------------------TPSGEPWP 441
COG3903 COG3903
Predicted ATPase [General function prediction only];
769-991 8.37e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.54  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  769 EQRASQLRLQ----NLRASCEALYSEMDPEERLRFAT-------TRHLRPDMKTHLDRPLvvELGRDGARGPVGGKARPE 837
Cdd:COG3903   513 DQLAWLARLDaehdNLRAALRWALAHGDAELALRLAAalapfwfLRGLLREGRRWLERAL--AAAGEAAAALAAAAALAA 590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345091034  838 AAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPPEARSERGRGPGPEGGRR 917
Cdd:COG3903   591 AAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAA 670

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 345091034  918 HHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKAQPAHEA 991
Cdd:COG3903   671 AAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAAA 744
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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