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Conserved domains on  [gi|310923189|ref|NP_001185617|]
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leptin receptor isoform 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 431-533 5.14e-43

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 151.34  E-value: 5.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  431 NINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHP--ISEPKDCYLQSDGFYECIFQPIFLLSG 508
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 310923189  509 YTMWIRINHSLGSLDSPPTCVLPDS 533
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 329-420 3.67e-20

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 85.76  E-value: 3.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  329 TTQDVIYFPPKIlTSVGSNVSFHCIYKK---ENKIVPSKEIVWWMNLaEKIPQSQYDVVSDHVSKVTFFNLNETKPrgkf 405
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 310923189  406 tydAVYCCNE-HECHH 420
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
ObR_Ig super family cl39908
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-233 4.20e-20

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


The actual alignment was detected with superfamily member pfam18589:

Pssm-ID: 465812  Cd Length: 105  Bit Score: 86.25  E-value: 4.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  126 NWNIQCWLKGDLKLFICYVESLFKNLFRNYnyKVHLLYVLPEV-LEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPtaK 204
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADS--KVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGPGFYECTIQPL--Y 76

                          90       100
                  ....*....|....*....|....*....
gi 310923189  205 LNDTLLMCLKITSGGVIFQSPLMSVQPIN 233
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPID 105
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-330 6.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 6.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189 237 PDPPLGLHMEITDDGNLKISWSSPPLVPFPLQ-YQVKYSENSTTVIREADK-IVSATSLLVDSILPGSSYEVQVRGKRLD 314
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|....*.
gi 310923189 315 GpgiWSDWSTPRVFTT 330
Cdd:cd00063   81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 741-820 1.93e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189   741 VQSLSAYPLNSSCVIVSWiLSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKY-YIHDHFIPIEKYQFSLYPIFMEGV 819
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSW-EPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGE 82


                   .
gi 310923189   820 G 820
Cdd:smart00060  83 G 83
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 431-533 5.14e-43

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 151.34  E-value: 5.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  431 NINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHP--ISEPKDCYLQSDGFYECIFQPIFLLSG 508
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 310923189  509 YTMWIRINHSLGSLDSPPTCVLPDS 533
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 329-420 3.67e-20

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 85.76  E-value: 3.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  329 TTQDVIYFPPKIlTSVGSNVSFHCIYKK---ENKIVPSKEIVWWMNLaEKIPQSQYDVVSDHVSKVTFFNLNETKPrgkf 405
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 310923189  406 tydAVYCCNE-HECHH 420
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-233 4.20e-20

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 86.25  E-value: 4.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  126 NWNIQCWLKGDLKLFICYVESLFKNLFRNYnyKVHLLYVLPEV-LEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPtaK 204
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADS--KVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGPGFYECTIQPL--Y 76

                          90       100
                  ....*....|....*....|....*....
gi 310923189  205 LNDTLLMCLKITSGGVIFQSPLMSVQPIN 233
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPID 105
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-330 6.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 6.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189 237 PDPPLGLHMEITDDGNLKISWSSPPLVPFPLQ-YQVKYSENSTTVIREADK-IVSATSLLVDSILPGSSYEVQVRGKRLD 314
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|....*.
gi 310923189 315 GpgiWSDWSTPRVFTT 330
Cdd:cd00063   81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-317 1.60e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189   237 PDPPLGLHMEITDDGNLKISWSSPP---LVPFPLQYQVKYSENSTTViREADKIVSATSLLVDSILPGSSYEVQVRGKRL 313
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 310923189   314 DGPG 317
Cdd:smart00060  80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
238-320 3.10e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  238 DPPLGLHMEITDDGNLKISWSSPPLVPFPLQ-YQVKYSE-NSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDG 315
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITgYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 310923189  316 PGIWS 320
Cdd:pfam00041  81 EGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
224-333 1.30e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189 224 SPLMSVQPiNMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFpLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSS 303
Cdd:COG3401  315 SNVVSVTT-DLTPPAAPSGLTATAVGSSSITLSWTASSDADV-TGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTT 392

