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Conserved domains on  [gi|339276005|ref|NP_001229837|]
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R-spondin-1 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 1.38e-52

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


:

Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 166.07  E-value: 1.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339276005   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 339276005  122 KGRCYPACPEGSSAANGTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 4.10e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 45.73  E-value: 4.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 339276005  148 CEMSEWSPWGPCSKKqqlCGfrRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 1.38e-52

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 166.07  E-value: 1.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339276005   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 339276005  122 KGRCYPACPEGSSAANGTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 4.10e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.73  E-value: 4.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 339276005  148 CEMSEWSPWGPCSKKqqlCGfrRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 100-142 1.23e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 39.04  E-value: 1.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 339276005 100 EHCEACFSH--NFCTKCKEGLYLHKGRCYPACPEGSSAANGTMEC 142
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVC 48
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 141-227 3.13e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339276005 141 ECSSPAQCemSEWSPWGPCSKKqqlCGfrRGSEERTRRVLHAPVGDH--AACsdtkETRRCTVRRVPCP----------E 208
Cdd:PTZ00441 233 EVERTASC--GPWDEWTPCSVT---CG--KGTHSRSRPILHEGCTTHmvEEC----EEEECPVEPEPLPvpapvpptpeD 301

                         90
                 ....*....|....*....
gi 339276005 209 GQKRRKGGQGRRENANRNL 227
Cdd:PTZ00441 302 DNPRPTDDEFAVPNFNEGL 320
FU smart00261
Furin-like repeats;
92-133 6.03e-03

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 34.02  E-value: 6.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 339276005    92 NKCIKCKiEHCEACFSH--NFCTKCKEGLYLHKGRCYPACPEGS 133
Cdd:smart00261   2 GECKPCH-PECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPGT 44
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 1.38e-52

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 166.07  E-value: 1.38e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339276005   42 KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLH 121
Cdd:pfam15913   2 SGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLH 81

                          90       100
                  ....*....|....*....|.
gi 339276005  122 KGRCYPACPEGSSAANGTMEC 142
Cdd:pfam15913  82 KGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 4.10e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.73  E-value: 4.10e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 339276005  148 CEMSEWSPWGPCSKKqqlCGfrRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRR 203
Cdd:pfam19028   1 CVVSEWSEWSECSVT---CG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 100-142 1.23e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 39.04  E-value: 1.23e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 339276005 100 EHCEACFSH--NFCTKCKEGLYLHKGRCYPACPEGSSAANGTMEC 142
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVC 48
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 141-227 3.13e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.87  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339276005 141 ECSSPAQCemSEWSPWGPCSKKqqlCGfrRGSEERTRRVLHAPVGDH--AACsdtkETRRCTVRRVPCP----------E 208
Cdd:PTZ00441 233 EVERTASC--GPWDEWTPCSVT---CG--KGTHSRSRPILHEGCTTHmvEEC----EEEECPVEPEPLPvpapvpptpeD 301

                         90
                 ....*....|....*....
gi 339276005 209 GQKRRKGGQGRRENANRNL 227
Cdd:PTZ00441 302 DNPRPTDDEFAVPNFNEGL 320
FU smart00261
Furin-like repeats;
92-133 6.03e-03

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 34.02  E-value: 6.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 339276005    92 NKCIKCKiEHCEACFSH--NFCTKCKEGLYLHKGRCYPACPEGS 133
Cdd:smart00261   2 GECKPCH-PECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPGT 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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