                         90       100       110
                 ....*....|....*....|....*....|
gi 310923189 304 YEVQVRGKrlDGPGIWSDWSTPRVFTTQDV 333
Cdd:COG3401  393 YYYKVTAV--DAAGNESAPSEEVSATTASA 420
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 741-820 1.93e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189   741 VQSLSAYPLNSSCVIVSWiLSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKY-YIHDHFIPIEKYQFSLYPIFMEGV 819
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSW-EPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGE 82


                   .
gi 310923189   820 G 820
Cdd:smart00060  83 G 83
 
Name Accession Description Interval E-value
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 431-533 5.14e-43

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 151.34  E-value: 5.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  431 NINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHP--ISEPKDCYLQSDGFYECIFQPIFLLSG 508
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADSKVNLRYRRSELSCEDRSTSSLkgGSMVKECDCQGPGFYECTIQPLYLNST 80

                          90       100
                  ....*....|....*....|....*
gi 310923189  509 YTMWIRINHSLGSLDSPPTCVLPDS 533
Cdd:pfam18589  81 YIMWLEISHGLGPLQSPPMSVKPID 105
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 329-420 3.67e-20

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 85.76  E-value: 3.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  329 TTQDVIYFPPKIlTSVGSNVSFHCIYKK---ENKIVPSKEIVWWMNLaEKIPQSQYDVVSDHVSKVTFFNLNETKPrgkf 405
Cdd:pfam06328   1 EPCGHISPSPPV-VRLGSNVTASCILKEnccSHLGVEAQIIVWKLGL-ELIPGSQYTVLNDTVSSVTLPNLNSTRA---- 74

                          90
                  ....*....|....*.
gi 310923189  406 tydAVYCCNE-HECHH 420
Cdd:pfam06328  75 ---LLTCCLLwGGQLQ 87
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 126-233 4.20e-20

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 86.25  E-value: 4.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  126 NWNIQCWLKGDLKLFICYVESLFKNLFRNYnyKVHLLYVLPEV-LEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPtaK 204
Cdd:pfam18589   1 NWNISCETNGDLDLMTCRWNTTKWSLLADS--KVNLRYRRSELsCEDRSTSSLKGGSMVKECDCQGPGFYECTIQPL--Y 76

                          90       100
                  ....*....|....*....|....*....
gi 310923189  205 LNDTLLMCLKITSGGVIFQSPLMSVQPIN 233
Cdd:pfam18589  77 LNSTYIMWLEISHGLGPLQSPPMSVKPID 105
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-330 6.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 6.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189 237 PDPPLGLHMEITDDGNLKISWSSPPLVPFPLQ-YQVKYSENSTTVIREADK-IVSATSLLVDSILPGSSYEVQVRGKRLD 314
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|....*.
gi 310923189 315 GpgiWSDWSTPRVFTT 330
Cdd:cd00063   81 G---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-317 1.60e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189   237 PDPPLGLHMEITDDGNLKISWSSPP---LVPFPLQYQVKYSENSTTViREADKIVSATSLLVDSILPGSSYEVQVRGKRL 313
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                   ....
gi 310923189   314 DGPG 317
Cdd:smart00060  80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
238-320 3.10e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189  238 DPPLGLHMEITDDGNLKISWSSPPLVPFPLQ-YQVKYSE-NSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDG 315
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITgYEVEYRPkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 310923189  316 PGIWS 320
Cdd:pfam00041  81 EGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
224-333 1.30e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189 224 SPLMSVQPiNMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFpLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSS 303
Cdd:COG3401  315 SNVVSVTT-DLTPPAAPSGLTATAVGSSSITLSWTASSDADV-TGYNVYRSTSGGGTYTKIAETVTTTSYTDTGLTPGTT 392

                         90       100       110
                 ....*....|....*....|....*....|
gi 310923189 304 YEVQVRGKrlDGPGIWSDWSTPRVFTTQDV 333
Cdd:COG3401  393 YYYKVTAV--DAAGNESAPSEEVSATTASA 420
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 741-820 1.93e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923189   741 VQSLSAYPLNSSCVIVSWiLSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKY-YIHDHFIPIEKYQFSLYPIFMEGV 819
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSW-EPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGE 82


                   .
gi 310923189   820 G 820
Cdd:smart00060  83 G 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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